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Predictive Value of miRNA-181a in Pediatric Acute Lymphoblastic Leukemia

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Journal of Cancer Therapy 2020年第11期11卷 673-682页

作者： Asmaa El Desoky Hosny Badrawy Dina Ismail Abd El Razik khaled F. riad Omina N. Abdelhamid Eman Hassan Translational Hematology and Oncology Research (THOR) Department Learner Institute Case Western Reserve University Cleve-land Ohio USA Department of Clinical Pathology South Egypt Cancer Institute Assiut University Assiut Egypt Department of Pediatric Oncology South Egypt Cancer Institute Assiut University Assiut Egypt

Background: Acute lymphoblastic leukemia (ALL), a common pediatric malignant neoplasia, showed high relapse rate after induction therapy. Some miRNAs have been shown to regulate normal hematopoiesis and their disruption could contribute to leukemogenesis: Recently, specific miRNA, including miR-181a, was shown to be involved in the pathogenesis of ALL, serving as a biomarker for diagnosis and relapse of ALL. Aim of the Study: To evaluate miR-181a expression level as a predictive marker for children with acute lymphoblastic leukemia. Patients and Methods: 40 pediatric ALL patients were included in this study. miR-181a expression was assessed at diagnosis before start of treatment. Samples were either peripheral blood or bone marrow aspirate sample. Patients were evaluated clinically and laboratory after the induction therapy.

关键词： miR-181a Micro-RNA ALL

Propofol sedation in routine endoscopy:A case series comparing target controlled infusion vs manually controlled bolus concept

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World Journal of Gastrointestinal Endoscopy 2024年第1期16卷 11-17页

作者： riad Sarraj Lorenz Theiler Nima Vakilzadeh Niklas Krupka Reiner Wiest Department of Visceral Surgery and Medicine Inselspital University HospitalBern 3010Switzerland Clinic for Anesthesia PerioperativeEmergency&Intensive Care MedicineKantonsspital AarauAarau 5001Switzerland Department of Nephrology and Hypertension University Hospital LausanneLausanne 1011Switzerland

BACKGROUND Many studies have addressed safety and effectiveness of non-anaesthesiologist propofol sedation(NAPS)for gastrointestinal(GI)endoscopy Target controlled infusion(TCI)is claimed to provide an optimal sedation regimen by avoiding under-or *** To assess safety and performance of propofol TCI sedation in comparison with nurse-administered *** Fouty-five patients undergoing endoscopy under TCI propofol sedation were prospectively included from November 2016 to May 2017 and compared to 87 patients retrospectively included that underwent endoscopy with *** were matched for age and endoscopic *** recorded time of sedation and endoscopy,dosage of medication and adverse *** There was a significant reduction in dose per time of propofol administered in the TCI group,compared to the NAPS group(8.2±2.7 mg/min vs 9.3±3.4 mg/min;P=0.046).The time needed to provide adequate sedation levels was slightly but significantly lower in the control group(5.3±2.7 min vs 7.7±3.3 min;P<0.001),nonetheless the total endoscopy time was similar in both *** differences between TCI and bolus-sedation was observed for mean total-dosage of propofol rate as well as adverse *** This study indicates that sedation using TCI for GI endoscopy reduces the dose of propofol necessary per minute of *** may translate into less adverse ***,further and randomized trials need to confirm this trend.

关键词： Sedation Endoscopy Propofol Target controlled infusion Non-anaesthesiologist propofol sedation Adverse event

Correlation between DKK-1 Level and Bone Density Status in Children on Maintenance Haemodialysis

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Open Journal of Nephrology 2024年第1期14卷 48-61页

作者： Manal Abd El-Salam Marwa Mohamed Anwar Rasha Mahmoud Gouda Naglaa Abou El Fattah Nadia Youssef riad Department of Pediatrics Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Internal Medicine Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Clinical Pathology National Heart Institute Cairo Egypt

