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Therapeutic potential of snake venom in cancer therapy:current perspectives

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Asian Pacific Journal of Tropical Biomedicine 2013年第2期3卷 156-162页

作者： Vivek Kumar Vyas keyur Brahmbhatt Hardik Bhatt Utsav Parmar Institute of Pharmacy Nirma UniversityAhmadabad 382481GujaratIndia Arihant School of Pharmacy and Bio Research Institute

Many active secretions produced by animals have been employed in the development of new drugs to treat diseases such as hypertension and *** venom toxins coutributed significantly to the treatment of many medical *** are many published studies describing and elucidating the anti-cancer potential of snake *** therapy is one of the main areas for the use of protein peptides and enzymes originating from animals of different *** of these proteins or peptides and enzymes from snake venom when isolated and evaluated may bind specifically to cancer cell membranes,affecting the migration and proliferation of these *** of substances found in the snake venom present a great potential as anti-tumor *** this review,we presented the main results of recent years of research involving the active compounds of snake venom that have anticancer activity.

关键词： Snake venom Cytotoxin Anticancer agents Apoptosis inducer

Scrupulous recognition of biologically important acids by fluorescent ＂turn off-on＂ mechanism of thaicalix reduced silver nanoparticles

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Chinese Chemical Letters 2017年第2期28卷 312-318页

作者： Savan M.Darjee keyur D.Bhatt Urvi S.Panchal Vinod K.Jain Department of Chemistry School of Sciences Gujarat University Ahmedabad 380009 India Department of Chemistry C.U. Shah University Wadhwan 363030 India

Water dispersible silver nanoparticles（AgNps） were prepared using thiacalix[4]arene tetrahydrazide（TCTH） as a reducing and stabilizing ***-AgNps were characterized by surface plasmon resonance（SPR）,transmission electron microscopy（TEM） and energy dispersive X-ray（EDX）.Relatively uniform 20 nm spherical particles of TCTH-AgNps were efficiently formed over a pH range of 5-9 and from 10-40 ℃.The interaction behavior of TCTH-AgNps with different amino acids was investigated using spectrophotometry and *** the amino acids tested,only tryptophan and histidine showed fluorescence quenching and fluorescence enhancement,*** linear detection range by Stern-Volmer plot was 5 nmol/L to 0.48 μmol/L for tryptophan and 4 nmol/L to 0.54 μmol/L for ***-AgNps were able to effectively reduce the levels of gram-positive bacteria,gram-negative bacteria,and *** properties argue for the potential use of TCTH-AgNps as detectors of histidine and tryptophan and as antibiotics.

关键词： Silver nanoparticles Fluorescent sensor Colorimetric sensor Thiacalixarene

Computer Modelling of Compact 28/38 GHz Dual-Band Antenna for Millimeter-Wave 5G Applications

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Computer Modeling in Engineering & Sciences 2023年第12期137卷 2867-2879页

作者： Amit V.Patel Arpan Desai Issa Elfergani Hiren Mewada Chemseddine Zebiri keyur Mahant Jonathan Rodriguez Raed Abd-Alhameed Department of Electronics and Communication Engineering Chandubhai S Patel Institute of Technology(CSPIT)Charotar University of Science and Technology(CHARUSAT)Changa388421India The Instituto de Telecomunica珲es Campus Universitário de SantiagoAveiro3810-193Portugal School of Engineering and Informatics University of BradfordBradfordBD71DPUK Electrical Engineering Department Prince Mohammad Bin Fahd UniversityAl Khobar31952Saudi Arabia Department of Electronics Laboratoire d’Electronique de Puissance et Commande Industrielle(LEPCI)University of Ferhat AbbasSétif19000Algeria

A four-element compact dual-band patch antenna having a common ground plane operating at 28/38 GHz is proposed formillimeter-wave communication systems in this ***-input-multiple-output(MIMO)antenna geometry consists of a slotted ellipse enclosed within a hollow circle which is orthogonally rotated with a connected partial ground at the *** overall size of the four elements MIMO antenna is 2.24λ×2.24λ(at 27.12GHz).The prototype of four-element MIMOresonator is designed and printed using Rogers RTDuroid 5880 withε_(r)=2.2 and loss tangent=0.0009 and having a thickness of 0.8 *** covers dual-band having a fractional bandwidth of 15.7%(27.12-31.34 GHz)and 4.2%(37.21-38.81 GHz)for millimeter-wave applications with a gain of more than 4 dBi at both *** proposed antenna analysis in terms ofMIMOdiversity parameters(Envelope Correlation Coefficient(ECC)and Diversity Gain(DG))is also carried *** experimental result in terms of reflection coefficient,radiation pattern,gain and MIMOdiversity parameter correlates very well with the simulated ones that show the potential of the proposed design for MIMO applications at millimeter-wave frequencies.

