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Primary Lymphoma of the Larynx: A Case Report and Literature Review

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Open Journal of Clinical Diagnostics 2015年第2期5卷 81-85页

作者： khaled khamassi Madiha Mahfoudhi Habib Jaafoura Khaoula Ouertani Wafa Kaabachi Lobna Bougacha Rim Lahiani Mamia Ben Salah Department of Otorhinolaryngology—Head and Neck Surgery Charles Nicolle Hospital Tunis Tunisia Department of Internal Medicine A Charles Nicolle Hospital Tunis Tunisia

Background: Primary non-hodgkin lymphoma of the larynx is a rare entity accounting for 1% of laryngeal tumors. Fewer than 100 cases have been reported in the literature. Case presentation: A 52-year-old man, presented with a two-month history of dysphonia. Nasofibroscopy showed left submucosal bulging of the laryngeal supraglottic floor. Cervical computed tomography showed extensive left supraglottic mass, with partial lysis of the thyroid cartilage. Direct laryngoscopy showed left submucosal bulging of the supraglottic floor. Transmucosal biopsies were performed. Histological study concluded to the presence of a diffuse large-cell B lymphoma. The patient was treated with chemotherapy followed by external radiotherapy. Evolution was favourable. Conclusion: Although primary laryngeal non-hodgkin lymphoma is rare, it should be considered in the differential diagnosis of a mass in the neck region, especially in the supraglottic area. Direct laryngoscopy with biopsy makes the diagnosis. Treatment and prognosis depend on the stage and the grade of the lymphoma.

关键词： Larynx Lymphoma Laryngoscopy Chemotherapy Radiotherapy

Exploring the influence of optical and thermal parameters on the effectiveness of parabolic trough collector receiver units

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Clean Energy 2024年第4期8卷 15-33页

作者： khaled Mohamad Engineering and Natural Sciences Faculty SDU UniversityAlmatyKazakhstan

This study investigates the optimization of physical parameters in a parabolic trough collector receiver unit to improve its thermal and optical *** parameters include the transmissivity,reflectivity,absorptivity,emissivity and thermal conductivity of the outer cover and absorber *** study utilizes a novel experimental design and a simulation model that accounts for the infrared reflectivity inside the *** simulation results were validated by the experimental data,with a maximum deviation of 8%.The study analyses the effects of varying the physical parameters on the heat transfer fluid temperature,total plant efficiency,temperature profiles,temperature gradients and thermal *** study finds that increasing the reflectivity and decreasing the emissivity of the outer cover and the absorber pipe significantly enhance the performance,with maximum increases of 25.8%and 26.5%in total efficiency,*** study also finds that increasing the thermal conductivity of the absorber pipe reduces the temperature gradients and thermal stress,with maximum decreases of 42.2%and 29%,*** study provides valuable insights for optimizing the receiver design and operation in solar-thermal systems.

关键词： parabolic trough collector heat transfer fluid receiver unit outer cover absorber pipe

Management of Intracranial Complications of Sinusitis

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Open Journal of Clinical Diagnostics 2015年第2期5卷 86-95页

作者： khaled khamassi Madiha Mahfoudhi Ayoub Ben Yahia Nour Ben Moussa Nawel Halila Adnen Boubaker Lobna Bougacha Rim Lahiani Mamia Ben Salah Department of Otorhinolaryngology—Head and Neck Surgery Charles Nicolle Hospital Tunis Tunisia Department of Internal Medicine A Charles Nicolle Hospital Tunis Tunisia Department of Neurosurgery National Institute of Neurosurgery Tunis Tunisia

