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Metabolomics signature of blood pressure salt sensitivity and its link to cardiovascular disease:A dietary salt-intervention trial

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Science China Life Sciences 2024年第8期 1666-1675页

作者： Zhennan Lin Jianxin Li Fangchao Liu Jie Cao Shufeng Chen Jichun Chen keyong huang Yaqin Wang Hongfan Li Yan Wang Jianfeng huang Dongfeng Gu Xiangfeng Lu Key Laboratory of Cardiovascular Epidemiology Department of EpidemiologyFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical College/National Center for Cardiovascular Diseases Medical School Southern University of Science and Technology

Individuals with a high degree of salt sensitivity(SS) have a greater risk of cardiovascular disease(CVD),but whether SS fosters CVD by influencing metabolomics homeostasis remains unclear.This study aimed to reveal the role of the SS-related metabolomics signature in the development of CVDs,based on the Meta Salt study,which was a dietary salt-intervention trial conducted at four centers in China in 2019.A total of 528 participants were recruited and underwent 3 days of baseline observations,a 10-day low-salt intervention,and a 10-day highsalt intervention.Plasma untargeted metabolomics,lipidomics,and BP measurements were scheduled at each stage.Participants were grouped into extreme SS,moderate SS,and salt-resistant(SR) individuals according to their BP responses to salt.Linear mixed models were used to identify SS-related metabolites and determine the relationship between the SS-related metabolomics signature and arterial stiffness.Mendelian randomization(MR) analyses were applied to establish the causal pathways among the SS-related metabolites,BP,and CVDs.Among the 713 metabolites,467 were significantly changed after the high-salt intervention.Among them,the changes in 30 metabolites from the low-salt to the high-salt intervention differed among the SS groups.Of the remaining nonsalt-related metabolites,the baseline levels of 11 metabolites were related to SS.These 41 metabolites explained 23% of the variance in SS.Moreover,SS and its metabolomics signature were positively correlated with arterial stiffness.MR analyses demonstrated that the SS-related metabolites may affect CVD risk by altering BP,indicating that the increase in BP was the consequence of the changes in SS-related metabolites rather than the cause.Our study revealed that the metabolomics signature of SS individuals differs from that of SR individuals and that the changes in SS-related metabolites may increase arterial stiffness and foster CVDs.This study provides insight into understanding the biology and targets of SS and its role in CVDs.

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Temporal trend in mortality of cardiovascular diseases and its contribution to life expectancy increase in China, 2013 to 2018

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Chinese Medical Journal 2022年第17期135卷 2066-2075页

作者： Xue Xia Yue Cai Xiang Cui Ruixian Wu Fangchao Liu keyong huang Xueli Yang Xiangfeng Lu Shiyong Wu Dongfeng Gui Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBejing 100037China Center for Health Statistics and Information National Health CommissionBejing 100044China Department of Occupational and Environmental Health Tianjn Key Laboratory of EnvironmentNutrtion and Public HealthSchool of Public HealthTianjin Medical UniversityTianjin 300070China School of Medicine Southern University of Science and TechnologyShenzhenGuangdong 518055China

