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ROR2 regulates the survival of murine osteosarcoma cells in lung capillaries

Journal of Cancer Metastasis and Treatment 2020年第1期6卷 611-621页

作者： Diem Thi Phuong Tran Takahiro Kuchimaru Mongkol Pongsuchart kha the nguyen John Clyde Co Soriano Tetsuya Kadonosono Shinae Kizaka-Kondoh School of Life Science and Technology Tokyo Institute of TechnologyYokohama 226-8501Japan Center for Molecular Medicine Jichi Medical UniversityTochigi 329-0498Japan

Aim:Lung metastasis is a leading cause of death in patients with osteosarcoma(OS).No effective therapy exists that improves the five-year overall survival rate of OS patients with ***,finding novel therapeutic targets will help develop new treatment strategies for OS patients with lung ***:Based on analysis of gene expression profiles between sublines of the Dunn OS LM8 cell line with high(LM8-H)and low(LM8-L)metastatic ability,we have identified Wnt signal-related genes that play an important role in lung metastasis of *** of the genes was investigated by establishing sublines of gene knockout and assessing their metastatic ability using a mouse lung metastasis *** molecular mechanism underlying the function of the genes was further investigated by in vitro ***:We have identified that receptor tyrosine kinase-like orphan receptor 2(ROR2),a receptor of the non-canonical Wnt signaling pathway,was involved in OS cell survival in lung capillaries during ***8-H knocked out of Ror2(H/Ror2-KO)significantly reduced lung metastasis by decreasing the viability in lung capillaries 48 h after intravenous *** vitro study revealed that ROR2 increased anoikis resistance through AKT *** of ROR2 expression in H/Ror2-KO cells restored their metastatic ability and viability in lung ***:The results demonstrate a novel ROR2 function in OS lung metastasis and may inform new treatment strategies for OS patients.

关键词： Osteosarcoma lung metastasis cell survival lung capillary ROR2

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Assessment of the physicochemical properties and biological activity of Vietnamese single-bulb black garlic

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Food Bioscience 2022年第5期49卷 436-445页

作者： Cao Thi Hue Luc Quang Tan Hoang Van Hung Quynh Thi Ngoc Le Thanh Hoa nguyen nguyen Thi Lan Huong nguyen Manh Ha Dinh kha Trinh Department of Biotechnology Thuyloi University175 Tay SonDong DaHanoiViet Nam Thai nguyen University-Lao Cai Campus Group 13Binh Minh WardLao Cai CityLao Cai ProvinceViet Nam Hanoi University of Industry 298 Cau DienBac Tu LiemHanoiViet Nam

This study assessed the quality and biological activity of Vietnamese single-bulb black garlic(SBG)by investigating the effect of different temperatures(60,65,70,and 75℃)on physicochemical properties during the heat treatment *** optimal treating conditions accounted for the highest concentration of antioxidants were 70℃for 42 *** SBG.70 had a higher content of reducing sugar,protein,flavonoid,and polyphenol in comparison with the white garlic and the *** activity of single-bulb white garlic and SBG were measured via DPPH,phosphomolybdenum,and H2O2 radicals,as well as a reduction *** antimicrobial activity was assessed by the multi-concentration dilution method;the sample treated at 70℃displayed the strongest activity against four microbial strains with MIC values for ***,***,***,and *** of 64,128,128,and 64μg/mL,***,only two SBG samples aged at 70℃and 75℃were bacteriostatic to *** with MIC values of 32 and 64μg/mL,respectively.

关键词： Single-bulb black garlic Different temperature Physicochemical Antioxidant content Antioxidant activity Antimicrobial activity

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电子束辐照对蓝莓的长效冷藏保鲜效果

电子束辐照对蓝莓的长效冷藏保鲜效果

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作者： nguyen XUAN kha 安徽农业大学

学位级别：硕士

蓝莓,杜鹃花科,越橘属,因其甜美的口味、丰富的营养成分、强大的保健功能,广受欢迎。由于皮质薄、果肉柔软多汁,采后呼吸代谢旺盛,蓝莓在常温(25℃±5℃)下放置2～4d,低温(2℃±2℃)下放置7～10d就失去商品价值,严重制约了蓝莓产业的发... 详细信息