Background: Renal osteodystrophy (ROD) is a bone disorder resulting from chronic kidney disease (CKD) and related metabolic diseases. Dickkopf-related protein-1 (DKK-1) is critical in regulating bone biology. This study aimed to evaluate the serum DKK-1 level as a bone marker in children with CKD who undergo regular hemodialysis (HD). Subjects and Methods: This case-control study involved 40 children with CKD on HD and 40 healthy children as controls. The study measured serum DKK-1 levels and performed a dual-energy X-ray absorptiometry scan (DEXA) in line with routine laboratory investigations. Results: There was a significant increase in the serum level of DKK-1 in the patient group compared to the control group. The DKK-1 levels were 2540.65 (2215.4 - 2909.2) pg/ml and 1110.45 (885.45 - 1527.65) pg/ml, respectively, with a p-value of less than 0.001. In the hemodialysis group, 25 patients (62.5%) had low bone mineral density (BMD) with a Z-score of under -2.0. Eighteen of these patients had low BMD in both the neck of the femur and lumbar spines. Additionally, there was a significant increase in serum DKK-1 level in patients with low BMD (2567.35 (2303.8 - 3108.1) pg/ml) compared to patients with normal BMD (2454 (1859 - 2820) pg/ml) (p = 0.041). There was also a significant positive correlation between DKK1 level and phosphorus, alkaline phosphatase, and Parathormone serum levels. In conclusion, the study indicates a clear correlation between DKK-1 and BMD in children undergoing maintenance hemodialysis. DKK1 is a promising biomarker for CKD-MBD.

关键词： DKK-1 Children Haemodialysis Bone Density Status

Correlation between Wnt Signalling Inhibitors (Dickkopf-1 & Sclerostin) and the Intimal Medial Thickness in Children on Maintenance Hemodialysis

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Open Journal of Nephrology 2024年第3期14卷 397-412页

作者： Manal Abd El-Salam Mohamed Hamdi Ali Nadia Youssef riad Rasha Abd El Samad Fawaz Shima Mohamed Department of Pediatrics Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt Tbilisi State Medical University Tbilisi Georgia Department of Clinical Pathology National Heart Institute Cairo Egypt Department of Radiology Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt

Background: Wnt signalling inhibitors (Dickkopf-1 and Sclerostin) signalling play a role in vascular development and may contribute to calcification. Aim: To investigate the association between Dickkopf-1 and sclerostin serum concentrations in children undergoing maintenance hemodialysis with intimal medial thickness and peak systolic velocity of the main arteries. Patients and Methods: A study was conducted on 40 children undergoing maintenance hemodialysis and controls of the same age and sex. The study measured the initial medial thickness (IMT) and peak systolic velocity (PSV) of the main vessels (carotid, ulnar, and femoral). Dickkopf-1 and sclerostin serum levels in both groups were assessed, and a routine investigation was performed. Results: The findings indicate that the levels of serum Dickkopf-1 and Sclerostin were significantly higher in the hemodialysis group 2540.65 (2215.4 - 2909.2 pg/ml) and 1.17 (0.85 - 2.03 ng/ml)respectively (P = 0.001), compared to their control group it was 1110.45 (885.45 - 1527.65 pg/ml) and 0.28 (0.25 - 0.32 ng/ml)) respectively P = 0.001. Additionally, there was a significant increase in intima-media thickness (IMT) with a decrease in peak systolic velocity (PSV) in the main blood vessels, including the carotid, ulnar, and femoral arteries. A significant correlation was also observed between Dickkopf-1 and sclerostin levels and IMT of the carotid, ulnar, and femoral arteries. Conclusion: Wnt signalling inhibitors (Dickkopf-1 and Sclerostin) exert effects beyond the bone and significantly contribute to early vascular calcification in pediatric patients undergoing maintenance hemodialysis.

关键词： Wnt Signalling Vascular Calcification Hemodialysis Children

Low testing rates and high BRCA prevalence: Poly (ADP-ribose) polymerase inhibitor use in Middle East BRCA/homologous recombination deficiency-positive cancer patients

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World Journal of Clinical Oncology 2024年第7期15卷 848-858页

