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Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19:A review

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World Journal of Gastroenterology 2021年第1期27卷 37-54页

作者： khaled Mohamed Mohamed Koriem Medical Physiology Department Medical Research DivisionNational Research CentreDokki 12622CairoEgypt

The term lipidome is mentioned to the total amount of the lipids inside the biological *** lipid enters the human gastrointestinal tract through external source and internal *** absorption pathway of lipids in the gastrointestinal tract has many ways;the 1st way,the lipid molecules are digested in the lumen before go through the enterocytes,digested products are re-esterified into complex lipid *** 2nd way,the intracellular lipids are accumulated into lipoproteins(chylomicrons)which transport lipids throughout the whole *** lipids are re-synthesis again inside the human body where the gastrointestinal lipids are:(1)Transferred into the endoplasmic reticulum;(2)Collected as lipoproteins such as chylomicrons;or(3)Stored as lipid droplets in the *** lipids play an important role in many stages of the viral replication *** specific lipid change occurs during viral infection in advanced viral replication *** are 47 lipids within 11 lipid classes were significantly disturbed after viral *** virus connects with blood-borne lipoproteins and apolipoprotein E to change viral *** viral interest is cholesterol-and lipid raft-dependent *** conclusion,lipidome is important in gastrointestinal fat absorption and coronavirus disease 2019(COVID-19)infection so lipidome is basic in gut metabolism and in COVID-19 infection success.

关键词： Lipidome Gastrointestinal tract Fat metabolism COVID-19 Viral infection Future therapy

Analytical approximate solution for nonlinear space-time fractional Klein Gordon equation

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Chinese Physics B 2013年第1期22卷 33-38页

作者： khaled A. Gepreel Mohamed S. Mohameda Mathematics Department Faculty of Science Zagazig University Zagazig Egypt Mathematics Department Faculty of Science Taif University Taif Saudi Arabi Mathematics Department Faculty of Science Al-Azhar University Nasr City 11884 Cairo Egypt

The fractional derivatives in the sense of Caputo and the homotopy analysis method are used to construct an approximate solution for the nonlinear space-time fractional derivatives Klein-Gordon equation. The numerical results show that the approaches are easy to implement and accurate when applied to the nonlinear space-time fractional derivatives Klein- Gordon equation. This method introduces a promising tool for solving many space-time fractional partial differential equations. This method is efficient and powerful in solving wide classes of nonlinear evolution fractional order equations.

关键词： homotopy analysis method nonlinear space-time fractional Klein-Gordon equation Caputo derivative

Postoperative outcomes after open splenectomy versus laparoscopic splenectomy in cirrhotic patients:a meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 14-20页

作者： khaled Al-raimi Shu-Sen Zheng Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of Medicine

BACKGROUND： Laparoscopic splenectomy is considered the gold standard for resecting normal-to-moderately bigger spleens in benign conditions, and in addition could be tried for patients with malignant splenic disorders. However, the safety of laparoscopic splenectomy in patients with hyper- splenism is not well-known. This study aimed to investigate the efficacy and safety of laparoscopic splenectomy for pa- tients with hypersplenism secondary to liver cirrhosis by com- paring with the open splenectomy.

关键词： open splenectomy laparoscopic splenectomy cirrhosis

Effect of vehicle safety recalls on the perception towards other vehicles from the same country of origin

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第5期6卷 493-503页

作者： khaled Shaaban Amro Maher Anusorn Singhapakdi Department of Civil and Architectural Engineering Qatar University Doha Qatar Beacom School of Business University of South Dakota Vermillion SD 57069 USA Department of Marketing Old Dominion University Norfolk VA 23529 USA

A vehicle safety recall significantly impacts the demand for these specific manufacturer *** effect of this recall on the other manufacturers from the same country of origin(COO) that are not involved in the recall is poorly *** purpose of this study is to examine the impact of a vehicle safety recall on other vehicle brands originating from the same *** study uses a case study related to Toyota recalls and the impact of the crises on the attitudes toward three other Japanese brands-namely,Honda,Nissan,and Mazda.A questionnaire was conducted with 375 participants who are familiar with the *** findings from the questionnaire indicated that product-harm crises have an indirect negative effect on brands from the same ***,brands from the transgressor’s COO should not make the transgressor’s betrayal salient,which might hurt their *** example,if Honda makes the betrayal of Toyota salient through comparative advertising,Honda’s efforts might hurt the company directly through consumers’ image of Japanese *** research should examine the extent to which comparative advertising impacts non-transgressing brands that originate from the same country as the transgressing *** current results suggest that the non-transgressing companies might even assist the transgressing company to recover from such crises if consumers perceive a strong association between the non-transgressing brands and transgressing brands.

