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Tympanometry Comparison of Diabetic Type I and Diabetic Type II Rats

Journal of Diabetes Mellitus 2023年第1期13卷 58-67页

作者： Susan Amin Ahmed Alaradi Ahmed Alekri Ali Alaysreen Ammar Kheyami Hasan Baksh khalid nazzal Abdullah Altamimi Omar Alhamdan Amer Kamal School of Medicine Royal College of Surgeons in Ireland (RCSI-Bahrain) Busaiteen Bahrain Department of Physiology Arabian Gulf University (AGU) Manama Bahrain

Hearing impairment affects over two-thirds of adults with diabetes. We investigated whether rat models of type 1 and type 11 diabetes display impaired auditory function. Tympanometry measurements were conducted in Sprague-Dawley rats (control, n = 20), streptozotocin-induced type I diabetic Sprague-Dawley rats (n = 20) at 42 - 56 days old;Zucker rats (Hos: ZFDM-Lean (fa/+, n = 20) and Zucker Type 2 Diabetic rats (ZFDM (Hos: ZFDM-fa/fa);n = 20)), 90 days old. All rats were male. Control animals had normal type A tympanograms. Tweny one (75%) of the tympanic membranes in the diabetic type I group produced abnormal tympanograms: 46% were type B, 28% had no peak found, and 1% were type C. The ear canal measurements were lower in the left ear in type I mice (0.19 ± 0.07) and higher in the left ear for type II mice (0.23 ± 0.15 ml) compared to the controls of 0.39 ± 0.14 ml) and (0.2 ± 0.12 ml) respectively (P < 0.0001). The compliances for the right ear and left ear were lower for the type II diabetic group (0.18 ± 0.05 ml) and (0.18 ± 0.05 ml) compared to the control group (0.28 ± 0.19 ml) and (0.28 ± 0.49 ml) (P < 0.0001) respectively. In conclusion, control rats exhibited type A tympanograms with a highly functional middle ear system. Diabetic type I rats (n = 20) mostly exhibited type B tympanograms with a less compliant middle ear system. Compliance was reduced in the diabetic type I and II animals compared to the control. Future studies should utilise histological methods alongside tympanometry. Sections of the middle ear could be used to analyze ossicle size and confirm size differences. This information would be useful in avenues for treatment options for hearing loss in diabetes.

关键词： Diabetes Tympanometry Auditory Function Compliance Ear Canal

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The Value of Tocotrienols in the Prevention and Treatment of Cancer

The Value of Tocotrienols in the Prevention and Treatment of...

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作者： Paul W.Sylvester Amal Kaddoumi Sami nazzal khalid A.El Sayed College of Pharmacy University of Louisiana at MonroeMonroeLouisiana

Tocopherols and tocotrienols represent the 2 subgroups that make up the vitamin E family of compounds, but only tocotrienols display potent anticancer *** in vitro experimental evidence has been very promising,oral supplementation of tocotrienols in animal and human studies has produced inconsistent results. However,recent studies have now clarified the reasons for these discrepancies observed between in vitro and in vivo *** absorption of tocotrienols into the circulation is mediated in large part by carrier transporter

关键词： tocotrienols breast cancer intestinal absorption lipid nanoparticles tocotrienol analogues

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