Intracranial complications of sinusitis are rare. However, they have an important morbidity and mortality rate, and can be a source of disabling neurological sequelae in the absence of a rapid diagnosis and adequate treatment. We carry a retrospective study of 23 patients having sinusitis with intracranial complications, treated between 1996 and 2011. All patients underwent complete ENT and neurological examination, biological investigations and sinonasal and cerebral CT. An intraveinous large-spectrum antibiotherapy was administered to all patients. Twenty patients underwent surgery. It included evacuation of the intracranial collection, sinus drainage, with or without cranialization of the frontal sinus. Evolution was assessed on clinical biological and radiological criteria. Mean age was 25 years and sex-ratio was 3.6. Neurological signs were the most frequent symptoms. Rhinological signs were essentially purulent rhinorrhea (14 cases) and nasal obstruction (12 cases). Nasal endoscopy showed pus in the middle meatus in 10 cases. On CT, intracranial complications included subdural empyema (11 cases), extradural empyema (7 cases) and brain abscess (5 cases). Associated cerebral thrombophlebitis was noted in 4 cases. Three patients with extradural empyema had had an exclusive medical treatment. All other patients (20 cases) were operated. Clinical and radiological evolution was favorable after initial treatment in 14 cases (60.8%). Six patients required secondary surgery. Two patients have died despite intensive care. The intracranial complications of sinusitis are serious and source of important morbidity and mortality. Management should rapid and adequate, combining effective antibiotic therapy and eventually neurosurgical treatment.

关键词： Sinusitis Intracranial Headache Computed Tomography Empyema Abscess Antibiotics Drainage Cranialization

Otosclerosis: Contribution of Computed Tomography and Radio-Anatomical Correlations

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Open Journal of Clinical Diagnostics 2015年第2期5卷 74-80页

作者： khaled khamassi Madiha Mahfoudhi Hejer Mbarek Farah Hedhili Ayoub Ben Yahia Lobna Bougacha Jihen Ben Hafdhallah Najla Mnif Rim Lahiani Mamia Ben Salah Department of Otorhinolaryngology—Head and Neck Surgery Charles Nicolle Hospital Tunis Tunisia Department of Internal Medicine A Charles Nicolle Hospital Tunis Tunisia Department of Radiology Charles Nicolle Hospital Tunis Tunisia

Otosclerosis is an osteodystrophia of the otic capsule, responsible for hearing loss by blocking of the stapes footplate. The purpose of this study was to evaluate the reliability of computed tomography (CT) in the positive diagnosis of otosclerosis, to compare the radiological findings to those intraoperatively, and to seek a correlation between imaging data and postoperative audiometric results. This is a retrospective study of 60 patients having otosclerosis, treated in our department between 2009 and 2011. All patients underwent an otoscopic examination, pure tone and vocal audiometry, impedancemetry and petrous CT scan. At petrous CT scan, a footplate thickening was found in 9 cases. Labyrinthine bone hypodensity was noted in 51 cases. Sensitivity of CT in the diagnosis of otosclerosis was 100%. Regarding the operative findings and their correlation with imaging, we found that among the 7 facial canal procidences reported intraoperatively, CT had identified 6, with a sensitivity of 86%. Of the 53 facial nerve in normal position intraoperatively, CT had only identified 34, with a specificity of 64%. Regarding the ossicles, there were 6 cases of abnormalities of the incus, among them 3 were identified on CT, with a sensitivity of 50%. The 54 patients with normal ossicular chain intraoperatively were all identified as such on CT, with a specificity of 100% (p = 0.001). For correlation between imaging and postoperative results, it was found that patients with extended otosclerosis had lower postoperative audiometric improvement than those having localized disease (p < 0.05). Computed tomography is necessary for the diagnosis of otosclerosis. It also helps, with good sensitivity and specificity, seeking for anatomical variants that the surgeon could possibly encounter during surgical procedure. Finally, there is a statistically significant correlation between imaging data and postoperative audiometric results, allowing establishing a functional prognosis even before

关键词： Otosclerosis Computed Tomography Hearing Loss Audiometry

Comparative analysis on the performance of different types of input-and command-shaping controllers in minimizing payload residual vibration of an overhead crane with an inclined supporting track

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International Journal of Mechanical System Dynamics 2024年第1期4卷 22-33页

