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Long-term outcomes of pediatric liver transplantation in acute liver failure vs end-stage chronic liver disease:A retrospective observational study

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World Journal of Transplantation 2023年第3期13卷 96-106页

作者： Amr M Alnagar Abdul R Hakeem khaled daradka Eirini Kyrana Marumbo Methga KarthikeyanPalaniswamy Sanjay Rajwal Jamila Mulla Moira O'meara Vivek Upasani Dhakshinamoorthy Vijayanand Raj Prasad Magdy S Attia Department of General Surgery Faculty of MedicineAlexandria UniversityAlexandria 21615Egypt Liver and Transplant Surgery The Leeds Teaching HospitalsNHS Foundation TrustLeeds LS97TFUnited Kingdom

BACKGROUND Children with acute liver failure(ALF)who meet the criteria are eligible for super-urgent transplantation,whereas children with end-stage chronic liver disease(ESCLD)are usually transplanted *** liver transplantation(PLT)in ALF and ESCLD settings has been well described in the literature,but there are no studies comparing the outcomes in these two *** To determine if there is a difference in post-operative complications and survival outcomes between ALF and ESCLD in *** This was a retrospective observational study of all primary PLTs performed at a single center between 2000 and *** and ESCLD groups were compared for pretransplant recipient,donor and operative parameters,and post-operative outcomes including graft and patient *** Over a 20-year study period,232 primary PLTs were performed at our center;195 were transplanted for ESCLD and 37 were transplanted for *** ALF recipients were significantly older(median 8 years vs 5.4 years;P=0.031)and heavier(31 kg vs 21 kg;P=0.011).Living donor grafts were used more in the ESCLD group(34 vs 0;P=0.006).There was no difference between the two groups concerning vascular complications and rejection,but there were more bile leaks in the ESCLD ***-transplant patient survival was significantly higher in the ESCLD group:1-,5-,and 10-year survival rates were 97.9%,93.9%,and 89.4%,respectively,compared to 78.3%,78.3%,and 78.3%in the ALF group(P=0.007).However,there was no difference in 1-,5-,and 10-year graft survival between the ESCLD and ALF groups(90.7%,82.9%,77.3%vs 75.6%,72.4%,and 66.9%;P=0.119).CONCLUSION Patient survival is inferior in ALF compared to ESCLD recipients;the main reason is death in the 1st year post-PLT in ALF *** the ALF children overcome the 1st year after transplant,their survival stabilizes,and they have good long-term outcomes.

关键词： Pediatric liver transplantation Acute liver failure End-stage chronic liver disease Graft failure Patient survival Complications

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Comparative analysis on the performance of different types of input-and command-shaping controllers in minimizing payload residual vibration of an overhead crane with an inclined supporting track

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International Journal of Mechanical System Dynamics 2024年第1期4卷 22-33页

作者： Mohammed Alfares khaled Alhazza Mechanical Engineering Department College of Engineering and PetroleumKuwait UniversityKuwait CityKuwait

Reducing the effects of external disturbance on overhead crane systems is crucial,as they can impair the controller performance and cause excessive vibrations or oscillations of the *** such external disturbance is the inclination of the supporting track of the crane trolley,which causes the system dynamics model to *** open-loop control strategy is widely utilized to control the payload sway motion and generally does not require any alterations in the physical structure of a system or the installation of sensors and/or *** and command shaping are two common open-loop control techniques applied to control overhead *** this paper,the effect of moving an overhead crane system along an inclined supporting track is *** addition,the ability of different types of input-and command-shaping control schemes to suppress the residual vibrations due to trolley track inclination is *** types of input-shaping controllers,which are double-step,zero vibration,and one command waveform(WF)shaper based on a trigonometric function,are used and tested.A linear equation of motion of the overhead crane resting on an inclined surface is developed to simulate the overhead crane and payload *** effectiveness of the different types of open-loop controllers to suppress residual vibrations is verified by both simulation and experimental *** addition,a new WF command shaper is proposed and designed to overcome track inclination while eliminating payload residual vibration.A comprehensive comparative analysis,both numerically and experimentally,is performed on the new proposed shaper to measure its effectiveness in handling inclination when compared to other types of open-loop *** new shaper outperforms other controllers in eliminating payload residual vibration for a wider range of inclination angles.