关键词： Connected ground diversity parameters dual-band antenna fifth generation(5G) mmwave multiple input multiple output(MIMO)

Turn-on fluorescence probe for selective detection of Hg(Ⅱ)by calixpyrrole hydrazide reduced silver nanoparticle: Application to real water sample

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Chinese Chemical Letters 2016年第5期27卷 731-737页

作者： keyur D. Bhatt Disha J. Vyas Bharat A. Makwana Savan M. Darjee Vinod K. Jain Hemangini Shah Department of Chemistry C.U. Shah University Wadhwan 363030 India Department of Chemistry School of Sciences Gujarat University Ahmedabad 380009 India

A simple and quick method for the synthesis of water dispersible stable silver nanoparticles has been developed. Calix[4]pyrrole octahydrazide （CPOH）, has been successfully used as a reducing as well as stabilizing agent for the synthesis of silver nanoparticles. CPOH-AgNps have been duly characterized by SPR, PSA, TEM and EDX-ray. The ability of CPOH-AgNps as selective and sensitive sensor for various ions （Pb（Ⅱ）, Cd（II）, Mn（Ⅱ）, Fe（Ⅲ）, Ni（Ⅱ）, Zn（Ⅱ）, Hg（Ⅱ）, Co（Ⅱ）, Cu（Ⅱ）） by colorimetry and spectrofluorimetry has been explored. CPOH-AgNps were found to be selective only for Hg（Ⅱ） ions. Nanomolar concentration of Hg（Ⅱ） ions can also be determined by spectrofluorimetry by increase in fluorescence intensity. Linear range of detection of Hg（Ⅱ） ions in water was found to be from 1nmol/L to mol/L. The method has been successfully applied for determination of Hg（Ⅱ） ions in ground water and industrial effluent waste water samples.

关键词： Calixpyrrole Silver nanoparticles Fluorescence study Colorimetric sensor Water samplesHg(Ⅱ) ions

Simultaneous analysis of allopurinol and oxypurinol using a validated liquid chromatography–tandem mass spectrometry method in human plasma

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Journal of Pharmaceutical Analysis 2017年第1期7卷 56-62页

作者： Dhiraj M. Rathod keyur R. Patel Hiren N. Mistri Arvind G. Jangid Pranav S. Shrivastav Mallika Sanyal Department of Chemistry Kadi Sarva Vishwavidyalaya Gandhinagar Ahmedabad 382015 India Bioanalytical Research Department Accutest Research Lab Bodakdev Ahmedabad 380059 India Department of Chemistry School of Sciences Gujarat University Ahmedabad 380009 India Department of Chemistry St. Xavier's College Navrangpura Ahmedabad 380009 India

The present study describes a simple, reliable and reproducible liquid chromatography–tandem mass spectrometry method(LC–MS/MS) for the simultaneous determination of allopurinol and its active metabolite,oxypurinol in human plasma for a pharmacokinetic/bioequivalence study. After protein precipitation(PPT) of100 μL plasma sample with 1.0% formic acid in acetonitrile, the recovery of the analytes and allopurinol-d2 as an internal standard ranged from 85.36% to 91.20%. The analytes were separated on Hypersil Gold(150 mm×4.6 mm, 5 μm) column using 0.1% formic acid-acetonitrile(98:2, v/v) as the mobile *** was done using electrospray ionization in the positive mode. The calibration concentration range was established from 60.0 to 6000 ng/m L for allopurinol and 80.0–8000 ng/m L for oxypurinol. Matrix effect in human plasma, expressed as IS-normalized matrix factors ranged from 1.003 to 1.030 for both the analytes. The developed method was found suitable for a clinical study with 300 mg allopurinol tablet formulation in healthy subjects.