作者： Mohammed Alfares khaled Alhazza Mechanical Engineering Department College of Engineering and PetroleumKuwait UniversityKuwait CityKuwait

Reducing the effects of external disturbance on overhead crane systems is crucial,as they can impair the controller performance and cause excessive vibrations or oscillations of the *** such external disturbance is the inclination of the supporting track of the crane trolley,which causes the system dynamics model to *** open-loop control strategy is widely utilized to control the payload sway motion and generally does not require any alterations in the physical structure of a system or the installation of sensors and/or *** and command shaping are two common open-loop control techniques applied to control overhead *** this paper,the effect of moving an overhead crane system along an inclined supporting track is *** addition,the ability of different types of input-and command-shaping control schemes to suppress the residual vibrations due to trolley track inclination is *** types of input-shaping controllers,which are double-step,zero vibration,and one command waveform(WF)shaper based on a trigonometric function,are used and tested.A linear equation of motion of the overhead crane resting on an inclined surface is developed to simulate the overhead crane and payload *** effectiveness of the different types of open-loop controllers to suppress residual vibrations is verified by both simulation and experimental *** addition,a new WF command shaper is proposed and designed to overcome track inclination while eliminating payload residual vibration.A comprehensive comparative analysis,both numerically and experimentally,is performed on the new proposed shaper to measure its effectiveness in handling inclination when compared to other types of open-loop *** new shaper outperforms other controllers in eliminating payload residual vibration for a wider range of inclination angles.

关键词： overhead cranes open-loop control input and command shaping payload residual vibrations

Calculus bovis in hepatocellular carcinoma:Tumor molecular basis,Wnt/β-catenin pathway role,and protective mechanism

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World Journal of Gastroenterology 2024年第35期30卷 3959-3964页

作者： khaled Mohamed Mohamed Koriem Department of Medical Physiology Medical Research and Clinical Studies InstituteNational Research CentreGiza 12622Egypt

In this editorial,we comment on the recent article by Huang et *** editorial focuses specifically on the molecular mechanisms of hepatocellular carcinoma(HCC),mechanism of Wnt/β-catenin pathway in HCC,and protective mechanism of Calculus bovis(CB)in *** cancer is the fourth most common cause of cancer-related deaths *** most prevalent kind of primary liver cancer,HCC,is typically brought on by long-term viral infections(hepatitis B and C),non-alcoholic steatohepatitis,excessive alcohol consumption,and other conditions that can cause the liver to become chronically inflamed and *** is a wellknown traditional remedy in China and Japan and has been used extensively to treat a variety of diseases,such as high fever,convulsions,and *** in lipid metabolism,cholesterol metabolism,bile acid metabolism,alcohol metabolism,and xenobiotic detoxification lead to fatty liver disease and liver ***,which is a tricarboxylic acid cycle intermediate,is vital to energy production and mitochondrial *** is also thought to be a signaling molecule in metabolism and in the development and spread of liver *** Wnt/β-catenin pathway is made up of a group of proteins that are essential for both adult tissue homeostasis and embryonic *** is frequently caused by the dysregulation of the Wnt/β-catenin signaling *** HCC liver carcinogenesis,Wnt/β-catenin signaling is activated by the expression of downstream target *** between the liver and the gut exists via the portal vein,biliary tract,and systemic ***"gutliver axis"controls intestinal *** of the main factors contributing to the development,progression,and treatment resistance of HCC is the abnormal activation of the Wnt/β-Catenin signaling ***,understanding this pathway is essential to treating *** ingredients of CB,particularly oleanolic acid,ergosterol,and ursolic acid,have anti-p

关键词： Hepatocellular carcinoma MicroRNAs Wnt/β-catenin pathway Calculus bovis Apoptosis

A review of mechanism of action of outdoor exposure in preventing myopia incidence and progression

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1144-1155页

作者： Chikezie Grand Ihesiulor khaled Alzahrani Hema Rhadhakrishnan Division of Pharmacy&Optometry School of Health SciencesFaculty of BiologyMedicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom Department of Ophthalmology King Fahad Armed Forces HospitalJeddah 23311Saudi Arabia

Various studies have suggested several environmental,pharmacological,medical,and optical interventions and some are in use but their efficacy in myopia control may be transient,and the cellular,molecular,and biochemical mechanisms involved *** exposure is currently regarded as an effective and enduring strategy in the control of myopia development and ***,the mechanism behind the effect of outdoor exposure and its association with genetic predisposition and other relatively more significant environmental factors on myopia is still a *** review focuses on survey-based and intervention-based studies carried out to propose a mechanism that accounts for myopia development and important for its control.