关键词： overhead cranes open-loop control input and command shaping payload residual vibrations

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A review of mechanism of action of outdoor exposure in preventing myopia incidence and progression

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1144-1155页

作者： Chikezie Grand Ihesiulor khaled Alzahrani Hema Rhadhakrishnan Division of Pharmacy&Optometry School of Health SciencesFaculty of BiologyMedicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom Department of Ophthalmology King Fahad Armed Forces HospitalJeddah 23311Saudi Arabia

Various studies have suggested several environmental,pharmacological,medical,and optical interventions and some are in use but their efficacy in myopia control may be transient,and the cellular,molecular,and biochemical mechanisms involved *** exposure is currently regarded as an effective and enduring strategy in the control of myopia development and ***,the mechanism behind the effect of outdoor exposure and its association with genetic predisposition and other relatively more significant environmental factors on myopia is still a *** review focuses on survey-based and intervention-based studies carried out to propose a mechanism that accounts for myopia development and important for its control.

关键词： outdoor exposure daylight exposure myopia control myopia

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Robust Malicious Executable Detection Using Host-Based Machine Learning Classifier

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Computers, Materials & Continua 2024年第4期79卷 1419-1439页

作者： khaled Soliman Mohamed Sobh Ayman M.Bahaa-Eldin Department of Computer and Systems Engineering Ain Shams UniversityCairo11517Egypt Department of Computer Engineering Technology ElSewedy University of TechnologyCairo44629Egypt

The continuous development of cyberattacks is threatening digital transformation endeavors worldwide and leadsto wide losses for various organizations. These dangers have proven that signature-based approaches are insufficientto prevent emerging and polymorphic attacks. Therefore, this paper is proposing a Robust Malicious ExecutableDetection (RMED) using Host-based Machine Learning Classifier to discover malicious Portable Executable (PE)files in hosts using Windows operating systems through collecting PE headers and applying machine learningmechanisms to detect unknown infected files. The authors have collected a novel reliable dataset containing 116,031benign files and 179,071 malware samples from diverse sources to ensure the efficiency of RMED *** most effective PE headers that can highly differentiate between benign and malware files were selected totrain the model on 15 PE features to speed up the classification process and achieve real-time detection formalicious executables. The evaluation results showed that RMED succeeded in shrinking the classification timeto 91 milliseconds for each file while reaching an accuracy of 98.42% with a false positive rate equal to 1.58. Inconclusion, this paper contributes to the field of cybersecurity by presenting a comprehensive framework thatleverages Artificial Intelligence (AI) methods to proactively detect and prevent cyber-attacks.

关键词： Portable executable malware intrusion detection cybersecurity zero-day threats Host IntrusionDetection System(HIDS) machine learning Anomaly-based Intrusion Detection System(AIDS) deep learning

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Defamiliarizing Reality for Mental and Physical Subjection:Rereading Harold Pinter's The Room and The Dumb Waiter as Political Comedies

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Fudan Journal of the Humanities and Social Sciences 2024年第1期17卷 159-191页

作者： Ahmed Abdulkhair Abulmagd khaled Faculty of Languages&Translation Al-Azhar UniversityNasr CityCairoEgypt

While Pinter's earliest plays have been recognized in the modernist history of theatre as comedies of menace and his later plays as political comedies,this article argues that his earliest plays are equally very liable to be interpreted as political *** of their absurdist dramatization of people's helpless exposure to external,unidentifiable threats,a common post-WWII characteristic feature of human experience,I claim that The Room and The Dumb Waiter(both written 1957,staged 1960),two model examples of Pinter's earliest oeuvres,do not simply follow the aesthetic of absurdist theatre to express human *** audience's experience of viewing the theatrical performances of both plays in terms of discursive cyclicality or character normality is subverted into one of changeability,strangeness,and *** foreground the political implications of such revolutionary theatrical experience,Pinter's plays are examined in the light of his unique use of defamiliarization,relying not on Brecht's traditional techniques of singing,dancing,image-projecting,or captioning,but on a simple,dual technique of image destruction and *** consists of divesting characters of their normality and portraying them instead as individuals who identify only with unusual images of place,time,body,and *** this special technique of defamiliarization,both plays are examined to reveal Pinter's central political theme of undermining reality for purposes of mental and physical subjections.

