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Cloning and characterization of 66 kDa streptavidin-binding peptides(SBP)of Pisum sativum *** specific to ***

BIOCELL 2019年第3期43卷 155-166页

作者： MAHMOUD MOUSTAFA saad ALAMRI TAREK TAHA ALI SHATI SULAIMAN ALRUMMAN MOHAMED ALKAHTANI Department of Biology College of ScienceKing Khalid University9004AbhaKingdom of Saudi Arabia Department of Botany Faculty of ScienceSouth Valley UniversityQenaEgypt Environmental Biotechnology Department Genetic Engineering and Biotechnology Research Institute(GEBRI)City of Scientific Research and Technological Applications(SRTA-City)New Borg El-Arab City21934AlexandriaEgypt

The aim of the current research was to clone and to characterize the partial 66 kDa streptavidin-binding peptide(SBP)found in the germinated embryos of Pisum sativum *** pea(*** ***)embryos possess prominent 66 kDa SBPs that gradually disappeared after few hours of germination in germinated embryos,but not in the *** total RNA was isolated from embryos of *** but could not be isolated from the *** partial nucleotides sequences of 66 kDa SBPs of embryonic stalk(*** ***)were cloned and identified using pMOSBlue vector.66 kDa(SBP)gene from the embryos of *** *** possesses 327 bp having an open reading frame(ORF)region in a part of the gene that encoded for 108 amino *** showed similarity among 66 kDa SBPs *** ***,with *** seed biotinylated protein(SBP65)and *** sbp65a mRNA with DNA distance matrix between 0.0094 to ***-TOF mass spectrometry analysis of 66 kDa(SBP)proteins showed it had similar short peptides to 19 proteins found in different organisms,especially Convicilin precursor,and the seed biotinylated protein in *** alignment results of both nucleotide sequences and amino acid residues either from cloning or MALDI-TOF-MS showed differences with related species,especially *** mRNA was found in the cotyledons during seeds germination,which means no metabolic activities and this part may act only as food reservoirs for growing newly embryos.

关键词： Cloning Embryo 66 kDa Pisum sativum Streptavidin-binding peptides(SBP)

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Silent Cerebral Infarctions in Type II Diabetes Mellitus Patients;Could Brain MRI Be a Routine Investigation?

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Open Journal of Medical Imaging 2014年第3期4卷 112-116页

作者： Mohamed Hamdy Ibrahim Taha Kamel Alloush Marwa Adel Shaaban Mohammed khalid Abdul Rahim Mohammad Ahmad M. saad Internal Medicine Department Gulf Medical University Ajman UAE Neurology Department Faculty of medicine Ain shams University Cairo Egypt Radiology Department Fayoom University Fayoom Egypt Radiology Department Misr University for Science and Technology Cairo Egypt

Objective: To study the prevalence of silent cerebral infarction in Type II diabetes mellitus. Patients and Methods: The study was a prospective on 80 patients recruited from neurology, endocrine outpatient clinics. Patients were type II diabetics as described by the American Diabetes Association, 2011 criteria. All patients underwent full metabolic profiles to diagnose diabetes mellitus and MRI brain scans to detect cerebral infarction. Results: Silent cerebral infarctions were detected in 60% of patients (48/80 patients) predominately along periventricular white matter area and subcortical areas (Basal ganglia, Thalamus). Conclusion: Asymptomatic Type II diabetes mellitus patients could have vascular cerebral changes without neurological symptoms. MRI brain scans could be recommended as routine diagnosis (if possible) for early cerebral infarct detection in type II diabetic patients.

关键词： Prevalence Silent Brain Infarction Diabetes Mellitus

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Saudi Consensus for GLP-1 RAs Switching Guidance: Consensus Report

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International Journal of Clinical Medicine 2022年第1期13卷 22-35页