Backgrounds::Cardiovascular disease(CVD)remains the leading cause of deaths nationwide.However,little is understood about its temporal trend and corresponding influence on longevity improvements.We aimed to describe the updated tendency in CVD mortality and to quantify its impact on life expectancy(LE)increase in China.Methods::All-cause mortality rates were calculated with population sizes from the National Bureau of Statistics and death counts from the National Health Commission.We estimated CVD mortality rates by allocating age-and sex-based mortality envelopes to each CVD subtype based on its proportion derived from the Disease Surveillance Points system.The probability of CVD premature deaths and LE were calculated with life tables and we adopted Arriaga’s method to quantitate age-and cause-specific contributions to LE gains.Results::During 2013 to 2018,the age-standardized mortality rate of CVD decreased from 289.69(95%confidence interval[CI]:289.03,290.35)/100,000 to 272.37(95%CI:271.81,272.94)/100,000,along with a decline in probability of CVD premature deaths from 9.05%(95%CI:9.02%,9.09%)to 8.13%(95%CI:8.10%,8.16%).The gap in CVD mortality across sexes expanded with more remarkable declines in females,especially for those aged 15 to 64 years.Among major subtypes,the probability of premature deaths from hemorrhage stroke declined fastest,while improvements of ischemic stroke and ischemic heart disease were limited,and there was an increase in stroke sequelae.LE in China reached 77.04(95%CI:76.96,77.12)years in 2018 with an increase of 1.38 years from 2013.Of the total LE gains,21.15%(0.29 years)were attributed to reductions of CVD mortality in the overall population,mostly driven by those aged>65 years.Conclusions::The general process in reducing CVD mortality has contributed to longevity improvements in China.More attention should be paid to prevention and control of atherosclerotic CVD and stroke sequelae,especially for the elderly.Working-age males also deserve additional attention due to inadequate im

关键词： Aged Cardiovascular diseases Causes of death Hemorrhagic stroke Ischemic stroke Longevity Mortality,premature Myocardial ischemia Life expectancy China

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Fruit and vegetable consumption,cardiovascular disease,and all-cause mortality in China

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Science China(Life Sciences) 2022年第1期65卷 119-128页

作者： Jun Wang Fangchao Liu Jianxin Li keyong huang Xueli Yang Jichun Chen Xiaoqing Liu Jie Cao Shufeng Chen Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng huang Dongfeng Gu Xiangfeng Lu Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijing 100037China Tianjin Key Laboratory of Environment Nutrition and Public Health/Department of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjin 300070China Division of Epidemiology Guangdong Provincial People’s Hospital and Cardiovascular InstituteGuangzhou 510080China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China Department of Cardiology Fujian Provincial HospitalFuzhou 350014China Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinan 250062China Sichuan Center for Disease Control and Prevention Chengdu 610041China Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityZhengzhou 450001China Department of Epidemiology and Health Statistics School of Public HealthShenzhen University Health Science CentreShenzhen 518060China School of Medicine Southern University of Science and TechnologyShenzhen 518055China

Evidence about the response patterns of fruit and vegetable consumption with the risk of cardiovascular disease(CVD)and allcause mortality was inconsistent.These associations were examined using a large-scale,population-based Chinese cohort comprising 100,728 participants.A food-frequency questionnaire was used to assess fruit and vegetable consumption.Outcomes were ascertained by interviewing individuals or their proxies and checking hospital records or death certificates.Cox proportional hazards regression was used to calculate hazard ratios(HRs)with 95% confidence intervals(CIs).At the 736,668 person-years of follow-up,3,677 CVD cases and 5,466 deaths were identified.The multivariable-adjusted HRs for CVD across increasing quartiles of total fruit and vegetable consumption were 1(reference),0.94(95%CI=0.85-1.04),0.89(95%CI=0.80-0.98),and 0.85(95%CI=0.77-0.95).Moreover,participants in the highest quartile displayed a 13% lower risk of all-cause mortality(HR=0.87;95%CI=0.80-0.95).A nonlinear dose-response relation was found for CVD,without additional benefits beyond a consumption of600 g d-1,whereas the all-cause mortality risk decreased along with higher consumption,with a linear trend.These associations remained significant for fruit consumption but not for vegetable consumption.Our findings indicated that greater fruit and vegetable consumption was significantly associated with a lower risk of CVD and all-cause mortality.Increasing fruit and vegetable consumption,especially fruit,in the general population would prevent CVD and premature mortality.

