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Modeling and simulation of the“IL-36 cytokine”and CAR-T cells interplay in cancer onset

International Journal of Modeling, Simulation, and Scientific Computing 2022年第3期13卷 207-222页

作者： khaled a.a-utaibi Alessandro Nutini Ayesha Sohail Robia.arif Sumeyye Tunc Sadiq M.Sait Computer Science and Software Engineering Department University of Ha’il Ha’ilSaudi Arabia Biology and Biomechanics Department Centro Studi Attivita Motorie via di Tiglio 94 LuccaItaly Department of Mathematics Comsats University Isla.abad Lahore 54000Pakistan Vocational School of Sciences Physiotherapy Programme Medipol University UnkapanıAtat¨urk BulvarıNo.27Halic Campus34083 FatihIstanbulTurkey Center for Communications and IT Research Research Institute King Fahd University of Petroleum&Minerals Dhahran 31261Saudi Arabia

Background:CAR-T cells are chimeric antigen receptor(CAR)-T cells;they are targetspecific engineered cells on tumor cells and produce T cell-mediated antitumor ***-T cell therapy is the“first-line”therapy in immunotherapy for the treatment of highly clonal neoplasms such as lymphoma.and *** adoptive therapy is currently being studied and tested even in the case of solid tumors such as osteosarcoma since,precisely for this type of tumor,the use of immune checkpoint inhibitors remained *** CAR-T is a promising therapeutic technique,there are therapeutic limits linked to the persistence of these cells and to the tumor’s immune ***-T cell engineering techniques are allowed to express interleukin IL-36,and seem to be much more efficient in antitumoral ***-36 is involved in the long-term antitumor action,allowing CAR-T cells to be more efficient in their antitumor action due to a“cross-talk”action between the“IL-36/dendritic cells”axis and the a.aptive ***:This a.alysis makes the model useful for evaluating cell dynamics in the case of tumor relapses or specific understanding of the action of CAR-T cells in certain types of *** model proposed here seeks to quantify the action and interaction between the three fundamental elements of this antitumor activity induced by this type of adoptive immunotherapy:IL-36,“armored”CAR-T cells(i.e.,engineered to produce IL-36)and the tumor cell population,focusing exclusively on the action of this interleukin and on the antitumor consequences of the so modified CAR-T *** model was developed and numerical simulations were carried out during this *** development of the model with stability a.alysis by conditions of Routh–Hurwitz shows how IL-36 makes CAR-T cells more efficient and persistent over time and more effective in the antitumoral treatment,making therapy more effective a.ainst the“solid tumor”.Findings:Primary malignant bone tumors are

关键词： IL-36 bone remodeling mathematical model BMUs CAR-T cells

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(Sm/Eu/Tm)^(3+) doped tantalum semiconductor system for photovoltaic and electrochemical functionality amplification

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Journal of Rare Earths 2024年第8期42卷 1586-1594,I0007页

作者： Shaan Bibi Jaffri Khuram Shahzad Ahmad Isaac Abra.ams Ibrahim a.a Materials and Environmental Chemistry Lab Lab-E21Department of Environmental SciencesFatima Jinnah Women UniversityRawalpindiPakistan School of Physical and Chemical Sciences Queen Mary University of LondonLondonUnited Kingdom Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh11451Saudi Arabia

This work reports the synthesis,cha.acterization,and energy focused applications of the novel lanthanides co-doped tantalum pentoxide hetero-system(Sm^(3+)-Eu^(3+)-Tm^(3+):Ta_(2)O_(5)).Ln^(3+)-doped Ta_(2)O_(5) express excellent opto-electronic features reflected by the narrow band gap energy of 3.87 *** vibrations confirm the presence of Ta-O-Ta.and Ta-O *** synthesized system possesses orthorhombic geometry with 59.46 nm particle *** the smoother and compact morphology,the synthesized material succeeds in augmenting the performance of different systems aimed at energy *** ambient perovskite solar cell device fabricated with the Ln^(3+)-doped Ta_(2)O_(5) as an electron transport layer excels in achieving an efficiency and fill factor of 14.17% and 76% under artificial *** device was marked by the negligible hysteresis behavior showing profound photovoltaic *** electrochemical activity of the Ln^(3+)-doped Ta_(2)O_(5) decorated electrode was evaluated for electrical charge storage potential with pseudoca.acitive behavior,With the highest specific ca.acitance of 355.39 F/g and quicker ionic diffusion rate,the designed electrode excels conventionally used ***-ca.alysis of water with Ln^(3+)-doped Ta_(2)O_(5) material indicates its ca.acity for H_(2) production with the lowest overpotential and Tafel slope values of 148 and 121.2 mV/dec,while the O_(2) generation is compa.atively *** the stable electrochemical output,this rare earth modified material has the potential to replace conventionally used environmentally perilous and costly materials.

