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Harnessing the power of bioprinting for the development of next-generation models of thrombosis

Bioactive Materials 2024年第12期42卷 328-344页

作者： Yanyan Liu Tao Huang Nicole Alexis Yap khoon lim Lining Arnold Ju School of Biomedical Engineering The University of SydneyDarlingtonNSW2008Australia Charles Perkins Centre The University of SydneyCamperdownNSW 2006Australia School of Medical Sciences The University of SydneyDarlingtonNSW 2008Australia The University of Sydney Nano Institute(Sydney Nano) The University of SydneyCamperdownNSW2006Australia Heart Research Institute CamperdownNewtownNSW 2042Australia

Thrombosis,a leading cause of cardiovascular morbidity and mortality,involves the formation of blood clots within blood *** animal models and in vitro systems have limitations in recapitulating the complex human vasculature and hemodynamic conditions,limiting the research in understanding the mechanisms of *** has emerged as a promising approach to construct biomimetic vascular models that closely mimic the structural and mechanical properties of native blood *** review discusses the key considerations for designing bioprinted vascular conduits for thrombosis studies,including the incorporation of key structural,biochemical and mechanical features,the selection of appropriate biomaterials and cell sources,and the challenges and future directions in the *** advancements in bioprinting techniques,such as multimaterial bioprinting and microfluidic integration,have enabled the development of physiologically relevant models of *** future of bioprinted models of thrombosis lies in the integration of patient-specific data,real-time monitoring technologies,and advanced microfluidic platforms,paving the way for personalized medicine and targeted *** the field of bioprinting continues to evolve,these advanced vascular models are expected to play an increasingly important role in unraveling the complexities of thrombosis and improving patient *** continued advancements in bioprinting technologies and the collaboration between researchers from various disciplines hold great promise for revolutionizing the field of thrombosis research.

关键词： Bioprinting Thrombosis Microfluidics Mechanobiology Platelets

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Locally Advanced Anaplastic Thyroid Carcinoma with Long-Term Survival of More Than 7 Years after Combined Surgery Including Tracheal Resection and Radiotherapy: Case Report

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第4期4卷 309-316页

作者： Weizhong Ernest Fu Ming Yann lim khoon Leong Chuah Li-Chung Mark Khoo Department of Otolaryngology Tan Tock Seng Hospital Singapore City Singapore Department of Pathology Tan Tock Seng Hospital Singapore City Singapore

Background: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies with a mean survival time of 6 months regardless of treatment. Aim: To present a case of locally advanced anaplastic thyroid carcinoma with long-term survival. A 10-year literature review of locally advanced ATC with long-term survival (more than 2 years) is also presented. Case presentation: We present a case of locally advanced anaplastic thyroid carcinoma (ATC) with tracheal invasion in a 67-year-old elderly Chinese man who was treated with radical surgery encompassing total thyroidectomy, neck dissection and tracheal resection followed by adjuvant radiotherapy. Long-term disease-free survival is more than 7 years to date. Conclusion: The prognosis of ATC remains poor as it is characterized by aggressive and extensive disease at presentation, the inability in most patients to perform radical enough surgery in order to achieve clear margins, high morbidity of complete extirpation and limited response to radiotherapy or chemotherapy. However, if complete surgical resection is possible, patients should be treated aggressively with a combination of surgery and adjuvant radiotherapy.

关键词： Anaplastic Thyroid Survival Trachea

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Weather Impact on Heat-Related Illness in a Tropical City State, Singapore

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Atmospheric and Climate Sciences 2018年第1期8卷 97-110页

作者： Hai-Yan Xu Xiuju Fu Chin Leong lim Stefan Ma Tian Kuay lim Paul Anantharajah Tambyah Mohd Salahuddin Habibullah Gary Kee khoon Lee Lee Ching Ng Kee Tai Goh Rick Siow Mong Goh Lionel Kim Hock Lee Institute of High Performance Computing Singapore Lee Kong Chian School of Medicine Nanyang Technological University Singapore Ministry of Health Singapore Urban Redevelopment Authority Singapore National University of Hospital Singapore Rolls-Royce Singapore Pte Ltd. Singapore National Environment Agency Singapore Saw Swee Hock School of Public Health National University of Singapore Singapore

In this article we propose a novel hurdle negative binomial (HNB) regression combined with a distributed lag nonlinear model (DLNM) to model weather factors’ impact on heat related illness (HRI) in Singapore. AIC criterion is adopted to help select proper combination of weather variables and check their lagged effect as well as nonlinear effect. The process of model selection and validation is demonstrated. It is observed that the predicted occurrence rate is close to the observed one. The proposed combined model can be used to predict HRI cases for mitigating HRI occurrences and provide inputs for related public health policy considering climate change impact.

关键词： Distributed Lag Nonlinear Model Heat-Related Illness Hurdle Model Negative Binomial distribution Weather Factors

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