关键词： fruit vegetable cardiovascular disease mortality

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Long-term exposure to fine particulate matter modifies the association between physical activity and hypertension incidence

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Journal of Sport and Health Science 2022年第6期11卷 708-715,F0003页

作者： Qiong Liu keyong huang Fengchao Liang Xueli Yang Jianxin Li Jichun Chen Xiaoqing Liu Jie Cao Chong Shen Ling Yu Yingxin Zhao Ying Deng Ying Li Dongsheng Hu Xiangfeng Lu Yang Liu Dongfeng Gu Fangchao Liu Jianfeng huang Department of Epidemiology National Center for Cardiovascular DiseasesFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijing 100037China School of Public Health and Emergency Management Southern University of Science and TechnologyShenzhen 518055China Tianjin Key Laboratory of Environment Nutrition and Public HealthDepartment of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjin 300070China Division of Epidemiology Guangdong Provincial People’s Hospital and Cardiovascular InstituteGuangzhou 510080China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China Department of Cardiology Fujian Provincial HospitalFuzhou 350014China Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinan 250062China Center for Chronic and Noncommunicable Disease Control and Prevention Sichuan Center for Disease Control and PreventionChengdu 610041China Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityZhengzhou 450001China Department of Biostatistics and Epidemiology School of Public HealthShenzhen University Health Science CenterShenzhen 518071China Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30322USA School of Medicine Southern University of Science and TechnologyShenzhen 518055China

Background:The trade-off between the benefits of regular physical activity(PA)and the potentially detrimental effects of augmented exposure to air pollution in highly polluted regions remains unclear.This study aimed to examine whether ambient fine particulate matter(PM_(2.5))exposure modified the impacts of PA volume and intensity on hypertension risk.Methods:We included 54,797 participants without hypertension at baseline in a nationwide cohort of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project.PA volume and intensitywere assessed by questionnaire,and high-resolution(1 km×1 km)PM_(2.5)estimates were generated using a satellite-based model.Results:During 413,516 person-years of follow-up,12,100 incident hypertension cases were identified.PM_(2.5)significantly modified the relationship between PA and hypertension incidence(p_(interaction)<0.001).Increased PA volume was negatively associated with incident hypertension in the low PM_(2.5)stratum(<59.8μg/m^(3),ptrend<0.001),with a hazard ratio of 0.81(95%confidence interval(95%CI):0.74-0.88)when comparing the fourth with the first quartile of PA volume.However,the health benefits were not observed in the high PM_(2.5)stratum(≥59.8μg/m^(3),p_(trend)=0.370).Moreover,compared with light PA intensity,vigorous intensity was related to a 20%(95%CI:9%-29%)decreased risk of hypertension for participants exposed to low PM_(2.5),but a 17%(95%CI:4%-33%)increased risk for those with high PM_(2.5)levels.Conclusion:PA was associated with a reduced risk of hypertension only among participants with low PM_(2.5)exposure.Our findings recommended regular PA to prevent hypertension in less polluted regions and reinforced the importance of air quality improvement.

关键词： Air pollution Cohort study Hypertension Particulate matter Physical activity

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Integrating polygenic and clinical risks to improve stroke risk stratification in prospective Chinese cohorts

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Science China(Life Sciences) 2023年第7期66卷 1626-1635页

作者： Qingmei Cui Fangchao Liu Jianxin Li Xiaoge Niu Zhongying Liu Chong Shen Dongsheng Hu keyong huang Shufeng Chen Jie Cao Xiaoqing Liu Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Jianfeng huang Ying Li Zhibin Hu Hongbing Shen Dongfeng Gu Xiangfeng Lu Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100037China Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijing100037China Department of Nephrology Henan Provincial Key Laboratory of Kidney Disease and ImmunologyHenan Provincial Clinical Research Center for Kidney DiseaseHenan Provincial People’s Hospital and People’s Hospital of Zhengzhou UniversityZhengzhou450053China Department of Epidemiology and Biostatistics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing211166China Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityZhengzhou450001China Department of Prevention Medicine Shenzhen University School of MedicineShenzhen518060China Division of Epidemiology Guangdong Provincial People’s Hospital and Cardiovascular InstituteGuangzhou510080China Department of Cardiology Fujian Provincial People’s HospitalFuzhou350014China Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinan250062China Sichuan Center for Disease Control and Prevention Chengdu610041China Research Units of Cohort Study on Cardiovascular Diseases and Cancers Chinese Academy of Medical SciencesBeijing100730China School of Medicine Southern University of Science and TechnologyShenzhen518055China

