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Review:Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform

Nano Research 2022年第3期15卷 2196-2225页

作者： Nawamin Sa-nguanmoo Katawut Namdee mattaka khongkow Uracha Ruktanonchai YongXiang Zhao Xing-Jie Liang CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology of ChinaBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Nanotechnology Center(NANOTEC) National Science and Technology Development AgencyPathum Thani 12120Thailand National Center for International Research of Biotargeting Theranostics Guangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumour Theranostics and TherapyGuangxi Medical UniversityNanning 530021China

Vaccination is the most effective way to prevent coronavirus disease 2019(COVID-19).Vaccine development approaches consist of viral vector vaccines,DNA vaccine,RNA vaccine,live attenuated virus,and recombinant proteins,which elicit a specific immune *** use of nanoparticles displaying antigen is one of the alternative approaches to conventional *** is due to the fact that nano-based vaccines are stable,able to target,form images,and offer an opportunity to enhance the immune *** diameters of ultrafine nanoparticles are in the range of 1–100 *** application of nanotechnology on vaccine design provides precise fabrication of nanomaterials with desirable properties and ability to eliminate undesirable *** be successful,nanomaterials must be uptaken into the cell,especially into the target and able to modulate cellular functions at the subcellular *** advantages of nano-based vaccines are the ability to protect a cargo such as RNA,DNA,protein,or synthesis substance and have enhanced stability in a broad range of pH,ambient temperatures,and humidity for long-term ***,nano-based vaccines can be engineered to overcome biological barriers such as nonspecific distribution in order to elicit functions in antigen presenting *** this review,we will summarize on the developing COVID-19 vaccine strategies and how the nanotechnology can enhance antigen presentation and strong immunogenicity using advanced technology in nanocarrier to deliver *** discussion about their safe,effective,and affordable vaccines to immunize against COVID-19 will be highlighted.

关键词： COVID-19 SARS-CoV-2 vaccine nanotechnology antigen presenting cells(APCs)

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Flavonoids kaempferide and 4,2’-dihydroxy-4’,5’,6’-trimethoxychalcone inhibit mitotic clonal expansion and induce apoptosis during the early phase of adipogenesis in 3T3-L1 cells

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Journal of Integrative Medicine 2019年第4期17卷 288-295页

作者： Supakanya Kumkarnjana Rutt Suttisri Ubonthip Nimmannit Apirada Sucontphunt mattaka khongkow Thongchai Koobkokkruad Nontima Vardhanabhuti Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmaceutical SciencesChulalongkorn University Nano-Cosmeceuticals Laboratory National Nanotechnology CenterNational Science and Technology Development Agency

Objective: Kaempferide and 4,2'-dihydroxy-4',5',6'-trimethoxychalcone (DTMC) are two major flavonoids found in Chromolaena odoraia Linn, leaf extract. The aim of this study was to elucidate the mechanism by which these two flavonoids exerted their effect on adipogenesis. The inhibitory effect of kaempferide and DTMC on adipocyte differentiation and their mechanisms involving mitotic clonal expansion (MCE) and apoptosis during the early stage of adipogenesis were investigated. Methods: Confluent 3T3-L1 preadipocytes were induced to differentiate and exposed to the flavonoids during various phases of difTerentiaiion. Intracellular lipid accumulation, cell density and expression of the transcription factors peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding pro-teins a were assessed using AdipoRed, Oil red 0 and Western blot assays. Effects of both flavonoids on cell proliferation and apoptosis were also determined by carboxyfluorescein diacetate succinimidyl ester and annexin V-fluorescein isothiocyanate/propidium iodide-staining assays, respectively. Results: Kaempferide and DTMC showed significant, concentration-dependent anti-adipogenic activity and effect on cell density in the early phase of adipogenesis. The expression of the transcription factors seemed to be reduced when the treatment was prolonged or in the early phase of adipogenesis. These flavonoids interrupted MCE via inhibition of preadipocyte proliferation and induction of apoptosis. DTMC was nearly three times more potent than kaempferide in inducing apoptosis. Conclusion: Kaempferide and DTMC exerted their anti-adipogenic activity through inhibition of MCE, either by suppressing cell proliferation or by inducing apoptosis during the early phase of differentiation.

