检索结果-南通市图书馆

Sensitivity analysis of chronic hepatitis C virus infection with immune response and cell proliferation

International Journal of Biomathematics 2020年第3期13卷 55-78页

作者： khondoker nazmoon nabi Chandra NPoddert Department of Mathematics Bangladesh University of Engineering and Technology(BUET)Dhaka 1000 Bangladesh Department of Mathematics University of Dhaka Dhaka 1000Bangladesh

A new mathematical model of chronic hepatitis C virus(HCV)infection incorporating humoral and cell-mediated immune responscs,distinct cell proliferation rates for both uninfected and infected hepatocytes,and antiviral treatment all at once,is formulated and analyzed *** of the model elucidates the existence of multiple equilibrium ***,the model has a locally asymptotically stable disease-free equilibrium(DFE)whenever the basic reproduction number is less than *** sensitivity analysis(***)result exhibits that the most influential(negatively sensitive)parameters on the epidemic threshold are the drug efficacy of blocking virus production and the drug efficacy of removing ***,LSA does not accurately assess uncertainty and scnsitivity in the system and may mislead us since by default this technique holds all other parameters fixed at baseline *** overcome this pitfall,one of the most robust and efficient global sensitivity analysis(GSA)methods,which is Latin hypercube sampling-partial rank correlation coefficient technique,elucidates that the proliferation rate of infected hepatocytes and the drug efficacy of killing infected hep-atocytes are highly sensitive parameters that affect the transmission dynamics of HCV in any *** study suggests that cell proliferation of the infected hepatocytes can be very crucial in controlling disease ***,a future HCV drug that boosts cell-mediated immune response is expected to be quite effective in controlling disease outbreak.

关键词： Chronic hepatitis immune response cell proliferation sensitivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：