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Prevalence and clinical significance of antiphospholipid antibodies among hospitalized COVID-19 patients

Asian Pacific Journal of Tropical Medicine 2021年第8期14卷 350-355页

作者： Cesarius Singgih Wahono Hani Susianti Tri Wahyudi Iman Dantara Perdana Aditya Rahman Mirza Zaka Pratama Indah Adhita Wulanda khoirunisah dwi hartanti Elvira Sari Dewi Kusworini Handono Rheumatology and Immunology Division Department of Internal MedicineFaculty of MedicineUniversity of BrawijayaIndonesia Department of Clinical Pathology Faculty of MedicineUniversity of BrawijayaIndonesia Basic Nursing Department Faculty of MedicineUniversity of BrawijayaIndonesia

Objective:To describe the prevalence of antiphospholipid antibodies in coronavirus disease-19(COVID-19)and to find potential associations between antiphospholipid antibody positivity and clinical ***:From September to November 2020,clinical and laboratory data were collected from 50 COVID-19 patients hospitalized at Saiful Anwar General Hospital in Malang,*** antibodies were measured by finding Ig M anti-β2 glycoprotein,lupus anticoagulant,and Ig M/Ig G *** characteristics,thrombotic events,ICU admission,and mortality during hospitalization were *** severity was defined by the Guidelines for the Prevention and Control of COVID-19,***:Among 50 patients,5 patients(10.0%)were positive for antiphospholipid antibodies:4 patients(80.0%)had Ig M anti-β2 glycoprotein and 1 patient had Ig G anti-cardiolipin(20.0%)and Ig M anti-cardiolipin(20.0%),none of lupus anticoagulant was *** antibodies were associated with anosmia(OR 8.1;95%CI 1.1-57.9;P=0.018),nausea and vomiting(OR 12.4;95%CI 1.2-122.6;P=0.010),diarrhea(OR 9.8;95%CI 1.3-70.9;P=0.010),cardiovascular disease(OR 1.4;95%CI 1.0-1.9;P=0.001),chronic kidney disease(OR 12.0;95%CI 1.6-90.1;P=0.05),acute coronary syndrome(OR 29.3;95%CI 2.0-423.7;P=0.001),moderate(OR 0.11;95%CI 0.01-1.10;P=0.031)and severe(OR 18.5;95%CI 1.8-188.4;P=0.002)disease severity,and in-hospital mortality(OR 8.1;95%CI 1.1-57.9;P=0.018).However,there is no correlation between the presence of antiphospholipid antibody and ICU ***:In summary,the prevalence of antiphospholipid antibodies in COVID-19 patients is low,mainly against Ig M anticardiolipin,and is associated with an acute coronary syndrome,gastrointestinal manifestations,moderate and severe disease severity,and increased risk of mortality.

关键词： Antiphospholipid antibodies COVID-19 COVID-19 disease severity Mortality

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