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Current updates of CRIsPR/Cas9-mediated genome editing and targeting within tumor cells:an innovative strategy of cancer management

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Cancer Communications 2022年第12期42卷 1257-1287页

作者： khaled s.allemailem Mohammed A Alsahli Ahmad Almatroudi Faris Alrumaihi Fahd Khaleefah Alkhaleefah Arshad Husain Rahmani Amjad Ali Khan Department of Medical Laboratories College of Applied Medical SciencesQassim UniversityBuraydahSaudi Arabia Department of Laboratory and Blood Bank Al Rass General HospitalAl RassSaudi Arabia Department of Basic Health sciences College of Applied Medical SciencesQassim UniversityBuraydahSaudi Arabia

Clustered regularly interspaced short palindromic repeats-associated protein(CRIsPR/Cas9),an adaptive microbial immune system,has been exploited as a robust,accurate,efficient and programmable method for genome targeting and *** innovative and revolutionary technique can play a significant role in animal modeling,in vivo genome therapy,engineered cell therapy,cancer diagnosis and *** CRIsPR/Cas9 endonuclease system targets a specific genomic locus by single guide RNA(sgRNA),forming a heteroduplex with target *** streptococcus pyogenes Cas9/sgRNA:DNA complex reveals a bilobed architecture with target recognition and nuclease ***/Cas9 assembly can be hijacked,and its nanoformulation can be engineered as a delivery system for different clinical ***,the efficient and safe delivery of the CRIsPR/Cas9 system to target tissues and cancer cells is very challenging,limiting its clinical *** delivery strategies of this system may have many advantages,but disadvantages such as immune system stimulation,tumor promotion risk and small insertion size outweigh these ***,there is a desperate need to develop an efficient non-viral physical delivery system based on simple *** delivery strategies of CRIsPR/Cas9 by a nanoparticle-based system have shown tremendous potential,such as easy and large-scale production,combination therapy,large insertion size and efficient in vivo *** review aims to provide in-depth updates on streptococcus pyogenic CRIsPR/Cas9 structure and its mechanistic *** addition,the advances in its nanoformulation-based delivery systems,including lipid-based,polymeric structures and rigid NPs coupled to special ligands such as aptamers,TAT peptides and cell-penetrating peptides,are ***,the clinical applications in different cancers,clinical trials and future prospects of CRIsPR/Cas9 delivery and genome targeting are also discussed.

关键词： cancer clinical trials CRIsPR/Cas9 genome editing mechanism nanoparticles structure

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