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Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15K to 333.15K

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Chinese Journal of Chemical Engineering 2015年第5期23卷 812-815页

作者： Md khalid Anwer Faiyaz Shakeel Department of Pharmaceutics College of Pharmacy Salman Bin Abdulaziz University Center of Excellence in Biotechnology Research King Saud University Department of Pharmaceutics College of Pharmacy King Saud University

The aim of present study was to measure and correlate the solubility of poorly water-soluble flavonoid diosmin in water, ethanol, isopropyl alcohol （IPA）, polyethylene glycol-400 （PEG-400） and β-cyclodextrin （β-CD） aqueous solution （0.02 mol·L^-1 ）. The solubility of diosmio was measured using the shake flask method from （298.15 to 333.15） K at atmospheric pressure. The experimental solubilities of diosmin were regressed by the modified Apelblat model with a relative deviation in the range of 0.048% to 5.940%. The correlation coefficients were observed in the range of 0.9957 to 0.9995. The solubility of diosmin was found to be increased with temperature in all sample matrices investigated. The mole fraction solubility of diosmin was found to be higher in 5-CD aqueous solution and PEG-400 as compared to water, ethanol and IPA. Based on solubility data of present study, diosmin was considered as practically insoluble in water, insoluble in ethanol ＆ IPA and soluble in PEG- 400 and β-CD aqueous solution.

关键词： Apelblat model Cyclodextrin Diosmin Solubility Thermodynamics

The association between mycotic pneumonia and neonatal septicemia

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Journal of Biosafety and Biosecurity 2024年第3期6卷 137-141页

作者： Salman khalid Salman Yasir Mufeed Abdulateef Sawsan Qahtan Taha al-Quhli Department of Microbiology College of MedicineUniversity of AnbarIraq

Background:Candida species are the fourth most common etiological agents of late-onset infection in the neonatal intensive care unit(NICU)and are responsible for considerable morbidity and ***:From November 2023 to February 2024,we investigated the association of mycotic pneumonia with septicemia in 60 neonates,and their roles of mycotic pneumonia in the morbidity and mortality of neonates in two NICUs in the al-Ramadi Teaching Hospital for Maternity and ***:all infants in this study had been diagnosed with septicemia and treated with empirical antimicrobial *** early morning nasogastric tube(NG-tube)was used to collect swallowed sputum by suction for culture and sensitivity ***:The average white blood count for the neonates was 8547±5884.5 cells/mm^(2).The mean C-reactive protein was 39.3±26 mg/l,the mean serum albumin was 2.9±0.2 g/dl and the positive bacterial blood culture was 28(46.7%).9(15%)neonates died during the study *** NG-tube culture identified fungal growth in all *** these,49(81.6%)were identified as Candida albicans,6(10%)as Candida tropicalis,and 5(8.3%)as Cryptococcus *** bacterial culture results from the NG-tube samples identified 13(21.6%)patients with gram-positive bacteria and 47(78.3%)with gram-negative ***:We found a prevalence of Candida *** neonates in addition to microbial oxygen tube contamination,indicating a biosafety breach in the neonatal *** infection requires global attention as a probable cause of respiratory failure in neonatal septicemia.

关键词： Neonatal sepsis Mycotic pneumonia Anti-Mycotic therapy NG-tube culture Nosocomial infections

Productivity Improvement Model without Increasing Operation’s Risk and Fatigue

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Engineering（科研） 2011年第11期3卷 1124-1131页

作者： Adel al-Shayea khalid al-Saleh khalid al-Yami Abdulaziz El-Tamimi 不详

Productivity improvement of an operation without increasing operation risk and operation fatigue that increase the needed relaxation allowance is an important subject in process design. This research subject stimulates researchers to focus on improving the productivity of the whole production process by changing the technique of performing significant operations in the process. However, two important issues that affect the implementation of any new technique were not considered in the pervious research works. These are the risk magnitude of the new technique on the workplace environment and the fatigue level that affect human's health. In this paper, a model was developed that maximize the productivity of the production process by selecting the best technique to perform significant process operations among proper candidate techniques that improve these operations productivity while minimizing these operations risk and fatigue.