关键词： Allopurinol Oxypurinol Liquid chromatography–tandem mass spectrometry Bioequivalence study

An improved LC–MS/MS method for the quantification of alverine and para hydroxy alverine in human plasma for a bioequivalence study

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Journal of Pharmaceutical Analysis 2017年第2期7卷 95-102页

作者： Dhiraj M.Rathod keyur R.Patel Hiren N.Mistri Arvind G.Jangid Pranav S.Shrivastav Mallika Sanyal Department of Chemistry Kadi Sarva VishwavidyalayaGandhinagarAhmedabad-382015India Bioanalytical Research Department Accutest Research LabBodakdevAhmedabad-380059India Department of Chemistry School of SciencesGujarat UniversityAhmedabad-380009India Department of Chemistry St.Xavier's CollegeNavrangpuraAhmedabad-380009India

A highly sensitive and selective high performance liquid chromatography–tandem mass spectrometry method was developed and validated for the quantification of alverine（ALV） and its active metabolite, para hydroxy alverine（PHA）, in human plasma. For sample preparation, solid phase extraction of analytes was performed on Phenomenex Strata-X cartridges using alverine-d5 as the internal standard. The analytes were separated on Symmetry Shield RP18（150 mm×3.9 mm, 5 μm） column with a mobile phase consisting of acetonitrile and10 mM ammonium formate（65：35, v/v）. Detection and quantitation was done by electrospray ionization mass spectrometry in the positive mode using multiple reaction monitoring. The assay method was fully validated over the concentration range of 15.0–15,000 pg/mL for ALV and 30.0–15,000 pg/mL for PHA. The intra-day and inter-day accuracy and precision（% CV） ranged from 94.00% to 96.00% and 0.48% to 4.15% for both the analytes. The mean recovery obtained for ALV and PHA was 80.59% and 81.26%, respectively. Matrix effect,expressed as IS-normalized matrix factor ranged from 0.982 to 1.009 for both the analytes. The application of the method was demonstrated for the specific analysis of ALV and PHA for a bioequivalence study in 52 healthy subjects using 120 mg ALV capsules. The assay reproducibility was also verified by reanalysis of 175 incurred subject samples.

关键词： Alverine Para hydroxy alverine Liquid chromatography–tandem mass spectrometry Bioequivalence study Human plasma

Symmetric-Key Based Homomorphic Primitives for End-to-End Secure Data Aggregation in Wireless Sensor Networks

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Journal of Information Security 2015年第1期6卷 38-50页

作者： keyur Parmar Devesh C. Jinwala Department of Computer Engineering S. V. National Institute of Technology Surat India

In wireless sensor networks, secure data aggregation protocols target the two major objectives, namely, security and en route aggregation. Although en route aggregation of reverse multi-cast traffic improves energy efficiency, it becomes a hindrance to end-to-end security. Concealed data aggregation protocols aim to preserve the end-to-end privacy of sensor readings while performing en route aggregation. However, the use of inherently malleable privacy homomorphism makes these protocols vulnerable to active attackers. In this paper, we propose an integrity and privacy preserving end-to-end secure data aggregation protocol. We use symmetric key-based homomorphic primitives to provide end-to-end privacy and end-to-end integrity of reverse multicast traffic. As sensor network has a non-replenishable energy supply, the use of symmetric key based homomorphic primitives improves the energy efficiency and increase the sensor network’s lifetime. We comparatively evaluate the performance of the proposed protocol to show its efficacy and efficiency in resource-constrained environments.

关键词： Wireless Sensor Network Security Concealed Data Aggregation In-Network Processing Secure Data Aggregation Homomorphic Encryption Homomorphic MAC

Liquid chromatography-tandem mass spectrometry method for simultaneous determination of albendazole and albendazole sulfoxide in human plasma for bioequivalence studies

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Journal of Pharmaceutical Analysis 2016年第4期6卷 226-234页

作者： Dhiraj M.Rathod keyur R.Patel Hiren N.Mistri Arvind G.Jangid Pranav S.Shrivastav Mallika Sanyal Department of Chemistry Kadi Sarva Vishwavidyalaya Bioanalytical Research Department Accutest Research Lab Department of Chemistry School of SciencesGujarat University Department of Chemistry St.Xavier's College

