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Hospitalizations for Osteoporosis-Related Fractures: Analysis from Eastern Saudi Arabia

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Open Journal of Orthopedics 2020年第6期10卷 117-123页

作者： Mir Sadat-ali AbdulAziz H. al-Shams Zainab R. al Ghanim khaleel I. al Batran Yousef M. al Jamaan Abrar S. Hashishi Faisal M. al Anaz Abdul Raheem A. al Talib Fatima Abdulmohsen Mohamed The Department of Orthopaedic Surgery King Fahd Hospital of the University Imam Abdul Rahman Bin Faisal University Al Khobar KSA

Background and Objectives: Osteoporosis causes fragility fractures which increase the morbidity and mortality in the elderly. Our objective was to look at the hospital admissions due to fragility fractures and site of fractures. Methods: This is a retrospective study of a 2-year period (2017-2018), in which we evaluated all the admissions of fragility fractures at King Fahd Hospital of the University, al Khobar, Saudi Arabia. A Fragility Fracture is a fracture which occurs in patients with low bone mass due to a fall from a standing height. The data were gathered from the Quadru Med patient care system for patients over the age of 50 years: sex, site of fracture, previous fractures, and treatment meted out. The hospitalization rate for fragility fractures was calculated by taking into consideration of all the adult admissions to the orthopaedic department. Ethical approval was obtained from the Institutional Review Board of the Hospital and the Imam Abdul Rahman Bin Faisal University, Dammam. Results: During the study period 187 patients with fragility fractures were admitted. The mean age was 68.55 ± 12.43 years;fracture femur was the most common with 136 (72.7%), tibia 15 (8%) and spine 14 (7.5%). At the time of discharge based on the T score of spine 50 were osteopenic and 45 were osteoporotic. Overall adult admission for the study period was 1410 patients and 13.26% were patients with fragility fractures. There were 3 (1.6%) deaths within the first 30 days in the hospital. Conclusions: Fracture femur was the most common fragility fracture seen in our study. Orthopaedic surgeons should be ready to treat all fragility fractures and treat osteoporosis appropriately so that a second fracture is prevented.

关键词： Fragility Fractures Saudi Arabia Osteopenia Osteoporosis

Mechanistic Study of Ruthenium(III) Catalyzed Oxidation of Cyclohexanone by Acidic Bromate

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Journal of Surface Engineered Materials and Advanced Technology 2018年第2期8卷 27-36页

作者： Yasir Arafat Lone Masood Ayoub Kaloo Faizan Danish khaleel Department of Chemistry Lovely Professional University Phagwara India Department of Chemistry Government Degree College Shopian India Department of Chemistry Islamic University of Science and Technology Awantipora India

In this work, kinetics and mechanism of Ru(III) catalyzed oxidation of cyclohexanone by acidified solution of potassium bromate has been studied. Present study employ mercuric acetate Hg (OAc)2 as a scavenger for Br¯?ion to prevent parallel oxidation by bromine. The kinetics and mechanism have also been studied in the temperature range of 30°C - 45°C. The reaction exhibits first order kinetics with respect to Ru (III), while zero order kinetics with respect to KBrO3 and HClO4. The influence of Hg(OAc)2 and ionic strength on the rate of reaction was found to be insignificant. Positive effect in the reaction mixture was also observed upon addition of chloride ion;while as the negative effect was revealed with acetic acid. A suitable mechanism in conformity with the kinetic observations has been proposed and the rate law is derived on the basis of obtained data. The various activation parameters such as energy of activation (ΔE*), Arrhenius factor (A), entropy of activation (ΔS*) were calculated from the rate measurements at 30°C, 35°C - 40°C and 45°C.

关键词： Kinetics Ru (III) Oxidation Ketone Bromate Acidic Order

Gate Lip Hydraulics under Sluice Gate

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Modern Instrumentation 2013年第1期2卷 16-19页

作者： Ahmed Y. Mohammed Moayed S. khaleel Department of Dam and Water Resources College of Electronic Engineering University of Mosul Mosul Iraq

This paper present the effect of the lower gate lip on the coefficient of contraction, velocity and discharge which have been made in a rectangular flume with four gates opening from (2 to 4.5) cm, five different discharges from (6.2 to 18.15) l/s and five different gate cases (vertical and inclined vertically) by angle (45)° with and opposite flow direction with horizontal and sharp lower lip. The values of coefficients of contraction (Cc) and discharge (Cd) increases when gate slope increases with flow direction and the lower lip is horizontal, these increases are (16)% and (18)% respecttively, while these values decreases when gate slope increases opposite flow direction and the lower lip is horizontal these decreases are (13)% and (11)% respectively. The values of coefficient of velocity (Cv) remain constant and don’t effect with changes of gate slope or gate lip.

