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Individualized coefficient of variability cut-off values for reducing the risk of hypoglycemia in Chinese type 1 diabetes mellitus(T1DM)patients

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Chinese Medical Journal 2024年第2期137卷 244-246页

作者： Jiaqi Li keyu Guo Liyin Zhang Jianan Ye xia.Li Zhiguang Zhou Lin Yang National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology(Central South University)Ministry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China

To the Editor:Type 1 diabetes mellitus(T1DM)is a progressive disease caused by severe islet b-cell function impairment,resulting in high glucose variability(GV)in patients.[1]While intensive insulin treatment enabled T1DM patients to achieve near-normal glucose,reflected by reduced hemoglobin A1c(HbA1c)levels,stricter HbA1c targets were associated with an increased risk of hypoglycemia,which would compromise patients’quality of life and survival.[2]Recent studies suggest that GV reflects hypoglycemia better than HbA1c alone,and continuous glucose monitoring(CGM)provides a more comprehensive glycemic profile for better glucose indices assessment.[3]Therefore,we aimed to explore the relationship between the coefficient of variability(CV)of blood glucose and hypoglycemia in T1DM patients with different HbA1c levels and to identify the optimal cut-off values of CV for reducing the hypoglycemia risk in Chinese T1DM patients.

关键词： T1DM patients mellitus

Nonreciprocal Photon Blockade Based on Zeeman Splittings Induced by a Fictitious Magnetic Field

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Chinese Physics Letters 2024年第7期41卷 36-46页

作者：苏欣金飚兵唐江山夏可宇 College of Engineering and Applied Sciences National Laboratory of Solid State Microstructuresand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China Research Institute of Superconductor Electronics(RISE)&Key Laboratory of Optoelectronic Devices and Systems with Extreme Performances of MOE School of Electronic Science and EngineeringNanjing UniversityNanjing 210023China

Quantum nonreciprocity, such as nonreciprocal photon blockade, has attracted a great deal of attention due to its unique applications in quantum information processing. Its implementation primarily relies on rotating nonlinear systems, based on the Sagnac effect. Here, we propose an all-optical approach to achieve nonreciprocal photon blockade in an on-chip microring resonator coupled to a V-type Rb atom, which arises from the Zeeman splittings of the atomic hyperfine sublevels induced by the fictitious magnetic field of a circularly polarized control laser. The system manifests single-photon blockade or multi-photon tunneling when driven from opposite directions. This nonreciprocity results from the directional detunings between the countercirculating probe fields and the V-type atom, which does not require the mechanical rotation and facilitates integration. Our work opens up a new route to achieve on-chip integrable quantum nonreciprocity, enabling applications in chiral quantum technologies.

关键词： effect reciprocal quantum

碳中和目标下负排放策略的综合效应——基于N‑DSGE模型的数值模拟分析

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中国人口·资源与环境 2024年第2期34卷 13-22页

作者：沈维萍夏克郁陈迎华夏银行研究院北京100005 中国社会科学院金融研究所博士后科研流动站北京100710 中国社会科学院大学应用经济学院北京102488 中国社会科学院生态文明研究所北京100006

全球气候变化已达“气候紧急状态”,包括中国在内的诸多国家和地区先后宣布碳中和目标和净零排放承诺。在气候变化减缓和传统的适应措施之外,自然科学领域和气候经济学领域探讨负排放技术经济可行性的研究越来越多,但从可持续发展经济... 详细信息

全球气候变化已达“气候紧急状态”,包括中国在内的诸多国家和地区先后宣布碳中和目标和净零排放承诺。在气候变化减缓和传统的适应措施之外,自然科学领域和气候经济学领域探讨负排放技术经济可行性的研究越来越多,但从可持续发展经济学视角对负排放技术综合效应的评估还比较少。该研究基于可持续发展经济学的生态价值理论,将气候变化综合评估模型与宏观经济学动态随机一般均衡(DSGE)模型相结合,构建包含自然生态系统部门的N‑DSGE模型,对负排放技术的气候效应、生态效应、经济效应以及福利效应进行综合评估。评估结果表明:①当可用技术条件下传统减排措施达到最大减排潜力后,可以依靠负排放技术实现净零排放乃至净负排放。②低强度、小规模实施负排放技术具有正向的气候、生态和经济效应,然而随着负排放技术实施强度增大,气候效应增强,经济效应削弱,社会综合福利明显降低。③敏感性分析证明了评估结果的稳健性,并进一步表明负排放技术的实施效果会受到传统减排水平和自然碳汇能力的影响。基于评估结果,应谨慎扩大负排放技术实施规模和实施强度,加强科学技术研发,降低技术成本;对不同负排放技术采取差异化发展策略;加强负排放技术实施的治理,尽可能避免和最小化其负面影响,促进气候、生态和经济等可持续发展目标的协同;部署负排放技术不应放松传统减排的努力,应降低碳达峰峰值,同时提升自然生态系统的碳汇能力。

