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Secondary antiviral metabolites from fungi with special reference to coronaviruses

BIOCelL 2022年第8期46卷 1979-1988页

作者： MOHAMED SALEM MOHAMMAD el-METWALLY WESAMelDIN SABER SALLY NEGM ATTALLA el-KOTT YASSER MAZROUA ABEER MAKHLOUF MAHMOUD MOUSTAFA Department of Chemistry Faculty of Science and ArtKing Khalid UniversityMohailAssirSaudi Arabia Department of Chemistry Faculty of ScienceAl-Azhar UniversityCairoEgypt Botany and Microbiology Department Faculty of ScienceDamanhour UniversityEl-BeheraEgypt Microbial Activity Unit Department of MicrobiologySoilsWater and Environment Research InstituteAgricultural Research CenterGizaEgypt Life Sciences Department College of Science and ArtKing Khalid UniversityMohailAseerSaudi Arabia Unit of Food Bacteriology Central Laboratory of Food HygieneMinistry of HealthSharkiaEgypt Department of Biology College of ScienceKing Khalid UniversityAbhaSaudi Arabia Zoology Department Faculty of ScienceDamanhour UniversityEl-BeheraEgypt Department of Business Administration Community CollegeKing Khalid UniversityAbhaSaudi Arabia Department of Agricultural Economics Faculty of AgricultureTanta UniversityTantaEgypt Department of Botany Faculty of AgricultureMenoufia UniversitySheben El-KomMenoufiaEgypt Botany and Microbiology Department Faculty of ScienceSouth Valley UniversityQenaEgypt

Profound inspection of the life forms on the earth teaches how to be the complexity of interrelationships among the various *** of the emergence of novel viruses all the time and the inadequate of vaccines and antivirals,viral contagions are amongst the most causative diseases affecting people *** exemplify a massive source of bioactive molecules as,many fungal secondary metabolities like Oxoglyantrypine,Carneic acid F,Scedapin C,Asteltoxin E,Phomanolide,Norquinadoline A and Quinadoline B have antiviral *** review deals with how secondary metabolites of fungi can help in the war against viruses in general and especially Coronaviruses moreover several pieces of literature pointed out that many clusters of fungi in different biotopes are waiting to be exploited.

关键词： COVID-19 SARS-CoV-2 Antibiotics Virus Fungi

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A Rare Cause of Gastrointestinal Bleeding: Cholecystoenteric Fistula

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Case Reports in Clinical Medicine 2014年第9期3卷 521-523页

作者： Iliass Charif Hossam Benhammane Dafr-Allah Benajah Said Ait Laalim khalid Mazaz Adil Ibrahimi Mounia el Yousfi Department of Gastroenterology Hassan II University Hospital Faculty of Medicine and Pharmacy of Fez Sidi Mohammed Ben Abdellah University Fez Morocco Department of Surgery Hassan II University Hospital Faculty of Medicine and Pharmacy of Fez Sidi Mohammed Ben Abdellah University Fez Morocco

A 60-year-old woman presented to the emergency department of our university hospital for several episodes of upper gastro-intestinal bleeding (hematemesis and melena). The endoscopic examination (Figure 1) showed a large ulcer at the front of the bulb, with a calculation within it and a visible vessel on the banks of the ulcer treated by putting two clips. Computer tomography (CT), demonstrated a sclerotic, atrophic and multi gallstone gallbladder, with a calculation protruding in the duodenum. The patient underwent surgery which consisted on partial cholecystectomy with duodenal suture and closing of cystic duct.

关键词： Gastrointestinal Bleeding Cholecystoenteric Fistula

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Empty Sella Syndrome: A Case Report and Literature Review

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Neuroscience & Medicine 2015年第1期6卷 42-45页

作者： Kiran Kumar Mohammed khalid Alyaa Fadhil Pankaj Lamba Shaikh Altaf Basha Salwa Abd el Zaher Mabrouk Ibrahim Department of Internal Medicine GMCH & RC Ajman UAE Department of Ophthalmology GMCH & RC Ajman UAE Department of Ophthalmology GMCH & RC Ajman UAE