The utility of the polygenic risk score(PRS)to identify individuals at higher risk of stroke beyond clinical risk remains unclear,and we clarified this using Chinese population-based prospective cohorts.Cox proportional hazards models were used to estimate the 10-year risk,and Fine and Gray’s models were used for hazard ratios(HRs),their 95%confidence intervals(CIs),and the lifetime risk according to PRS and clinical risk categories.A total of 41,006 individuals aged 30–75 years with a mean follow-up of 9.0 years were included.Comparing the top versus bottom 5%of the PRS,the HR was 3.01(95%CI 2.03–4.45)in the total population,and similar findings were observed within clinical risk strata.Marked gradients in the 10-year and lifetime risk across PRS categories were also found within clinical risk categories.Notably,among individuals with intermediate clinical risk,the 10-year risk for those in the top 5%of the PRS(7.3%,95%CI 7.1%–7.5%)reached the threshold of high clinical risk(≥7.0%)for initiating preventive treatment,and this effect of the PRS on refining risk stratification was evident for ischemic stroke.Even among those in the top 10%and 20%of the PRS,the 10-year risk would also exceed this level when aged≥50 and≥60 years,respectively.Overall,the combination of the PRS with the clinical risk score improved the risk stratification within clinical risk strata and distinguished actual high-risk individuals with intermediate clinical risk.

关键词： stroke polygenic risk score clinical risk score utility stratification

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附着水滴光学窗口偏振成像特性研究

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工程热物理学报 2024年第4期45卷 1125-1131页

作者：杨佳辰王新新朱克勇黄勇北京航空航天大学航空科学与工程学院北京100191

偏振成像技术作为一种前沿的成像技术,在近些年来发展迅速。相比于传统的成像技术,偏振成像技术在提供二维空间光强分布的基础上,增加了偏振维度的信息,提高了成像的准确度。本文对附着水滴光学窗口模型开展偏振成像特性的研究,用蒙特... 详细信息

偏振成像技术作为一种前沿的成像技术,在近些年来发展迅速。相比于传统的成像技术,偏振成像技术在提供二维空间光强分布的基础上,增加了偏振维度的信息,提高了成像的准确度。本文对附着水滴光学窗口模型开展偏振成像特性的研究,用蒙特卡洛光线追踪法完成了数值模拟,用Stokes矢量记录偏振维的信息,分析了光源类型、水滴直径和水滴接触角对成像效果的影响规律,对提高成像质量具有重要意义。

关键词：偏振成像附着水滴光学窗口蒙特卡洛光线追踪法

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Longitudinal association of egg consumption habits with blood lipids among Chinese adults: results from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China project

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Chinese Medical Journal 2022年第6期135卷 747-749页

作者： Xinyu Zhang Fangchao Liu Jianxin Li Sihan huang Xue Xia keyong huang Qiong Liu Jichun Chen Xueli Yang Xiaoqing Liu Jie Cao Chong Shen Ling Yu Yingxin Zhao Ying Deng Ying Li Dongsheng Hu Jianfeng huang Xiangfeng Lu Dongfeng Gu Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijing 100037China Department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhouHenan 450001China Department of Occupational and Environmental Health School of Public HealthTianjin Medical UniversityTianjin 300070China Division of Epidemiology Guangdong Provincial People's Hospital and Cardiovascular InstituteGuangzhouGuangdong 510080China Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Cardiology Fujian Provincial HospitalFuzhouFujian 350014China Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinanShandong 250062China Center for Chronic and Noncommunicable Disease Control and Prevention Sichuan Center for Disease Control and PreventionChengduSichuan 610041China Department of Biostatistics and Epidemiology School of Public HealthShenzhen University Health Science CenterShenzhenGuangdong 518071China School of Medicine Southern University of Science and TechnologyShenzhenGuangdong 518055China

