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Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy

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World Journal of Gastroenterology 2012年第16期18卷 1915-1920页

作者： khaleel r fareed Irshad N Soomro Khalid Hameed Arvind Arora Dileep N Lobo Simon L Parsons Srinivasan Madhusudan Laboratory of Molecular Oncology Academic Unit of OncologySchool of Molecular Medical SciencesFaculty of Medicine and Health SciencesUniversity of Nottingham Nottingham University Hospitals Nottingham NG5 1PBUnited Kingdom Department of Pathology Nottingham University HospitalsNottingham NG5 1PBUnited Kingdom Division of Gastrointestinal Surgery Nottingham Digestive Diseases CentreNIHR Biomedical Research UnitNottingham University HospitalsNottingham NG7 2UHUnited Kingdom Department of Surgery Nottingham University HospitalsNottingham NG5 1PBUnited Kingdom

AIM:To examine cytokeratin-18(CK-18) and caspasecleaved CK-18 expression in tumours and correlate with clinicopathological outcomes including tumour regression grade(TrG) ***:Formalin-fixed human gastro-oesophageal cancers were constructed into tissue *** first set consisted of 122 gastric/gastro-oesophageal cancer cases not exposed to neoadjuvant chemotherapy and the second set consisted of 97 gastric/gastrooesophageal cancer cases exposed to pre-operative platinum-based *** of CK-18 and caspase-cleaved CK-18 was investigated using ***:CK18 was commonly expressed in gastrooesophageal tumours(92.6%).Fifty-six point seven percent of tumours previously exposed to neoadjuvant chemotherapy were positive for caspase-cleaved CK-18 expression compared to only 24.6% of tumours not previously exposed to neoadjuvant chemotherapy(P = 0.009).In patients who received neoadjuvant chemotherapy,caspase-cleaved cytokeratin-18 expression correlated with favourable TrG response(TrG 1,2 or 3,P = 0.043).CONCLUSION:This is the largest study to date of CK-18 and caspase-cleaved CK-18 expression in gastrooesophageal *** provide the first evidence that caspase-cleaved CK-18 predicts tumour regression with neoadjuvant chemotherapy.

关键词： Tumour regression grade Gastro-oesophageal cancers Chemotherapy Full length cytokeratin-18 Caspase-cleaved cytokeratin-18

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A new hydrophobic deep eutectic solvent composed of menthol and tris(2-ethylhexyl) phosphate for solvent bar microextraction of parabens from biological fluids

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Emerging Contaminants 2024年第2期10卷 135-145页

作者： Nabil N.AL-Hashimi Husam Abed Alfattah khaleel I.Assaf Asma A.Fakhoury Saja H.Hamed Amjad H.El-Sheikh Khairi M.Fahelelbom The Hashemite University Faculty of Pharmaceutical SciencesDepartment of Pharmaceutical ChemistryP.O.Box 330127Zarqa13133Jordan The Hashemite University Faculty of ScienceDepartment of ChemistryP.O.Box 150459Zarqa13115Jordan Al-Balqa Applied University Faculty of ScienceDepartment of Chemistry19117 Al-SaltJordan The Hashemite University Faculty of Pharmaceutical SciencesDepartment of Pharmaceutics and Pharmaceutical TechnologyP.O.Box 330127Zarqa13133Jordan Al Ain University College of PharmacyDepartment of Pharmaceutical SciencesP.O.Box 64141Al AinAl AinUnited Arab Emirates

Parabens are antimicrobial preservatives with extensive applications in cosmetics,toiletries,pharmaceuticals,and *** the legitimate concerns relating to their potential to disrupt multiple endocrine functions,it becomes imperative to prioritize the development of innovative bioanalytical techniques for effectively monitoring their presence in biological *** this study,an efficient solvent bar microextraction(SBME)was established,utilizing new hydrophobic deep eutectic solvents(DEs)to determine methylparaben and propylparaben in urine and plasma *** DEs comprising menthol and tris(2-ethylhexyl)phosphate(M-TEHP)at various molar ratios were synthesized for the first time to enhance the extraction capacity and promote the eco-friendliness of the DE used as an extraction ***-transform infrared(FT-Ir)and proton nuclear magnetic resonance(1H NMr)spectroscopies were employed to confirm and investigate the properties of the successful synthesis(M-TEHP)DE at a molar ratio of 1:*** synthesized DE exhibits low microbial toxicity and can be considered an eco-friendly solvent for ***,quantum-chemical calculations were utilized to predict synthesized DE's structure and interaction energy with selected *** influential operational factors of DE-SBME on the extraction efficiency(EE%)of both parabens were evaluated using response surface methodology based on central composite design,and a total of 30 extraction tests were conducted to determine the optimal *** optimized DE-SBME,in combination with HPLC-DAD,exhibited low detection limits(0.54–0.91μg L^(−1)),excellent linearity(r^(2)≥0.9993),precise results(rSDs≤7.6%),satisfactory recoveries(92–97%)and negligible matrix ***,it had remarkable effectiveness and applicability in determining selected parabens in real urine and plasma samples.

