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High nitrogen stainless steel drug-eluting stent-Assessment of pharmacokinetics and preclinical safety in vivo

Bioactive Materials 2020年第4期5卷 779-786页

作者： Shanshan Chen Zhifeng Yao Yongbiao Guan Hui Yang M.babar Shahzad Yizhe Wu Bingchun Zhang Li Shen Ke Yang Institute of Metal Research Chinese Academy of Sciences72 Wenhua RoadShenyang110016China Shanghai Institute of Cardiovascular Diseases Department of CardiologyZhongshan HospitalFudan University180 Fenglin RoadShanghai200032China National Beijing Center for Drug Safety Evaluation and Research Beijing Institute of Pharmacology and ToxicologyAcademy of Military Medical Sciences27 Taiping RoadHaidian DistrictBeijing100850People's Republic of China

Pharmacokinetic analyses were performed using 20 pigs for 120-days implantation,while one sirolimus-eluting stent was implanted into one of their coronary *** different time points,the residual sirolimus on the stent,delivered locally(to artery wall),regionally(to adjacent and downstream muscle)and systemically(to plasma and visceral organs),was detected throughout 120 *** safety evaluation was performed using 32 pigs for 180-days implantation to study the safety of metal platform material and the effectiveness of sirolimus eluting coating on the HNS *** neointima area,restenosis rate and inflammatory grade for HNS and control group stents were detected and *** 80%sirolimus was eluted from the sirolimuseluting stents after 30-days implantation in ***,there was sustained sirolimus in the artery wall,cardiac muscle and heart throughout 120-days implantation,and sirolimus accumulated to the peak at 90-days *** was inferred that the sirolimus eluting stent in this study was covered by neointima before 90-days implantation,indicating that the sirolimus eluting coating on the HNS stent was safe and *** little sirolimus was distributed in visceral organs after 14-days *** sirolimus-eluting stent exhibited lower restenosis rate and lower inflammatory grade than control group,which verified that the sirolimus-eluting coating design in this study was reasonable and *** addition,there were no significant difference in restenosis rate and inflammatory score between HNS bare-metal stent and drug-eluting stents,illustrating that HNS has good bio-compatibility and is suitable to use as coronary artery stent material.

关键词： Sirolimus-eluting stent Pharmacokinetics Preclinical safety Tissue response

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Essential oils used in aromatherapy: A systemic review

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Asian Pacific Journal of Tropical Biomedicine 2015年第8期5卷 589-598页

作者： babar Ali Naser Ali Al-Wabel Saiba Shams Aftab Ahamad Shah Alam Khan Firoz Anwar College of Pharmacy and Dentistry Buraydah Colleges Siddhartha Institute of Pharmacy Health Information Technology Department Jeddah Community College King Abdulaziz University Department of Pharmacy Oman Medical College Department of Biochemistry Faculty of Science King Abdulaziz University

Nowadays, use of alternative and complementary therapies with mainstream medicine has gained the momentum. Aromatherapy is one of the complementary therapies which use essential oils as the major therapeutic agents to treat several diseases. The essential or volatile oils are extracted from the flowers, barks, stem, leaves, roots, fruits and other parts of the plant by various methods. It came into existence after the scientists deciphered the antiseptic and skin permeability properties of essential oils. Inhalation, local application and baths are the major methods used in aromatherapy that utilize these oils to penetrate the human skin surface with marked aura. Once the oils are in the system, they remodulate themselves and work in a friendly manner at the site of malfunction or at the affected area. This type of therapy utilizes various permutation and combinations to get relief from numerous ailments like depression, indigestion, headache, insomnia, muscular pain, respiratory problems, skin ailments, swollen joints, urine associated complications etc. The essential oils are found to be more beneficial when other aspects of life and diet are given due consideration. This review explores the information available in the literature regarding therapeutic, medical, cosmetic, psychological, olfactory, massage aromatherapy, safety issues and different plants used in aromatherapy. All the available information was compiled from electronic databases such as Academic Journals, Ethnobotany, Google Scholar, PubM ed, Science Direct, Web of Science, and library search.