To the Editor:According to guidelines from western countries as well as China,dietary patterns with low intake of cholesterol have been widely recommended for maintaining ideal lipid levels.As one of the major sources of both high-quality protein and dietary cholesterol,eggs have always been the focus in terms of diet.Although increased lipid levels induced by high egg intake have been revealed by randomized controlled trials(RCTs),they may not be sufficient to reflect the impacts of habitual egg intake due to high doses of egg intake of more than 7 eggs/week or even 14 eggs/week.Further,RCTs typically have shorter intervention periods of about 3 months,which may not observe a stable association due to homeostasis in cholesterol metabolism of human beings.[1,2]Up to now,only three cohorts assessed the associations of egg intake with lipid levels or dyslipidemia,and the findings were still controversial.One recent cohort study has reported the non-significant association between higher egg intake(≥7 vs.1 eggs/week)and lipid profiles.On the other hand,another cohort from Spain found that compared with4 eggs/week had no significant influence on total cholesterol(TC)and triglyceride(TG),but significantly decreased high-density lipoprotein cholesterol(HDL-C)levels.[4]However,none of these cohorts were from developing countries,and the association between moderate egg intake and lipid profiles has not been well illustrated.Egg consumption in China,a representative of developing countries,is relatively higher,and it may be possible to better explore the appropriate range of egg intake.

关键词： intake metabolism doses

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Prevalence of familial hypercholesterolemia and its association with coronary artery disease:A Chinese cohort study

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Chronic Diseases and Translational Medicine 2023年第2期9卷 134-142页

作者： Xiapikatijiang Aihaiti Shufeng Chen Jianxin Li Zhennan Lin Qingmei Cui Xue Xia Fangchao Liu Chong Shen Dongsheng Hu keyong huang Yingxin Zhao Fanghong Lu Xiaoqing Liu Jie Cao Ling Yu Ying Li Huan Zhang Zhenyan Fu Liancheng Zhao Jianfeng huang Dongfeng Gu Xiangfeng Lu Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical UniversityBejingChina Department of Epidemiology and Biostatistics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsuChina School of Public Health Zhengzhou UniversityZhengzhouHenanChina School of Public Health Shenzhen UniversityShenzhenGuangdongChina Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinanShandongChina Division of Epidemiology Guangdong Provincial People's Hospital Guangdong Cardiovascular InstituteGuangzhouGuangdongChina Department of Cardiology Fujian Provincial People's HospitalFuzhouFujianChina Center for Genetic Epidemiology and Genomics School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric DiseasesSoochow University Medical CollegeSuzhouJiangsuChina Department of Cardiology First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina School of Medicine Southern University of Science and TechnologyShenzhenGuangdongChina

Background:Familial hypercholesterolemia(FH)is underrecognized,and its association with coronary artery disease(CAD)remains limited,especially in China.We aimed to investigate the prevalence of FH and its relationship with CAD in a large Chinese cohort.Methods:FH was defined using the Make Early Diagnosis to Prevent Early Death(MEDPED)criteria.The crude and age-sex standardized prevalence of FH were calculated based on surveys of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project during 2007−2008.The associations of FH with incident CAD and its major subtypes were estimated with the cohort-stratified multivariate Cox proportional hazard models based on the data from the baseline to the last follow-up(2018−2020).Results:Among 98,885 included participants,190 participants were defined as FH.Crude and age−sex standardized prevalence and 95%confidence interval(CI)of FH were 0.19%(0.17%-0.22%)and 0.13%(0.10%-0.16%),respectively.The prevalence varied across age groups and peaked in the group of 60-<70 years(0.28%),and the peak prevalence(0.18%)in males was earlier,yet lower than the peak crude prevalence in females(0.41%).During a mean follow-up of 10.7 years,2493 cases of incident CAD were identified.After multivariate adjustment,FH patients had a 2.03-fold greater risk of developing CAD compared to non-FH participants.Conclusions:The prevalence of FH was estimated to be 0.19%in the participants,and it was associated with an elevated risk of incident CAD.Our study suggests that early screening of FH has certain public health significance for the prevention of CAD.