An empty sella occurs due to herniation of the arachnoid through an incompetent diaphragma sellae. Over time, cerebrospinal fluid (CSF) pulsations may enlarge the sella and compress the gland against the floor of the sella. Empty sella syndrome is considered as a less common entity and is usually asymptomatic and an incidental finding. However, it can be a manifestation of increased intracranial pressure and can be occasionally severe. Compression of the pituitary gland may affect function, or traction on the optic chiasm and nerves may cause visual symptoms. An empty sella may be classified as primary when this occurs in persons who have not received pituitary radiation or pituitary surgery, while an empty sella discovered following such procedures is classified as secondary empty sella. In this report, we presented a 41-year-old multiparous patient who presented to us with symptoms of headache and left sided hemi-sensory disturbance. Examination was unrevealing except for the fact that she was obese. On evaluation, she was detected to have impaired blood sugars, dyslipidemia and vitamin insufficiency. MRI brain revealed presence of Empty Sella. Further hormonal analysis was normal. She was treated conservatively and regular follow-up was advised.

关键词： Empty Sella Syndrome Empty Sella Pituitary Dysfunction

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Effect of Ketamine Instillation on Acute and Chronic Post Mastectomy Pain, a Dose Finding Clinical Study

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Open Journal of Anesthesiology 2022年第4期12卷 146-159页

作者： Fatma el Sherif Hany elmorabaa Khaled Mohamed Fares Sahar Abdel-Baky Mohamed Nourhan M. elgalaly khalid Rezk Moaaz Tohamy Department of Anesthesia ICU and Pain Management South Egypt Cancer Institute Assiut University Assiut Egypt Department of Anesthesia ICU and Pain Management Faculty of Medicine Assuit University Assiut Egypt

Background: Uncontrolled acute postoperative pain is considered a risk factor for the development of chronic pain afterward. Objectives: To explore the most effective dose of ketamine instillation (1 of 3 doses: 1, 2, or 3 mg/kg) for acute and chronic post mastectomy pain (PMP). Methods: Ninety female patients with cancer breast, aged (18 - 60 yrs), weighted (50 - 90 kg), scheduled for modified radical mastectomy, randomly allocated into 3 groups to receive ketamine instillation after surgical homeostasis before wound closure (1 of 3 doses;1, 2, or 3 mg/kg as A, B or C groups respectively) patients were followed up for 48 h for acute pain (total morphine consumption, the first request of analgesia and visual analog scale at rest and movement (VASR/M), chronic pain by Leeds assessment of neuropathic signs and symptoms (LANSS) for six-months, hemodynamics, and side effects. Results: Median total dose of morphine consumption was 8 mg (5 - 10) versus 6 mg (6 - 7) in A and B groups respectively in the first 48 h postoperatively. Lowest VASR/M was recorded in C then B and lastly A group (P = 0.037). No patients in the C group requested analgesia versus thirty (100%) and nine (30%) patients in the A and B groups respectively with the first request of analgesia was 12 h (5 - 36) in the A group versus 30 h (12 - 36) in the B group respectively (P Conclusion: Ketamine instillation effectively controlled acute post mastectomy pain (PMP) in a dose-dependent manner and reduced the incidence and severity of chronic pain in patients who undergoing a modified radical mastectomy.

关键词： Acute Pain Breast Cancer Chronic Pain Ketamine Instillation Modified Radical Mastectomy

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Impact of Consumption of Olive and Argane Oils on Anthropometric Profile of Postmenopausal Women in Morocco

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Journal of Agricultural Science and Technology(B) 2015年第5期5卷 357-364页

作者： Hanane Labraimi Mohamed el Mzibri Abdelfettah Derouiche Zoubida Charrouf Amina Barkat khalid E1Kari Hassan Aguenaou Najat Mokhtar High Institute of Nursing Professions and Health Rabat 10000 Morocco Joint Unit of Research in Nutrition and Alimentation (URAC 39) University lbn Tofail/CNESTEN Rabat 10000 Morocco Joint Unit of Research in Nutrition and Alimentation (URAC 39) University Ibn Tofail/University Hassan 11 MohammadiaCasablanca 20000 Morocco Joint Unit of Research in Nutrition and Alimentation (URAC 39) Sciences Faculty University Mohammed 1I Rabat 10000Morocco National Center of Reference in Neonatology and Nutrition Children Hospital of Avicenne/Unit of Research in Nutrition andAlimentation (URAC 39) University Ibn Tofail Rabat 10000 Morocco