作者： Saud Alsifri Hussein Elbadawi Fahad Alsabaan Abdulraouf Almahfouz khalid Alyahya Eman Shesha Laila Abu Esba Meshal Alnais Raed Aldahash Turky alharbi Saleh Aljaser Emad R. Issak Endocrinology Department Alhada & Taif Armed Forces Hospitals Taif Saudi Arabia My Clinic Medical Center Jeddah Saudi Arabia Endocrinology Department Security Forces Hospital Riyadh Saudi Arabia Section of Endocrinology Department of Medicine The King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia Pharmacy Department Prince Sultan Military Medical City Riyadh Saudi Arabia Diabetes Center King Salman Hospital Riyadh Saudi Arabia King Abdulaziz Medical City Riyadh Saudi Arabia Internal Medicine and Diabetes King Khalid Hospital Hail Saudi Arabia Department of Medicine King Abdulaziz Medical City National Guard Riyadh Saudi Arabia Family Medicine Department Prince Sultan Military Medical City Riyadh Saudi Arabia King Saud bin Abdulaziz University for Health Science Riyadh Saudi Arabia Medicine Department Faculty of Medicine Ain-Shams University Cairo Egypt

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) provide adequate glycemic control, weight reduction, low risk of hypoglycemia, and CV risk reduction. Their usage for type 2 DM (T2DM) is recommended mainly when hypoglycemia or weight gain should be considered, also, whenever initial therapy is failed. There are many recent updates in the treatment paradigm of T2DM. There are many types of GLP-1RAs, with a knowledge gap regarding switching between the different types. A Saudi task force gathered to develop an explicit, evidence-based consensus for switching between GLP-1RAs, when, why, and how? This article contains the expert panel’s recommendations as a contribution to complement the knowledge gap in this area from the national perspective. As an alternative to intensifying therapy, switching from one GLP-1RA to another has various advantages. Improvements in glycemic control, weight loss, adherence, and medications with established cardiovascular benefits are among them. Also, switching needs to be individualized upon many discussed factors like the dose of the previous GLP1-RA and gastrointestinal adverse effects. Discussion with patients about the why and how to switch is critical.

关键词： Glucagon-Like Peptide-1 Receptor Agonists Switching Type 2 DM Glycemic Control

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Saudi Consensus for Low-Premixed Insulin Analogues in Type 2 Diabetes: Consensus Report

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International Journal of Clinical Medicine 2021年第4期12卷 165-182页

作者： Abdulrahman Alshaikh Mohammed Aljamal Saud Alsifri Ali Alrumaih Samia Bokhari Mohammed Almuzaini khalid Alyahya Abdulaziz Bin Shaikh Turky alharbi Rashid Aljuwair Fahad Alsabaan Emad R. Issak Medicine Department College of Medicine King Abdulaziz University Jeddah KSA Supply Chain Department King Fahd Armed Forces Hospital Jeddah KSA Endocrinology Department Alhada & Taif Armed Forces Hospitals Taif KSA Endocrinology Department King Fahad Armed Forces Hospital Jeddah KSA Pharmacy Department Prince Sultan Military Medical City Riyadh KSA Family Medicine Department Prince Sultan military Medical City Riyadh KSA Endocrinology Department Dahran Medical Complex Dahran KSA Endocrinology Department Security Forces Hospital Riyadh KSA Medicine Department Faculty of Medicine Ain-Shams University Cairo Egypt

Dear Dr. Martin Hovland, We learned from the literature that premixed insulins are short-acting insulin or rapid-acting insulin analogue mixed with intermediate-acting insulin in a fixed ratio, addressing FBG and PPBG in one injection. There are two categories;high-mix and low-mix premixed insulins. We, a Saudi task force, gathered to develop an explicit, evidence-based consensus for the use of the low-mix premixed insulin for better glycemic control. The treatment with premixed aspart 30 was non-inferior to treatment with premixed insulin lispro 25. In addition, Self-monitored blood glucose levels were comparable. Safety profiles were similar between both treatments, as was the incidence of hypoglycemic episodes. The switch between both products of the low-mix family can be carried out without any problem. Both products of the low-mix premixed insulin analogues aspart 30/70 and premixed insulin lispro 25/75 have comparable efficacy and safety as shown from the medical literature. Therefore, we can change from one to another safely as demonstrated by the US FDA statement. In addition, the ergonomic features of KwikPen’s design and function may offer important advantages for the user during insulin administration.