蓝莓,杜鹃花科,越橘属,因其甜美的口味、丰富的营养成分、强大的保健功能,广受欢迎。由于皮质薄、果肉柔软多汁,采后呼吸代谢旺盛,蓝莓在常温(25℃±5℃)下放置2～4d,低温(2℃±2℃)下放置7～10d就失去商品价值,严重制约了蓝莓产业的发展。电子束辐照是一种物理加工方式,通过杀灭食物表面及内部的有害微生物、抑制生理变化,延长果实的保鲜期。本文通过设计不同的辐照剂量梯度 0.0kGy(未辐照为对照组)、1.0kGy、1.5kGy、2.0kGy、2.5kGy、3.0kGy,分析冷藏过程中蓝莓果实中的细菌、霉菌及酵母菌的杀灭效果,以及不同剂量电子束辐照对冷藏蓝莓果实贮藏品质、生理与功能特性的影响作用。1.1.0～3.0kGy剂量范围的电子束辐照处理,显著降低细菌、霉菌与酵母菌微生物的数量,并且与辐照剂量呈显著正相关关系。蓝莓中细菌、霉菌、酵母菌的D10值分别为 1.54 kGy、1.69 kGy、2.40 kGy。冷藏至 105 d,1.5～3.0 kGy 辐照蓝莓组微生物数量显著低于对照组,但是四个辐照组之间没有显著性差异。2.在整个冷藏期(105 d),辐照处理显著降低了蓝莓的腐烂率。贮藏末期,1.5～3.0kGy辐照组的失重率达到30%,但腐烂率低于8%,虽然失去鲜食价值,但依然具有加工价值。1.5～3.0kGy辐照组蓝莓保鲜期可达到60d,腐烂率低于5%,失重率15%左右。同时,各辐照处理组相比对照组,有效延缓蓝莓果皮的亮度(L值)下降、抑制果皮变色(a值与b值)。3.在贮藏前期,辐照处理对蓝莓的硬度没有显著性影响。贮藏至30～60d,2.0kGy辐照组果实硬度显著高于对照组。在贮藏后期,1.5～3.0kGy辐照组抑制了TSS和可溶性糖的降解,但对果实的pH值没有显著性影响。4.贮藏45d内,辐照处理组花青素和总酚含量显著高于对照组,尤其是1.5kGy辐照组花青素含量最高,3.0kGy辐照组总酚含量最高。各辐照处理组的DPPH自由清除率显著高于对照组,其中2.0kGy组效果最好。5.2.0～3.0kGy辐照处理显著提高了果实的多酚氧化酶(PPO)活,但1.0～1.5kGy的剂量对多酚氧化(PPO)酶活没有显著影响。在贮藏后期,1.5～2.0kGy辐照组的过氧化物酶(POD)活性显著高于对照组和其他辐照处理组;1.5～2.5kGy辐照组的局半乳糖醛酸酶(PG)活性,显著低于对照组;贮藏前期,1.5～2.5Gy辐照组的纤维素酶(Cx)活性显著低于对照组,延缓软化。综上所述,1.5kGy～2.0kGy剂量电子束辐照处理,能显著降低冷藏过程中蓝莓果实中的细菌、霉菌及酵母菌数量,蓝莓的品质及生理特性保持最佳,可延长蓝莓的保鲜期至60d,冷藏期90～105d。

关键词：蓝莓电子束辐照微生物冷藏保鲜

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Results of Testing Maize Hybrids on Lands Shifting from Rice-Growing Areas of Less Efficiency in the Mekong Delta

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Journal of Agricultural Science and Technology(B) 2015年第4期5卷 241-246页

作者： Le Quy kha Institute of Agricultural Sciences for Southern Vietnam 121 Nguyen Binh Khiem Street District 1 Ho Chi Minh City Vietnam

Forecasters predict that by 2020 there will be 4.5 or 5 million tons per annum maize supply deficiency in Vietnam. As a result of this projection, the government responded by shifting 80,000 ha of low-efficiency rice production areas into maize production （2014-2015） and this area of production for maize is expected to increase to 150,000 ha by 2016-2020. Nevertheless, not all commercial maize hybrids could be suitable for rice-growing land in the Mekong Delta and a national project of hybrid maize development for Mekong Delta has been conducted since early 2014. In the project, yield trials of 20 maize hybrids, sourced from Vietnamese institutions and the private sector including Syngenta （NK67） and Dekalb （DK9901）, were sown in Dong Thap, Hau Giang and Long An provinces situated in the Mekong Delta, in minor acid sulphate soils with a pH of 5.0-5.5. The trial included three replications in an Alpha lattice design conducted during spring-summer in 2014. The hybrids flowered at 50-52 d after planting and physiologically matured between 93-97 d after planting. This suggested they would be suitable for cropping systems, which was comprised of three seasons per year. To determine which hybrid is best suited for the region, researchers evaluated yield and ear characteristics. The average yield of the genotypes across locations was 52.03, 54.92 and 57.60 quintals/ha, respectively, and the heritability of genotypes in each location was 0.51, 0.81 and 0.61, respectively. The mean yield of DK9901 was 58.19 quintals/ha, ranking the 7th among 20 hybrids, and NK67 was 47.58 quintals/ha, ranking the 19th. The grand mean was 54.92 quintals/ha and heritability for all genotypes was 0.79. The highest yield was produced by the Southern seed company hybrid SSC474 （69.39 quintals/ha）, which yielded significantly more maize than DK9901 （58.19 quintals/ha） at P 〈 0.05, followed by VS71 from National Maize Research Institute （NMRI） at 63.52 quintals/ha, and LCH9A from NMRI at 63.39 quin

关键词： Maize (Zea mays L.) hybrid Mekong Delta rice-growing land yield trials.

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蚁穴越南白蚁穴住宅

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室内设计与装修 2015年第9期 46-51页

作者： nguyen Hai Long Tran Thi Ngu Ngon Ngo Ly kha 秋落

白蚁穴住宅位于越南中部沿海城市岘港.这里的气候反差明显,要么阳光明媚要么阴雨连绵,而且每年都免不了频繁光顾的热带风暴.此外,岘港也因占城烧结砖塔遗迹（Champa baked-brick Towers）而闻名,它们从4世纪开始建造,工期一直延续到了1... 详细信息

白蚁穴住宅位于越南中部沿海城市岘港.这里的气候反差明显,要么阳光明媚要么阴雨连绵,而且每年都免不了频繁光顾的热带风暴.此外,岘港也因占城烧结砖塔遗迹（Champa baked-brick Towers）而闻名,它们从4世纪开始建造,工期一直延续到了15世纪晚期,其中最著名的就要数“美山圣地”了.

关键词：蚁穴住宅越南沿海城市热带风暴阳光砖塔工期

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