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Nanosuspension enhances dissolution rate and oral bioavailability of Terminalia arjuna bark extract in vivo and in vitro

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Asian Pacific Journal of Tropical Biomedicine 2020年第4期10卷 164-171页

作者： Fatiqa Zafar Nazish Jahan khalil-ur-rahman Muhammad Rafique Asi Waseeq-Ul-Islam Zafar Department of Chemistry University of OkaraOkaraPakistan Department of Chemistry University of AgricultureFaisalabadPakistan Department of Biochemistry University of AgricultureFaisalabadPakistan Food Toxicology Lab Plant Protection DivisionNuclear Institute for Agriculture and BiologyFaisalabadPakistan Department of Computer Science COMSATS University of Information and TechnologyIslamabadPakistan

Objective:To enhance the dissolution rate and oral bioavailability of Terminalia arjuna bark extract by formulating its ***:Nanoprecipitation approach was used for the formulation of nanosuspension using polysorbate-80 as a *** formulated nanosuspension was assessed for particle size,polydispersity index,zeta potential value and for in vitro dissolution *** bioavailability studies were carried out in Wistar male albino rats by administering a single dose(50 mg/***)of the formulated nanosuspension and coarse *** storage stability of the formulated nanosuspension was determined after three months of storage at room temperature and under the refrigerated *** assay was carried out to evaluate the toxicity of the formulated nanosuspension using two mutant strains(Salmonella typhimurium TA100 and Salmonella typhimurium TA98).Results:The mean particle size of the formulated nanosuspension was 90.53 nm with polydispersity index and zeta potential values of 0.175 and-15.7 m V,*** arjuna nanosuspension showed improved dissolution rate and 1.33-fold higher oral bioavailability than its coarse *** formulated nanosuspension also showed better stability under the refrigerated condition and was non-mutagenic against both ***:Our study demonstrates that nanosuspension technology can effectively enhance the dissolution rate and oral bioavailability of Terminalia arjuna bark extract.

关键词： Terminalia arjuna Nanosuspension Bioavailability Stability Toxicity Polysorbate-80

Einstein Hybrid Structure of q-Rung Orthopair Fuzzy Soft Set and Its Application for Diagnosis of Waterborne Infectious Disease

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1863-1892页

作者： Rana Muhammad Zulqarnain Hafiz khalil ur Rehman Imran Siddique HijazAhmad Sameh Askar Shahid Hussain Gurmani School of Mathematical Sciences Zhejiang Normal UniversityJinhua321004China Department of Mathematics Government College UniversityFaisalabad38000Pakistan Department of Mathematics University of SargodhaSargodha40100Pakistan Section of Mathematics International Telematic University UninettunoCorso Vittorio Emanuele IIRoma3900186Italy Near East University Operational Research Center in HealthcareNear East BoulevardNicosia/Mersin 1099138Turkey Department of Statistics and Operations Research College of ScienceKing Saud UniversityPO Box 2455Riyadh11451Saudi Arabia

This research is devoted to diagnosing water-borne infectious diseases caused by floods employing a novel diagnosis approach,the Einstein hybrid structure of q-rung orthopair fuzzy soft *** approach integrates parts of fuzzy logic and soft set theory to develop a robust alternative for disease detection in stressful situations,especially in areas affected by *** to the traditional intuitionistic fuzzy soft set and Pythagorean fuzzy soft set,the q-rung orthopair fuzzy soft set(q-ROFSS)adequately incorporates unclear and indeterminate *** major objective of this investigation is to formulate the q-rung orthopair fuzzy soft Einstein hybrid weighted average(q-ROFSEHWA)operator and its specific ***,our stated operator is implementing intelligentmulti-criteria group decision-making(MCGDM)*** are severe natural catastrophes that raise the risk of diseases and epidemics,particularly those caused by contaminants in the water,such as gastrointestinal diseases,respiratory infections,vector-borne diseases,skin infections,and water-borne *** designed MCGDM strategy tackles the prevalence of certain conditions in flood-affected patients.A comparative investigation determined that the suggested method for detecting water-borne infectious disease due to floods is more effective and productive than conventional methods because of its logical structure.