关键词： Low-Mix Premixed Insulin Lispro 25/75 Aspart 30/70

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Deep Learning Enabled Intelligent Healthcare Management System in Smart Cities Environment

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Computers, Materials & Continua 2023年第2期74卷 4483-4500页

作者： Hanan Abdullah Mengash Lubna A.alharbi Saud S.Alotaibi Sarab AlMuhaideb Nadhem Nemri Mrim M.Alnfiai Radwa Marzouk Ahmed S.Salama Mesfer Al Duhayyim Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Science College of Computers and Information TechnologyTabuk UniversityTabuk71491Saudi Arabia Department of Information Systems College of Computing and Information SystemUmm Al-Qura UniversitySaudi Arabia Department of Computer Science College of Computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia Department of Information Systems College of Science and Arts at MuhayelKing Khalid UniversitySaudi Arabia Department of Information Technology College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Electrical Engineering Faculty of Engineering&TechnologyFuture University in EgyptNew Cairo11845Egypt Department of Computer Science College of Sciences and Humanities-AflajPrince Sattam bin Abdulaziz UniversitySaudi Arabia

In recent times,cities are getting smart and can be managed effectively through diverse architectures and *** cities have the ability to support smart medical systems that can infiltrate distinct events(i.e.,smart hospitals,smart homes,and community health centres)and scenarios(e.g.,rehabilitation,abnormal behavior monitoring,clinical decision-making,disease prevention and diagnosis postmarking surveillance and prescription recommendation).The integration of Artificial Intelligence(AI)with recent technologies,for instance medical screening gadgets,are significant enough to deliver maximum performance and improved management services to handle chronic *** latest developments in digital data collection,AI techniques can be employed for clinical decision making *** the other hand,Cardiovascular Disease(CVD)is one of the major illnesses that increase the mortality rate across the ***,wearables can be employed in healthcare systems that instigate the development of CVD detection and *** this motivation,the current study develops an Artificial Intelligence Enabled Decision Support System for CVD Disease Detection and Classification in e-healthcare environment,abbreviated as AIDSS-CDDC *** proposed AIDSS-CDDC model enables the Internet of Things(IoT)devices for healthcare data ***,the collected data is saved in cloud server for *** by,training 4484 CMC,2023,vol.74,no.2 and testing processes are executed to determine the patient’s health *** accomplish this,the presented AIDSS-CDDC model employs data preprocessing and Improved Sine Cosine Optimization based Feature Selection(ISCO-FS)*** addition,Adam optimizer with Autoencoder Gated RecurrentUnit(AE-GRU)model is employed for detection and classification of *** experimental results highlight that the proposed AIDSS-CDDC model is a promising performer compared to other existing models.

关键词： Smart cities e-healthcare decision support system cardiovascular disease deep learning feature selection

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Improved Bat Algorithm with Deep Learning-Based Biomedical ECG Signal Classification Model

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Computers, Materials & Continua 2023年第2期74卷 3151-3166页

作者： Marwa Obayya Nadhem NEMRI Lubna A.alharbi Mohamed K.Nour Mrim M.Alnfiai Mohammed Abdullah Al-Hagery Nermin M.Salem Mesfer Al Duhayyim Department of Biomedical Engineering College of EngineeringPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Information Systems College of Science and Art at MahayilKing Khalid UniversitySaudi Arabia Department of Computer Science College of Computers and Information TechnologyTabuk UniversitySaudi Arabia Department of Computer Sciences College of Computing and Information SystemUmm Al-Qura UniversitySaudi Arabia Department of Information Technology College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Computer Science College of ComputerQassim UniversitySaudi Arabia Department of Electrical Engineering Faculty of Engineering and TechnologyFuture University in EgyptNew Cairo11835Egypt Department of Computer Science College of Sciences and Humanities-AflajPrince Sattam Bin Abdulaziz UniversitySaudi Arabia

With new developments experienced in Internet of Things(IoT),wearable,and sensing technology,the value of healthcare services has *** evolution has brought significant changes from conventional medicine-based healthcare to real-time observation-based *** Electrocardiogram(ECG)signals are generally utilized in examination and diagnosis of Cardiovascular Diseases(CVDs)since it is quick and non-invasive in *** to increasing number of patients in recent years,the classifier efficiency gets reduced due to high variances observed in ECG signal patterns obtained from *** such scenario computer-assisted automated diagnostic tools are important for classification of ECG *** current study devises an Improved Bat Algorithm with Deep Learning Based Biomedical ECGSignal Classification(IBADL-BECGC)*** accomplish this,the proposed IBADL-BECGC model initially pre-processes the input ***,IBADL-BECGC model applies NasNet model to derive the features from test ECG *** addition,Improved Bat Algorithm(IBA)is employed to optimally fine-tune the hyperparameters related to NasNet ***,Extreme Learning Machine(ELM)classification algorithm is executed to perform ECG classification *** presented IBADL-BECGC model was experimentally validated utilizing benchmark *** comparison study outcomes established the improved performance of IBADL-BECGC model over other existing methodologies since the former achieved a maximum accuracy of 97.49%.

