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Different expression patterns of duplicated phanTASTICA-like genes in Lotus japonicus suggest their divergent functions during compound leaf development

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Cell Research 2005年第8期15卷 665-677页

作者： Jiang hong LUO1, Jun YAN1, Lin WENG1, Jun YANG1, Zhong ZHAO3, Jiang Hua CHEN1, Xiao He HU1, Da LUO1,2,* 1National Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Bio- logical Sciences, and Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China 2School of Life Science and Biotechnology, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China 3Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai 200433, China National Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences and Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences Shanghai China Department of Biochemistry School of Life Sciences Fudan University Shanghai China School of Life Science and Biotechnology Shanghai Jiao Tong University Shanghai China

Recent studies on leaf development demonstrate that the mechanism on the adaxial-abaxial polarity pattern formation could be well conserved among the far-related species, in which phanTASTICA (PAHN)-like genes play important roles. In this study, we explored the conservation and diversity on functions of phan-like genes during the compound leaf development in Lotus japonicus, a papilionoid legume. Two phan-like genes in L. japonicus, Ljphana and Ljphanb, were found to originate from a gene duplication event and displayed different expression patterns during compound leaf development. Two mutants, reduced leaflets1 (rel1) and reduced leaflets3 (rel3), which exhibited decreased adaxial identity of leaflets and reduced leaflet initiation, were identified and investigated. The expression patterns of both Ljphans in rel mutants were altered and correlated with abnormalities of compound leaves. Our data suggest that Ljphana and Ljphanb play important but divergent roles in regulating adaxial-abaxial polarity of compound leaves in L. japonicus.

关键词： adaxial identity Ljphana Ljphanb gene duplication rel mutants Lotus japonicus.

用有限体积法对粘弹性流体的扩张流动进行数值模拟

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特种油气藏 2009年第1期16卷 75-78页

作者：姜海梅尹洪军苏宇驰黄本辉提高油气采收率教育部重点实验室大庆石油学院黑龙江大庆163318 中海油服务股份有限公司北京101149 中海油服湛江分公司广东湛江524057

采用phan-Thien-Tanner(PTT)本构方程,描述油藏条件下以第一法向应力差为主要特征的聚合物溶液的流变性。利用有限体积法对粘弹性聚合物溶液在突扩孔道内的流动特征进行数值模拟;绘制了流函数和速度等值线图、轴向距离与中心线速度图;... 详细信息

采用phan-Thien-Tanner(PTT)本构方程,描述油藏条件下以第一法向应力差为主要特征的聚合物溶液的流变性。利用有限体积法对粘弹性聚合物溶液在突扩孔道内的流动特征进行数值模拟;绘制了流函数和速度等值线图、轴向距离与中心线速度图;研究了粘弹性的变化对微观波及效率的影响。数值模拟结果表明,聚合物溶液的粘弹性是影响波及效率的主要因素。凸角处的流动区域随着弹性的增加而不断增大,因此滞留区域不断减小,微观波及效率不断增大;具有粘弹特性的聚合物溶液相比于纯粘性的牛顿流体更利于提高驱油效率。

关键词： PTT 本构方程有限体积法聚合物溶液粘弹性波及效率数值模拟

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PET/MR的图像融合精度测试研究

中国临床医学影像杂志 2014年第12期25卷 882-886页

作者：赵珑辛军张少敏孙洪赞刘长平翟伟中国医科大学附属盛京医院放射科辽宁沈阳110004

目的:运用专用测试体模和Na源在模拟实际临床状态下测试PET/MR一体机(Philips Ingenuity TF PET/MR扫描仪)全身3D采集方式的图像融合精度。材料和方法:使用Philips公司提供的测试体模及其配套的Na源,先将Na源分别放置于模型的规定位置... 详细信息

目的:运用专用测试体模和Na源在模拟实际临床状态下测试PET/MR一体机(Philips Ingenuity TF PET/MR扫描仪)全身3D采集方式的图像融合精度。材料和方法:使用Philips公司提供的测试体模及其配套的Na源,先将Na源分别放置于模型的规定位置对采集和扫描的数据进行融合校准,再将相同的6个Na源分别固定于检查床两测,在检查床负重10 kg和60 kg时分别采集PET/MR图像数据。重建图像后,分别在PET和MR图像的横断层面勾画Na源的轮廓,计算出Na源在PET和MR上的重心位置。对两个位置进行对比,算出差值。结果:检查床负重10 kg时最大偏差出现在上段右侧,为3.01 mm;检查床负重60 kg时最大偏差出现在中段右侧,为4.66 mm。结论:本研究方法可以比较精确地测量PET/MR图像融合精度,并有效地指导PET/MR仪器的验收和质量控制等。