关键词： Hydrophobic deep eutectic solvent Solvent bar microextraction Parabens response surface methodology and central composite design HPLC-DAD Urine and plasma

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Incidence and predictors of hypocalcemia in end-stage renal disease patients on denosumab therapy: A systematic review and metaanalysis

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World Journal of Meta-Analysis 2024年第3期12卷 68-78页

作者： Abdul Hannan Siddiqui Misbah Shaikh Afia Salman Muhammad Ahmed Ali Fahim Fizzah Batool Tahreem Mari Sarah Musani Muneeb fareed rooma rehan Amna Hassni Urooj Nizami Ayesha Amir Abdul Moeed Salim r Surani Department of Internal Medicine Dow University of Health SciencesKarachi 74200SindhPakistan Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

BACKGrOUND Denosumab inhibits the receptor activator of nuclear factor *** markedly increases bone mineral density and has been proven to reduce the risk of ***,numerous adverse effects,notably hypocalcemia,are prevalent in patients with end-stage renal disease(ESrD).AIM To analyze the incidence and predictors of hypocalcemia caused by denosumab compared to control in patients with *** We conducted this study in accordance with the Preferred reporting Items for Systematic reviews and Meta-analyses ***,Scopus,Cochrane Central,and EMBASE were systematically searched from inception through March *** original studies investigating the effects of denosumab on patients with ESrD compared to control were *** primary outcomes of our study were the incidence of mild,severe,and very severe *** outcomes included serum levels of intact parathyroid hormone,calcium,and *** results were pooled and analyzed using a random-effects *** Seven articles comprising 3240 patients were included in our *** treated with denosumab had a significantly increased incidence of mild hypocalcemia[risk ratio(rr):2.79;95%confidence interval(CI):0.99-7.91;P=0.05;I^(2)=37%]and of very severe hypocalcemia(rr:9.58;95%CI:1.58-57.98;P=0.01;I^(2)=49%).However,an increase in the occurrence of severe hypocalcemia was non-significant(rr:4.23;95%CI:0.47-38.34;P=0.20;I^(2)=96%).Alternatively,denosumab showed a significant decrease in serum intact parathyroid hormone[mean difference(MD):-433.20,95%CI:-775.12 to-91.28,I2=98%,P=0.01],while there was a non-significant decrease in phosphate(MD:-0.47,95%CI:-1.35 to 0.41,I^(2)=88%,P=0.30)and calcium levels(MD:-0.33,95%CI:-0.95 to 0.29,I^(2)=94%,P=0.29).CONCLUSION Our study demonstrated that denosumab is significantly associated with mild and very severe hypocalcemia in patients with ESrD making it necessary to detect and prevent this side effect of treatmen

关键词： Denosumab End-stage renal disease Hypocalcemia Parathyroid hormone Dialysis

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Characteristics, management, and outcome of squamous carcinoma of the conjunctiva in a single tertiary cancer center in Jordan

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1132-1138页

作者： Ata rajeh fareed Barakat Samer Khurma khaleel Al rawashdeh Osama H.Ababneh Ibrahim AlNawaiseh Mustafa Mehyar Ghadeer Abdeen Imad Jaradat Mona Mohammad Yacoub A.Yousef Department of Surgery (Ophthalmology) King Hussein Cancer Centre (KHCC) Department of Pathology King Hussein Cancer Centre (KHCC) Department of Ophthalmology The University of Jordan and Jordan University Hospital Department of Medical Oncology King Hussein Cancer Centre (KHCC) Department of radiation Oncology King Hussein Cancer Centre (KHCC)

AIM： To evaluate the features and outcome of management of malignant conjunctival squamous tumors in King Hussein Cancer Center（a referral tertiary cancer center in the Middle East）. METHODS： retrospective case series of 31 eyes for 31 patients with conjunctival squamous neoplasia. Main outcome measures included： age, gender, laterality, tumor location, pathological features, tumor stage, treatment modality, and outcome. rESULTS： Twenty（65%） patients were males and median age was 58 y. Twenty-two（71%） eyes had the tumor in the nasal quadrant. Tumor invasion to nearby structures was seen in 19（61%） eyes, including the cornea, fornix, eyelid, and orbit in 17（55%）, 1（3%）, 2（6%）, and 3（10%） eyes, respectively. Eye salvage was achieved by surgical excision with cryotherapy followed by topical chemotherapy in 28（90%） eyes, and orbital exenteration was necessary in 3（10%） eyes due to orbital tumor invasion. Tumor recurrence was seen in 7（23%） eyes, and the significant predictive factors for recurrence were tumor extension onto the nearby structures（P=0.04）, tumor invasiveness（P=0.038）, and tumor TNM stage（P=0.031）. No significant change in visual acuity was seen, and disease related mortality was 6%（2 patients, both had orbital invasion by invasive squamous carcinoma）. CONCLUSION： Conjunctival squamous carcinoma is more common in males. Advanced American Joint Committee on Cancer（AJCC） T-stage, tumor local invasion, more pathologically aggressive tumors, and surgical treatment alone（without adjuvant therapy） are associated with higher risk for recurrence, and orbital invasion is the most important poor prognostic factor for metastasis and death. Treatment strategies should be affected by tumor characteristics at presentation.

关键词： conjunctiva squamous cell carcinoma metastasis

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Phase-field modeling of void evolution and swelling in materials under irradiation

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Science China(Physics,Mechanics & Astronomy) 2011年第5期54卷 856-865页

作者： HENAGEr Charles H Jr khaleel Mohammad Pacific Northwest National Laboratory Richland WA 99352 USA

Void swelling is an important phenomenon observed in both nuclear fuels and cladding materials in operating nuclear reactors. In this work we develop a phase-field model to simulate void evolution and void volume change in irradiated materials. Important material processes, including the generation of defects such as vacancies and self-interstitials, their diffusion and annihilation, and void nucleation and evolution, have been taken into account in this model. The thermodynamic and kinetic properties, such as chemical free energy, interfacial energy, vacancy mobility, and annihilation rate of vacancies and interstitials, are expressed as a function of temperature and/or defect concentrations in a general manner. The model allows for parametric studies of critical void nucleus size, void growth kinetics, and void volume fraction evolutions. Our simulations demonstrated that void swelling displays a quasi-bell shape distribution with temperature often observed in experiments.

关键词： radiation void swelling vacancies interstitials phase-field model

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