关键词： q-rung orthopair fuzzy soft set q-ROFSEHWA operator MCGDM environmental disaster water-born infection disease

Volcanically Driven Terrestrial Environmental Perturbations during the Carnian Pluvial Episode in the Eastern Tethys

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 753-770页

作者： Naveed ur rahman XIAN Benzhong FANG Linhao CHEN Sirui CHEN Peng Zaheen ULLAH WANG Pengyu National Key Laboratory of Petroleum Resources and Engineering Beijing 102249China College of Geosciences China University of PetroleumBeijing 102249China Centre for Earth and Space Sciences University of SwatSwat 19120Pakistan

The Carnian Pluvial Episode(CPE)fingerprints global environmental perturbations and biological extinction on land and oceans and is potentially linked to the Wrangellia Large Igneous Province(LIP).However,the correlation between terrestrial environmental changes and Wrangellia volcanism in the Ordos Basin during the CPE remains poorly *** of negative carbon isotopic excursions(NCIEs),mercury(Hg),Hg/TOC,and Hg enrichment factor(HgEF)from oil shales in a large-scale terrestrial Ordos Basin in the Eastern Tethys were correlated with marine and other terrestrial *** three significant NCIEs in the study section were consistently correlated with those in the CPE successions of Europe,the UK,and South and North *** U-Pb geochronology indicates a Ladinian-Carnian age for the Chang 7 Member.A comprehensive overview of the geochronology,NCIE correlation,and previous bio-and chronostratigraphic frameworks shows that the Ladinian-Carnian boundary is located in the lower part of Chang 7 in the Yishicun *** may be a more reliable proxy for tracing volcanic eruptions than the Hg/TOC ratio because the accumulation rates of TOC content largely vary in terrestrial and marine *** records of Hg,Hg/TOC,HgEF,and NCIEs in the Ordos Basin aligned with Carnian successions worldwide and were marked by similar anomalies,indicating a global response to the Wrangellia LIP during the ***,a warm-humid climate,enhancement of detrital input,and NCIEs are synchronous with the CPE interval in the Ordos Basin,which suggests that the CPE combined with the regional Qinling Orogeny should dominate the enhanced rate of terrigenous input and paleoenvironmental evolution in the Ordos Basin.

关键词： Chang 7 Member oil shale Carnian Pluvial Episode volcanism environmental perturbations

Annual growth of Fagus orientalis is limited by spring drought conditions in Iran’s Golestan Province

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Journal of Forestry Research 2024年第1期35卷 128-142页

作者： khalil Ghorbani Jahangir Mohammadi Laleh Rezaei Ghaleh Department of Water Engineering Faculty of Water and Soil EngineeringGorgan University of Agricultural Sciences and Natural ResourcesGorganIran Department of Forestry Gorgan University of Agricultural Sciences and Natural ResourcesGorganIran Department of Water Engineering Faculty of AgricultureUrmia UniversityUrmiaIran

Due to the lack of a uniform and accurate defi-nition of‘drought’,several indicators have been introduced based on different variables and methods,and the efficiency of each of these is determined according to their relationship with *** relationship between two drought indices,SPI(standardized precipitation index)and SPEI(standard-ized precipitation-evapotranspiration index)in different sea-sons was investigated using annual rings of 15 tree samples to determine the effect of drought on the growth of oriental beech(Fagus orientalis Lipsky)in the Hyrcanian forests of northern *** different evapotranspiration calcula-tion methods were evaluated on SPEI efficiency based on Hargreaves-Samani,Thornthwaite,and Penman-Monteith methods using the step-by-step M5 decision tree regression *** results show that SPEI based on the Penman-Monteith in a three-month time scale(spring)had similar temporal changes and a better relationship with annual tree rings(R^(2)=0.81)at a 0.05 significant *** change and a decreasing trend in the time series of annual tree rings are similar to the variation in the SPEI based on the Penman-Monteith *** affecting evapotranspiration,temperature,wind speed,and sunshine hours(used in the Penman-Monteith method),increased but precipitation *** non-linear modeling methods,SPEI based on Penman-Monteith best illustrated climate changes affecting tree growth.