关键词：碳中和目标负排放技术 N‑DSGE模型生态价值福利效应

Reversible Optical Isolators and Quasi-Circulators Using a Magneto-Optical Fabry-Pérot Cavity

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Chinese Physics Letters 2024年第4期41卷 59-68页

作者：张天天周文鹏李志向唐宇涛许帆吴浩东张涵唐江山阮亚平夏可宇 College of Engineering and Applied Sciences National Laboratory of Solid State Microstructuresand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Shenzhen Shaanxi Coal Hi-tech Research Institute Co. LtdShenzhen 518083China School of Physics Nanjing UniversityNanjing 210023China Jiangsu Key Laboratory of Artificial Functional Materials Nanjing UniversityNanjing 210023China

Nonreciprocal optical devices are essential for laser protection,modern optical communication and quantum information processing by enforcing one-way light *** conventional Faraday magneto-optical nonreciprocal devices rely on a strong magnetic field,which is provided by a permanent *** a result,the isolation direction of such devices is fixed and severely restricts their applications in quantum *** this work,we experimentally demonstrate the simultaneous one-way transmission and unidirectional reflection by using a magneto-optical Fabry-Pérot cavity and a magnetic field strength of 50 *** optical isolator and a three-port quasi-circulator are realized based on this nonreciprocal cavity *** isolator achieves an isolation ratio of up to 22 dB and an averaged insertion loss down to 0.97 *** quasi-circulator is realized with a fidelity exceeding 99% and an overall survival probability of 89.9%,corresponding to an insertion loss of~0.46 *** magnetic field is provided by an electromagnetic coil,thereby allowing for reversing the light circulating *** reversible quasi-circulator paves the way for building reconfigurable quantum networks.

关键词： quantum reciprocal insertion

Three methods for the single-photon transport in a chiral cavity quantum electrodynamics system

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Chinese Optics Letters 2022年第6期20卷 52-60页

作者： Jiang-Shan Tang Lei Tang keyu xia College of Engineering and Applied Sciences National Laboratory of Solid State Microstructuresand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China School of Physics Nanjing UniversityNanjing 210023China

We investigate the single-photon transport problem in the system of a whispering-gallery mode microresonator chirally coupled with a two-level quantum emitter[QE].Conventionally,this chiral QE-microresonator coupling system can be studied by the master equation and the single-photon transport ***,we provide a new approach,based on the transfer matrix,to assess the single-photon transmission of such a ***,we prove that these three methods are *** corresponding relations of parameters among these approaches are precisely *** transfer matrix can be extended to a multiple-resonator system interacting with two-level QEs in a chiral ***,our work may provide a convenient and intuitive form for exploring more complex chiral cavity quantum electrodynamics systems.

关键词： chiral cavity QED system master equation method single-photon transport theory transfer matrix method

Broad-intensity-range optical nonreciprocity based on feedback-induced Kerr nonlinearity

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Photonics Research 2021年第7期9卷 1218-1225页

作者： LEI TANG JIANGSHAN TANG HAODONG WU JING ZHANG MIN xia. keyu xia College of Engineering and Applied Sciences National Laboratory of Solid State MicrostructuresCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Department of Automation Tsinghua UniversityBeijing 100084China Center for Quantum Information Science and Technology Tsinghua National Laboratory for Information Science and Technology(TNList)Beijing 100084China Department of Physics University of ArkansasFayettevilleArkansas 72701USA

Nonreciprocal light propagation plays an important role in modern optical systems,from photonic networks to integrated photonics. We propose a nonreciprocal system based on a resonance-frequency-tunable cavity and intensity-adaptive feedback control. Because the feedback-induced Kerr nonlinearity in the cavity is dependent on the incident direction of light,the system exhibits nonreciprocal transmission with a transmission contrast of 0.99 and an insertion loss of 1.5 dB. By utilizing intensity-adaptive feedback control,the operating intensity range of the nonreciprocal system is broadened to 20 dB,which relaxes the limitation of the operating intensity range for nonlinear nonreciprocal systems. Our protocol paves the way to realize high-performance nonreciprocal propagation in optical systems and can also be extended to microwave systems.