关键词： Sluice Gate Coefficient of Contraction Coefficient of Velocity Coefficient of Discharge

Phytochemical Determination and Antibacterial Activity of Punica granatum Peel Extracts against Plant Pathogenic Bacteria

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American Journal of Plant Sciences 2016年第1期7卷 159-166页

作者： Ayad Ismael khaleel Kamaruzaman Sijam Tavga Sulaiman Rashid Khairulmazmi Bin Ahmad Plant Protection Department Faculty of Agriculture Universiti Putra Malaysia Serdang Malaysia

Plant pathogenic bacteria are recognized to be harmful microbes able to decrease the quantity and quality of crop production in the world. Punica granatum peel was screened for its potential use as biological control agent for plant pathogenic bacteria. P. granatum peel was successfully extract using n-hexane, methanol and ethyl acetate by maceration. The highest yield obtained by ethyl acetate showed that ethyl acetate extracted more compounds that readily soluble to methanol and n-hexane. For in-vitro antibacterial activity, three different species of plant pathogenic bacteria were used namely Erwinia carotovorum subsp. Carotovorum, Ralstonia solanacearum, and Xanthomonas gardneri. For all crude extracts, four different concentrations 25, 50, 100 and 200 mg/ml were used in cup-plate agar diffusion method. Streptomycin sulfate at concentration 30 μg/ml was used as positive control while each respective solvent used for peel extraction was used as negative control. The results obtained from in vitro studies showed only ethyl acetate extract possessed antibacterial activity tested on the plant pathogenic bacteria. Methanol and n-hexane did not show any antibacterial activity against plant pathogenic bacteria selected where no inhibition zones were recorded. R. solanacearum recorded the highest diameter of inhibition zones for all range of concentrations introduced followed by E. carotovorum subsp. Carotovorum and X. gardneri. For the minimum inhbitory concentration (MIC) and minimum bactericidal concentration (MBC), only the ethyl acetate extract was subjected to the assay as only ethyl acetate extract exhibited antibacterial activity. The minimum concentration of ethyl acetate extract that was able to inhibit plant pathogenic bacteria was recorded at a concentration of 3.12 mg/ml which inhibited R. solancearum and E. carotovorum subsp. Carotovorum, followed by X. gardneri at concentration 6.25 mg/ml. For the minimum bactericidal concentration (MBC), the results show

关键词： Punica granatum Plant Extraction Pathogenic Bacteria Phytochemical Screening

Hyperthermia for Breast Cancer Treatment Using Slotted Circular Patch Antenna

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Circuits and Systems 2019年第3期10卷 37-44页

作者： Mussa Elsaadi Yousef Aid Mustafa Abbas Amani Embarek khaleel Salih Electronic and Electrical Engineering Tobruk University Tobruk Libya

The primary intent of this paper is to investigate the potential of using a slotted circular patch antenna at 2.45 GHz for breast tumor hyperthermia treatment. A cancer treatment model consisting of a microstrip patch antenna and breast phantom comprising tumor is designed and simulated in CST Studio Suite 2018. The radiation properties of the proposed antenna attain 3 dB beam width of 74.1°and 70.5°for the E-Plane and the H-plane, respectively. The breast phantom is exposed to the designed antenna radiation for 10 minutes, leading to raise the breast phantom temperature by 8.5°C and 11.4°C once the antenna pumped power is 1.5 and 2 watt, respectively. By considering 10 minutes as an exposure time, the breast temperature as a function of the applied antenna power is studied and compared with previous published results.