作者： Naveed Syed Ashish Vittalrao Chintakuntlawar Deepti Vilasini Aisha Mohamed Al Salami riad Al Hasan Imrana Afrooz Kanishka Uttam Chandani Ashok Uttam Chandani Aref Chehal Department of Hematology and Oncology Sheikh Shakbout Medical CityAbu Dhabi 11001United Arab Emirates Department of Oncology Mayo ClinicRochesterNY 790339United States Department of Oncology Sheikh Shakbout Medical CityAbu Dhabi 11001United Arab Emirates Clinical Research Sheikh Shakbout Medical CityAbu Dhabi 11001United Arab Emirates Department of Internal Medicine Landmark Medical CenterRhode IslandRI 02895United States

BACKGROUND Poly(ADP-ribose)polymerase inhibitors(PARPis)are approved as first-line therapies for breast cancer gene(BRCA)-positive,human epidermal growth factor receptor 2-negative locally advanced or metastatic breast *** are also effective for new and recurrent ovarian cancers that are BRCA-or homologous recombination deficiency(HRD)-***,data on these mutations and PARPi use in the Middle East are *** To assess BRCA/HRD prevalence and PARPi use in patients in the Middle East with breast/ovarian *** This was a single-center retrospective study of 57 of 472 breast cancer patients tested for BRCA mutations,and 25 of 65 ovarian cancer patients tested for *** adult patients participated in at least four visits to the oncology service at our center between August 2021 and May *** were summarized using descriptive statistics and compared using counts and *** to treatment was assessed using Response Evaluation Criteria in Solid Tumors *** Among the 472 breast cancer patients,12.1%underwent BRCA testing,and 38.5%of 65 ovarian cancer patients received HRD *** mutations were found in 25.6%of the tested patients:26.3%breast cancers had germline BRCA(gBRCA)mutations and 24.0%ovarian cancers showed ***,40.0%of gBRCA-positive breast cancers and 66.0%of HRD-positive ovarian cancers were Middle Eastern and Asian patients,*** treatment was used in 5(33.3%)gBRCA-positive breast cancer patients as first-line therapy(n=1;7-months progression-free),for maintenance(n=2;>15-months progression-free),or at later stages due to compliance issues(n=2).Four patients(66.6%)with HRD-positive ovarian cancer received PARPi and all remained *** Lower testing rates but higher BRCA mutations in breast cancer were *** reflected United Arab Emirates demographics,with breast cancer in Middle Eastern and ovarian cancer in Asian patients.

关键词： Homologous recombination repair BRCA1 BRCA2 Homologous recombination deficiency Ovarian cancer Breast cancer Poly(ADP-ribose)polymerase inhibitors Olaparib DNA double-strand breaks

Hydrogeochemical characteristics of groundwater and quality assessment for the purposes of drinking and irrigation in Bougaa area,Northeastern Algeria

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Acta Geochimica 2020年第5期39卷 642-654页

作者： riad Kouadra Abdeslam Demdoum Department of Geological Sciences University of Freres Mentouri Constantine 1ConstantineAlgeria Department of Earth Sciences Ferhat Abbas University Setif1SetifAlgeria

In the northern part of Algeria,the intensive exploitation of groundwater resources and pollution has considerably affected the aquifer water quality,especially in rural areas where groundwater is the main source of water supply for most *** study was performed to evaluate the groundwater quality and its suitability for drinking and irrigation purposes through the hydrogeochemical study on the groundwater in Bougaa region(Northeastern Algeria).Fourteen groundwater samples were collected and analyzed for p H,T,EC,TDS,and major *** samples are suitable for drinking based on the permissible limits of the Bureau of Indian standards(Indian standard specification for drinking water(IS 10500:2012),but only 35%of the samples are good enough for drinking purposes based on the water quality index of the *** of groundwater samples from various parameters and methods such as"Electrical conductivity,Sodium adsorption ratio,Soluble sodium percentage,Magnesium adsorption ratio,Residual sodium carbonate,Permeability index,Kelly’s ratio,Wilcox’s diagram,and US salinity laboratory classification"showed that groundwater in the area is chemically suitable for irrigation *** Piper trilinear diagram suggests that the groundwater mainly belongs to the hydrochemical facies Ca–Mg–Cl and Na–*** combination of ionic ratios,Gibbs plots,and saturation indices show that water–rock interaction,particularly the dissolution of carbonate,evaporation minerals,and ion exchange processes affects hydrogeochemistry of the *** processes such as evaporation and anthropogenic pollution from various sources can also have major impacts on groundwater salinity.