关键词： Lanthanide doping Rare earth materials Perovskite solar cells Superca.acitors Water splitting

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Compa.ative a.alysis on the performance of different types of input-and command-shaping controllers in minimizing payload residual vibration of an overhead crane with an inclined supporting track

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International Journal of Mechanical System Dynamics 2024年第1期4卷 22-33页

作者： Mohammed Alfares khaled Alhazza Mechanical Engineering Department College of Engineering and PetroleumKuwait UniversityKuwait CityKuwait

Reducing the effects of external disturbance on overhead crane systems is crucial,as they can impair the controller performance and cause excessive vibrations or oscillations of the *** such external disturbance is the inclination of the supporting track of the crane trolley,which causes the system dynamics model to *** open-loop control strategy is widely utilized to control the payload sway motion and generally does not require any alterations in the physical structure of a system or the installation of sensors and/or *** and command shaping are two common open-loop control techniques applied to control overhead *** this paper,the effect of moving an overhead crane system along an inclined supporting track is *** addition,the ability of different types of input-and command-shaping control schemes to suppress the residual vibrations due to trolley track inclination is *** types of input-shaping controllers,which are double-step,zero vibration,and one command waveform(WF)shaper based on a trigonometric function,are used and tested.A linear equation of motion of the overhead crane resting on an inclined surface is developed to simulate the overhead crane and payload *** effectiveness of the different types of open-loop controllers to suppress residual vibrations is verified by both simulation and experimental *** addition,a new WF command shaper is proposed and designed to overcome track inclination while eliminating payload residual vibration.A comprehensive compa.ative a.alysis,both numerically and experimentally,is performed on the new proposed shaper to measure its effectiveness in handling inclination when compared to other types of open-loop *** new shaper outperforms other controllers in eliminating payload residual vibration for a wider range of inclination angles.

关键词： overhead cranes open-loop control input and command shaping payload residual vibrations

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A review of mechanism of action of outdoor exposure in preventing myopia incidence and progression

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1144-1155页

作者： Chikezie Grand Ihesiulor khaled Alzahrani Hema Rhadhakrishnan Division of Pharmacy&Optometry School of Health SciencesFaculty of BiologyMedicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom Department of Ophthalmology King Fahad Armed Forces HospitalJeddah 23311Saudi Arabia

Various studies have suggested several environmental,pharmacological,medical,and optical interventions and some are in use but their efficacy in myopia control may be transient,and the cellular,molecular,and biochemical mechanisms involved *** exposure is currently regarded as an effective and enduring strategy in the control of myopia development and ***,the mechanism behind the effect of outdoor exposure and its association with genetic predisposition and other relatively more significant environmental factors on myopia is still a *** review focuses on survey-based and intervention-based studies carried out to propose a mechanism that accounts for myopia development and important for its control.

关键词： outdoor exposure daylight exposure myopia control myopia

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Robust Malicious Executable Detection Using Host-Based Machine Learning Classifier

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Computers, Materials & Continua 2024年第4期79卷 1419-1439页

作者： khaled Soliman Mohamed Sobh Ayman M.Ba.aa-Eldin Department of Computer and Systems Engineering Ain Shams UniversityCairo11517Egypt Department of Computer Engineering Technology ElSewedy University of TechnologyCairo44629Egypt

The continuous development of cyberattacks is threatening digital transformation endeavors worldwide and leadsto wide losses for various organizations. These dangers have proven that signature-based approaches are insufficientto prevent emerging and polymorphic attacks. Therefore, this paper is proposing a Robust Malicious ExecutableDetection (RMED) using Host-based Machine Learning Classifier to discover malicious Portable Executable (PE)files in hosts using Windows operating systems through collecting PE headers and applying machine learningmechanisms to detect unknown infected files. The authors have collected a novel reliable da.aset containing 116,031benign files and 179,071 malware samples from diverse sources to ensure the efficiency of RMED *** most effective PE headers that can highly differentiate between benign and malware files were selected totrain the model on 15 PE features to speed up the classification process and achieve real-time detection formalicious executables. The evaluation results showed that RMED succeeded in shrinking the classification timeto 91 milliseconds for each file while reaching an accuracy of 98.42% with a false positive rate equal to 1.58. Inconclusion, this paper contributes to the field of cybersecurity by presenting a comprehensive framework thatleverages Artificial Intelligence (AI) methods to proactively detect and prevent cyber-attacks.