关键词： Complementary therapy Aromatherapy Essential oils Inhalation

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An Investigation into Infection Prevention and Control Practices among Close Contacts of COVID-19 Positive Cases Identified during Trace Test and Quarantine Activities at District Quetta (Unmatched Case-Control Study)

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Open Journal of Epidemiology 2021年第4期11卷 360-370页

作者： muhammad Arif Abid Saeed muhammad Abdullah Ambreen Chaudhary Zakir Hussain Mirza Zeeshan Iqbal Baig Zubair Ahmed Khoso Mir Abdul Qadir Sheikh Ahmed Saher Sultan Zahra Gauhar Ayesha babar Kawish Ehsan Larik Department of Health FELTP Pakistan Quetta Pakistan Department of Health WHO Quetta Pakistan Department of Health FELTP Pakistan Islamabad Pakistan Department of Health IPH Quetta Quetta Pakistan Department of Community & Preventive Dentistry AMC NUMS Rawalpindi Pakistan Department of Health BMC Quetta Pakistan Department of Health PIO Rawalpindi Pakistan

The second wave of COVID-19 pandemic has started globally, right now 220 countries are infected and a total of 71,351,695 confirmed cases and 1,612,372 deaths due to COVID-19 have been reported. Infection Prevention and Control (IPC) measures for COVID-19 all have proved vital in decreasing the transmission rates among the communities. Methodology: Unmatched Case-Control Study was conducted where cases were defined as “every PCR positive contact (symptomatic or asymptomatic) for any index case” similarly controls were defined as “every PCR negative contact (symptomatic or asymptomatic) for any index case who was home quarantined for 14 days based on suspicion by PDSRU team”. A simple random technique was used and 300 individuals were made part of this study. Results: The major findings of this study shows that PCR positive contacts poorly adopted certain COVID-19 IPC measures of interest in their daily life hence got infected. The odds for all the variables of interest were found to be statistically significant among cases as compared to controls like the odds for knowingly and intentionally contacted with a COVID-19 positive case was 13.7 times more among the PCR positive contacts as compare to PCR negative contacts (p = 0.00, C.I = 7.62 - 24.90), similarly, the odds of being a family member of the index COVID-19 case was 7.07 times more among the PCR positive contacts as compared to the PCR negative contacts (p = 0.00, C.I = 3.25 - 15.86). Conclusion: Before the development and availability of a vaccine, the only tools that can help prevent the spread of COVID-19 are IPC measures.

关键词： COVID-19 IPC Measures Contact PCR PDSRU

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Evidence-based approach to providing informed consent for hip fracture surgery during the COVID-19 era

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World Journal of Orthopedics 2021年第6期12卷 386-394页

作者： Rory Cuthbert David Ferguson babar Kayani Saeef Haque Aoun Ali Asif Parkar Peter Bates Krishna Vemulapalli Department of Trauma&Orthopaedic Surgery Queen's Hospital-RomfordLondon RM70AGUnited Kingdom Department of Trauma&Orthopaedic Surgery Royal London HospitalLondon E11FRUnited Kingdom

BACKGROUND Hip fractures are the most common reason for inpatient orthopaedic trauma *** surgical intervention for hip fractures has remained a clinical priority throughout the coronavirus disease 2019(COVID-19)*** this,there is a paucity of clinical guidance addressing the informed consent process for hip fracture surgery in COVID-19 positive *** is of paramount medicolegal importance in a high-risk patient *** To quantify the additional perioperative risks for COVID-19 positive patients undergoing hip fracture surgery and provide clinicians with an evidence-based framework to establish an informed consent *** Two hundred and fifty nine consecutive patients undergoing surgical intervention for hip fractures in four hospitals in the United Kingdom were recruited.51 patients were confirmed positive for *** outcomes were analyzed over a 30-d postoperative ***-19 positive and COVID-19 negative patients were compared after adjustment for confounding *** COVID-19 positive patients had more intensive care admissions(27%vs 5%,P<0.001),longer inpatient stays(median 23 d vs 9 d,P<0.001)and a higher 30-d mortality(29%vs 10%,P=0.001)than COVID-19 negative *** complications were evident in 74.5%of COVID-19 positive patients.35.3%of COVID-19 positive patients suffered postoperative lower respiratory tract infections with 13.7%developing acute respiratory distress syndrome(ARDS)and 9.8%experiencing symptomatic thromboembolic *** The COVID-19 pandemic has created uncertainty in the medical community worldwide and poses unique challenges in providing informed consent for ***-19 positive patients undergoing hip fracture surgery should be consented for the additional risk of postoperative complications(including lower respiratory tract infection,ARDS,deep vein thrombosis and pulmonary embolism),increased requirement for intensive care admission,lo