关键词： Risks Productivity Improvement Optimization Relaxation allowance Fatigue Standard Productivity Costs

Bethesda System for Reporting Thyroid Cytopathology:A three-year study at a tertiary care referral center in Saudi Arabia

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World Journal of Clinical Oncology 2017年第2期8卷 151-157页

作者： Mohamed Abdulaziz al Dawish Asirvatham alwin Robert aljuboury Muna alkharashi Eyad Abdullah al Ghamdi khalid al Hajeri Mohammed A Thabet Rim Braham Department of Endocrinology Prince Sultan Military Medical City Department of Pathology Prince Sultan Military Medical City Department of General Surgery Prince Sultan Military Medical City Department of Radiology Prince Sultan Military Medical City Department of Endocrinology Henri Mondor Hospital

AIM To stratify the malignancy risks in thyroid nodules in a tertiary care referral center using the Bethesda system. METHODS From January, 2012 to December, 2014, a retrospective analysis was performed among 1188 patients(15-90 years) who had 1433 thyroid nodules and fine-needle aspiration at Prince Sultan Military Medical City, Saudi Arabia. all thyroid cyto-pathological slides and ultra sound reports were reviewed and classified according to the Bethesda System for Reporting Thyroid Cytopathology. Age, gender, cytological features and histological types of the thyroid cancer were collected from patients' medical chart and cytopathology reports. RESULTS There were 124 total cases of malignancy on resection, giving an overall surgical yield malignancy of 33.6%.Majority of the thyroid cancer nodules(n = 57, 46%) in Bethesda VI category followed by Bethesda IV(n = 25, 20.2%). almost 40% of the cancer nodules in 31-45 age group in both sex. Papillary thyroid carcinoma(PTC) was the most common form of thyroid cancer among the study population(111, 89.6%) followed by 8.9% of follicular thyroid carcinoma(FTC), 0.8% of medullary carcinoma and 0.8% of anaplastic carcinoma. Among the Bethesda IV category 68% thyroid nodules were PTC and 32% FTC. CONCLUSION The malignancy values reported in our research were constant and comparable with the results of other published data with respect to the risk of malignancy. Patients with follicular neoplasm/suspicious for follicular neoplasm and suspicious of malignancy categories, total thyroidectomy is indicted because of the substantial risk of malignancy.

关键词： Bethesda Total thyroidectomy Thyroid nodules Risk of malignancy Fine needle aspiration

Analysis of the Smart Player’s Impact on the Success of a Team Empowered with Machine LeAnalysis of the Smart Player’s Impact on the Success of a Team Empowered with Machine Learningarning

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Computers, Materials & Continua 2021年第1期66卷 691-706页

作者： Muhammad Adnan Khan Mubashar Habib Shazia Saqib Tahir alyas khalid Masood Khan Mohammed A.al Ghamdi Sultan H.almotiri Lahore Garrison University Lahore54792Pakistan Computer Science Department Umm Al-Qura UniversityMakkah City715Saudi Arabia

The innovation and development in data science have an impact in all trades of *** commercialization of sport has encouraged players,coaches,and other concerns to use technology to be in better position than r their *** the past,the focus was on improved training techniques for better physical *** days,sports analytics identify the patterns in the performance and highlight strengths and weaknesses of potential *** analytics not only predict the performance of players in the near future but it also performs predictive modeling for a particular behavior of a player in the *** impact of a smart player on the success of a team is always a big question mark before the start of a *** fans always want to know performance analysis of these superstar players and they always are interested to get to know more about their favorite player and they always have high hopes from their favorite *** learning(ML)based techniques help in predicting the performance of an individual player as well as for the whole *** statistics are very vital and useful for management,fans,and expert *** our proposed framework,the adaptive back propagation neural network(ABPNN)model is used for the prediction of a player’s *** data is collected from football websites,and the results are stored in the cloud for fast fetching of *** can be retrieved anywhere in the world through cloud *** results are computed with 94%accuracy and the performance of the smart player is formulated for the success of a team.

关键词： Machine learning adaptive feed forwarded neural network adaptive back propagation neural network cloud computing fetching

Glassy phase and thermodynamics for random field Ising model on spherical lattice in magnetic field

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Chinese Physics B 2010年第10期19卷 525-533页

作者： khalid Bannora Galal Ismail Wafaa Hassan Mathematics Department Faculty of Science Zagazig University Mathematics and Physics Department Faculty of Engineering Port Said Branch of Suez Canal University

Phase diagram and thermodynamic parameters of the random field Ising model （RFIM） on spherical lattice are studied by using mean field theory. This lattice is placed in an external magnetic field （B）. The random field （hi） is assumed to be Gaussian distributed with zero mean and a variance （hi2） = HRF2. The free energy （F）, the magnetization （M） and the order parameter （q） are calculated. The ferromagnetic （FM） spin-glass （SG） phase transition is clearly observed. The critical temperature （Tc） is computed under a critical intensity of random field HRF = V/2/πJ. The phase transition from FM to paramagnetic （PM） occurs at TC = J/k in the absence of magnetic field. The critical temperature decreases as HRF increases in the phase boundary of FM-to-SG. The magnetic susceptibility （X） shows a sharp cusp at TC and the specific heat （C） has a singularity in small random field. The internal energy （U） has a similar behaviour to that obtained from the Monte Carlo simulation.