关键词： Kaempferide 4,2'-Dihydroxy-4',5',6'-trimethoxychalcone Mitotic clonal expansion Apoptosis Anti-adipogenic 3T3-L1 adipocytes

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Cationic liposome of hen egg white lysozyme for enhanced its stability,activity and accessibility in gastro-intestinal tract

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Food Bioscience 2023年第3期53卷 704-714页

作者： mattaka khongkow Natchanon Rimsueb Angkana Jantimaporn Thitiphorn Janyaphisan Weerapong Woraprayote Wonnop Visessanguan Uracha Rungsardthong Ruktanonchai National Nanotechnology Center NANOTEC National Science and Technology Development Agency NSTDAPathum Thani12120Thailand National Center for Genetic Engineering and Biotechnology BIOTEC National Science and Technology Development Agency NSTDAPathum Thani12120Thailand

Hen egg white lysozyme(HEWL)is a food-derived antimicrobial protein,exhibiting bacteriolytic activity against several bacteria including foodborne enteric *** has been approved for using in food,pharmacological and therapeutic ***,using HEWL through the ingestion is still a challenge due to its poor stability and low bioavailability in the gastro-intestinal tract(GIT).Herein,liposomes incorporating with dimethyl dioctadecyl ammonium bromide(DDAB)were fabricated to encapsulate HEWL(Lip_HEWL_DDAB)for oral ***_HEWL_DDAB was spherical with an average diameter of 162.7±1.6 nm and zeta potential of 37.1±4.3 *** Lip_HEWL_DDAB had high entrapment efficiency of 80%and 11%loading efficiency of *** formulated Lip_HEWL_DDAB were highly physicochemical stable in both simulated gastric fluid(SGF)and simulated intestinal fluid(SIF)and capable of enhancing the intestinal absorption via their mucoadhesive property while retaining antimicrobial activity against enteric *** was released from Lip_HEWL_DDAB via diffusion mechanism at higher extent than those without the ***,the prepared Lip_HEWL_DDAB was non-toxic at below 6.25μg/ml to intestinal cells and was able to deliver HEWL across an in vitro intestinal epithelium model,resulting in enhanced anti-microbial/anti-inflammatory activities,compared to their free-and unmodified-liposomal ***,our modified cationic liposome is a new and promising strategy for improving oral delivery of HEWL with enhanced nutraceutical functions.

关键词： Cationic liposome Lysozyme Oral delivery Dimethyl dioctadecyl ammonium bromide(DDAB) Liposome

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Vesicular carriers containing phenylethyl resorcinol for topical delivery system; liposomes, transfersomes and invasomes

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Asian Journal of Pharmaceutical Sciences 2018年第5期13卷 472-484页

作者： Thanaporn Amnuaikit Tunyaluk Limsuwan Pasarat khongkow Prapaporna Boonme Department of Pharmaceutical Technology Faculty of Pharmaceutical Sciences Prince of Songkla University Institute of Biomedical Engineering Faculty of Medicine Prince of Songkla University Nanotec-PSU Center of Excellence on Drug Delivery System

Topical administration of phenylethyl resorcinol(PR) has attracted much attention as skin lightening agent with potent anti-tyrosinase activity. Two novel types of elastic carriers were developed to overcome the limitation of PR as topical delivery by increasing the solubility, stability and decreasing skin irritation compared to conventional liposomes. In addition, it also promotes skin penetration of PR to reach deep skin layer at the target site. The lead formulations were obtained from the invasomes containing 1%(w/v) d-limonene mixed with 10%(v/v) absolute ethanol as the skin enhancer, and transfersomes containing 15%(w/w) sodium deoxycholate(SDC) as edge activator. All formulations gave a vesicle size 50%, and good stability on storage at 30 °C at 75% RH for 4 months. Transfersomes have a lower degree of deformability(6.63%) than invasomes(25.26%). In contrast, the liposomes as rigid vesicles do not show a deformable property. This characteristic affects the skin permeation, and thus, transfersomes with high elastic property provided a significantly higher cumulative amount, steady state flux( J ss) and permeability coefficient( K p) compared to other formulations. However, in vitro PR accumulation in full-thickness newborn pig skin demonstrated that the application of elastic carrier formulations gave significantly higher accumulation than liposomes, and gave anti-tyrosinase activity up to 80%. These results are straightforwardly related to the results of cellular level study. Transfersomes and invasomes showed higher tyrosinase inhibition activity and melanin content reduction when compared to liposomes in B16 melanoma cells. In addition, acute irritation test in rabbits confirmed that these formulations are safe for skin application. Therefore, elastic vesicle carriers have theefficiency to deliver PR into the deep skin in both quantity and effectiveness which are better

关键词： Phenylethyl resorcinol Transfersomes Invasomes Tyrosinase inhibition

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