关键词： Hyperthermia Treatment Breast Cancer Microstrip Antenna Design

Oxidation of HDPE in the Presence of PVC Grafted with Natural Polyphenols (Tannins) as Antioxidant

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Open Journal of Polymer Chemistry 2015年第2期5卷 9-16页

作者： Hussein A. Shnawa Moayad I. khaleel Faise J. Muhamed Polymer Research Center University of Basrah Basrah Iraq State Company for Petrochemical Industries Basrah Iraq

In the current research study, an attempt is made to modification of polyvinyl chloride (PVC) by grafting with biologically based phenolic resin, namely, tannins. The reaction was carried out at 110°C in DMF solution. FTIR spectra show the presence of phenolic hydroxylic groups and other functional groups of tannins into the PVC-tannins derivative. Evaluation of the new PVC derivative as polymeric antioxidant for high density polyethylene (HDPE) was the main purpose of this study. Samples of HDPE containing (0.0, 0.5 and 2.0) %W/W from PVC-tannins and pure HDPE were exposed to thermal program by differential scanning calorimetry (DSC) by temperature sweep from 100°C to 350°C. DSC scans of the thermal oxidation process of pure HDPE as well as HDPE with PVC derivative show oxidation exothermic stage started at 195°C and continues to 285°C. The samples of polyethylene contain the PVC-tannins show more resistance to oxidation reactions until 215°C for HDPE sample stabilized with 0.5% and 221°C for HDPE stabilized with 2.0%. Faster initiation of degradation rate was observed when HDPE contained PVC-tannins. According to the DSC analysis, the PVC derivative can participate in stabilization mechanism of HDPE but at limited performance.

关键词： HDPE Tannins PVC Modification Polymeric Antioxidant Thermal Oxidation

Aspartate transaminase to platelet ratio index in hepatitis C virus and Schistosomiasis coinfection

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World Journal of Gastroenterology 2015年第46期21卷 13132-13139页

作者： Moutaz Derbala Mohammed Elshiekh Elbadri aliaa Mohamed Amer Saad al Kaabi khaleel Hassan Sultan Yasser Medhat Kamel Eman Hassan Satti Elsayed Tony Yervant Avades Prem Chandra Fatma M Shebl Gastroenterology and Hepatology Hamad Medical CorporationHamad General Hospital Gastroenterology and Hepatology Theodor Bilharz Research Institute Medical Department Weill Cornell Medical College Laboratory Medicine and pathology Hematology SectionHamad Medical CorporationHamad General Hospital General Medicine Medical EducationHamad Medical CorporationHamad General Hospital Department of Laboratory Medicine and Pathology Hamad Medical CorporationHamad General Hospital Medical Research Center Hamad Medical CorporationHamad General Hospital Chronic Disease Epidemiology DepartmentYale School of Public Health

AIM: To assess the diagnostic accuracy,of aminotransferase-to-platelet ratio index(APRI) alone and with antischistosomal antibody(Ab) in patients with hepatitis C virus(HCV) and schistosomiasis coinfection. METHODS: This retrospective study included medical records of three hundred and eighty three Egyptianmen patients who had undergone percutaneous liver biopsy between January 2006 to April 2014 in tertiary care hospital in Qatar for diagnosis or monitoring purpose were selected. Data of patients > 18 years of age were included in the study. The values of HCV RNA titer and antischistosomal antibody titer were also taken into consideration. Patients were excluded from the study if they had any other concomitant chronic liver disease,including; history of previous antiviral or interferon therapy,immunosuppressive,therapy,chronic hepatitis B infection,human immunodeficiency virus co-infection,autoimmune hepatitis,decompensated liver disease,hepatocellular carcinoma,prior liver transplantation,and if no data about the liver biopsy present. RESULTS: Median age of patients was 46 years. About 7.1% had no fibrosis,whereas 30.4%,37.5%,20.4%,and 4.6% had fibrosis of stage Ⅰ,Ⅱ,Ⅲ,and Ⅳ respectively. In bivariate analysis,APRI score,levels of AST,platelet count and age of patient showed statistically significant association with liver fibrosis(P al antibody titer(P = 0.52) and HCV RNA titer(P = 0.79) failed to show a significant association. The respective AUC values for no fibrosis,significant fibrosis,severe fibrosis and cirrhosis of APRI score were 63%,73.2%,81.1% and 88.9% respectively. This showed good sensitivity and specificity of APRI alone for grading of liver fibrosis. But the inclusion of anti-Schistosoma antibody did not improve the prediction of fibrosis stage. CONCLUSION: The study results suggest that noninvasive biochemical markers like APRI are sensitive and specific in diagnosing the degree of fibrosis and cirrhosis in patient