关键词： Portable executable malware intrusion detection cybersecurity zero-day threats Host IntrusionDetection System(HIDS) machine learning Anomaly-based Intrusion Detection System(AIDS) deep learning

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Calculus bovis in hepatocellular carcinoma:Tumor molecular basis,Wnt/β-catenin pathway role,and protective mechanism

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World Journal of Gastroenterology 2024年第35期30卷 3959-3964页

作者： khaled Mohamed Mohamed Koriem Department of Medical Physiology Medical Research and Clinical Studies InstituteNational Research CentreGiza 12622Egypt

In this editorial,we comment on the recent article by Huang et *** editorial focuses specifically on the molecular mechanisms of hepatocellular carcinoma(HCC),mechanism of Wnt/β-catenin pathway in HCC,and protective mechanism of Calculus bovis(CB)in *** cancer is the fourth most common cause of cancer-related deaths *** most prevalent kind of primary liver cancer,HCC,is typically brought on by long-term viral infections(hepatitis B and C),non-alcoholic steatohepatitis,excessive alcohol consumption,and other conditions that can cause the liver to become chronically inflamed and *** is a wellknown traditional remedy in China.and Ja.an and has been used extensively to treat a variety of diseases,such as high fever,convulsions,and *** in lipid metabolism,cholesterol metabolism,bile acid metabolism,alcohol metabolism,and xenobiotic detoxification lead to fatty liver disease and liver ***,which is a tricarboxylic acid cycle intermediate,is vital to energy production and mitochondrial *** is also thought to be a signaling molecule in metabolism and in the development and spread of liver *** Wnt/β-catenin pathway is made up of a group of proteins that are essential for both adult tissue homeostasis and embryonic *** is frequently caused by the dysregulation of the Wnt/β-catenin signaling *** HCC liver carcinogenesis,Wnt/β-catenin signaling is activated by the expression of downstream target *** between the liver and the gut exists via the portal vein,biliary tract,and systemic ***"gutliver axis"controls intestinal *** of the main factors contributing to the development,progression,and treatment resistance of HCC is the abnormal activation of the Wnt/β-Catenin signaling ***,understanding this pathway is essential to treating *** ingredients of CB,particularly oleanolic acid,ergosterol,and ursolic acid,have anti-p

关键词： Hepatocellular carcinoma MicroRNAs Wnt/β-catenin pathway Calculus bovis Apoptosis

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Defamiliarizing Reality for Mental and Physical Subjection:Rereading Harold Pinter's The Room and The Dumb Waiter as Political Comedies

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Fudan Journal of the Humanities and Social Sciences 2024年第1期17卷 159-191页

作者： Ahmed Abdulkhair Abulmagd khaled Faculty of Languages&Translation Al-Azhar UniversityNasr CityCairoEgypt

While Pinter's earliest plays have been recognized in the modernist history of theatre as comedies of menace and his later plays as political comedies,this article argues that his earliest plays are equally very liable to be interpreted as political *** of their absurdist dra.atization of people's helpless exposure to external,unidentifiable threats,a common post-WWII cha.acteristic feature of human experience,I claim that The Room and The Dumb Waiter(both written 1957,staged 1960),two model examples of Pinter's earliest oeuvres,do not simply follow the aesthetic of absurdist theatre to express human *** audience's experience of viewing the theatrical performances of both plays in terms of discursive cyclicality or cha.acter normality is subverted into one of changeability,strangeness,and *** foreground the political implications of such revolutionary theatrical experience,Pinter's plays are examined in the light of his unique use of defamiliarization,relying not on Brecht's traditional techniques of singing,dancing,image-projecting,or captioning,but on a simple,dual technique of image destruction and *** consists of divesting cha.acters of their normality and portraying them instead as individuals who identify only with unusual images of place,time,body,and *** this special technique of defamiliarization,both plays are examined to reveal Pinter's central political theme of undermining reality for purposes of mental and physical subjections.

关键词： Defamiliarization Comedy of menace Political comedy Subjection Harold Pinter

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Sexual dimorphism of G protein-coupled receptor signaling in the brain

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Neural Regeneration Research 2024年第8期19卷 1635-1636页

作者： Sa.a Aljoudi Hamdan Hamdan khaled S.Abd-Elrahman Department of Physiology and Immunology College of Medicine and Health SciencesKhalifa UniversityAbu DhabiUnited Arab Emirates Healthcare Engineering Innovation Center(HEIC) Khalifa UniversityAbu DhabiUnited Arab Emirates Department of Anesthesiology Pharmacology and Therapeuticsand Djavad Mowafaghian Center for Brain HealthUniversity of British ColumbiaVancouverBCCanada Department of Pharmacology and Therapeutics College of Medicine and Health ScienceKhalifa UniversityAbu DhabiUnited Arab Emirates Department of Pharmacology and Toxicology Faculty of PharmacyAlexandria UniversityAlexandriaEgypt

