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Novel ins.ghts.on oral s.uamous.cell carcinoma management us.ng long non-coding RNAs

Oncology Res.arch 2024年第10期32卷 1589-1612页

作者： s.r s. Davray D. Bas. s. kheur s. Pal J.K. Nagar s. s.nap A. Rudagi B.M. Gupta s. Cancer and Trans.ational Res.arch Centre Dr. D. Y. Patil Biotechnology and Bioinformatics Institute Dr. D. Y. Patil Vidyapeeth Tathawade Pune 411033 India Bioinformatics.Centre Dr. D. Y. Patil Biotechnology and Bioinformatics Institute Dr. D. Y. Patil Vidyapeeth Pune 411033 India Department of Oral Pathology and Microbiology Dr. D. Y. Patil Dental College & Hospital Dr. D. Y. Patil Vidyapeeth Pune 411018 India Department of s.rgical Oncology Dr. D. Y. Patil Medical College Hospital & Research Centre Dr. D. Y. Patil Vidyapeeth Pune 411018 India

Oral s.uamous.cell carcinoma (Os.C) is.one of the mos. prevalent forms.of head and neck s.uamous.cell carcinomas.(HNs.C) with a poor overall s.rvival rate (about 50%), particularly in cas.s.of metas.as.s. RNA-bas.d cancer biomarkers.are a relatively advanced concept, and non-coding RNAs.currently have s.own promis.ng roles.in the detection and treatment of various.malignancies. This.review underlines.the function of long non-coding RNAs.(lncRNAs. in the Os.C and its.s.bs.quent clinical implications. LncRNAs. a clas. of non-coding RNAs. are larger than 200 nucleotides.and res.mble mRNA in numerous.ways. However, unlike mRNA, lncRNA regulates.multiple druggable and non-druggable s.gnaling molecules.through s.multaneous.interaction with DNA, RNA, proteins. or microRNAs.depending on concentration and localization in cells. Upregulation of oncogenic lncRNAs.and down-regulation of tumor s.ppres.or lncRNAs.are evident in Os.C tis.ues.and body fluids.s.ch as.blood and s.liva indicating their potential as.valuable biomarkers. Targeted inhibition of candidate oncogenic lncRNAs.or over-expres.ion of tumor s.ppres.or lncRNAs.s.owed potential therapeutic roles.in in-vivo animal models. The types.of lncRNAs.that are expres.ed differentially in Os.C tis.ue and bodily fluids.have been s.s.ematically documented with s.ecificity and s.ns.tivity. This.review thoroughly dis.us.es.the biological functions.of s.ch lncRNAs.in Os.C cell s.rvival, proliferation, invas.on, migration, metas.as.s. angiogenes.s. metabolis., epigenetic modification, tumor immune microenvironment, and drug res.s.ance. s.bs.quently, we addres.ed the diagnos.ic and therapeutic importance of lncRNAs.in Os.C pre-clinical and clinical s.s.ems. providing details.on ongoing res.arch and outlining potential future directions.for advancements.in this.field. In es.ence, this.review could be a valuable res.urce by offering comprehens.ve and current ins.ghts.into lncRNAs.in Os.C for res.archers.in fundamental and clinical do

关键词： Cancer diagnos.s Head and neck cancer Long non-coding RNA (lncRNA) Non-coding RNA Oral s.uamous.cell carcinoma (Os.C)

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