关键词： cohort study coronary artery disease familial hypercholesterolemia prevalence

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Impacts of PM_(2.5) on Ambulatory Blood Pressure Monitoring Indicators Attenuated by Blood Pressure Control Status and Treatment-Two Cities and Two Municipalities,China,2017−2019

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China CDC weekly 2021年第45期3卷 948-953页

作者： Fangchao Liu Zhennan Lin Xinyan Wang Xueli Yang Qiong Liu Xiaolong Xing Jie Cao Jianxin Li keyong huang Weli Yan Tingting Liu Wei Li Shufeng Chen Xiangfeng Lu Dongfeng Gu Jianfeng huang Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijingChina Center for Reproductive Medicine Tianjin Central Hospital of Gynecology ObstetricsTianjinChina Tianjin Key Laboratory of Environment Nutrition and Public HealthDepartment of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjinChina Department of Clinical Epidemiology&Clinical Trial Unit Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Cardiology Renmin Hospital of Wuhan UniversityWuhanHubeiChina Function Test Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medicine Southern University of Science and TechnologyShenzhenGuangdongChina

Summary What is already known about this topic?Short-term PM_(2.5) exposure has been associated with hourly,24-hour,daytime,and nighttime blood pressure(BP)levels,and further studies focusing whether and how the assoc... 详细信息

关键词： Blood monitoring indicators

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Study design,general characteristics of participants,and preliminary findings from the metabolome,microbiome,and dietary salt intervention study(MetaSalt)

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Chronic Diseases and Translational Medicine 2021年第4期7卷 227-234页

作者： Zengliang Ruan Jianxin Li Fangchao Liu Jie Cao Shufeng Chen Jichun Chen keyong huang Yaqin Wang Hongfan Li Yan Wang Zhongyu Xue Laiyuan Wang Jianfeng huang Dongfeng Gu Xiangfeng Lu Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China School of Medicine Southern University of Science and TechnologyShenzhenGuangdong 518055China

Background:High sodium intake is an important risk factor for hypertension and cardiovascular disease.However,the association between gut microbiota composition and metabolomic profiles with dietary sodium intake and blood pressure(BP)is not well-understood.The metabolome,microbiome,and dietary salt intervention(MetaSalt)study aimed to investigate microbial and metabolomic profiles related to dietary sodium intake and BP regulation.Methods:This family-based intervention study was conducted in four communities across three provinces in rural northern China in 2019.Probands with untreated prehypertension or stage-1 hypertension were identified through community-based BP screening,and family members including siblings,offspring,spouses,and parents were subsequently included.All participants participated in a 3-day baseline examination with usual diet consumption,followed by a 10-day low-salt diet(3 g/d of salt or 51.3 mmol/d of sodium)and a 10-day high-salt diet(18 g/d of salt or 307.8 mmol/d of sodium).Differences in mean BP levels were compared according to the intervention phases using a paired Student’s t-test.Results:A total of 528 participants were included in this study,with a mean age of 48.1 years,36.7%of whom were male,76.8%had a middle school(69.7%)or higher(7.1%)diploma,23.4%had a history of smoking,and 24.4%were current drinkers.The mean arterial pressure at baseline was 97.2±10.5 mm Hg for all participants,and significantly decreased during the low-salt intervention(93.8±9.3,P<0.0001)and subsequently increased during the high-salt intervention(96.4±10.0,P<0.0001).Conclusions:Our dietary salt intervention study has successfully recruited participants and will facilitate to evaluate the effects of gut microbiota and metabolites on BP regulation in response to sodium burden,which will provide important evidence for investigating the underlying mechanisms in the development of hypertension and subsequent cardiovascular diseases.Trial registration:The study was registered in the Chinese Clinical Trial Regis

关键词： Dietary sodium Metabolome Microbiota Blood pressure Hypertension

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