关键词： Data science ECG signals improved bat algorithm deep learning biomedical data data classification machine learning

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Gene expression of 49 kDa apyrase,cytoskeletal proteins,ATPase,ADPase and amino acid contents of Pisum sativum(L.)cells germinated in Euryops arabicus(*** Jaub.&Spach)water extract

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BIOCELL 2019年第2期43卷 81-87页

作者： MAHMOUD MOUSTAFA saad ALAMRI HOIDA ZAKI NAGLAA LOUTFY TAREK TAHA ALI SHATI MOHAMED ALKAHTANI SAJDA SIDDIQI Department of Biology College of ScienceKing Khalid University9004AbhaKingdom of Saudi Arabia(KSA) Department of Botany Faculty of ScienceSouth Valley UniversityQenaEgypt Environmental Biotechnology Department Genetic Engineering and Biotechnology Research Institute(GEBRI)City of Scientific Research and Technological Applications(SRTA-City)New Borg El-Arab City21934AlexandriaEgypt

The present research reports of quick and marked changes induced by plant extract of Euryops arabicus in the gene expression of 49-kDa apyrases,cytoskeletal proteins,ATPases,ADPase and amount of amino acid of pea(Pisum sativum ***).Pellets of cytoskeletals proteins(27000 xg)were probed with anti-apyrase antibody,biotinylated anti-rat,actin and alpha and beta-tubulin for Western *** and ADPase activities were determined based on the hydrolytic efficacy of adenine triphosphate and adenine *** 72 hours,the abundance of apyrases,cytoskeletal proteins and amount of amino acid in pellets of 27000 xg of germinated pea seeds in *** extracts were sharply increased than those sown in distilled *** the samples exhibited that the stems had more amount from apyrases,cytoskeletal proteins,amino acids and ATPase and ADPase activities than primary leaves and primary roots that were germinated either on *** water extract or in distilled *** on the enzyme’s capability to hydrolyse nucleotide triphosphate and nucleotide diphosphate as well as the direct association between expression of 49-kDa apyrase and cytoskeletal proteins,*** water extract had an important effect on plant germinations.

关键词： Cytoskeletal proteins ATPase ADPase Pisum sativum Euryops arabicus

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Irritable Bowel Syndrome and Dietary Habits in Northern Saudi Arabia

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Health 2019年第3期11卷 289-297页

作者： Saleh Hadi alharbi Fahad A. Alateeq Khalil Ibrahim Alshammari Abdulaziz saad Sharea Alshammri Naif Abdulmohsen Naif Alabdali Motab Ali Saud Alsulaiman Sami Mamdouh Ibrahim Algothi Abdulrahman Sulaiman Altoraifi Maha Qasem Almutairi Hussain Gadelkarim Ahmed Faculty of Medicine Al-Imam Mohammad Ibn Saud Islamic University Riyadh KSA College of Medicine University of Hail Hail KSA Department of Histopathology and Cytology FMLS University of Khartoum Khartoum Sudan

Background: dietary habit is one of the most universally recounted initiators of irritable bowel syndrome (IBS). The objective of the present study was to determine the role of some dietary habits in the etiology of IBS in Northern Saudi Arabia. Methodology: In this community based cross-sectional survey, data about IBS were obtained from 930 Saudi volunteers living in the city of Hail, Northern Saudi Arabia. IBS was diagnosed using Rome IV criteria. Results: The prevalence of IBS was 11% among males vs. 12.5% among females. The prevalence of IBS symptoms among males was 30% vs. 36.5% females. IBS was significantly associated with reduced water intake, the RR (95% CI) = 1.1800 (1.0146 to 1.3722), P = 0.0316. In the present study, the majority of the study population 904/929 (97.3%) didn’t accustom to vegetables/fruits intake. Conclusion: IBS is prevalent in Northern Saudi Arabia, both among males and females with relatively increasing among females. Low water intake and insufficient fibers intake (particularly, in vegetables and fruits) might be behind the growing prevalence of IBS in Saudi Arabia.

