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Incubation temperature induced developmental plasticity of cold responsive physiological phenotypes in Japanese Quails

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Avian Research 2024年第3期15卷 385-394页

作者： Yingxin Kou Rongmiao Zhang Xiaoqian Li na Zhu Yihang Huang Shuping Zhang College of Life and Environmental Sciences Minzu University of ChinaBeijing100081China

Embryonic development is a critical period for phenotype *** variation during embryonic development can induce changes in postnatal phenotypes of *** thyroxine secretion and aerobic metabolic activity of small birds are important phenotypes closely related to their winter *** the context of climate change,it is necessary to determine whether temperature variation during incubation in birds leads to developmental plasticity of these cold responsive *** incubated Japanese Quail(Coturnix japonica)eggs at 36.8℃,37.8℃,and 38.8℃,and raised the chicks to 35-day old at 22℃with same raising conditions,then all the quails were exposed to gradually temperature dropping environment(from 15℃to 0℃).After cold treatment,serum T3 level,resting metabolic rate,skeletal muscle and liver metabolomes of the birds were *** serum T3 levels were significantly lower in the 38.8℃group and significantly higher in the 36.8℃group compared to the 37.8℃*** metabolic rate in the 38.8℃group was significantly lower compared to the 37.8℃*** with the 37.8℃group,metabolites involved in the tricarboxylic acid cycle in the liver were significantly lower in the 38.8℃group,and metabolites related to lipid oxidation metabolism and fatty acid biosynthesis were significantly lower in the skeletal muscles in the 38.8℃group but significantly higher in the 36.8℃*** results indicate that incubation temperature variation can lead to developmental plasticity in cold responsive physiological *** incubation temperature may impair the capacity of birds coping with cold challenge.

关键词： Cold response Developmental plasticity Incubation temperature Metabolic rate Metabolomes Precocial bird Thyroxin

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Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury

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Neural Regeneration Research 2024年第8期19卷 1822-1827页

作者： Yuhui Kou Yusong Yuan Qicheng Li Wenyong Xie Hailin Xu na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma Medicine BeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina Department of Central Laboratory and Institute of Clinical Molecular Biology Peking University People’s HospitalBeijingChina

Macrophages play an important role in peripheral nerve regeneration,but the specific mechanism of regeneration is still *** preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide closely involved in peripheral nerve ***,the mechanism by which neutrophil peptide 1 enhances nerve regeneration remains *** study was designed to investigate the relationship between neutrophil peptide 1 and macrophages in vivo and in vitro in peripheral nerve crush *** functions of RAW 264.7 cells we re elucidated by Cell Counting Kit-8 assay,flow cytometry,migration assays,phagocytosis assays,immunohistochemistry and enzyme-linked immunosorbent *** debris phagocytosis was observed using the CUBIC(Clear,Unobstructed Brain/Body Imaging Cocktails and Computational analysis)optical clearing technique during Wallerian *** inflammatory factor expression in different polarization states was detected using a protein *** results showed that neutrophil peptide 1 promoted the prolife ration,migration and phagocytosis of macrophages,and CD206 expression on the surfa ce of macrophages,indicating M2 *** axonal debris clearance rate during Wallerian degeneration was enhanced after neutrophil peptide 1 *** peptide 1 also downregulated inflammatory factors interleukin-1α,-6,-12,and tumor necrosis factor-αin invo and in ***,the results suggest that neutrophil peptide 1 activates macrophages and accelerates Wallerian degeneration,which may be one mechanism by which neutrophil peptide 1 enhances peripheral nerve regeneration.

关键词： axonal debris inflammatory factors macrophages neutrophil peptide 1 peripheral nerve injury peripheral nerve regeneration RAW 264.7 cells sciatic nerve Wallerian degeneration

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Multivariate chemical analysis:From sensors to sensor arrays

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Chinese Chemical Letters 2024年第7期35卷 14-24页

作者： Xueling Yu Lixing Fu Tong Wang Zhixin Liu na Niu Ligang Chen College of Chemistry Chemical Engineering and Resource UtilizationKey Laboratory of Forest Plant EcologyNortheast Forestry UniversityHarbin 150040China

Chemical sensor arrays can obtain more comprehensive analyte information through high-dimensional *** is of great significance in the analysis of multi-component complex *** review summarizes the development and status of chemical sensor *** focused on the design of chemical sensor arrays based on various sensing *** addition,several pattern recognition methods in chemometrics are *** applications of chemical sensor arrays in food monitoring,medical diagnosis,and environmental monitoring are *** on the analysis of the limitations of current sensor array technology,the direction of the array is also *** review aims to help the broad readership understand the research state of chemical sensor arrays and their development prospects.

