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TheArabidopsis RING Domain Protein BOI Inhibits Flowering via CO-dependent and CO-independent Mechanisms

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Molecular Plant 2015年第12期8卷 1725-1736页

作者： khoa Thi nguyen Jeongmoo Park Eunae Park Ilha Lee Giltsu Choi Department of Biologicar Sciences KAIST Daejeon 305-701 Korea School of Biological Sciences Seoul National University Seou1151-747 Korea These authors contributed equally to this article.

BOTRYTIS SUSCEPTIBLE1 INTERACTOR （BOI） and its three homologs （BOIs） are RING domain-containing proteins that repress flowering. Here, we investigated how BOIs repress flowering. Genetic analysis of the boiQ quadruple mutant indicates that BOIs repress flowering mainly through FLOWERING LOCUS T （FT）. BOIs repress the expression of FT by CONSTANS （CO）-dependent and -independent mechanisms： in the CO-dependent mechanism, BOIs bind to CO, inhibit the targeting of CO to the FT locus, and thus repress the expression of FT; in the CO-independent mechanism, BOIs target the FT locus via a mechanism that requires DELLAs but not CO. This dual repression of FT makes BOIs strong repressors of flowering in both CO-dependent and CO-independent pathways in Arabidopsis thaliana. Our finding that BOIs inhibit CO targeting further suggests that, in addition to modulating CO mRNA expression and CO protein stability, flowering regulation can also modulate the targeting of CO to FT.

关键词： CO BOI DELLA flowering DNA binding

Minimizing Warpage for Macro-Size Fused Deposition Modeling Parts

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Computers, Materials & Continua 2021年第9期68卷 2913-2923页

作者： Thanh Thuong Huynh Tien V.T.nguyen Quoc Manh nguyen Trieu khoa nguyen Department of Mechanical Engineering Can Tho UniversityCampus IICan ThoVietnam Faculty of Mechanical Technology Industrial University of Ho Chi Minh CityHo Chi Minh70000Vietnam Mechanical Engineering Department National Kaohsiung University of Science and TechnologyKaohsiung80778Taiwan Faculty of Mechanical Engineering Hung Yen University of Technology and EducationHung Yen16000Vietnam

In this study,we investigated warpage and corner lifting minimization for three-dimensional printed parts generated by macro-size fused deposition modeling(FDM).First,the reasons for warpage were theoretically *** approach revealed that the thermal deformation and differential volumetric shrinkage of the extruded molten plastic resulted in warpage of FDM *** addition,low adhesion between the deposited model and the heated or non-heated printing bed may intensify warpage *** a next step,initial small-size and medium-size models were used to identify parameters to manage and minimize warpage in a way that would reduce material consumption and running ***,a macro-size model was built to experimentally investigate and verify the technical solutions to minimize the warpage of FDM *** conclusion,an improved part with reduced warpage was efficiently produced after detailed consideration of thermal effects and adhesion *** exists to widen the application scope of FDM technology in manufacturing for processes like thermoforming that involve mold core fabrication with *** technology,which has applications not only in mechanical engineering but also in related engineering fields,is convenient and could readily be applied to practical manufacturing industries.

关键词： Fused deposition modeling corner lifting volumetric shrinkage thermal deformation acrylonitrile butadiene styrene filament

The first-line management of psychogenic non-epileptic seizures(PNES)in adults in the emergency:a practical approach

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Acta Epileptologica 2020年第1期2卷 48-58页

作者： Dènahin Hinnoutondji Toffa Laurence Poirier Dang khoa nguyen Neurosciences Division Centre de Recherche du Centre Hospitalier de l’Universitéde Montréal900 Rue Saint-DenisMontreal(QC)H2X 0A9Canada. Neurology Department Centre Hospitalier de l’Universitéde MontréalMontrealQuebecCanada. Faculty of Medicine McGill UniversityMontrealCanada.

Distinguishing non-epileptic events,especially psychogenic non-epileptic seizures(PNES),from epileptic seizures(ES)constitutes a diagnostic *** are frequent,especially when video-EEG recording,the gold-standard for PNES confirmation,cannot be *** issue is further complicated in cases of combined PNES with *** emergency units,a misdiagnosis can lead to extreme antiepileptic drug escalade,unnecessary resuscitation measures(intubation,catheterization,etc.),as well as needless biologic and imaging *** of the acute window,an incorrect diagnosis can lead to prolonged hospitalization or increase of unhelpful antiepileptic drug *** recognition is thus desirable to initiate adequate treatment and improve *** experience-based strategies and a thorough review of the literature,we aimed to present the main clinical clues for physicians facing PNES in non-specialized units,before management is transferred to epileptologists and *** such conditions,patient recall or witness-report provide the first orientation for the diagnosis,recognizing that collected information may be *** analysis of an event(live or based on home-video)may lead to a clinical diagnosis of PNES with a high confidence ***,a fluctuating course,crying with gestures of frustration,pelvic thrusting,eye closure during the episode,and the absence of postictal confusion and/or amnesia are highly suggestive of ***,induction and/or inhibition tests of PNES have a good diagnostic value when *** may also be a useful biomarker to distinguish PNES from epileptic seizures,especially following bilateral tonic-clonic ***,regardless the level of certainty in the diagnosis of the PNES,it is important to subsequently refer the patient for epileptological and neuropsychiatric follow-up.

