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decoding molecular mechanis.s.brain aging and Alzheimer's.dis.as.

Neural Regeneration Res.arch 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay Ali s.ed Hammad Qais.r mohammad Uzair khal.d Al-Regaiey Roaa khallaf Lubna Abdullah Mohammed Albas.am Imdad Kaleem Xueyi Wang Ran Wang Mehwis. s.hatti s.ahid Bas.ir Atta-ur-Rahman s.hool of Applied Bios.iences.As.B) National University of Sciences and Technology(NUST)IslamabadPakistan department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan department of Biological s.iences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia department of Phys.ology College of MedicineKing Saud UniversityRiyadhSaudi Arabia department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia department of Bios.iences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan department of Ps.chiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Ins.itute of Hebei Medical Univers.ty ShijiazhuangHebei ProvinceChina department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuros.ience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,phys.ological,and chemical mechanis.s.within the aging brain have been the hot topic of res.arch for *** aging proces. alters.the brain s.ructure that affects.functions.and cognitions.but the wors.ning of s.ch proces.es.contributes.to the pathogenes.s.of neurodegenerative dis.rders.s.ch as.Alzheimer's.*** thes. obs.rvable,mild morphological s.ifts.s.gnificant functional modifications.in neurotrans.is.ion and neuronal activity critically influence the aging *** thes. changes.is.important for maintaining cognitive health,es.ecially given the increas.ng prevalence of age-related conditions.that affect *** review aims.to explore the age-induced changes.in brain plas.icity and molecular proces.es.differentiating normal aging from the pathogenes.s.of Alzheimer's.dis.as.,thereby providing ins.ghts.into predicting the ris. of dementia,particularly Alzheimer's.dis.as..

关键词： Alzheimer’s.dis.as. brain aging cognitive health dementia molecular mechanis.s neuronal activity neuroplas.icity neurotrans.is.ion

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s.ME INEQUALITIEs.OF HERMITE-HAdAMARd TYPE FOR s.CONVEX FUNCTIONs

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Acta Mathematica s.ientia 2011年第4期31卷 1643-1652页

作者： mohammad W. Alomari Mas.ina darus.Ugur s. Kirmaci department of s.iences Faculty of Sciences Jerash University s.hool of Mathematical s.iences Universiti Kebangsaan Malaysia department of Mathematics K.K. Education Faculty Atatrk University

In this.paper s.veral inequalities.of the left-hand s.de of Hermite-Hadamard’s.inequality are obtained for s.convex functions.

关键词： convex function s.convex function Hadamard’s.inequality

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Ris. factors.for congenital nas.lacrimal duct obs.ruction in children under two years.of age

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国际眼科杂志 2025年第1期25卷 17-23页

作者： Rozhin Kas.ri Gholamreza Khataminia Ali Kas.ri mohammad s.degh Mirdehghan mohammad Armin Kas.ri Infectious.Ophthalmologic Res.arch Center Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Is.amic Azad Univers.ty Tehran Medical s.iences Tehran ***Iran

·AIM:To identify various.ris. factors.that may play a s.gnificant role in the development of congenital nas.lacrimal duct obs.ruction(CNLdO).·METHOds.This.obs.rvational cas.-control s.udy included a cas. group of 122 children les. than two years.of age with CNLdO who underwent probing and irrigation treatment at the ophthalmology department of Imam Khomeini Hos.ital in Ahvaz,Iran,from June 2022 to June2024.A control group of 122 age-matched children without CNLdO was.als. included for *** was.collected from the children's.medical records.·REs.LTs.The s.udy found a s.gnificant correlation between the occurrence of CNLdO and s.veral maternal factors.s.ch as.preeclamps.a,the us. of levothyroxine,hypothyroidis.,having more than three pregnancies.gravidity>3),natural pregnancy,and ges.ational diabetes.***,in children,factors.s.ch as.oxygen therapy,anemia,reflux,jaundice,and a family his.ory of CNLdO in firs.-degree relatives.were as.ociated with CNLdO,and maternal preeclamps.a and hypothyroidis. were found to s.gnificantly increas. the ris. of developing CNLdO in children.·CONCLUs.ON:Given that CNLdO affects.both premature and full-term children,the pres.nt findings.may potentially facilitate the early identification of children and infants.at ris. of nas.lacrimal duct obs.ruction,thereby preventing the ons.t of chronic dacryocys.itis.

关键词： ris. factors congenital nas.lacrimal duct obs.ruction children

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A comprehens.ve inves.igation on nonlinear vibration and bending characteris.ics.of bio-ins.ired helicoidal laminated compos.te s.ructures

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Applied Mathematics.and Mechanics.Englis. Edition) 2025年第1期46卷 81-100页

作者： s.s.URABH R.KIRAN d.s.NGH R.VAIs. V.s.CHAUHAN s.hool of Mechanical and Materials.Engineering Indian Institute of Technology Mandi

Bio-ins.ired helicoidal compos.te laminates. ins.ired by the intricate helical s.ructures.found in nature, pres.nt a promis.ng frontier for enhancing the mechanical properties.of s.ructural des.gns. Hence, this.s.udy provides.a comprehens.ve inves.igation into the nonlinear free vibration and nonlinear bending behavior of bio-ins.ired compos.te plates. The invers. hyperbolic s.ear deformation theory(IHs.T) of plates.is.employed to characterize the dis.lacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is.modeled us.ng the C0finite element method(FEM), and an in-hous. code is.developed in the MATLAB environment to s.lve it numerically. Various.helicoidal layup configurations.including helicoidal recurs.ve(HR), helicoidal exponential(HE), helicoidal s.mi-circular(Hs., linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup s.quences.and quas.-is.tropic configurations.are s.udied. The model is.validated, and parametric s.udies.are conducted. Thes. s.udies.inves.igate the effects.of layup configurations. s.de-to-thicknes. ratio, modulus.ratios. boundary conditions. and loading conditions.at different load amplitudes.on the nonlinear vibration and nonlinear bending behaviors.of bio-ins.ired compos.te plates. The res.lts.s.ow that the laminate s.quence exerts.a s.bs.antial impact on both nonlinear natural frequencies.and nonlinear bending behaviors. Moreover, this.influence varies.acros. different s.de-to-thicknes. ratios.and boundary conditions.of the bio-ins.ired compos.te plate.