关键词： COVID-19 Hip fractures Mortality Morbidity Outcome assessment Informed consent

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An Efficient Scheme for Interference Mitigation in 6G-IoT Wireless Networks

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Computers, Materials & Continua 2021年第12期69卷 3889-3902页

作者： Fahd N.Al-Wesabi Imran Khan Nadhem Nemri Mohammed A.Al-Hagery Huda G.Iskander Quang Ngoc Nguyen babar Shah Ki-Il Kim Department of Computer Science King Khalid UniversityMuhayel AseerKSA Department of Electrical Engineering University of Engineering and TechnologyPeshawarPakistan Department of Information Systems King Khalid UniversityMayahel AseerKSA Department of Computer Science College of ComputerQassim UniversitySaudi Arabia Faculty of Computer and IT Sana’a UniversitySana’aYemen Department of Communications and Computer Engineering Faculty of Science and EngineeringWaseda UniversityShinjuku-kuTokyo169-0051Japan College of Technological Innovation Zayed UniversityAbu DhabiUAE Department of Computer Science and Engineering Chungnam National UniversityDaejeon34134Korea

The Internet of Things(IoT)is the fourth technological revolution in the global information industry after computers,the Internet,and mobile communication *** combines radio-frequency identification devices,infrared sensors,global positioning systems,and various other *** sensing equipment is connected via the Internet,thus forming a vast *** these physical devices are connected to the Internet,the user terminal can be extended and expanded to exchange information,communicate with anything,and carry out identification,positioning,tracking,monitoring,and triggering of corresponding events on each device in the *** real life,the IoT has a wide range of applications,covering many fields,such as smart homes,smart logistics,fine agriculture and animal husbandry,national defense,and *** of the most significant factors in wireless channels is interference,which degrades the system *** the existing QR decomposition-based signal detection method is an emerging topic because of its low complexity,it does not solve the problem of poor detection ***,this study proposes a maximumlikelihood-based QR decomposition *** main idea is to estimate the initial level of detection using the maximum likelihood principle,and then the other layer is detected using a reliable *** optimal candidate is selected from the feedback by deploying the candidate points in an unreliable *** results show that the proposed algorithm effectively reduces the interference and propagation error compared with the algorithms reported in the literature.

关键词： 6G networks internet of things resource allocation optimization

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基于一种高性价比频率梳发生器的高速256-QAM波分复用相干光通信系统

基于一种高性价比频率梳发生器的高速256-QAM波分复用相干光通信...

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作者： babar Ali（李尔）北京邮电大学

学位级别：硕士

在过去的三十年里,由于波分复用（WDM）技术具有显著的可扩展性,该技术已被有效地用于扩展光通信系统的频谱效率（SE）和满足日益增长的带宽利用率（BW）。尽管如此,网络流量的快速发展扭转了这种局面。目前的趋势表明,网络流量的增长... 详细信息