关键词： Climate change Drought index Hyrcanian forests SPEI'Annual growth rings Fagus orientalis

Facile synthesis of samarium and cerium doped double perovskite cobaltite with enhanced dielectric response

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Journal of Rare Earths 2024年第7期42卷 1317-1327,I0005页

作者： Yasir Abbas M.Kamran M.Anis-ur-Rehman Applied Thermal Physics Laboratory Department of PhysicsCOMSATS University IslamabadIslamabad 45550Pakistan

The investigation of Sm-Ce doping on structure,conduction,and dielectric response of Bi_(2)Ca_(2-2x)Sm_(x)CexCoO_(6)(x=0.000,0.025,0.050,0.075)(BCSCCO)are *** the specimens were synthesized by a facile synthesis technique named the co-precipitation route.X-ray diffraction(XRD)reveals that BCSCCO crystallizes into one phase with space group P21/*** crystallite size,dislocation density,lattice parameters,lattice strain,unit cell volume,and bulk density were determined using XRD *** structural properties of Bi_(2)Ca_(2)CoO_(6)were examined using calculations based on the density functional *** and experimental values discrepancy is less than 1%.A scanning electron microscope was used for performing a microstructural *** SEM images demonstrate the homogeneous distribution of grains with a range of sizes(0.054-0.090μm).The alternating current(ac)conductivity,dielectric permittivity,and tangent loss were also studied as a function of frequency(20 Hz-3 MHz)at different temperatures(100-500℃).All synthesized samples were examined using non-linear Debye's function to determine their spreading factor and relaxation *** specimen with the lowest crystallite size(∼23 nm)exhibits a high dielectric permittivity(∼3.80×10^(6)).The conduction mechanism was examined in the studied samples with the use of Jonscher's power *** power law indicates that the BCSCCO(x=0.000,0.025)follows correlated barrier hopping,whereas the x=0.050 and 0.075 compositions follow non-overlapping polaron *** studied specimen Bi_(2)Ca_(1.9)0Sm_(0.05)0Ce_(0.05)_(0)CoO_(6)with the highest density(∼5.65 g/cm^(3))displays a high electrical conductivity(∼46.1 S/cm).These findings correspond to those published for ceramics made from calcium cobaltite using solid-state reactions(5.0-26.0 S/cm).

关键词： Bismuth calcium samarium cerium cobaltite (BCSCCO) Spreading factor Conduction mechanism Rare earths

OAM-based diffractive all-optical classification

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Advanced Photonics 2024年第1期6卷 6-7页

作者： Md Sadman Sakib rahman Aydogan Ozcan University of California Electrical and Computer Engineering DepartmentLos AngelesCaliforniaUnited States University of California Bioengineering DepartmentLos AngelesCaliforniaUnited States University of California California NanoSystems Institute(CNSI)Los AngelesCaliforniaUnited States

Object classification is an important aspect of machine *** practices in object classification entail the digitization of object information followed by the application of digital algorithms such as deep neural *** execution of digital neural networks is power-consuming,and the throughput is *** existing von Neumann digital computing paradigm is also less suited for the implementation of highly parallel neural network architectures.^(1)

关键词： consuming digit neural

Effects of multiple shapes for steady flow with transformer oil+Fe_(3)O_(4)+TiO_(2) between two stretchable rotating disks

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 373-388页

作者： M.rahman M.TurKYILMAZOGLU Z.MUSHTAQ Department of Mathematics Mirpur University of Science and TechnologyMirpur 10250Pakistan Department of Mathematics Hacettepe UniversityBeytepeAnkara 06532Turkiye

In this study,we examine the effects of various shapes of nanoparticles in a steady flow of hybrid nanofluids between two stretchable rotating *** steady flow of hybrid nanofluids with transformer oil as the base fluid and Fe_(3)O_(4)+TiO_(2)as the hybrid nanofluid is *** shapes of Fe_(3)O_(4)+TiO_(2)hybrid nanofluids,including sphere,brick,blade,cylinder,and platelet,are *** shape exists in the same volume of a *** leading equations(partial differential equations(PDEs))are transformed to the nonlinear ordinary differential equations(ODEs)with the help of similarity *** system of equations takes the form of ODEs depending on the boundary conditions,whose solutions are computed numerically by the bvp4c MATLAB *** outputs are compared with the previous findings,and an intriguing pattern is discovered,such that the tangential velocity is increased for the rotation parameter,while it is decreased by the stretching values because of the lower *** the reaction rate parameter,the concentration boundary layer becomes shorter,and the activation energy component increases the rate at which mass transfers come to the higher disk but have the opposite effect on the bottom *** ranges of various parameters taken into account are Pr=6.2,Re=2,M=1.0,φ_(1)=φ_(2)=0.03,K=0.5,S=-0.1,Br=0.3,Sc=2.0,α_(1)=0.2,γ=0.1,E_(n)=2.0,and q=1.0,and the rotation factor K is within the range of 0 to 1.