关键词： Chemical sensor arrays Sensing materials Pattern recognition methods Analytical application

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Astronomical forcing and sedimentary noise modeling of lake-level changes in the Middle Eocene Chezhen Sag,Bohai Bay Basin,eastern China

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Frontiers of Earth Science 2024年第2期18卷 446-459页

作者： Xuwei LUAN Jinliang ZHANG na LI Tao CHEN Long SUN Xuecai ZHANG Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China Management Center of Oil and Gas Exploration Sinopec Shengli OilfieldDongying 257000China

The accurate determination of geological age is a key to understanding the history and process of paleolake evolution and oil and gas exploration in continental lake ***,improving the accuracy of geological age has always been a difficult scientific problem.A 609-m-thick,continuous lacustrine mudstone and sandstone succession in Chezhen Sag(eastern China)provides an ideal middle Eocene sedimentary record for establishing a high-resolution stratigraphic chronology *** on spectrum analysis and sliding window spectrum analysis of the natural gamma(GR)logging data of well Che 271(C271)in Chezhen Sag,the periods of 405 kyr and 40.1 kyr were filtered by a Gaussian bandpass filter,and a“floating”astrochronological time scale(ATS)was *** total number of 405 kyr eccentricity cycles were 13.6 and 40.1 kyr obliquity cycles were 138 which recorded from the upper member 4(Es4U)to the member 3(Es3)of the Eocene Shahejie Formation,and the depositional duration was 5.53 *** Coefficient(COCO)analysis and evolutionary Correlation Coefficient(eCoCo)analysis found that the optimal sedimentary rate of different *** noise simulation revealed the history of paleolake water changes in the Middle Eocene in the Chezhen Sag,according to which four sequences are *** study shows that the lake level change of Chezhen Sag in the middle Eocene shows prominent 1.2 Myr cycles and an antiphase well-coupled relationship with obliquity ***,we propose a model to explain the relationship between the orbital cycle and lake level change in the continental lake *** the obliquity of the earth increases,the middle and high latitudes of the earth will be closer to the sun,the direct sunlight will be higher,and the meridional sunshine will increase,thus accelerating the evaporation process of lake basin *** the seasonal changes are obvious(maximum period of 1.2 Myr ultra-long obliquity),this effect is more signific

关键词： Chezhen Sag cyclostratigraphy astrochronological time scale sedimentary noise

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Therapeutic strategies of targeting nonapoptotic regulated cell death (RCD) with smallmolecule compounds in cancer

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2815-2853页

作者： Xin Jin Wenke Jin Linlin Tong Jia Zhao Lan Zhang na Lin Department of Ultrasound Department of Medical Oncology and Department of Hematologythe First Hospital of China Medical UniversityChina Medical UniversityShenyang 110001China Sichuan Engineering Research Center for Biomimetic Synthesis of natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Regulated cell death(RCD)is a controlled form of cell death orchestrated by one or more cascading signaling pathways,making it amenable to pharmacological *** subroutines can be categorized as apoptotic or non-apoptotic and play essential roles in maintaining homeostasis,facilitating development,and modulating *** evidence has recently revealed that RCD evasion is frequently the primary cause of tumor *** non-apoptotic RCD subroutines have garnered attention as promising cancer therapies due to their ability to induce tumor regression and prevent relapse,comparable to ***,they offer potential solutions for overcoming the acquired resistance of tumors toward apoptotic *** an increasing understanding of the underlying mechanisms governing these non-apoptotic RCD subroutines,a growing number of small-molecule compounds targeting single or multiple pathways have been discovered,providing novel strategies for current cancer *** this review,we comprehensively summarized the current regulatory mechanisms of the emerging non-apoptotic RCD subroutines,mainly including autophagy-dependent cell death,ferroptosis,cuproptosis,disulfidptosis,necroptosis,pyroptosis,alkaliptosis,oxeiptosis,parthanatos,mitochondrial permeability transition(MPT)-driven necrosis,entotic cell death,NETotic cell death,lysosome-dependent cell death,and immunogenic cell death(ICD).Furthermore,we focused on discussing the pharmacological regulatory mechanisms of related small-molecule *** brief,these insightful findings may provide valuable guidance for investigating individual or collaborative targeting approaches towards different RCD subroutines,ultimately driving the discovery of novel small-molecule compounds that target RCD and significantly enhance future cancer therapeutics.