关键词： Defamiliarization Comedy of menace Political comedy Subjection Harold Pinter

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Sexual dimorphism of G protein-coupled receptor signaling in the brain

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Neural Regeneration Research 2024年第8期19卷 1635-1636页

作者： Sara Aljoudi Hamdan Hamdan khaled S.Abd-Elrahman Department of Physiology and Immunology College of Medicine and Health SciencesKhalifa UniversityAbu DhabiUnited Arab Emirates Healthcare Engineering Innovation Center(HEIC) Khalifa UniversityAbu DhabiUnited Arab Emirates Department of Anesthesiology Pharmacology and Therapeuticsand Djavad Mowafaghian Center for Brain HealthUniversity of British ColumbiaVancouverBCCanada Department of Pharmacology and Therapeutics College of Medicine and Health ScienceKhalifa UniversityAbu DhabiUnited Arab Emirates Department of Pharmacology and Toxicology Faculty of PharmacyAlexandria UniversityAlexandriaEgypt

G protein-coupled receptors(GPCRs)represent the most substantial family of membrane receptors that are targeted by *** and Drug Administration-approved *** of the preclinical research to understand the pharmacology of... 详细信息

关键词： drugs clinical targeted

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A Measurement Study of the Ethereum Underlying P2P Network

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Computers, Materials & Continua 2024年第1期78卷 515-532页

作者： Mohammad ZMasoud Yousef Jaradat Ahmad Manasrah Mohammad Alia khaled Suwais Sally Almanasra Electrical Engineering Department Al-Zaytoonah University of JordanAmman11733Jordan Mechanical Engineering Department Al-Zaytoonah University of JordanAmman11733Jordan Computer Science Department Al-Zaytoonah University of JordanAmman11733Jordan Faculty of Computer Studies Arab Open UniversityRiyadh11681Saudi Arabia

This work carried out a measurement study of the Ethereum Peer-to-Peer(P2P)network to gain a better understanding of the underlying *** was applied because it pioneered distributed applications,smart contracts,and ***,its application layer language“Solidity”is widely used in smart contracts across different public and private *** this end,we wrote a new Ethereum client based on Geth to collect Ethereum node ***,various web scrapers have been written to collect nodes’historical data fromthe Internet Archive and the Wayback Machine *** collected data has been compared with two other services that harvest the number of *** has collectedmore than 30% more than the other *** data trained a neural network model regarding time series to predict the number of online nodes in the *** findings show that there are less than 20% of the same nodes daily,indicating thatmost nodes in the network change *** poses a question of the stability of the ***,historical data shows that the top ten countries with Ethereum clients have not changed since *** popular operating system of the underlying nodes has shifted from Windows to Linux over time,increasing node *** results have also shown that the number of Middle East and North Africa(MENA)Ethereum nodes is neglected compared with nodes recorded from other *** opens the door for developing new mechanisms to encourage users from these regions to contribute to this ***,the model has been trained and demonstrated an accuracy of 92% in predicting the future number of nodes in the Ethereum network.