关键词： Automotive recalls Vehicle safety Car accidents Vehicle defects Safety ratings

Vision Navigation Based PID Control for Line Tracking Robot

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Intelligent Automation & Soft Computing 2023年第1期35卷 901-911页

作者： Rihem Farkh khaled Aljaloud College of Engineering Muzahimiyah BranchKing Saud UniversityP.O.Box 2454Riyadh11451Saudi Arabia

In a controlled indoor environment,line tracking has become the most practical and reliable navigation strategy for autonomous mobile robots.A line tracking robot is a self-mobile machine that can recognize and track a painted line on *** general,the path is set and can be visible,such as a black line on a white surface with high contrasting *** robot’s path is marked by a distinct line or track,which the robot follows to *** scientific contributions from the disciplines of vision and control have been made to mobile robot vision-based ***,automated map generation,autonomous navigation and path tracking is all becoming more frequent in vision applications.A visual navigation line tracking robot should detect the line with a camera using an image processing *** paper focuses on combining computer vision techniques with a proportional-integral-derivative(PID)control-ler for automatic steering and speed control.A prototype line tracking robot is used to evaluate the proposed control strategy.

关键词： Line tracking robot vision navigation PID control image processing OpenCV raspberry pi

Multiple sclerosis: New insights and trends

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 429-440页

作者： khaled Mohamed Mohamed Koriem Department of Medical Physiology Medical Research DivisionNational Research Centre

Multiple sclerosis(MS) is the most famous autoimmune disease attacking the central nervous system. It attacks people from age 20–50 years old and the females' attacks double than males' attacks. MS is an autoimmune disease affecting principally the central nervous system that cause nerve sheath demyelination followed by axon damage and paralysis. MS symptoms include muscle weakness, weak reflexes, muscle spasm, difficult in move, miss-coordination and unbalance with others. There are many factors may be responsible for MS: microbial, viral, smoking, stress, environmental toxins, contaminated diet, and gout. MS is wide spread in the populations in North Europe and this related to lack of vitamin D due to decrease of sunlight exposure. MS biomarkers include nitric oxide, interleukin-6, nitric oxide synthase, fetuin-A and osteopontin. MS is not a genetic disease where MS occurs when human leukocyte antigen system related genes are changed in chromosome 6. The physiology of MS is monitored by activation of immuneinflammatory, oxidative, and nitrosative stress pathways. MS is including two main steps:(1) myelin sheath destruction and formation of lesions and,(2) inflammation. Four types of MS can be distinguished: relapsing-remitting, primary progressive, secondary progressive and progressive relapsing. Nine treatments have been accepted for relapsingremitting MS type: interferon b-1a, interferon b-1b, mitoxantrone, natalizumab, glatiramer acetate, fingolimod, dimethyl fumarate, teriflunomide, and alemtuzumab, however,the only treatment used is mitoxantrone for progressive MS but many of MS treatments side effects are recorded. Complementary treatments also used in MS treatments such as:vitamin D, Yoga, medicinal plants, oxygen therapy, acupuncture and reflexology.

关键词： Multiple sclerosis Diagnosis Genetics Physiology Treatments

A lipidomic concept in infectious diseases

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 265-274页

作者： khaled Mohamed Mohamed Koriem Department of Medical Physiology Medical Research Division National Research CentreDokki Cairo Egypt