在过去的三十年里,由于波分复用（WDM）技术具有显著的可扩展性,该技术已被有效地用于扩展光通信系统的频谱效率（SE）和满足日益增长的带宽利用率（BW）。尽管如此,网络流量的快速发展扭转了这种局面。目前的趋势表明,网络流量的增长速度超过了通信系统效率的提升速度。在过去的十年里,大容量光纤通信系统有了一些突破性的发展。基于先进调制格式的波分复用相干光通信系统结合数字信号处理技术可有效提升通信系统的SE和BW。在这些系统中,光谱保护带（G波段）b/w相邻信道被最小化,但代价是对光学效率有着更高的要求,特别是频率或波长的稳定性有更严格的要求。光频梳（Optical frequency,OF）是实现低成本、低复杂度的多载波稳定传输的最具吸引力的解决方案,在高数据距离传输中仍是一个卓有成效的领域。OF低相位噪声效率促成了波分复用光通信网络的一场革命。本文提出了一种激光频率梳发生器（CE-LFCG）,通过使用一个连续波激光器,一个电光相位调制器（EPM）和一个Mech-Zehnder调制器（MZM）。调制器均是由一个无线电频率（RF）发电机驱动,无需额外的电子或光学放大器和滤波器。在C波段,CE-LFCG产生了多条具有可接受音噪比的等间距平坦线,并通过Optisystem完成了所有仿真。本文主要研究工作如下:（1）提出了一种基于CE-LFCG的信号连续波激光器。CE-LFCG成功地在c波段产生了等间距的梳线,其中一条线代表单个激光器的输出。本文提出的连续波激光器可以产生不同频率比（10、33、50、100）GHz的等间距梳线,梳线的数量随频率比（10、33、50、100）的不同而变化。（2）提出了适用于中长距离（100*N,N=（5,16,25,35,50）km）的高SE大容量双偏振WDM相干光通信系统。本系统采用CE-LFCG作为光载波发生器和本振,采用先进的调制格式256-QAM。仿真结果表明,该方案通过不同信道的四个不同频率可以实现320 Gbps比特率、20Gsymbol/s的信号传输。其他仿真参数详见第4章的表4-1。（3）提出将数字信号处理（DSP）技术引入接收端信号。DSP是现代相干光通信系统不可缺少的技术。采用先进的DSP算法对传播过程中的非线性损耗和色散进行补偿,然后对提出的CE-LFCG-based DP 256-QAM WDM相干系统在不同传输链路长度上的百分比误差向量（EVM%）和OSNR、EVM%和发射功率、OSNR和log10BER、发射功率和log10BER之间的关系进行详细分析。

关键词：光谱效率数字信号处理光学频率梳频谱比波分复用

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Outcomes of total pancreatectomy with islet autotransplantation:A systematic review and meta-analysis

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World Journal of Transplantation 2023年第1期13卷 10-24页

作者： Shrouq Khazaaleh Sumbal babar Mohammad Alomari Zaid Imam Pravallika Chadalavada Adalberto Jose Gonzalez Bara El Kurdi Department of Internal Medicine Cleveland Clinic Fairview HospitalClevelandOH 44126United States Department of Internal Medicine-Infectious Diseases Division University of Texas Health Science Center at San AntonioSan AntonioTX 78249United States Department of Gastroenterology and Hepatology Cleveland Clinic FloridaWestonFI 33324United States Department of Gastroenterology and Hepatology William Beaumont HospitalRoyal OakMI 48073United States Department of Gastroenterology and Hepatology Cleveland Clinic FloridaWestonFI 33331United States Department of Gastroenterology and Hepatology University of Texas Health Science Center at San AntonioSan AntonioTX 78249United States

BACKGROUND Despite the increased use of total pancreatectomy with islet autotransplantation(TPIAT),systematic evidence of its outcomes remains *** To evaluate the outcomes of *** We searched PubMed,EMBASE,and Cochrane databases from inception through March 2019 for studies on TPIAT *** were extracted and analyzed using comprehensive meta-analysis *** random-effects model was used for all *** was assessed using the I2 measure and Cochrane *** bias was assessed using Egger’s *** Twenty-one studies published between 1980 and 2017 examining 1011 patients were *** studies were of adults,while three studied pediatric *** independence was achieved in 53.5%[95% Confidence Interval(CI):45-62,P<0.05,I2=81%]of adults compared to 51.9%(95%CI:17-85,P<0.05,I2=84%)of *** post-procedure was achieved in 31.8%(95%CI:26-38,P<0.05,I2=64%)of adults with considerable heterogeneity compared to 47.7%(95%CI:20-77,P<0.05,I2=82%)in *** hemoglobin(HbA1C)12 mo post-surgery was reported in four studies with a pooled value of 6.76%(P=0.27).Neither stratification by age of the studied population nor metaregression analysis considering both the study publication date and the islet-cell-equivalent/kg weight explained the marked heterogeneity between *** These results indicate acceptable success for *** studies should evaluate the discussed measures before and after surgery for comparison.

关键词： Islet autotransplantation Pancreatectomy Pancreatitis Narcotics

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Retrospective review of total neoadjuvant therapy

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 857-865页

作者： Laila babar Veli Bakalov Stephen Abel Obaid Ashraf Gene Grant Finley Moses S Raj Kristina Lundeen Dulabh K Monga Alexander V Kirichenko Rodney E Wegner Department of Internal Medicine Allegheny General HospitalPittsburghPA 15212United States Department of Radiation Oncology Allegheny General HospitalPittsburghPA 15212United States Department of Medical Oncology Allegheny General HospitalPittsburghPA 15212United States

BACKGROUND Neoadjuvant chemoradiotherapy(nCRT)followed by resection and postoperative multi-agent chemotherapy(maChT)is the standard of care for locally advanced rectal *** this approach,maChT administration can be delayed for several months,leading to concern for distant *** counteract this,a novel treatment approach known as total neoadjuvant therapy(TNT)has gained popularity,in which patients receive both maChT and nCRT prior to *** utilized the National Cancer Database to examine temporal trends in TNT usage,and any potential effect on *** To study the temporal trends in the usage of TNT and evaluate its efficacy compared to neoadjuvant *** We queried the National Cancer Database for patients with locally advanced rectal cancer,Stage II-III,from 2004-2015 treated with nCRT or *** was defined as maChT initiated≥90 d prior to nCRT *** survival was calculated from the date of diagnosis to the date of last contact or death using Kaplan-Meier curves to present the cumulative probability of survival,with logrank statistics to assess *** cox regression was used to identify predictors of survival and propensity score analysis accounted for *** We identified 9066 eligible patients,with 8812 and 254 patients receiving neoadjuvant chemoradiation followed by maChT and TNT,*** involvement,stage III disease,and treatment in recent years were predictive of TNT *** was greater use of TNT with more advanced stage,specifically>1 node involved(odds ratio[OR]=2.88,95%confidence interval[CI]:2.11-3.93,P<0.01)and stage III disease(OR=2.88,95%CI:2.11-3.93,P<0.01).From 2010 to 2012 the use of TNT increased(OR=2.41,95%CI:1.27-4.56,P<0.01)with a greater increase from 2013 to 2015(OR=6.62,95%CI:3.57-12.25,P<0.01).Both the TNT and neoadjuvant chemoradiation arms had a similar 5-year survival at 76%and 78%*** analysis with propensity score de

关键词： Total neoadjuvant therapy Neoadjuvant chemoradiation Multi-agent chemotherapy Locally advanced rectal cancer National cancer database Colorectal cancer Retrospective review Gastrointestinal oncology Temporal trends Surgical excision

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Comparative Study for ECHAM5 and SDSM in Downscaling Temperature for a Geo-Climatically Diversified Region, Pakistan

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Applied Mathematics 2014年第1期5卷 137-143页

作者： Dildar Hussain Kazmi Ghulam Rasul Jianping Li Suhail babar Cheema Research & Development Division Pakistan Metrological Department Islamabad Pakistan State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China

Pakistan is a country with diversified features in terms of geography and climate. It is an agriculture based country, mainly dependent on Indus water system. In Pakistan, there are loftyplateaus to the north and Arabian Sea in the south, while the interior portion is covered with plateaus or agriculture plains. For such a region, any attempt to monitor/analyze climatic data requires some more specific details. A statistical software “SDSM” is utilized for downscaling daily temperature data of Pakistan and the results generated are compared with the output of a recommended model “ECHAM5”. After analysis, it revealed that comparatively SDSM produced much better results. The outputs from both the approaches were correlated with the observed data;SDSM-observed gave values for correlation coefficient R2 in the range of 81% - 94% whereas ECHAM5-observed produced 73% - 87% for different meteorological stations of Pakistan. On the basis of this study, SDSM can be recommended for future scenario generation of temperature data of Pakistan as well.

关键词： Dynamic Statistical Future Scenario Generation

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Decoding China’s Development Path--Xi’s new book details goal of transnational prosperity while maintaining national aspirations and diversity

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Beijing Review 2020年第45期63卷 22-23页

作者： Makhdoom babarthe Daily Mail Pakistan

Many foreign sinologists often suffer from misconception and confusion about China,its governance,society and *** three volumes of Xi Jinping:The Governance of China,published in many languages,address the predicament of foreigners wanting to know about *** me,these books have been the best source to learn about contemporary China,its people,society,foreign policy and the driving spirit behind the country’s remarkable success.

关键词： details driving policy

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