关键词： outdoor exposure daylight exposure myopia control myopia

Robust Malicious Executable Detection Using Host-Based Machine Learning Classifier

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Computers, Materials & Continua 2024年第4期79卷 1419-1439页

作者： khaled Soliman Mohamed Sobh Ayman M.Bahaa-Eldin Department of Computer and Systems Engineering Ain Shams UniversityCairo11517Egypt Department of Computer Engineering Technology ElSewedy University of TechnologyCairo44629Egypt

The continuous development of cyberattacks is threatening digital transformation endeavors worldwide and leadsto wide losses for various organizations. These dangers have proven that signature-based approaches are insufficientto prevent emerging and polymorphic attacks. Therefore, this paper is proposing a Robust Malicious ExecutableDetection (RMED) using Host-based Machine Learning Classifier to discover malicious Portable Executable (PE)files in hosts using Windows operating systems through collecting PE headers and applying machine learningmechanisms to detect unknown infected files. The authors have collected a novel reliable dataset containing 116,031benign files and 179,071 malware samples from diverse sources to ensure the efficiency of RMED *** most effective PE headers that can highly differentiate between benign and malware files were selected totrain the model on 15 PE features to speed up the classification process and achieve real-time detection formalicious executables. The evaluation results showed that RMED succeeded in shrinking the classification timeto 91 milliseconds for each file while reaching an accuracy of 98.42% with a false positive rate equal to 1.58. Inconclusion, this paper contributes to the field of cybersecurity by presenting a comprehensive framework thatleverages Artificial Intelligence (AI) methods to proactively detect and prevent cyber-attacks.

关键词： Portable executable malware intrusion detection cybersecurity zero-day threats Host IntrusionDetection System(HIDS) machine learning Anomaly-based Intrusion Detection System(AIDS) deep learning

Defamiliarizing Reality for Mental and Physical Subjection:Rereading Harold Pinter's The Room and The Dumb Waiter as Political Comedies

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Fudan Journal of the Humanities and Social Sciences 2024年第1期17卷 159-191页

作者： Ahmed Abdulkhair Abulmagd khaled Faculty of Languages&Translation Al-Azhar UniversityNasr CityCairoEgypt

While Pinter's earliest plays have been recognized in the modernist history of theatre as comedies of menace and his later plays as political comedies,this article argues that his earliest plays are equally very liable to be interpreted as political *** of their absurdist dramatization of people's helpless exposure to external,unidentifiable threats,a common post-WWII characteristic feature of human experience,I claim that The Room and The Dumb Waiter(both written 1957,staged 1960),two model examples of Pinter's earliest oeuvres,do not simply follow the aesthetic of absurdist theatre to express human *** audience's experience of viewing the theatrical performances of both plays in terms of discursive cyclicality or character normality is subverted into one of changeability,strangeness,and *** foreground the political implications of such revolutionary theatrical experience,Pinter's plays are examined in the light of his unique use of defamiliarization,relying not on Brecht's traditional techniques of singing,dancing,image-projecting,or captioning,but on a simple,dual technique of image destruction and *** consists of divesting characters of their normality and portraying them instead as individuals who identify only with unusual images of place,time,body,and *** this special technique of defamiliarization,both plays are examined to reveal Pinter's central political theme of undermining reality for purposes of mental and physical subjections.

关键词： Defamiliarization Comedy of menace Political comedy Subjection Harold Pinter