关键词： Psychogenic non-epileptic seizures(PNES) Epilepsy Emergency Pseudostatus Prolactin dosage Homemade video

Influence of different land-use types on selected soil properties related to soil fertility in A Luoi District,Thua Thien Hue,Vietnam

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Soil Ecology Letters 2024年第1期6卷 131-140页

作者： khoa Phuc nguyen Tan Trong Tran Huy Dinh Le Phuong Thuy nguyen Hien Thao Thi Pham Dien Thanh nguyen Ngu Huu nguyen University of Agriculture and Forestry Hue UniversityHue CityThua Thien Hue 52000Vietnam School of Biotechnology Tan Tao UniversityTan Duc ECityDuc HoaLong An850000Vietnam

Land use type affects the physicochemical properties of *** value of OM and TN is high in acacia *** acidity of soil is considered a serious constraint for *** cash crops are acacia,cassava,banana,rice and *** fertility is affected by land-use types and land management,which exacerbates soil erosion and various other forms of soil degradation in the mountainous regions of *** study was conducted in A Luoi District,Thua Thien Hue,Vietnam to identify the effects of land-use types on specific soil physicochemical characteristics related to soil *** physicochemical properties,such as organic matter(OM),total nitrogen(TN),total phosphorous(TP),and K+were significantly affected by land-use *** results showed that the soils were sandy in rice but clay loam for acacia and *** mean bulk density value of acacia soil was significantly greater than that of other *** were higher in the acacia soils than those in the rice,maize,and banana *** OM content was significantly higher in the acacia,cassava,and banana soils than those in the rice and maize *** mean of exchangeable K+in the rice soil was higher compared to those in other soils and was affected by land-use *** high exchangeable acidity content in the soils was probably due to intensive ***,both land use type and management did not affect the CEC ***,the inappropriate land use caused the disturbance of soil physicochemical properties,indicating that the conditions of rice and maize soils are becoming worse than acacia ***,lowering the intensity of cultivation,adopting incorporated soil fertility management,and applying organic fertilizer should preserve the existing conditions and enhance soil properties.

关键词： Land-use types soil characteristics soil frility suitable crop Vietnam

GD2+ cancer stem cells in triple-negative breast cancer:mechanisms of resistance to breast cancer therapies

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Cancer Drug Resistance 2022年第3期5卷 721-726页

作者： khoa nguyen Emily McConnell Orielle Edwards Bridgette M.Collins-Burow Matthew E.Burow Department of Medicine Tulane University School of MedicineNew OrleansLA 70112USA

Research has led to the development of tailored treatment options for different cancers in different *** some treatments being able to provide remarkable responses,nearly all current treatments encounter the same issue:***,we discuss our experiences with how breast cancers resist *** focus of our discussion revolves around the cancer stem cell subpopulation and their mechanisms for resistance.

关键词： Drug resistance breast cancer therapy triple-negative breast cancer cancer stem cells

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非均匀杂波背景下雷达恒虚警检测技术研究

非均匀杂波背景下雷达恒虚警检测技术研究

作者： nguyen khoa SANG 南京理工大学

学位级别：硕士

雷达信号的恒虚警率(Constant False Alarm Rate, CFAR)处理技术是现代雷达信号处理的重要研究内容之一,在雷达目标自动检测中占有不可或缺的重要地位。CFAR处理技术的理论研究虽然已取得丰硕成果但现有的经典恒虚警检测算法一般难以在... 详细信息