关键词： Hepatitis C Schistosomiasis Aspartate transaminase

Mutations in FMN binding pocket diminish chromate reduction rates for Gh-ChrR isolated from <i>Gluconacetobacter hansenii</i>

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Natural Science 2013年第6期5卷 20-24页

作者： Janin A. khaleel Chunhong Gong Yanfeng Zhang Ruimin Tan Thomas C. Squier Hongjun Jin Fundamental & Computational Sciences Directorate Pacific Northwest National Laboratory Richland USA

A putative chromate ion binding site was identified proximal to a rigidly bound FMN from electron densities in the crystal structure of the quinone reductase from Gluconacetobacter hansenii (Gh-ChrR) (***). To clarify the location of the chromate binding site, and to understand the role of FMN in the NADPH-dependent reduction of chromate, we have expressed and purified four mutant enzymes involving the site-specific substitution of individual side chains within the FMN binding pocket that form non-covalent bonds with the ribityl phosphate (i.e., S15A and R17A in loop 1 between β1 sheet and α1 helix) or the isoalloxanzine ring (E83A or Y84A in loop 4 between the β3 sheet and α4 helix). Mutations that selectively disrupt hydrogen bonds between either the N3 nitrogen on the isoalloxanzine ring (i.e., E83) or the ribitylphos- phoate (i.e., S15) respectively result in 50% or 70% reductions in catalytic rates of chromate reduction. In comparison, mutations that disrupt π-π ring stacking interactions with the isoal-loxanzine ring (i.e., Y84) or a salt bridge with the ribityl phosphate result in 87% and 97% inhibittion. In all cases there are minimal alterations in chromate binding affinities. Collectively, these results support the hypothesis that chromate binds proximal to FMN, and implicate a structural role for FMN positioning for optimal chromate reduction rates. As side chains proximal to the β3/α4 FMN binding loop 4 contribute to both NADH and metal ion binding, we propose a model in which structural changes around the FMN binding pocket couples to both chromate and NADH binding sites.

关键词： Bioremediation Chromate Reduction Enzyme Redesign Site-Specific Mutagenesis Chromate Reductase Flavin Mononucleotide Promiscuous Enzyme Activities

Experimental Analysis of Sediment Deposition Due to the Effect of an Upstream Reservoir Backwater

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Journal of Civil Engineering and Architecture 2014年第9期8卷 1185-1193页

作者： Issa E. Issa Nadhir al-Ansari Moayad khaleel Sven Knutsson Department of Civil Environmental and Natural Resources Engineering Lule~ University of Technology Lulea 9718 7 Sweden Department of Dams and Water Resources Engineering University of Mosul Mosul 41002 Iraq

The phenomenon of aggradation due to sediment accumulation upstream reservoirs had been studied in this research. For this purpose, groups of experiments were conducted in a laboratory with 25 m long, 0.80 m wide and 0.70 m deep channel. A block was built at the end of the channel to work as a dam to impound water. The channel was supplied with drainage pipes on both sides to release water out in a manner similar to what happens in reservoirs. The bed of the channel was filled with sand of 0.80 mm median sieve diameter and 0.72 geometric standard deviation. The slope was 0.0093 for all experiments. Two sizes of sand were used representing the sediment. The median diameter and geometric standard deviation of the first were 0.365 mm and 0.46 mm, respectively. The second sample had 0.65 mm median diameter and 0.67 standard deviation. A total of 70 experiments were conducted in two groups to examine effects of sediment transport rate, particle size of sediment and flow velocity on aggradation characteristics. The results showed that there was a strong linear direct relationship between aggradation elements (length and depth) with the rate of sediment transport. Groups of dimensionless parameters affecting the aggradation characteristics were used to develop empirical equations to predict the length, maximum depth of aggradation and predict transient bed profile. The results of empirical approach were compared with the measurement data and previous numerical method. The results indicated that the percentage error was 19% to 31% for length of aggradation and -21% to 26% for maximum depth of aggradation. The results also showed that the sediment materials were deposited closer to the body of the dam when the released water from the dam is higher than the inflow.

关键词：实验室用回水影响泥沙淤积上游水库标准偏差平均直径水库上游筛孔直径