关键词： reciprocal nonlinearity intensity

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综合性医院病区分类管理评价指标体系构建

护理研究 2024年第13期38卷 2431-2434页

作者：刘滢夏丽莉王荣曹小彤江恒陈柯宇南京医科大学第一附属医院江苏210029

目的:构建综合性医院临床病区分类管理指标体系,为科学评价岗位价值奠定基础、对护理岗位管理提供理论依据。方法:对综合医院病区分类管理主要构成要素进行分析,根据专科属性结合各临床病区的工作量、护理难度等因素选择客观、可测量的... 详细信息

目的:构建综合性医院临床病区分类管理指标体系,为科学评价岗位价值奠定基础、对护理岗位管理提供理论依据。方法:对综合医院病区分类管理主要构成要素进行分析,根据专科属性结合各临床病区的工作量、护理难度等因素选择客观、可测量的指标,采用德尔菲专家咨询法构建临床病区分类管理指标体系。结果:2轮函询分别向15名专家发出函询表,回收率均为100%。2轮专家函询有12名专家提出修改意见,专家权威程度为0.89。最终形成包括护理工作量、护理工作难度、护理职业风险和工作压力负荷4个一级指标、11个二级指标、33个三级指标的评价体系。结论:构建的综合医院病区分类管理指标可为临床病区分类及临床护理管理实践提供理论基础。

关键词：综合性医院病区分类管理指标体系护理管理德尔菲法

Dynamic Nonreciprocity with a Kerr Nonlinear Resonator

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Chinese Physics Letters 2022年第12期39卷 28-34页

作者： Rui-Kai Pan Lei Tang keyu xia.Franco Nori College of Engineering and Applied Sciences National Laboratory of Solid State Microstructuresand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China College of Physics and Electronic Engineering Sichuan Normal UniversityChengdu 610101China Jiangsu Key Laboratory of Artificial Functional Materials Nanjing UniversityNanjing 210023China Shishan Laboratory Suzhou Campus of Nanjing UniversitySuzhou 215000China RIKEN Quantum Computing Center RIKEN Cluster for Pioneering ResearchWako-shiSaitama 351-0198Japan Physics Department The University of MichiganAnn ArborMichigan 48109-1040USA

On-chip optical nonreciprocal devices are vital components for integrated photonic systems and scalable quantum information *** optical isolators and circulators have attracted considerable attention because of their fundamental interest and their important advantages in integrated photonic ***,optical nonreciprocal devices based on Kerr or Kerr-like nonlinearity are subject to dynamical reciprocity when the forward and backward signals coexist simultaneously in a nonlinear ***,we theoretically propose a method for realizing on-chip nonlinear isolators and circulators with dynamic *** nonreciprocity is achieved via the chiral modulation on the resonance frequency due to coexisting self-and cross-Kerr nonlinearities in an optical ring *** work showing dynamic nonreciprocity with a Kerr nonlinear resonator can be an essential step toward integrated optical isolation.

关键词： Nonlinear nonlinear reciprocal

身体基本指数与重症肌无力的因果关联:一项两样本孟德尔随机化研究

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中国循证医学杂志 2024年第6期24卷 673-677页

作者：殷珂宇双思傅道森董文浩夏鹏张国坤沈蓉王德贵王青兰州大学护理学院兰州730000 兰州大学基础医学院人体解剖学教研室兰州730000

目的采用两样本孟德尔随机化分析探究4项身体基本指数(基础代谢率、体脂率、BMI及臀围)与重症肌无力(myasthenia gravis,MG)之间的因果关联。方法在大型公开可检索的数据库中获取全基因关联分析汇总数据,选取4项身体基本指数作为暴露因... 详细信息

目的采用两样本孟德尔随机化分析探究4项身体基本指数(基础代谢率、体脂率、BMI及臀围)与重症肌无力(myasthenia gravis,MG)之间的因果关联。方法在大型公开可检索的数据库中获取全基因关联分析汇总数据,选取4项身体基本指数作为暴露因素,MG作为结局因素,筛选出与暴露因素表型强相关的单核苷酸多态性作为工具变量,进行两样本孟德尔随机化分析,以评估暴露与疾病之间的潜在因果关系。结果逆方差加权法分析结果显示,基础代谢率[OR=1.39,95%CI(1.00,1.93),P=0.047]、体脂率[OR=1.61,95%CI(1.06,2.44),P=0.024]、臀围[OR=1.67,95%CI(1.29,2.17),P<0.001]升高均会增加MG发病风险,但BMI与MG没有显著的因果关联。结论基础代谢率、体脂率及臀围对MG存在致病效应,BMI与MG没有显著的因果关系。

关键词：身体基本指数重症肌无力孟德尔随机化因果关联