关键词： Regulated cell death(RCD) Non-apoptotic RCD subroutine Autophagy Ferroptosis Necroptosis Regulatory mechanism Small-molecule compound Cancer therapy

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Real-Time Co-optimization of Gear Shifting and Engine Torque for Predictive Cruise Control of Heavy-Duty Trucks

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 294-317页

作者： Hongqing Chu Xiaoxiang na Huan Liu Yuhai Wang Zhuo Yang Lin Zhang Hong Chen School of Automotive Studies Tongji UniversityShanghaiChina Department of Engineering University of CambridgeCambridgeUK State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchunChina Qingdao Automotive Research Institute Jilin UniversityQingdaoChina Dongfeng Commercial Vehicle Technology Center Dongfeng Motor CorporationWuhanChina

Fuel consumption is one of the main concerns for heavy-duty *** cruise control(PCC)provides an intriguing opportunity to reduce fuel consumption by using the upcoming road *** this study,a real-time implementable PCC,which simultaneously optimizes engine torque and gear shifting,is proposed for heavy-duty *** minimize fuel consumption,the problem of the PCC is formulated as a nonlinear model predictive control(MPC),in which the upcoming road elevation information is *** the solution of the nonlinear MPC is time consuming;thus,a real-time implementable solver is developed based on Pontryagin’s maximum principle and indirect shooting *** programming(DP)algorithm,as a global optimization algorithm,is used as a performance benchmark for the proposed ***,hardware-in-the-loop and real-truck experiments are conducted to verify the performance of the proposed *** results demonstrate that the MPC-based solution performs nearly as well as the DP-based solution,with less than 1%deviation for testing ***,the proposed co-optimization controller is implementable in a real-truck,and the proposed MPC-based PCC algorithm achieves a fuel-saving rate of 7.9%without compromising the truck’s travel time.

关键词： Heavy-duty truck Predictive cruise control Model predictive control Pontryagin’s maximum principle Real-truck implementation

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How Does Participation in Agricultural Cooperatives Affect the Performance of Family Farms?——Empirical Evidence from 553 Planting Family Farms in Xinjiang Corps

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Journal of Systems Science and Information 2024年

作者： Zhiping HUANG na LI Xishan Farmland The 12th Division of Xinjiang Production and Construction Corps School of Economics and Management University of Chinese Academy of Sciences

Participation in agricultural cooperative organizations is an important form of industrial chain organization expansion, but also an important way to effectively reduce industrial chain transaction costs and promote the quality and efficiency improvement of new agricultural business *** on the micro-survey data of 553 family farms in Xinjiang Corps in 2021, this paper uses stochastic frontier approach to measure the business performance of family farms in Xinjiang Corps, and discusses the action mechanism and difference in the influence of participation in agricultural cooperative organizations on the business performance of family farms. The research shows that participation in agricultural cooperative organizations can significantly improve the business performance of family farms through such mechanisms as easing the constraints of farm credit financing, reducing the transaction costs of agricultural products, and promoting the adoption of agricultural technologies. Compared with food farms, cotton and fruit and vegetable family farms have more obvious performance improvement in participating in agricultural cooperative organizations. Moreover, participation in agricultural cooperation organizations has a stronger effect on the performance improvement of farms in northern Xinjiang. It is found that the vertical extension of the industrial chain between”family farm+agricultural cooperative organization” and network marketers, chain supermarkets, industrial leading enterprises and agricultural production and marketing enterprises is conducive to the improvement of the business performance of family farms, among which the performance improvement effect of”family farm+agricultural cooperative organization+network marketers” mode is more obvious. The research provides a scientific reference for deepening the expansion of the industrial chain organization and promoting the quality-oriented growth of family farms in the new era.

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The Impact of Sleep Determination on Procrastination before Bedtime:The Role of Anxiety

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International Journal of Mental Health Promotion 2024年第5期26卷 377-387页

作者： na Liu Junxiu Wang Wanli Zang School of Sociology and Ethnology University of Chinese Academy of Social SciencesBeijing102488China School of Mental Health Wenzhou Medical UniversityWenzhou325000China Institute of Psychosocial Services Kangning Hospital of Wenzhou Medical UniversityWenzhou325000China Postgraduate School Harbin Sport UniversityHarbin150008China