关键词： Irritable Bowel Syndrome Dietary Habits Saudi Arabia

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Hydrothermal preparation of TiO_(2)-Ag nanoparticles and its antimicrobial performance against human pathogenic microbial cells in water

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BIOCELL 2018年第3期42卷 93-97页

作者： Mahmoud MOUSTAFA saad ALAMRI Mohamed ELNOUBY Tarek TAHA M.A.ABU-SAIED Ali SHATI Mohamed AL-KAHTANI Sulaiman ALRUMMAN Department of Biology College of ScienceKing Khalid University9004AbhaKingdom of Saudi Arabia(KSA Department of Botany Faculty of ScienceSouth Valley UniversityQenaEgypt Composite and Nanostructured Materials Research Department Advanced Technology and New Materials Research InstituteCity of Scientific Research and Technological Applications(SRTA-CITY)New Borg El-Arab City21934AlexandriaEgypt Environmental Biotechnology Department Genetic Engineering and Biotechnology Research Institute(GEBRI)City of Scientific Research and Technological Applications(SRTA-CITY)New Borg El-Arab City21934AlexandriaEgypt Polymer Materials Research Department Advanced Technology and New Materials Research InstituteCity of Scientific Research and Technological Applications(SRTA-CITY)New Borg El-Arab City21934AlexandriaEgypt

Water contaminated with pathogenic microbes is considered as one of the most common routes for transmitting diseases in human *** methods have been applied for the decontamination of microbes in contaminated *** the current study,an easy to do hydrothermal method has been used for the preparation of TiO_(2)-Ag *** obtained material was characterised using a scanning electron microscope(SEM)and fourier transform infra-red spectroscopy(FTIR).The morphological appearance of the obtained nanoparticles was in the shape of a sphere with a size range of 60-90 *** antimicrobial activity of the prepared nanoparticles was tested against several pathogenic bacteria and *** obtained results proved that the nanoparticles succeeded to affect all the tested microbes in the following order:Bacillus cereus ATCC6633>Pseudomonas aeruginosa ATCC9027=Klebsiella pneumoniae ATCC13883>Vibrio cholera ATCC700=Candida albicans ATCC 700=Escherichia coli NCTC10418>Staphylococcus aureus *** minimum inhibitory concentration(MIC)of the prepared nanoparticles varied among the tested microbes at range of 12 mg/ml and 25 mg/*** results encourage the application of prepared TiO_(2)-Ag nanoparticles for treatment of microbe-contaminated waters.

关键词： TiO_(2)-Ag nanoparticles Hydrothermal Antimicrobial activity Water treatment

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Impact of diabetes education on patients suffering from type 2 diabetes in Saudi Arabia

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TMR Non-Drug Therapy 2020年第3期3卷 137-145页

作者： Alruwaili Mofreh Alatni Adel Aldhafeeri khalid alharbi Muhammad Eradah Hospital for Mental Health Al-Jouf 72347Saudi Arabia AlRass General Hospital 4614 Airport DistrictUnit N0.8AlRassSaudi Arabia Hafer Albatin Central Hospital Hafar Albatin 31991Saudi Arabia Ministry of Health Riyadh 11176Saudi Arabia

Background:Diabetes health education is an integral component of diabetes *** aim of education is not only to provide knowledge and skills,but also to change patients’attitude and increase motivation towards therapeutic recommendation *** main objective of the study is to compare the impact of diabetes health education for patients with type 2 diabetes in terms of knowledge,health outcomes and effect on glycemic control(glycated hemoglobin,haemoglobin A1c).Methods:A cohort of 110 patients with newly diagnosed diabetes were included in this prospective *** characteristics were retrieved from the medical record of the Al-Jouf Diabetes Center,Saudi ***,diabetic health education program effectiveness and haemoglobin A1c were measured after 3 months health ***:Results showed a significant reduction in mean haemoglobin A1c after education,which was down by 1.47(t=6.07,P<0.001).Whereas,the mean haemoglobin A1c before diabetic education was 9.19±1.70%and after education,it was 7.72±0.80%.The difference is more significant in young Saudi males,those who were married and were more ***,there was no significant with respect to any socio-demographic ***:The findings demonstrate that diabetic education was effective in controlling diabetes and the beneficial effect of this intervention did not differ with respect to socio-economic conditions and demographic ***,early diabetic education can lead to decrease in diabetic related complications.

关键词： Diabetic education HbA1c Saudi Arabia Type 2 diabetes Cohort study

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