雷达信号的恒虚警率(Constant False Alarm Rate, CFAR)处理技术是现代雷达信号处理的重要研究内容之一,在雷达目标自动检测中占有不可或缺的重要地位。CFAR处理技术的理论研究虽然已取得丰硕成果但现有的经典恒虚警检测算法一般难以在不同环境中得到了性能的平衡,而大多恒虚警检测器都面对在非均匀杂波环境下的杂波边缘和多干扰目标环境中检测性能下降的问题。本文在分析了几种典型杂波模型的基础上,针对非均匀杂波背景下的雷达恒虚警检测技术进行了研究。论文的主要工作如下：1)在讨论了瑞利分布、对数正态分布及韦布尔分布等经典杂波分布模型的基础上,以韦布尔分布杂波为例,采用零记忆非线性变换(ZMNL)方法进行了非相干及相关杂波模拟仿真,为后续研究工作奠定基础。2)分析了传统的均值(ML, Mean Level)类和有序统计量(OS, Order Statistics)类的CFAR检测器,仿真比较了其在均匀杂波背景、多干扰目标杂波背景及存在杂波边缘背景下的性能,为后续CFAR检测器的设计讨论提供了性能评估依据。3)针对存在杂波边缘的非均匀杂波背景下,仿真分析了MLC-CFAR、Ⅵ-CFAR等CFAR检测算法,针对Ⅵ-CFAR在杂波边缘漏警概率增大和在多干扰目标环境检测性能下降的缺点,提出了一种多策略CFAR检测器(ACSVI-CFAR)。仿真分析表明ACSVI-CFAR检测器既改善了Ⅵ-CFAR在均匀背景的恒虚警损失及杂波边缘环境下的虚警概率控制能力,同时具有S-CFAR检测器在多干扰目标背景下的优异性能4)针对未知数目的多干扰目标杂波背景环境,在研究了排序数据方差(ODV)删除算法的基础上,仿真分析了基于排序数据方差的自适应删除最大似然恒虚警(ACMLH-CFAR)检测器,针对ACMLH-CFAR检测器在杂波边缘背景检测性能的不足,采用Ⅵ-CFAR算法的均值比对其进行改进,仿真结果表明,改进后的ACMLH-CFAR在杂波边缘性能得到了改善。

关键词：非均匀杂波杂波边缘多干扰目标恒虚警率 ACSVI-CFAR ODV ACMLH-CFAR

DYNAMICS OF GEAR SYSTEMS WITH DIFFERENT SPACING ERRORS AND TOOTH PROFILE MODIFICATIONS

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DYNAMICS OF GEAR SYSTEMS WITH DIFFERENT SPACING ERRORS AND T...

The Second International Conference on Dynamics Vibration and Control

作者： khoa nguyen Hsiang H.Lin Department of Mechanical Engineering The University of Memphis Memphis TN 38152 USA Department of Mechanical Engineering The University of Memphis Memphis TN 38152 USA

＜正＞This paper investigated the effectiveness of tooth profile modification for reducing dynamic loads in gears with different tooth spacing errors. The study examined the varying amplitudes and shapes of spacing error in the span of teeth over which the error occurs. The modification considered included both linear and parabolic tip relief. The analysis considered spacing error that varies around the entire

关键词： gear dynamics dynamic loads spacing error tooth profile modification

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孔子思想对越南阮朝早期皇帝道德规范的影响

文化学刊 2018年第1期 140-141页

作者： nguyen khoa HUY 湖南师范大学公共管理学院

孔子不仅是一位哲学家,还是一位伟大的政治家,孔子思想在越南的传播与发展经历了几个阶段。阮朝建国以后,早期皇帝对孔子思想很重视,促使孔子思想对越南阮朝早期的各方面都产生了深远影响,尤其是在皇帝道德规范方面。本文主要从尊天重... 详细信息

孔子不仅是一位哲学家,还是一位伟大的政治家,孔子思想在越南的传播与发展经历了几个阶段。阮朝建国以后,早期皇帝对孔子思想很重视,促使孔子思想对越南阮朝早期的各方面都产生了深远影响,尤其是在皇帝道德规范方面。本文主要从尊天重道、以民为本、视臣如手足三方面具体探讨孔子思想对越南阮朝早期皇帝道德规范的影响。

关键词：孔子思想道德规范越南阮朝影响

孔子思想对越南阮朝早期教育的影响(从1802年至1858年)

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文化学刊 2017年第1期 120-121页

作者： nguyen khoa HUY 湖南师范大学公共管理学院

孔子是中国古代伟大的思想家、教育家。孔子思想影响了世界上的很多国家,尤其是对越南阮朝早期教育产生了深刻影响。研究孔子思想对越南阮朝早期教育的影响具有深刻的理论意义与实践价值。本文主要从教育目的、教育对象、教育内容与教... 详细信息

孔子是中国古代伟大的思想家、教育家。孔子思想影响了世界上的很多国家,尤其是对越南阮朝早期教育产生了深刻影响。研究孔子思想对越南阮朝早期教育的影响具有深刻的理论意义与实践价值。本文主要从教育目的、教育对象、教育内容与教育方法四方面研究孔子思想对越南阮朝早期教育的影响。

关键词：孔子思想越南教育阮朝教育目的教育对象教育内容