G protein-coupled receptors(GPCRs)represent the most substantial family of membrane receptors that are targeted by *** and Drug Administration-approved *** of the preclinical research to understand the pharmacology of... 详细信息

关键词： drugs clinical targeted

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A Measurement Study of the Ethereum Underlying P2P Network

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Computers, Materials & Continua 2024年第1期78卷 515-532页

作者： Mohammad ZMasoud Yousef Ja.adat Ahmad Ma.asrah Mohammad Alia khaled Suwais Sally Alma.asra Electrical Engineering Department Al-Zaytoonah University of JordanAmman11733Jordan Mechanical Engineering Department Al-Zaytoonah University of JordanAmman11733Jordan Computer Science Department Al-Zaytoonah University of JordanAmman11733Jordan Faculty of Computer Studies Arab Open UniversityRiyadh11681Saudi Arabia

This work carried out a measurement study of the Ethereum Peer-to-Peer(P2P)network to gain a better understanding of the underlying *** was applied because it pioneered distributed applications,smart contracts,and ***,its application layer language“Solidity”is widely used in smart contracts across different public and private *** this end,we wrote a new Ethereum client based on Geth to collect Ethereum node ***,various web scrapers have been written to collect nodes’historical da.a fromthe Internet Archive and the Wayback Machine *** collected da.a has been compared with two other services that harvest the number of *** has collectedmore than 30% more than the other *** da.a trained a neural network model regarding time series to predict the number of online nodes in the *** findings show that there are less than 20% of the same nodes daily,indicating thatmost nodes in the network change *** poses a question of the stability of the ***,historical da.a shows that the top ten countries with Ethereum clients have not changed since *** popular operating system of the underlying nodes has shifted from Windows to Linux over time,increasing node *** results have also shown that the number of Middle East and North Africa(MENA)Ethereum nodes is neglected compared with nodes recorded from other *** opens the door for developing new mechanisms to encourage users from these regions to contribute to this ***,the model has been trained and demonstrated an accuracy of 92% in predicting the future number of nodes in the Ethereum network.

关键词： Ethereum measurement ethereum client neural network time series forecasting web-scarping wayback machine blockchain

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Mapping the metabolic responses to oxaliplatin-based chemotherapy with in vivo spatiotemporal metabolomics

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Journal of Pharmaceutical a.alysis 2024年第2期14卷 196-210页

作者： Mariola Olkowicz khaled Ra.adan Hernando Rosales-Solano Miao Yu Aizhou Wang Marcelo Cypel Janusz Pawliszyn Department of Chemistry University of WaterlooWaterlooONCanada Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian UniversityKrakowPoland Latner Thoracic Surgery Research Laboratories Toronto General Hospital Research InstituteUniversity Health NetworkTorontoONCanada The Jackson Laboratory JAX Genomic MedicineFarmingtonCTUSA Division of Thoracic Surgery Department of SurgeryUniversity Health NetworkUniversity of TorontoToronto Lung Transplant ProgramTorontoONCanada

Adjuvant chemotherapy improves the survival outlook for patients undergoing operations for lung metastases caused by colorectal cancer (CRC). However, a multidisciplinary approach that evaluates several factors related to patient and tumor cha.acteristics is necessary for ma.aging chemotherapy treatment in metastatic CRC patients with lung disease, as such factors dictate the timing and drug regimen, which may affect treatment response and prognosis. In this study, we explore the potential of spatial metabolomics for evaluating metabolic phenotypes and therapy outcomes during the local delivery of the anticancer drug, oxaliplatin, to the lung. 12 male Yorkshire pigs underwent a 3 h left lung in vivo lung perfusion (IVLP) with various doses of oxaliplatin (7.5, 10, 20, 40, and 80 mg/L), which were administered to the perfusion circuit reservoir as a bolus. Biocompatible solid-phase microextraction (SPME) microprobes were combined with global metabolite profiling to obtain spatiotemporal information about the activity of the drug, determine toxic doses that exceed therapeutic efficacy, and conduct a mechanistic exploration of associated lung injury. Mild and subclinical lung injury was observed at 40 mg/L of oxaliplatin, and significant compromise of the hemodynamic lung function was found at 80 mg/L. This result was associated with massive alterations in metabolic patterns of lung tissue and perfusate, resulting in a total of 139 discriminant compounds. Uncontrolled inflammatory response, abnormalities in energy metabolism, and mitochondrial dysfunction next to accelerated kynurenine and aldosterone production were recognized as distinct features of dysregulated metabolipidome. Spatial pharmacometabolomics may be a promising tool for identifying pathological responses to chemotherapy.

关键词： Pulmonary metastases Colorectal cancer Adjuvant chemotherapy In vivo lung chemo-perfusion Solid-phase microextraction(SPME)microprobes Spatial metabolomics

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