Worldwide, large studies have shown that the menopause is mainly associated with substantial changes in body composition that result in an increase in waist circumference, fat accumulation and specially weight gain. This overweight could be exacerbated by fat intake. Thus, this study was planned to evaluate the impact of the consumption of olive and argane oils on anthropometric profile and body composition of postmenopausal women. The nutritional intervention was conducted over a period of eight weeks, involving daily consumption of 25 mL of argane oil The anthropometric profile （weight, height and body mass index or olive oil in 151 postmenopausal women （55.49 ± 6.18 years old）. （BMI）） and body composition （fat mass （FM） and lean mass （LM）） were determined at 0 week （baseline）, and after the 4th and 8th weeks of nutritional intervention. Results clearly demonstrated that argane oil or olive oil consumption did not affect the anthropometric parameters and the body composition of postmenopausal women. Thus, argane and/or olive oils＇ regular diet does not lead to weight gain, and postmenopausal women could benefit from their impact on health for a better quality of life and to overcome all menopause associated problems. A longer period of nutritional intervention is required to confirm the trend down that was recorded.

关键词： Olive oil argane oil anthropometry postmenopausal women.

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The Relationship between Bone Mineral Density and Dietary Intake in Moroccan Children with Juvenile Idiopathic Arthritis

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International Journal of Clinical Medicine 2012年第5期3卷 400-406页

作者： A.Hassani S.Rostom D.el Badri I.Bouaadi A.Barakat B.Chkirat K.elkari R.Bahiri B.Amine N.Hajjaj-hassouni Department of Rheumatology El Eyachi HospitalUniversity Hospital of Rabat-SaleSaleMorocco Department of Pediatrics Hospital of ChildrenUniversity Hospital of Rabat-SaleRabatMorocco Department of Nutrition Faculty of Science of KenitraUniversity Ibn TofailKenitraMorocco

Background and objective: The aim of this study was to evaluate the association between dietary intake and bone mineral density in children with juvenile idiopathic arthritis (JIA). Methods: A cross-sectional study carried out in Morocco between May 2010 and June 2011, covering out patients with JIA. The characteristics of patients were collected. The nutritional status was assessed by a food questionnaire including data of food intake during 7 consecutive days using 24-hour dietary recall. Food intake was quantified using the software Bilnut (Bilnut version 2.01, 1991). Bone mineral density (BMD in g/cm2) was measured by DXA method (X-ray absorptiometry) on a Lunar Prodigy. Results: The study consisted of 33 patients with JIA (4 - 16 years old). The median age of patients was 10.4 ± 4.3 years. Median disease duration was 2 (1 - 4.5) years. The group of patients with low dietary intake of proteins was associated with low BMD (p = 0.03). Low BMD was related with low intake of magnesium (p = 0.007) and vitamin C (p = 0.04) in children aged between 4 and 9 years. Low intake of vitamin E and folate was associated with high BMD in the other range of children (p < 0.001). Conclusion: This study suggests that low intake of protein and of some micronutrients (magnesium, vitamin C, vitamin E and folate) influence bone mass in children with JIA. Prospective studies with a larger number of patients seem to be necessary in order to confirm our findings.

关键词： Juvenile Idiopathic Arthritis Macronutrients Vitamins Trace elements Bone Mineral Density

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An Investigation of ~4He+^(12)C and ~4He+^(16)O Reactions Using the Cluster Model

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Communications in Theoretical Physics 2012年第7期58卷 135-140页

作者： A.H.Al-Ghamdi Awad A.Ibraheem M.el-Azab Farid Physics Department Faculty of ScienceKing Abdul Aziz UniversityJeddahSaudi Arabia Physics Department Al-Azhar UniversityAssiut BranchAssiut 71524Egypt Physics Department King Khalid UniversityAbhaSaudia Arabia Physics Department Assiut UniversityAssiut 71516Egypt

The α-target semimicroscopic single folding potentials have been derived by folding a composite (repul-sive and attractive) effective α-α interaction with the α-cluster distribution density in the target nuclei. The obtained potentials are considered as the real part of the nuclear optical model potentials, while the imaginary parts are phe-nomenologicaly expressed using the Woods-Saxon form. Nine sets of measured experimental data of the 4He+12C and 4 He+16O elastic rainbow scattering over the energy range 80-240 MeV are analyzed using the obtained potentials. The data are successfully reproduced using the extracted potentials. The resulted reaction cross sections are also investigated and compared with the available corresponding data.