Objective:The importance of good sleep for energy recovery and overall physical and mental health cannot be ***,the increasing competitiveness of society,diversifying lifestyles,and the rapid spread of the internet and electronic devices have significantly impacted people’s sleep patterns,particularly through bedtime ***,this study aims to investigate the relationship and underlying mechanisms between sleep determination,anxiety,and bedtime procrastination among the Chinese ***:The study utilized data from a national survey—the China Residents’Sleep Condition Survey(November 2021,with 6,037 participants).By constructing mediation and moderation models,it analyzed the relationship and mechanisms between sleep determination and bedtime procrastination,highlighting the dual role of anxiety:as a mediator between sleep determination and bedtime procrastination,and as a moderator of their ***:There was a negative correlation between sleep determination and bedtime procrastination;anxiety was related to an increase in bedtime procrastination behaviors;In the interplay between sleep determination and pre-bedtime procrastination,the regulatory effect of anxiety is found to be more pronounced than its intermediary role,with anxiety significantly diminishing the inverse relationship between sleep determination and procrastination before ***:Bedtime procrastination can lead to sleep issues,thus reducing sleep *** sleep determination or alleviating pre-sleep anxiety can help inhibit bedtime procrastination *** and reducing bedtime procrastination is one of the effective measures to improve sleep quality.

关键词： Sleep determination bedtime procrastination anxiety mediation moderation

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Application of GNSS-PPP on Dynamic Deformation Monitoring of Offshore Platforms

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China Ocean Engineering 2024年第2期38卷 352-361页

作者： YU Li-na XIONG Kuan GAO Xi-feng LI Zhi FAN Li-long ZHANG Kai Institute of Ocean Energy and Intelligent Construction Tianjin University of TechnologyTianjin 300384China China Railway Construction Bridge Engineering Bureau Group Co.LTD Tianjin 300300China School of Civil Engineering Tianjin UniversityTianjin 300072China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Precision Blasting Jianghan UniversityWuhan 430056China

The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe *** Global navigation Satellite System-Precise Point Positioning(GNSS-PPP)has been considered for this purpose,its monitoring accuracy is relatively ***,the influence of background noise on the dynamic monitoring accuracy of GNSS-PPP remains ***,it is imperative to further validate the feasibility of GNSS-PPP for deformation monitoring of offshore *** address these concerns,vibration table tests with different amplitudes and frequencies are *** results demonstrate that GNSS-PPP can effectively monitor horizontal vibration displacement as low as±30 mm,which is consistent with ***,the spectral characteristic of background noise in GNSS-PPP is similar to that of GNSS-RTK(Real Time Kinematic).Building on this observation,an improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)has been proposed to de-noise the data and enhance the dynamic monitoring accuracy of *** monitoring application research is also undertaken,successfully extracting and analyzing the dynamic deformation of an offshore platform structure under environmental excitation using GNSS-PPP monitoring in conjunction with improved CEEMDAN *** comparing the de-noised dynamic deformation trajectories of the offshore platform during different periods,it is observed that the platform exhibits reversible alternating vibration responses under environmental excitation,with more pronounced displacement deformation in the direction of load *** research results confirm the feasibility and potential of GNSS-PPP for dynamic deformation monitoring of offshore platforms.

关键词： GNSS-PPP offshore platform dynamic deformation monitoring improved CEEMDAN de-noising

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Big Data Access Control Mechanism Based on Two-Layer Permission Decision Structure

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Computers, Materials & Continua 2024年第4期79卷 1705-1726页

作者： Aodi Liu na Wang Xuehui Du Dibin Shan Xiangyu Wu Wenjuan Wang He’nan Province Key Laboratory of Information Security Information Engineering UniversityZhengzhou450000China

Big data resources are characterized by large scale, wide sources, and strong dynamics. Existing access controlmechanisms based on manual policy formulation by security experts suffer from drawbacks such as low policymanagement efficiency and difficulty in accurately describing the access control policy. To overcome theseproblems, this paper proposes a big data access control mechanism based on a two-layer permission decisionstructure. This mechanism extends the attribute-based access control (ABAC) model. Business attributes areintroduced in the ABAC model as business constraints between entities. The proposed mechanism implementsa two-layer permission decision structure composed of the inherent attributes of access control entities and thebusiness attributes, which constitute the general permission decision algorithm based on logical calculation andthe business permission decision algorithm based on a bi-directional long short-term memory (BiLSTM) neuralnetwork, respectively. The general permission decision algorithm is used to implement accurate policy decisions,while the business permission decision algorithm implements fuzzy decisions based on the business *** BiLSTM neural network is used to calculate the similarity of the business attributes to realize intelligent,adaptive, and efficient access control permission decisions. Through the two-layer permission decision structure,the complex and diverse big data access control management requirements can be satisfied by considering thesecurity and availability of resources. Experimental results show that the proposed mechanism is effective andreliable. In summary, it can efficiently support the secure sharing of big data resources.

关键词： Big data access control data security BiLSTM

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