关键词： random field mean field theory magnetization specific heat and phase diagram

Antioxidant and antihyperlipidemic activity of Costus speciosus against atherogenic diet-induced hyperlipidemia in rabbits

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Journal of Integrative Medicine 2019年第3期17卷 181-191页

作者： Fatma Mohamed Hussein Shediwah khalid Mohammed Naji Hussein Saleh Gumaih Fatima A alhadi Amani Lutf al-Hammami Myrene Roselyn D'Souza Department of Biology Faculty of ScienceSana'a University Department of Chemistry Faculty of ScienceSana'a University Chemical Ecology Department of BiologyUniversity of Konstanz Department of Biochemistry Mount Carmel College

Objective: An extract of Costus speciosus(CSE), a herb widely used in folk medicine, was evaluated for its antioxidant, antihyperlipidemic and ameliorating effects on histopathological changes in atherogenic ***: Twenty-four male rabbits(Oryctolagus cuniculus) were divided into 4 groups. Three groups were fed a diet containing 3% saturated fat and 1.3% cholesterol for 40 d. One of these was sacrificed on the 40 th day and was called the pathogenic(P) group; the other two groups received treatment for another 30 d as follows: one received 0.8 g/(kgád) of CSE and the other was given 0.01 g/(kgád) of simvastatin. The normal group was sacrificed on the 70 th day and used as a ***: CSE showed radical-scavenging ability. Administration of CSE for a 30-day period resulted in a significant decrease in total cholesterol, triacylglycerol, low-density lipoprotein and aspartate aminotransferase compared to the P group, while levels of hemoglobin, packed corpuscular volume and red blood cells were elevated. With respect to studies performed on the heart, a decrease in malondialdehyde and an increase in reduced glutathione were noted. Total protein increased in the liver, heart and aorta after treatment with CSE and also a marked improvement in histopathological parameters was ***: The present findings indicate that the C. speciosus rhizome possesses antiatherogenic and antioxidant properties which may provide protective effects against oxidative stress in atherosclerotic rabbits.

关键词： Antioxidants Atherosclerosis Costus speciosus Lipid profile Myocardial infraction Simvastatin

Glassy behaviour of random field Ising spins on Bethe lattice in external magnetic field

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Chinese Physics B 2011年第6期20卷 416-425页

The thermodynamics and the phase diagram of random field Ising model （RFIM） on Bethe lattice are studied by using a replica trick. This lattice is placed in an external magnetic field （B）. A Gaussian distribution of random field （hi） with zero mean and variance （hi2 = H2RF is considered. The free-energy （F）, the magnetization （M） and the order parameter （q） are investigated for several values of coordination number （z）. The phase diagram shows several interesting behaviours and presents tricritical point at critical temperature Tc = J/k and when HRF = 0 for finite z. The free-energy （F） values increase as T increases for different intensities of random field （HRE） and finite z. The internal energy （U） has a similar behaviour to that obtained from the Monte Carlo simulations. The ground state of magnetization decreases as the intensity of random field HRF increases, The ferromagnetic （FM） paramagnetic （PM） phase boundary is clearly observed only when z →∞. While FM PM-spin glass （SG） phase boundaries are present for finite z. The magnetic susceptibility （X） shows a sharp cusp at Tc in a small random field for finite z and rounded different peaks on increasing HRF.

关键词： random field replica trick coordination number order parameter susceptibility and phase diagram

Studies on the Antibacterial Activity of Ceftiofur Sodium in Vitro and Birds

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Open Journal of Veterinary Medicine 2013年第1期3卷 16-21页

作者： khalid A. al-Kheraije Shaqra University Shaqra KSA

This study was carried out to evaluate the antibacterial activity of ceftiofur sodium as anti-infective chemotherapeutic agent belonged to the third generation of cephalosporins against different bacterial pathogens in vitro and birds. The obtained results showed that it was more effective and superior in its action than that the other compared antibacterial agents. The disc diffusion test revealed that most P. multocida isolates were highly sensitive to ceftiofur sodium with minimum inhibitory concentrations (MICs) ranging between 0.625 - 2.5 μg/ml and minimal bactericidal concentration (MBCs) equal or two folds of the MICs.

关键词： Ceftiofur Sodium (Excenel) Microorganisms Minimum Inhibitory Concentration (MICs) Minimum Bactericidal Concentration (MBCs) Chemotherapeutic Birds