关键词： Groundwater Irrigation Drinking WQI Sodium adsorption ratio Wilcox’s diagram

COVID-19 pandemic and challenges in pediatric gastroenterology practice

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World Journal of Gastroenterology 2020年第36期26卷 5387-5394页

作者： Jamal Kriem riad Rahhal Department of Pediatrics Central Michigan University/Covenant Medical CenterSaginawMI 48602United States Division of Pediatric Gastroenterology University of Iowa Children’s HospitalIowaIA 52242United States

The current coronavirus pandemic is imposing unpreceded challenges to the practice of pediatric *** are highlighted in their impact on performing aerosol-generating endoscopy procedures and the need to accommodate longer room turnaround time for disinfection,ensuring appropriate and consistent safety measures for patients,staff and providers,and emphasizing the importance for screening patients for active coronavirus disease(COVID)infection before endoscopy when *** patients are less likely to exhibit severe COVID-related symptoms so survey-based screening would not be a sensitive measure to identify patients with active *** address the restrictions of patients coming for face to face clinic encounters,there has been rapid expansion of telehealth services in a very short time period with several difficulties *** survive these challenges,pediatric gastroenterology practices need to adapt and accept flexibility in clinical operations with ongoing commitment to safety for patients and healthcare workers.

关键词： Coronavirus Pandemic Pediatric Gastroenterology Endoscopy Screening Telehealth

Flow computations past a triangular boattailed projectile

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Defence Technology（防务技术） 2020年第3期16卷 712-719页

作者： E.Elawwad A.Ibrahim A.Elshabkaa A.riad Armed Forces Research Center(ARC) Cairo11765Egypt Military Technical College(MTC) Cairo11766Egypt

This paper presents a computational study of the air flow past a triangular boattailed *** study shows that there is a single normal shock wave impinges the projectile at transonic *** supersonic speeds,the formed shock waves are smeared compared to a conical boattailed ***,there is a reduction of the wake region behind the triangular base and the rear stagnation point is nearer to the projectile base resulting in base drag ***,there is an improvement of the stability of the triangular boattailed projectile since a lower overturning moment is incurred.

关键词： Triangular base Boattailed projectile Drag reduction Range extension

The impact of climate change on groundwater quantity and quality in a semi-arid environment:a case study of Ain Azel plain(Northeast Algeria)

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Acta Geochimica 2023年第6期42卷 1065-1078页

作者： Hasna Aouati Abdeslam Demdoum Houria Kada riad Kouadra Emergent Materials Research Unit Ferhat Abbas UniversitySetifAlgeria Department of Earth Sciences Institute of Architecture and Earth SciencesFerhat Abbas UniversitySetifAlgeria Department of Geological Sciences University of Fréres Mentouri Constantine 1ConstantineAlgeria

In the last decade,North Africa has witnessed significant population growth,particularly those bordering the Mediterranean *** led to increased demand for groundwater,which is an essential source for various water uses such as drinking water supplies and ***,human activities play a crucial role in the different quantitative and qualitative changes in ***,climate changes such as a decrease in precipitation have also led to a shortage of water resources and a decline in the groundwater *** paper presents the impact of climate changes on groundwater resources in the Ain Azel region,Setif,northeastern *** analysis of longterm spatiotemporal variability in rainfall over 63 years(1958–2021)revealed a significant decline in groundwater recharge,especially after *** contrast,the Pettitt and Mann–Kendall tests show increased temperatures with breaks between 1984 and 1986.A piezometric analysis of the alluvial aquifer demonstrated a significant decline in groundwater levels in the last 20 *** analysis showed that groundwater in the region is dominated by Ca–Mg–Cl water type,which indicates the presence of water salinity *** Quality Index(WQI)analysis showed the deterioration of groundwater in the area,which may be caused by several factors:brine intrusion from the Salt Lake(Sebkha)in the north;the dissolution of evaporites(Triassic)and/or anthropogenic sources of agricultural and industrial *** findings provide an overview summarizing the state of groundwater,which will help improve groundwater resource management in the region in the coming years.

关键词： Climate changes Groundwater resources Pettitt and Mann–Kendall tests WQI Salt Lake