关键词：正电子发射断层显像术磁共振成像

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血浆骨桥蛋白对冠心病诊断及预后的评价作用

中国介入心脏病学杂志 2016年第4期24卷 181-185页

作者：李颖利张宝娓马为陈明李建平洪涛霍勇北京大学第一医院心内科北京100034

目的探讨血浆骨桥蛋白水平与冠状动脉粥样硬化病变严重程度的相关性,分析骨桥蛋白对于冠心病诊断和远期不良心血管事件的预测价值。方法入选2011年1月1日至2011年12月31日于北京大学第一医院因怀疑冠心病而行冠状动脉造影的患者788例,... 详细信息

目的探讨血浆骨桥蛋白水平与冠状动脉粥样硬化病变严重程度的相关性,分析骨桥蛋白对于冠心病诊断和远期不良心血管事件的预测价值。方法入选2011年1月1日至2011年12月31日于北京大学第一医院因怀疑冠心病而行冠状动脉造影的患者788例,根据冠状动脉造影检查中所见冠状动脉受累情况由轻到重将患者分为无病变组(38例)、冠状动脉粥样硬化组(119例)、单支病变组(172例)、双支病变组(189例)及三支±左主干病变组(270例)。用酶联免疫吸附测定(ELISA)法测定血浆骨桥蛋白浓度,分析血浆骨桥蛋白水平与冠状动脉病变的相关性,行受试者工作特征(ROC)曲线下面积分析骨桥蛋白对冠心病的预测价值并与冠心病的传统危险因素进行对比,分析血浆骨桥蛋白水平与患者预后的相关性。结果无病变、冠状动脉粥样硬化、单支病变、双支病变及三支±左主干病变5组的平均血浆骨桥蛋白浓度分别为(37.05±15.23)、(51.01±18.81)、(66.26±23.22)、(76.92±26.39)和(88.14±28.93)μg/L;血浆骨桥蛋白水平与冠状动脉病变血管受累情况的相关系数r=0.511,P71.55μg/L者发生复合终点事件118例(29.9%),差异有统计学意义(P=0.001)。结论随着冠状动脉粥样硬化病变程度的增加,血浆骨桥蛋白水平也随之升高;血浆骨桥蛋白水平对于冠心病诊断有较好的预测价值,对于冠心病患者的预后可能存在一定的预测价值。

关键词：冠心病冠状动脉粥样硬化骨桥蛋白诊断预后

血流储备分数与冠状动脉造影指导的治疗对急性冠状动脉综合征患者冠状动脉中度狭窄病变预后的影响

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中国介入心脏病学杂志 2016年第4期24卷 186-190页

作者：宋荟芬李红李响杨铎韩静贾若飞孟帅金泽宁首都医科大学附属北京安贞医院急诊中心北京100029

目的分析血流储备分数(FFR)与冠状动脉造影(CAG)指导的治疗对非ST段抬高急性冠状动脉综合征(NSTEACS)患者冠状动脉中度狭窄病变临床预后的影响。方法回顾性分析2014年7月1日至2015年7月30日在北京安贞医院行CAG显示为冠状动脉中度狭窄... 详细信息

目的分析血流储备分数(FFR)与冠状动脉造影(CAG)指导的治疗对非ST段抬高急性冠状动脉综合征(NSTEACS)患者冠状动脉中度狭窄病变临床预后的影响。方法回顾性分析2014年7月1日至2015年7月30日在北京安贞医院行CAG显示为冠状动脉中度狭窄病变且行FFR检查的NSTEACS患者,共142例(FFR组),与同时期仅行CAG的NSTEACS冠状动脉中度狭窄患者以1∶2进行匹配,后者共284例(CAG组)。分析随访期间主要不良心血管事件(MACE,包括心原性死亡、靶血管血运重建、非致死性心肌梗死)发生情况。结果 FFR组行经皮冠状动脉介入治疗(PCI)的患者比例(36.6%比46.8%,P=0.037)、住院费用[(3.24±1.62)万元比(4.16±3.23)万元,P=0.033]、非致死性心肌梗死发生率(2.2%比4.5%,P=0.040)及靶血管血运重建率(5.9%比11.7%,P=0.046)均低于CAG组,差异均有统计学意义;而两组患者总MACE发生率及心原性死亡率比较,差异均无统计学意义(均P>0.05)。结论在NSTEACS患者中,FFR结合CAG指导的治疗可减少支架置入比例和住院费用,并可改善该类患者的临床预后。

关键词：冠状动脉造影血流储备分数冠状动脉中度狭窄急性冠状动脉综合征经皮冠状动脉介入治疗

Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie Chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah Cathy Williams Jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated