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A novel HPTLC method for quantitative estimation of biomarkers in polyherbal formulation

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Asian Pacific Journal of Tropical Biomedicine 2015年第11期5卷 955-959页

作者： Zeeshan Ahmed Sheikh Sadia Shakeel Somia Gul Aqib Zahoor Saleha Suleman khan Faisal Haider Zaidi khan usmanghani Herbion Pakistan (Pvt.) Ltd. Dow College of Pharmacy Dow University of Health Sciences Faculty of Pharmacy Jinnah University for Women Karachi Department of Basic Medical Sciences College of MedicineKing Saud bin Abdulaziz University of Health Sciences

Objective: To explore the quantitative estimation of biomarkers gallic acid and berberine in polyherbal formulation Entoban ***: High performance thin layer chromatography was performed to evaluate the presence of gallic acid and berberine employing toluene: ethyl acetate: formic acid:methanol 12:9:4:0.5(v/v/v/v) and ethanol: water: formic acid 90:9:1(v/v/v), as a mobile phase ***: The R f values(0.58) for gallic acid and(0.76) for berberine in both sample and reference standard were found comparable under UV light at 273 nm and 366 nm respectively. The high performance thin layer chromatography method developed for quantization was simple, accurate and ***: The present standardization provides specific and accurate tool to develop qualifications for identity, transparency and reproducibility of biomarkers in Entoban syrup.

关键词： Quantitative estimation Gallic acid Berberine Ento

Acute Kidney Injury: Treatment with Unani Medicine—Case Report

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Chinese Medicine 2014年第2期5卷 118-122页

作者： Muhammad Shakil Ahmad Siddiqui khan usmanghani Faculty of Eastern Medicine Hamdard University Karachi Pakistan Rafah-e-Aam Dawakhana Ajmali (Clinics) and Rafah-e-Aam Herbal Laboratories Karachi Pakistan Faculty of Eastern Medicine Hamdard University Karachi Pakistan

A male named Anwer Jamal, age 45 years, married, visited Clinic Rafaheaam Dawakhana Ajmali on March 29, 2013, with history of glomerulonephritis, inherited renal diseases, hypertension and previously hooked on voltaren 50 (Diclofenic Sodium, 50 mg) and was not on dialysis. Different diagnostic parameters showed the patient was suffering from acute renal failure according to the RIFLE criteria. AKI is life threatening when kidneys suddenly is unable to filter waste products from blood. The patient was treated and managed with herbal medicines according to Unani system of medicine. Reversal of the parameter such as serum creatinine from 7.90 mg/dl (6.58 fold high) to 0.81mg/dl within two weeks clearly shows the remarkable recovery in a short period of time. During this period the other related parameters e.g. blood urea nitrogen (BUN), serum albumin, albuminuria, blood pressure were also normalized whereas clinical sign and symptom exhibited improvement.

关键词： Acute Kidney Injury Diagnosis Unani Treatment Outcome

Design, Development and Phytochemical Evaluation of a Poly Herbal Formulation Linkus Syrup

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Chinese Medicine 2014年第2期5卷 104-112页

作者： Zeeshan Ahmed Sheikh Aqib Zahoor Saleha Suleman khan khan usmanghani Department of Research and Development Herbion Pakistan (Pvt.) Limited 30/28 Korangi Industrial Area Karachi Pakistan Department of Research and Development Herbion Pakistan (Pvt.) Limited 30/28 Korangi Industrial Area Karachi Pakistan Faculty of Pharmacy Jinnah University for Women Karachi Pakistan

The present work has been carried out on polyherbal formulation named as Linkus Syrup. The herbal formulation consists of Glycyrrhiza glabra, Hyssopus officinalis, Piper longum and Alpinia galangal. The Linkus syrup physico-chemical evaluation such as pH, density, identification of polysaccharide, tanning agents, ascorbic acid and shelf life was complied. The TLC and quantitative determination of alkaloid were quantified. Determination of biomarker has been validated for the analysis of vasicine. The study result revealed that Linkus syrup formulation was well standardized at different levels such as physic-chemical consistency and assay of bio marker compound.

关键词： Syrup Crude Herb Anti-Tussive Anti-Bronchitis Anti-Pharyngitis Sore Throat Tracheitis HPLC

Quantitative Estimation of Gallic Acid as Biomarker in Lipitame Tablets by HPTLC Densitometry for Diabetic Dyslipidemia

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Chinese Medicine 2014年第4期5卷 170-178页

作者： Sheeraz Siddiqui khan usmanghani Aqib Zahoor Zeeshan Ahmed Sheikh Saleha Suleman khan Faculty of Eastern Medicine Hamdard University Karachi Pakistan Research and Development Department Herbion Pakistan (Pvt.) Limited Karachi Pakistan

Lipitame is a poly herbal formulation comprised of Terminalia arjuna, Terminalia belerica, Commiphora mukul and Phyllanthus emblica. The formulation is investigated for its analysis evaluation. Biomarkers of three herbs such as Terminalia arjuna, Terminalia belerica, and Phyllanthus emblica have been already cited to contain gallic acid, which was qualitatively and quantitatively estimated. In the present study rapid and inexpensive qualification methods for the quality control of Terminalia arjuna, Terminalia belerica, Commiphora mukul and Phyllanthus emblica on thin layer chromatography (TLC) were developed and validated. The solvent system used was toluene:ethyl acetate:formic acid:methanol (12:9:4:0.5). The scanning of plate was performed linearly at 273 nm (absorption) by use of a TLC Scanner III CAMAG with a deuterium source, and the area of spots corresponding to Gallic acid standard was integrated. It was found that gallic acid has been found in the Lipitame tablets on HPTLC densitometry assessment compared with authentic gallic acid reference standard.

关键词： Lipitame Tablets Quantitative Estimation Densitometry Diabetic Dyslipidemia

One-Month-Old Female Baby with Symmetrical Hydrocephalus: Treatment Option

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Chinese Medicine 2012年第3期3卷 113-115页

作者： Muhammad Shakil Ahmad Siddiqui khan usmanghani Ejaz Mohiuddin Laeequr Rahman Malik Faculty of Eastern Medicine Hamdard University Karachi Pakistan Rafah-e-Aam Dawakhana Ajmali (Clinics) and Rafah-e-Aam Herbal Laboratories Karachi Pakistan

A female infant, named Anum 1.8 kg was born on 9th August 2007 at Jinnah Postgraduate Medical Centre (JPMC) with a big head, Occipitofrontal Circumference (OFC) 36 cm. She was admitted on 29th August 2007 and was discharged on 5th September 2007 from Jinnah Postgraduate Medical Centre after the management of moderate birth asphyxia. Cranial ultrasound revealed moderate Hydrocephalus (symmetrical) with prominent third ventricle. Treatment and its effectiveness have been discussed.

关键词： Hydrocephalus Meningocele Herbal Treatment

Evaluation of Acute and Repeated Dose Toxicity of the Polyherbal Formulation Linkus Syrup in Experimental Animals

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Chinese Medicine 2014年第4期5卷 179-189页

作者： Allah Nawaz Saira Bano Zeeshan Ahmed Sheikh khan usmanghani Iqbal Ahmad Syed Faisal Zaidi Aqib Zahoor Irshad Ahmad Research and Development Department Herbion Pakistan (Pvt.) Limited Karachi Pakistan First Department of Internal Medicine Faculty of Medicine Graduate School of Medical & Pharmaceutical Sciences University of Toyama Toyama Japan Jinnah University for Women Karachi Pakisntan Baqai Institute of Pharmaceutical Sciences Baqai Medical University Karachi Pakistan Department of Basic Medical Sciences College of Medicine King Saud bin Abdulaziz University of Health Sciences Jeddah KSA Department of Pharmacy The Islamia University of Bahawalpur Bahawalpur Pakistan Clinical Pharmacy and Health Care Jinnah University for Women Karachi Pakistan

The objective of the present study was to evaluate the pre-clinical efficacy and toxicity of polyherbal cough syrup Linkus. Method: Animals (healthy Wistar albino rats;(150 - 250 g) of either sex) were housed under standard environmental conditions;i.e. 25°C ± 1°C and 12 h dark/light cycle. Food and water were available at libitum. The rats were treated orally with the recommended doses of the test drug (Linkus). After 15 minutes, they were individually placed in a closed Plexiglas chamber (20 × 10 × 10 cm) and exposed to citric acid (0.1 g/ml) inhalation for 7 minutes. The cough reflexes were produced and counted for the last 5 minutes and compared with those of the control animals. The following studies were conducted to evaluate the toxicity of the test drug in healthy Wistar albino rats: lethal dose50 (LD50);rats of either sex (n = 10/sex) were treated orally with doses (1 or 5 g/kg) of the test drug. Mortality and behavioral changes were observed for 1 week. Repeated dose toxicity on the healthy Wistar albino rats of both sexes (n = 5/dose/sex) was treated orally with doses of 20 mg/kg (adult human dose = ~1400 mg), 500 mg/kg (adult human dose = ~35,000 mg) and 1000 mg/kg (adult human dose = ~70,000 mg) of test drug (Linkus) for 14 days. Additionally, the control animals were treated orally with water for 14 days. Results: In female rats, the test drug (Linkus) at the dose of 300 mg/kg caused significant (p < 0.01) reduction in the cough reflexes as compared to the control. However, in male rats, a significant reduction was observed at the tested dose of 200 mg/kg (p < 0.05) and 300 mg/kg (p < 0.01). The test product did not cause mortality in rats at the given doses of 1 or 5 g/kg. Other signs of toxicity like hair loss and weight reduction were not observed. In female and male rats, the test drug (Linkus) at different doses did not show any abnormal effects on complete blood count profile of rats. Serum enzyme markers, i.e. alanine aminotransferase (ALT), ala

关键词： Cough Expectorant Alanine Amino Transferase (ALT) Polyherbal Gamma Glutamyl Transferase (GGT) Toxicity

Sentiment Analysis of Low-Resource Language Literature Using Data Processing and Deep Learning

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Computers, Materials & Continua 2024年第4期79卷 713-733页

作者： Aizaz Ali Maqbool khan Khalil khan Rehan Ullah khan Abdulrahman Aloraini Department of IT and Computer Science Pak-Austria Fachhochschule:Institute of Applied Sciences and TechnologyHaripur22620Pakistan Software Competence Center Hagenberg Softwarepark 32aHagenberg4232Austria Department of Computer Science School of Engineering and Digital SciencesNazarbayev UniversityAstana010000Kazakhstan Department of Information Technology College of ComputerQassim UniversityP.O.Box 1162BuraydahSaudi Arabia

Sentiment analysis, a crucial task in discerning emotional tones within the text, plays a pivotal role in understandingpublic opinion and user sentiment across diverse *** numerous scholars conduct sentiment analysisin widely spoken languages such as English, Chinese, Arabic, Roman Arabic, and more, we come to grapplingwith resource-poor languages like Urdu literature which becomes a challenge. Urdu is a uniquely crafted language,characterized by a script that amalgamates elements from diverse languages, including Arabic, Parsi, Pashtu,Turkish, Punjabi, Saraiki, and more. As Urdu literature, characterized by distinct character sets and linguisticfeatures, presents an additional hurdle due to the lack of accessible datasets, rendering sentiment analysis aformidable undertaking. The limited availability of resources has fueled increased interest among researchers,prompting a deeper exploration into Urdu sentiment analysis. This research is dedicated to Urdu languagesentiment analysis, employing sophisticated deep learning models on an extensive dataset categorized into fivelabels: Positive, Negative, Neutral, Mixed, and Ambiguous. The primary objective is to discern sentiments andemotions within the Urdu language, despite the absence of well-curated datasets. To tackle this challenge, theinitial step involves the creation of a comprehensive Urdu dataset by aggregating data from various sources such asnewspapers, articles, and socialmedia comments. Subsequent to this data collection, a thorough process of cleaningand preprocessing is implemented to ensure the quality of the data. The study leverages two well-known deeplearningmodels, namely Convolutional Neural Networks (CNN) and Recurrent Neural Networks (RNN), for bothtraining and evaluating sentiment analysis performance. Additionally, the study explores hyperparameter tuning tooptimize the models’ efficacy. Evaluation metrics such as precision, recall, and the F1-score are employed to assessthe effectiv

关键词： Urdu sentiment analysis convolutional neural networks recurrent neural network deep learning natural language processing neural networks

A novel fractional case study of nonlinear dynamics via analytical approach

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 276-290页

作者： Hassan khan Adnan khan Rasool Shah Dumitru Baleanu Department of Mathematics Abdul Wali khan UniversityMardan 23200Pakistan Department of Mathematics Faculty of Arts and SciencesCankaya UniversityAnkara 06530Turkey Institute of Space Sciences Magurele-BucharestRomania

The present work describes the fractional view analysis of Newell-Whitehead-Segal equations,using an innovative *** work is carried with the help of the Caputo operator of fractional *** analytical solutions of some numerical examples are presented to confirm the reliability of the proposed *** derived results are very consistent with the actual solutions to the problems.A graphical representation has been done for the solution of the problems at various fractional-order ***,the solution in series form has the desired rate of convergence and provides the closed-form *** is noted that the procedure can be modified in other directions for fractional order problems.

关键词： Homotopy Perturbation method Shehu transform Newell-Whitehead-Segel Equation Caputo operator

Electronic and thermoelectric properties of YbMg_(2)X_(2)(X=P,As,Sb,Bi)zintl compounds by first-principles method

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Journal of Rare Earths 2024年第1期42卷 147-154,I0006页

作者： Sajid khan Dil Faraz khan R.Neffati Tariq Usman Muhammad Waqar Ahsraf Shamim khan Saeed Ullah Jan G.Murtaza Department of Physics University of Science&Technology BannuBannu28100Pakistan Department of Physics Faculty of ScienceKing Khalid UniversityP.O.Box 9004AbhaSaudi Arabia Laboratoire de Physique de La Matiere Condensee Departement de PhysiqueFaculte des Sciences de TunisUniversite Tunis El ManarCampus Universitaire1060TunisTunisia Department of Physics Shaoxing UniversityShaoxing312000China Department of Mathematics&Natural Sciences Prince Mohammad Bin Fahd UniversityAlkhobar31952Saudi Arabia Materials Modeling Lab Department of PhysicsIslamia College Peshawar25120KhyberPakhtunkhwaPakistan

In this work the structural,electronic and thermoelectric properties of YbMg_(2)X_(2)(X=P,As,Sb,Bi)zintl compounds were investigated comprehensively using first principles *** electronic properties were studied using PBE GGA,TB-mBJ and hybrid(YS-PBE0)*** the structural parameters of optimized structures are in harmonious agreement to the available *** band structure study illustrates that the titled materials manifest metallic and semi metallic nature using PBE and TB-mBJ potentials while they show wide band gap semiconducting behavior by following hybrid(YS-PBE0)*** density of states(TDOS)and partial density of states(PDOS)were also calculated to glimpse the contribution of orbitals of atoms in the formation of *** properties were studied by using BoltzTraP2 code employed to *** get enormous values of Seebeck coefficient(S),power factor(PF)and thermoelectric figure of merit(ZT)for all the samples YbMg_(2)X_(2)(X=P,As,Sb,Bi),Moreover,the overwhelming transport properties for the titled compounds indicate the optimum level of carriers’concentration which pinpoints these materials to be better thermoelectrics in the 1-2-2 zintl family.

关键词： Zintl compounds Hybrid functional Band structure Thermoelectrics Rare earths