关键词： transformer oil Brinkman number skin friction coefficient double rotating disk Nusselt number Sherwood number

Pore-scale study of the effects of DTPA chelating agent flooding on oil recovery utilizing a clay-coated micromodel

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Petroleum Research 2024年第2期9卷 228-237页

作者： Hojjat Mohammadzadeh Jamshid Moghadasi khalil Shahbazi Shahin Kord Department of Petroleum Engineering Ahwaz Faculty of Petroleum EngineeringPetroleum University of TechnologyAhwazIran

The use of diethylenetriaminepentaacetic acid(DTPA)chelating agent has shown promising results for enhanced oil recovery(EOR)in prior *** mechanisms,mainly resulting from rock-fluid interaction,have been proposed for chelating agent flooding;however,little attention has been paid to fluid-fluid interaction thus *** assessment of these mechanisms has primarily relied on macroscopic techniques such as core *** paper aims to investigate the injection of DTPA brine and its dominant mechanisms at the pore scale using a clay-coated *** micromodel tests were performed under oil-wet and water-wet *** a more precise examination of fluid/fluid interactions,the dynamic interfacial tension(IFT)and Zeta potential were *** was observed that the injection of DTPA brine in water-wet state changed the saturation distribution and increased oil *** on visual inspections,this change in saturation distribution could potentially be linked to the formation of micro-dispersions and viscoelastic interfacial ***-dispersions facilitate flow to unswept areas,and viscoelastic interface formation reshapes the interface between oil and brine,causing disconnected oil droplets to coalesce and thus increase *** the oil-wet state,the micro-dispersion formation and wettability alteration can be the dominant mechanisms,and the amount of recovered oil was higher than that observed in the water-wet ***,Zeta potential measurements at the interface between brine and oil showed a more negative value for DTPA brine,which is effective in wettability alteration and micro-dispersions *** results indicate that IFT reduction was not significant enough to be considered the dominant mechanism,although it assists in DTPA brine penetration into the crude oil and subsequent micro-dispersion formation.

关键词： Enhanced oil recovery technique Chelating agent Micromodel Fluid/fluid interaction Micro-dispersions Viscoelastic interface

Polyhydroxyurethanes from Biobased Monomers and CO_(2):A Bridge between Sustainable Chemistry and CO_(2) Utilization

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Chinese Journal of Chemistry 2024年第6期42卷 652-685页

作者： Tharinee Theerathanagorn Tanika Kessaratikoon Hafeez ur Rehman Valerio D'Elia Daniel Crespy VISTEC Advanced Laboratory for Environment-Related Inorganic and Organic Syntheses Department of Materials Science and EngineeringVidyasirimedhi Institute of Science and Technology21210Wang ChanRayongThailand Department of Materials Science and Engineering Vidyasirimedhi Institute of Science and Technology21210Wang ChanRayongThailand

Polyhydroxyurethanes(PHUs)have received considerable attention in the last decade as potential alternatives to traditional phosgene-based polyurethanes(PUs).The development of suitable 5CC(five membered-ring cyclic carbonate)precursors bearing multiple carbonate moieties(multi-5CCs)is a key requisite for preparing PHUs by polyaddition reaction with bis-or *** sustainable PHUs from CO_(2)-based five-membered cyclic carbonates(5CCs)obtained from biobased epoxides is a valuable strategy to bridge CO_(2) utilization and the upcycling of renewable *** this context,while many multi-5CC monomers reported in the literature are oil-based,recent efforts have led to the development of a large variety of multifunctional 5CCs that are produced by the combination of CO_(2) and renewable resources such as fatty acids and vegetable oils,lignin,terpenes,and *** this work,recent crucial advances(2019—2023)on PHUs prepared from bis-and multi-5CCs produced from CO_(2) and(partially/potentially)biobased substrates are reviewed with respect to their synthesis,thermal and mechanical properties,and their recent,emerging applications.

关键词： CO_(2) conversion Polyhydroxyurethanes Cyclic carbonates Biobased compounds Fatty acids Functional polymers Monomers Renewable resources