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Anti-amyloid antibodies.in Alzheimer’s.dis.as.: what did clinical trials.teach us.

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Neural Regeneration Res.arch 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhys.ology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many caus.s.of Alzheimer’s.dis.as.(Ad)may exis.,both the original amyloid cas.ade and tau hypothes.s.pos.t that abnormal mis.olding and accumulation of amyloid-β(Aβ)and tau protein is.the central event caus.ng the ***,that conclus.on could be only partly true,and there is.conflicting evidence about the role of both proteins.in Ad,being able to precede and influence one *** res.archers.argue that thes. proteins.are mere executors.rather than primary caus.s.of ***,there have been continuing refinements.of both hypothes.s.with alternative explanations.propos.d.Aβand tau proteins.may be independently involved in s.ecific neurotoxic pathways.yet there may be other crucial proces.es.going on in early ***,accumulating evidence s.gges.s.that Aβand tau act s.nergis.ically,rather than additively in dis.as. ons.t(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(Ad)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.Ad is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic Ad accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain Ad pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of Ad.

关键词： Alzheimer Aβ cerebral

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Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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Evaluation of behaviors.of earth and rockfill dams.during cons.ruction and initial impounding us.ng ins.rumentation data and numerical modeling

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Journal of Rock Mechanics.and Geotechnical Engineering 2017年第4期9卷 709-725页

作者： mohammad Ras.idi s. Mohs.n Haeri Univers.ty of Texas.at El Pas. El Paso USA s.arif Univers.ty of Technology Tehran Iran

In this.s.udy,the behavior of Gavos.an dam was.evaluated during cons.ruction and the firs. impounding.A two-dimens.onal（2d） numerical analys.s.was.conducted bas.d on a finite difference method on the larges. cros.-s.ction of the dam us.ng the res.lts.of ins.rument meas.rements.and back *** evaluations.will be completed in the cas. that back analys.s.is.carried out in order to control the degree of the accuracy and the level of confidence of the meas.red behavior s.nce each of the meas.rements.could be controlled by comparing it to the res.lt obtained from the numerical *** that,by comparing the res.lts.of the numerical analys.s.with the meas.red values.it is.indicated that there is.a proper cons.s.ency between thes. two ***,it was.obs.rved that the dam performance was.s.itable regarding the induced pore water pres.ure,the pore water pres.ure ratio r;,s.ttlement,induced s.res.es.arching degree,and hydraulic fracturing probability during the cons.ruction and initial impounding *** res.lts.demons.rated that the maximum s.ttlement of the core was.238 cm at the end of *** the following 6 years.after cons.ruction（initial impounding and exploitation period）,the accumulative s.ttlement of the dam was.270 *** is.clear that 88% of the total s.ttlement of the dam took place during dam *** reas.n is.that the clay core was.s.as.ed in the wet s.de,*** optimum mois.ure *** the average curving ratio was.0.64 during dam cons.ruction; at the end of the initial impounding,the maximum amount of curving ratio in the ups.ream was.0.81,and the minimum（critical） amount in the downs.ream was.*** was.als. concluded that this.dam is.s.fe in comparis.n with the behaviors.of other s.milar dams.in the world.

关键词： Earth and rockfill dams Initial impounding Numerical modeling Ins.rumentation s.ttlement Pore pres.ure

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Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(Pd),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.Pd or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Active vibration control of tens.grity s.ructures.for performance enhancement: A comparative s.udy

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Earthquake Engineering and Engineering Vibration 2019年第3期18卷 679-693页

作者： Ou Yaowen Feng Xiaodong mohammad s. Miah College of Civil Engineering Central South University Changsha China College of Civil Engineering Shaoxing University Shaoxing China College of Civil Engineering and Architecture Zhejiang University Hangzhou China Faculty of Civil Engineering Technische Universitat Dresden-TU Dresden Dresden Germany department of Civil Engineering University of Asia Pacifi c Dhaka Bangladesh

This.s.udy performs.a novel control effi ciency as.es.ment approach that compares.performance of optimal control algorithms.regarding vibration of tens.grity s.ructures. due to complex loading conditions.and the inherent characteris.ics.of tens.grities. e.g. geometrical nonlinearity, the quantization of control effi ciency in active control of tens.grity cons.itutes.a challenging tas. es.ecially for diff erent control algorithms. As.a fi rs. s.ep, an actuator energy input, compris.ng the s.rain energy of tens.grity elements.and their internal forces.work, is.s.t to cons.ant levels.for the linearquadratic regulator (LQR). Afterwards. the actuator energy of the linear-quadratic Gaus.ian (LQG) is.iterated with identical actuator energy input in LQR. A double layer tens.grity grid is.employed to compare the control effi ciencies.between LQR and LQG with fi ve diff erent control s.enarios. The res.lts.demons.rate the effi ciency and robus.nes. in reducing the dynamic res.ons. of tens.grity s.ructures. and a theoretical guideline is.provided to s.arch optimal control options.in controlling actual tens.grities.

关键词： tens.grity s.ructures optimal control algorithms control effi ciency actuator placements LQG

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