An improved high performance liquid chromatography-tandem mass spectrometry（LC-MS/MS） method has been developed for sensitive and rapid determination of albendazole（ABZ） and its active metabolite,albendazole sulfoxide（ABZSO）,in the positive ionization *** method utilized solid phase extraction（SPE） for sample preparation of the analytes and their deuterated internal standards（ISs） from100 μL human *** chromatography was carried out on Hypurity C_（18） column using acetonitrile-2.0 mM ammonium acetate,pH 5.0（80：20,v/v） as the mobile *** assay exhibited a linear response over the concentration range of 0.200-50.0 ng/mL for ABZ and 3.00-600 ng/mL for *** recoveries of the analytes and ISs ranged from 86.03%-89.66%and 89.85%-98.94%,*** effect,expressed as IS-normalized matrix factors,ranged from 0.985 to 1.042 for the both *** method was successfully applied for two separate studies in healthy subjects using single dose of 400 mg conventional tablets and 400 mg chewable ABZ tablets,respectively.

关键词： Albendazole Albendazole sulfoxide LC-MS/MS Solid phase extraction Bioequivalence study

Antioxidative,antimicrobial and anti-inflammatory activities and release of ultra-filtered antioxidative and antimicrobial peptides during fermentation of sheep milk:In-vitro,in-silico and molecular interaction studies

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Food Bioscience 2022年第3期47卷 583-594页

作者： Jodhani keyur Ashokbhai Bethsheba Basaiawmoit Sujit Das Amar Sakure Ruchika Maurya Mahendra Bishnoi Kanthi Kiran Kondepudi Srichandan Padhi Amit Kumar Rai Zhenbin Liu Subrota Hatia Deptt.of Dairy Microbiology Anand Agricultural UniversityAnand388110GujaratIndia Deptt.of Rural Development and Agricultural Production North-Eastern Hill UniversityTura CampusTura794002MeghalayaIndia Deptt.of Agriculture Biotechnology Anand Agricultural UniversityAnand388110GujaratIndia Regional Center for Biotechnology FaridabadHaryana121001India Healthy Gut Research Group Food & Nutritional Biotechnology DivisionNational Agri-Food Biotechnology InstituteKnowledge CitySector 81SAS NagarPunjab140306India Institute of Bioresources and Sustainable Development Regional CentreTadong737102SikkimIndia School of Food and Biological Engineering Shaanxi University of Science and Technology18Xi'an710021China

The antioxidative,antimicrobial,and anti-inflammatory properties of fermented sheep milk with *** (KGL4),as well as the generation of antioxidative and antimicrobial peptides,are evaluated in the *** and antibacterial activities in sheep milk fermented with KGL4 increased with incubation hours,along with varied antioxidative properties (ABTS assay:35.12%,hydroxyl free radical scavenging assay:29.12%,superoxide free radical scavenging activity:36.38%).Antimicrobial activity of fermented sheep milk against *** (19 mm),*** (15.67 mm),*** (14 mm),and *** (13 mm) was also ***,after 48 h,the KGL4 showed maximum proteolysis (10.40 mg/ml) at 2.5% rate of addition sheep *** antioxidative and antimicrobial activities of fermented sheep milk fractions (3 kDa and 10 kDa permeates and retentates) were also *** highest ABTS activity (26.90%) was found in 10 kDa permeate,whereas the 3 kDa retentate had higher hydroxyl free radical scavenging activity (69.20%) and 3 kDa permeate showed maximum superoxide free radical scavenging activity (32.85%).The 10 kDa retentate had shown maximum antimicrobial activity against *** (13.67 mm) and *** (17.00 mm).Proteins spotted on 2D gel electrophoresis of KGL4 were varied from 10 to 70 ***-LC/MS was used to identify 5 novel peptide sequences from 2-D gel *** in the BIOPEP database confirmed the antioxidative and antimicrobial effects of the novel fermented sheep milk *** sheep milk with KGL4 (SMKGL4) significantly reduced excessive TNF-α,IL-6,& IL-1β production in LPS-activated RAW 264.7 cells.

关键词： Fermentation Sheep milk Lactobacillus fermentum Antioxidative Antimicrobial Anti-inflammatory Peptides