关键词： optical model elastic scattering folding potential cluster model

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A Parametric Study of Mesh Free Interpolation Based Recovery Techniques in Finite element elastic Analysis

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Computer Modeling in Engineering & Sciences 2019年第11期121卷 687-786页

作者： Mohd.Ahmed Mohamed Hechmi el Ouni Devinder Singh Nabil Ben Kahla College of Engineering Main CampusGregarK.K.UniversityAbha61421KSA Minitry of Information Soochan BhavanCGO ComplexDelhi110003India

The paper presents a parametric study on interpolation techniques based postprocessed error estimation in finite element elastic analysis by varying important parameters of recovery,interpolation scheme and type of patch *** quality of error estimation with recovery parameters is compared in terms of local and global effectivity of error estimation,rate of error convergence,and adaptively refined meshes.A mesh free moving least square interpolation technique with proven reliability and effectivity is introduced for improving the recovery of finite element solution *** post-processed finite element solutions of elastic problems are presented for performance study under different parameters of recovery *** study concludes that recovery parameters of interpolation method have pronounced effect on the recovery of finite element solution error and analysis in adaptive environment.

关键词： Effectivity error norm moving least square interpolation least square interpolation recovery techniques

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Prevalence of Neural Tube Defects: Moroccan Study 2008-2011

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Open Journal of Pediatrics 2015年第3期5卷 248-255页

作者： Mohammed Amine Radouani Naima Chahid Loubna Benmiloud Leila el Ammari Aicha Kharbach Larbi Rjimati Laila Acharrai khalid Lahlou Hassan Aguenaou Amina Barkat Department of Medicine and Neonatal Resuscitation National Center for Neonatology and Nutrition Rabat Morocco Faculté de Medicine et de Pharmacie de Rabat Université Mohammed V de Rabat Rabat Morocco Population Department Ministry of Health Rabat Morocco Joint Research Unit in Nutrition and Food URAC 39 (Ibn Tofail University—CNESTEN) Regional Designated Center of Nutrition Associated with AFRA/IAEA Kénitra Morocco

Background: Neural tube defects have a considerable importance because they can be prevented by supplementing Folic acid & Vitamin B12 during periconceptional period and fortification of staple foods. In Morocco, the Ministry of Health launched a national program for fortification of flour with folic acid. Our goal should be to evaluate the prevalence of neural tube defects after fortification. Description: This is a retrospective descriptive at the National Reference Centre for Nutrition and Neonatology of the Children’s Hospital of Rabat over 4 years. Data were identified from the registry of congenital malformations held at the perinatology unit. Results: During the 4 years, 674 congenital malformations were identified. The neural tube defects NTDs account for 11.9%. Their annual prevalence decreased significantly from 21.78 in 2008 to 12.1 per 10,000 total births in 2011. The most common form was anencephaly (60%). Neural tube defects were isolated in 85% of cases and associated with other malformations in 15% of cases. 49.4% of infants with neural tube defects were female and 50.6% were male. Perinatal mortality in newborns with neural tube defects was 63.8% versus 25.2% in malformed newborns without neural tube defects. Conclusions: The neural tube defects seem to be common in our context. Permanent epidemiological surveillance is needed to determine the true prevalence at the national as well as its temporal trends level.

关键词： Neural Tube Defects Anencephaly Spina Bifida Folic Acid Prevalence

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Lumbar Artery Pseudo-Aneurysm after Spinal Trauma and Transpedicular Fixation: A Case Report

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Open Journal of Modern Neurosurgery 2021年第2期11卷 65-72页

作者： Armel Junior Tokpo Guelord Metre Mpambia Fayçal Lakhdar Hassan Amadou Ali Oualid Mohammed Hmamouche Mohammed Benzagmout khalid Chakour Mohammed el Faiz Chaoui Teaching Hospital of Hassan 2 Fès Morocco

Introduction: A case of lumbar artery pseudo-aneurysm after surgery for lumbar vertebra burst fracture is presented. Only two cases secondary to spinal trauma and revealed after surgery have been described in the literature. A review of literature was conducted and a possible relationship with burst fracture or reduction maneuvers was discussed. Case Presentation: Here, we report a post traumatic lumbar burst facture with incomplete motor deficit of lower limbs after a fall. Surgical reduction and stabilization via posterior approach were performed. Post-operatively, a hemorrhage through surgical wound had been noticed. Pseudo-aneurysm of the lumbar artery at L3 level was diagnosed and embolisation was performed. Conclusion: This is a rare case of pseudo-aneurysm occurring in the setting of surgical stabilisation after a trauma. It was revealed by a hemorrhage discovered as a late complication. We should be aware of such potential complication as a delayed post surgery event in order to adapt the care.

关键词： Pseudo-Aneurysm Lumbar Spine Burst Fracture Embolisation

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