Infectious diseases resemble a great threat to the human health according to World Health Organization where about 17% of all deaths(z9.2 million deaths) in 2013 recorded are related to infectious diseases. The pathogenic microorganisms such as bacteria, viruses,fungi and parasites are the principle causes of infectious diseases. Ebola, AIDS, dengue,hepatitis, malaria, tuberculosis and schistosomiasis are among 216 infectious diseases found where the immunity represents the first line defense in infection. Lipidomic includes examination of different biological lipids in the biological cell. The lipidomic research covers all aspects of individual lipid molecule including its structure, function,connection with other cell constituents such as protein, lipid, and metabolite in both health and disease conditions. Details of cell biology obtained from different pathogens(viruses, bacteria, and parasites) provide a great data on molecular structure of hostpathogen relation and consequently on infection process. The lipids here play a very important role in many processes involved in host-pathogen relations. The role of lipid in host-pathogen link includes many processes in(1) structural host constituents,(2) host recognition,(3) intracellular transferring, and(4) energy and resource homeostasis during pathogen duplication. There are many lipid phosphatases, kinases, and lipases molecules that greatly involved in these processes and controlling pathogen expression and infection progress. The cell lipid metabolism depends on an adequate energy stores that push the infection to be accelerated and disease symptoms to be appeared. Consequently, future lipidomics studies are the basic for detecting the lipid role in host-pathogen relations which help in therapy advances and biomarkers development.

关键词： Lipidomics Virus Bacteria Parasite Membrane trigger

Daily, monthly and annual thermal performance of a linear Fresnel reflector to drive an organic Rankine-cycle system

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Clean Energy 2021年第4期5卷 673-689页

作者： Hassan Mahmood khaled Hossin Mechanical and Construction Engineering University of NorthumbriaNewcastle upon TyneUK Mechanical and Industrial Engineering Department American University of Ras Al KhaimahRas Al KhaimahUnited Arab Emirates Mechanical Engineering Department University of BenghaziBenghaziLibya

The organic Rankine cycle(ORC)coupled with a linear Fresnel reflector(LFR)utilizes a low-grade heat *** article presents the study of a small-scale LFR-ORC power-generation plant under the climatic conditions of Almatret,*** mathematical modelling is performed using thermodynamic equations and simulations are conducted to evaluate the optical performance of the LFR system and thermal performance of the ORC ***-62 is used as a heat-transfer fluid(HTF)in the solar field,whereas NOVEC^(TM) 649 is used as the working fluid in the ORC power *** LFR is integrated with a thermal-storage unit based on a two-tank system and stores the solar thermal energy via a heat *** thermal-energy output of the receiver tube of the LFR system is 108 kW and thermal losses are 7.872 kW during the peak time operation of a day at 1:00 *** mechanical power output of the ORC turbine is 7.296 kW using the specific design conditions and the two-tank thermal-storage system adds 4 operation hours to the power plant after sunset.

关键词： solar energy linear Fresnel reflector energy storage organic Rankine cycle

Protective effect of natural products and hormones in colon cancer using metabolome:A physiological overview

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 957-966页

作者： khaled Mohamed Mohamed Koriem Department of Medical Physiology Medical Research DivisionNational Research CentreDokkiCairoEgypt

Globally, the third cause of males cancer and the fourth cause of females cancer is colon cancer(CC). In Egypt, high CC percentage occurs in children and in individuals below 40 years of age. The complete loss of biological enzyme function is the main cause of CC and consequently CC increased in smoking and pollution exposure. The aim of this review is to focus on the application of metabolome as a physiological tool that can play an important role in preventing CC incidence by natural products and hormones. The dietary factors, intestinal micro-flora and endogenously produced metabolites are the main three causes that produce free radicals in the colon. A correlation occurs between the enzyme activity and CC polymorphisms or property. Nowadays metabolome is applied with the progress of different analytical methods, data bases and tools for cancer predication and stimulation especially in CC cases. Metabolism is defined as intracellular chemical reactions that produce chemical substances and energies sustaining life. Metabolic pathway networks are also composed of links that are defined as transformation of chemical structures between two metabolites and an enzyme reaction. The most important advantage of metabolome is its ability to analyze metabolites from any source, regardless of origin, where the application of liquid chromatography combined with mass spectra in metabolome analysis to a series of cancer cell lines that were progressively more tumorigenic due to the induction of 1,2,3 or 4 oncogenes to cell lines could be a metabolome example application. In conclusion, natural products and hormones are very important in preventing CC in humans and animal models where both natural products and hormones play a significant and important effect in regulating physiological process especially in CC cases. In this situation, metabolome must increase in its application in the future for the diagnosis of CC cases.

关键词： Colon cancer Metabolome Physiology Natural products Hormones