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Polyethylene glycol functionalized carbon nanotubes/gelatin-chitosan nanocomposite: An approach for significant drug release

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Bioactive Materials 2018年第3期3卷 236-244页

作者： Sadia Sharmeen A.F.M.Mustafizur Rahman Mostakima M.Lubna kh samaher salem Rafiqul Islam Mubarak A.khan Department of Applied Chemistry and Chemical Engineering University of DhakaDhaka 1000Bangladesh Institute of Radiation and Polymer Technology Bangladesh Atomic Energy CommissionDhaka 1000Bangladesh

This research work blooms the new idea of developing a safe and controlled drug releasing matrix using multi-walled carbon nanotubes(MWCNTs).In aqueous solution,uniform and highly stable dispersion of MWCNTs was obtained after secondary functionalization with polyethylene glycol(PEG)which was studied by Fourier transmission infrared spectroscopy(FTIR)and thermogravimetric analysis(TGA).Solution casting method was used to prepare MWCNTs/gelatin-chitosan nanocomposite films and the effect of MWCNTs on physico-mechanical,thermal and water uptake properties of the nanocomposites were *** of MWCNTs into the porous gelatin-chitosan matrix showed interesting stiffness and dampness along with developed microfibrillar structures within the pore walls intended at being used in tissue engineering of bone or cartilage.A common antibiotic drug,ciprofloxacin was incorporated into nanocomposite *** evaluation of the effect of MWCNTs on drug release rate by dissolution test and antimicrobial susceptibility test was *** release of the drug was found at early stages(~1 h),but the rate was reduced afterwards,showing a sustained *** was observed that for all microorganisms,the antibacterial activities of drug loaded MWCNTs/gelatin-chitosan nanocomposites were higher than that of drug loaded gelatin-chitosan composite films containing no *** statistical studies by ANOVA techniques also showed remarkable difference between the antibacterial activities,exhibited by MWCNTs-incorporated and non-incorporated composite films.

关键词： Carbon nanotubes Functionalization Nanocomposite Thermo-mechanical properties Drug dissolution Antibacterial activities

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Sensitive Integration of Multilevel Optimization Model in Human Activity Recognition for Smartphone and Smartwatch Applications

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Big Data Mining and Analytics 2021年第2期4卷 124-138页

作者： samaher Al-Janabi Ali Hamza Salman Department of Computer Science Faculty of Science for WomenUniversity of BabylonBabylon 964Iraq

This study proposes an intelligent data analysis model for finding optimal patterns in human activities on the basis of biometric features obtained from four sensors installed on smartphone and smartwatch devices. The proposed model, referred to as Scheduling Activities of smartphone and smartwatch based on Optimal Pattern Model(SA-OPM), consists of four main stages. The first stage relates to the collection of data from four sensors in real time(i.e., two smartphone sensors called accelerometer and gyroscope and two smartwatch sensors of the same name).The second stage involves the preprocessing of the data by converting them into graphs. As graphs are difficult to deal with directly, a deterministic selection algorithm is proposed as a new method to find the optimal root to split the graphs into multiple subgraphs. The third stage entails determining the number of samples related to each subgraph by using the optimization technique called the lion optimization algorithm. The final stage involves the generation of patterns from the optimal subgraph by using the association pattern algorithm called g Span. The pattern finder based on Forward-Backward Rules(FBR) generates the optimal patterns and thus aids humans in organizing their activities. Results indicate that the proposed SA-OPM model generates robust and authentic patterns of human activities.

关键词： optimization Ant Lion Optimization(ALO) g Span Forward-Backward Rules(FBR) Internet of Things(IoT) smartwatch smartphone

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Pregnancy outcome of day 3versus day 5 embryo transfer: A retrospective analysis

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Asian pacific Journal of Reproduction 2017年第2期6卷 89-92页

作者： samaher Alfaraj Fatima Alzaher Sahar Alshwaiaer Anwar Ahmed Department of Obstetrics and Gynecology Reproductive Endocrinology and Infertility UnitKing Abdul-Aziz Medical CityRiyadhSaudi Arabia Department of Obstetrics and Gynecology Ministry of HealthDammamSaudi Arabia Assistant Professor of Biostatistics Department of Epidemiology and Biostatistics College of Public Health and Health Informatics King Saud Bin Abdulaziz University for Health Sciences National Guard Health Affairs RiyadhKSA

Objective:To compare the pregnancy rate between day 3 and day 5 transfer regardless grades of embryos and number of transferred ***: Retrospective cohort, a total of seven hundred and four patients met our inclusion criteria, with 411 had day 3 embryo transfer and 293 had day 5 embryo transfer. The patients who were older than 40 years old were excluded. Embryo transfer was carried out in all patients in both transfer ***:Both clinical pregnancy rate and implantation rate did not show any statistically significant difference between the day 3 and day five transfer groups. These were 44%vs. 45% withP=0.82 and 19%vs. 19% withP=0.99 respectively. An increase of miscarriage rate with day 5 embryo transferred compare with day 3 (12.0%vs. 4.4%,P=0.01), but no significant difference was found about biochemical pregnancy rate (P=0.52).Conclusions:Transferring embryo at day 5 may not provide any additional benefit over day 3 transfers to patients. In addition, it increases the risk of miscarriage. Further studies of this issue needed for confirming our findings.

关键词： Embryo transfer Blastocyst Early cleavage stage Pregnancy outcomes Sequential culture media

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Relationship of Serum Leptin, BMI, Waist Circumference and Cholesterol Level among Teenagers in the Gaza Strip

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Pharmacology & Pharmacy 2014年第8期5卷 789-795页

作者： Mahmoud H. Taleb samaher J. Younis Baker Zabout Ahmed A. Najim Adham I. Ahmed Eyad S. El-Bayary Faculty of Intermediate Studies University of Palestine Gaza Palestine Faculty of Pharmacy Al-Azhar University Gaza Palestine Faculty of Sciences The Islamic University Gaza Palestine Ministry of Health Gaza Palestine

Leptin is one of the best known hormone markers for obesity. There is a limited anthropometric data in the Gaza Strip that reveals and arouses the nutritional status among all age groups especially adolescents aged 15 - 19 years old. The study aimed to assess the effect of Leptin hormone, lipid profiles, Body Mass Index (BMI) and waist circumference among secondary school age students in the Gaza Strip. Methodology: A cross sectional study included 442 cases of teenagers aged 15 - 19 years old from governmental and private schools in the Gaza strip. Blood samples were collected for analysis of Leptin hormone and lipid profile and measuring waist circumference for the teenager. Results: The mean of serum Leptin was (28.7) higher among cases than controls (28.1), but it was statistically insignificant (P = 0.85). It was found that there is a significant correlation between Leptin hormone and total cholesterol (Chol) (r = 0.24), high density cholesterol (HDL) (r = 0.27) and low density cholesterol (LDL) (r = 0.16). There was no relationship between Leptin hormone and triglycerides (TG) (r = -0.02). There was relationship between Leptin hormone and waist circumference in both males and females (r = 0.519, 0.544), respectively. There was no statistical significant deference noticed between Leptin hormone of obese objects and Leptin hormone of normal BMI objects of the same age (t-test = 0.93, P = 0.85). Conclusion: There are significant correlations between Leptin hormone and total Chol, HDL and LDL except for TG, and there were significant relationships between Leptin hormone and waist circumference which reflect the central obesity among males and females. There is no association between Leptin level and BMI.

关键词： Central Obesity Leptin Lipid Profile Gaza Strip Waist Circumference

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