关键词： Ethereum measurement ethereum client neural network time series forecasting web-scarping wayback machine blockchain

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Mapping the metabolic responses to oxaliplatin-based chemotherapy with in vivo spatiotemporal metabolomics

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Journal of Pharmaceutical Analysis 2024年第2期14卷 196-210页

作者： Mariola Olkowicz khaled Ramadan Hernando Rosales-Solano Miao Yu Aizhou Wang Marcelo Cypel Janusz Pawliszyn Department of Chemistry University of WaterlooWaterlooONCanada Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian UniversityKrakowPoland Latner Thoracic Surgery Research Laboratories Toronto General Hospital Research InstituteUniversity Health NetworkTorontoONCanada The Jackson Laboratory JAX Genomic MedicineFarmingtonCTUSA Division of Thoracic Surgery Department of SurgeryUniversity Health NetworkUniversity of TorontoToronto Lung Transplant ProgramTorontoONCanada

Adjuvant chemotherapy improves the survival outlook for patients undergoing operations for lung metastases caused by colorectal cancer (CRC). However, a multidisciplinary approach that evaluates several factors related to patient and tumor characteristics is necessary for managing chemotherapy treatment in metastatic CRC patients with lung disease, as such factors dictate the timing and drug regimen, which may affect treatment response and prognosis. In this study, we explore the potential of spatial metabolomics for evaluating metabolic phenotypes and therapy outcomes during the local delivery of the anticancer drug, oxaliplatin, to the lung. 12 male Yorkshire pigs underwent a 3 h left lung in vivo lung perfusion (IVLP) with various doses of oxaliplatin (7.5, 10, 20, 40, and 80 mg/L), which were administered to the perfusion circuit reservoir as a bolus. Biocompatible solid-phase microextraction (SPME) microprobes were combined with global metabolite profiling to obtain spatiotemporal information about the activity of the drug, determine toxic doses that exceed therapeutic efficacy, and conduct a mechanistic exploration of associated lung injury. Mild and subclinical lung injury was observed at 40 mg/L of oxaliplatin, and significant compromise of the hemodynamic lung function was found at 80 mg/L. This result was associated with massive alterations in metabolic patterns of lung tissue and perfusate, resulting in a total of 139 discriminant compounds. Uncontrolled inflammatory response, abnormalities in energy metabolism, and mitochondrial dysfunction next to accelerated kynurenine and aldosterone production were recognized as distinct features of dysregulated metabolipidome. Spatial pharmacometabolomics may be a promising tool for identifying pathological responses to chemotherapy.

关键词： Pulmonary metastases Colorectal cancer Adjuvant chemotherapy In vivo lung chemo-perfusion Solid-phase microextraction(SPME)microprobes Spatial metabolomics

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Magneto-Photo-Thermoelastic Excitation Rotating Semiconductor Medium Based on Moisture Diffusivity

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 107-126页

作者： khaled Lotfy A.M.S.Mahdy Alaa A.El-Bary E.S.Elidy Department of Mathematics Faculty of ScienceZagazig UniversityZagazig44519Egypt Department of Mathematics Faculty of ScienceTaibah UniversityMadinah42353Saudi Arabia Department of Mathematics and Statistics College of ScienceTaif UniversityTaif11099Saudi Arabia Arab Academy for Science Technology and Maritime TransportAlexandria1029Egypt

In this research,we focus on the free-surface deformation of a one-dimensional elastic semiconductor medium as a function of magnetic field and moisture *** problem aims to analyze the interconnection between plasma and moisture diffusivity processes,as well as thermo-elastic *** study examines the photothermoelasticity transport process while considering the impact of moisture *** employing Laplace’s transformation technique,we derive the governing equations of the photo-thermo-elastic *** equations include the equations for carrier density,elastic waves,moisture transport,heat conduction,and constitutive *** stresses,thermal conditions,and plasma boundary conditions are used to calculate the fundamental physical parameters in the Laplace *** employing numerical techniques,the Laplace transform is inverted to get complete time-domain solutions for the primary physical domains under ***,thermoelastic,and thermoelectric characteristics are employed in conjunction with a graphical analysis that takes into consideration the effects of applied forces on displacement,moisture concentration,carrier density,stress due to forces,and temperature distribution.

关键词： Moisture diffusivity semiconductor photothermoelastic rotation thermomechanical waves laplace transform

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Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： khaled Alok Timothy G.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

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