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Role of bevacizumab intraocular injection in the management of neovascular glaucoma

International Journal of Ophthalmology(English edition) 2021年第6期14卷 855-859页

作者： Fawaz al Sarireh Hamzeh Mohammad alrawashdeh khalid al zubi Khalil al Salem Department of Ophthalmology College of MedicineUniversity of MutahKarak 61710Jordan Department of Ophthalmology Sharif Eye CentersIrbid 410739Jordan

AIM:To assess the long-term effects of intraocular bevacizumab(Avastin)injections as an adjunctive drug to manage patients with neovascular glaucoma(NVG).METHODS:A retrospective study was conducted consisting of 34 eyes with secondary NVG caused by proliferative diabetic retinopathy(n=25),ischemic central retinal vein occlusion(n=8),and retinal ischemia resulting from persistent detachment(n=1)were managed by intraocular injections of bevacizumab(1.25 mg/0.05 m L),in addition to other *** main outcome measure was the change in the degree of iris *** outcomes included intraocular pressure and the number of additional interventions or antiglaucoma medications administered after ***:all patients were followed-up for at least 12 *** the last follow-up,complete regression of rubeosis irides was detectable in 13(38.2%)eyes and incomplete regression in 21 eyes(61.8%).The mean intraocular pressure was 45.32±7.185 mm Hg at baseline and significantly decreased to 26.15±5.679 mm Hg at the last follow-up visit(P=0.000005).Patients received an average of 4.97 *** additional treatments,12 eyes(35%)received laser photocoagulation and 6 eyes(18%)underwent *** further treatment was needed in 16 eyes(47.1%).CONCLUSION:Intravitreal bevacizumab injection can have a favorable effect in controlling intraocular pressure and pain control in patients with NVG because it decreases the angiogenesis and helps to augment the results of conventional *** primary cause of retinal ischemia should be always targeted.

关键词： bevacizumab intraocular injection neovascular glaucoma rubeosis irides

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