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Even and Odd Phase Coherent States Associated with the Pegg-Barnett Hermitian Phase Theory

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Chinese Physics Letters 1996年第4期13卷 273-276页

作者： zhu Jiu-yun KUANG Le-man Department of Physics Hu'nan Normal UniversityChangsha 410081

Even and odd phase coherent states associated with the Pegg-Barnett Hermitian phase theory are *** and odd coherent-state formalism of the Pegg-Barnett phase operator is given in terms of the projection operator in th... 详细信息

关键词： space. states. coherent

转录组和代谢组分析盐度对盐单胞菌合成羟基四氢嘧啶的影响

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水生生物学报 2024年第7期48卷 1193-1204页

作者：张蔓邢江娃朱德锐李永臻青海大学医学部基础医学研究中心西宁810016

为了明确不同盐度对Halomonas campaniensis XH26合成羟基四氢嘧啶(5-hydroxyectoine,5-HE)代谢通路和基础代谢的影响,研究采用无NaCl作为对照组,以12%、14%和16%NaCl浓度梯度作为高盐组。利用转录组测序和液质联用技术(LC-MS)分析了***... 详细信息

为了明确不同盐度对Halomonas campaniensis XH26合成羟基四氢嘧啶(5-hydroxyectoine,5-HE)代谢通路和基础代谢的影响,研究采用无NaCl作为对照组,以12%、14%和16%NaCl浓度梯度作为高盐组。利用转录组测序和液质联用技术(LC-MS)分析了*** XH26在不同NaCl浓度条件下的差异表达基因和差异代谢物,并利用qPCR对与Ectoine和5-HE合成密切相关的差异基因的表达量进行了相对定量分析验证。结果显示,5-HE合成量在高盐组间随盐梯度先增加后降低,并在14%NaCl浓度时达到最高。转录组结果显示,在186个KEGG代谢通路中,差异表达基因在ABC转运蛋白、双组分系统、鞭毛组装等通路中高度富集。筛选到与5-HE合成代谢相关的7个关键基因表达存在差异,包括lysC、ectA、ectB、ectC、ectD、doeC和doeD。qPCR验证结果与转录组学分析结果基本一致。代谢组分析共发现了1159个差异代谢物,主要富集在氨基酸代谢、辅因子-维生素代谢和碳水化合物等代谢通路。研究还筛选出了显著差异的相容性溶质,包括四氢嘧啶、羟基四氢嘧啶和甜菜碱。研究分析了菌株*** XH26的耐盐特性及盐适应机制,初步明确了5-HE产量及合成基因簇表达随盐度变化的规律,为高产5-HE的野生菌的优化和基因工程菌的构建提供了理论基础。

关键词：转录组学代谢组学盐单胞菌羟基四氢嘧啶

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Construction and evaluation of in-house methylation-sensitive SNaPshot system and three classification prediction models for identifying the tissue origin of body fluid

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第9期24卷 839-852页

作者： Yating FANG man CHEN Bofeng zhu Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification School of Forensic MedicineSouthern Medical UniversityGuangzhou510515China School of Basic Medical Sciences Anhui Medical UniversityHefei230031China Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou510515China

The identification of tissue origin of body fluid can provide clues and evidence for criminal case *** establish an efficient method for identifying body fluid in forensic cases,eight novel body fluid-specific DNA methylation markers were selected in this study,and a multiplex single base extension reaction(SNaPshot)system for these markers was constructed for the identification of five common body fluids(venous blood,saliva,menstrual blood,vaginal fluid,and semen).The results indicated that the in-house system showed good species specificity,sensitivity,and ability to identify mixed biological *** the same time,an artificial body fluid prediction model and two machine learning prediction models based on the support vector machine(SVM)and random forest(RF)algorithms were constructed using previous research data,and these models were validated using the detection data obtained in this study(n=95).The accuracy of the prediction model based on experience was 95.79%;the prediction accuracy of the SVM prediction model was 100.00%for four kinds of body fluids except saliva(96.84%);and the prediction accuracy of the RF prediction model was 100.00%for all five kinds of body *** conclusion,the in-house SNaPshot system and RF prediction model could achieve accurate tissue origin identification of body fluids.

关键词： DNA methylation Body fluid Forensic identification Single base extension reaction(SNaPshot) Machine learning

Pleural empyema with endobronchial mass due to Rhodococcus equi infection after renal transplantation: A case report and review of literature

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World Journal of Clinical Cases 2024年第1期12卷 224-231页

作者： Guo-Fu Liang Sheng Chao Zhou Sun Ke-Jing zhu Qian Chen Lei Jia Yu-Lin Niu Department of Organ Transplantation School of Clinical MedicineGuizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Organ Transplantation The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Kidney transplantation is the best option for patients with end-stage renal ***,the need for lifelong immunosuppression results in renal transplant recipients being susceptible to various *** equi(***)is a rare opportunistic pathogen in humans,and there are limited reports of infection with *** in post-renal transplant recipients and no uniform standard of *** article reports on the diagnosis and treatment of a renal transplant recipient infected with *** 21 mo postoperatively and summarizes the charac-teristics of infection with *** after renal transplantation,along with a detailed review of the ***,we present the case of a 25-year-old man who was infected with *** 21 mo after renal *** the clinical features at the time of presentation were not specific,chest computed tomography(CT)showed a large volume of pus in the right thoracic cavity and right middle lung atelectasis,and fiberoptic bronchoscopy showed an endobronchial mass in the right middle and lower lobe *** culture and metagenomic next-generation sequen-cing sequencing of the pus were suggestive of *** *** immunosup-pressive drugs were immediately suspended and intravenous vancomycin and azithromycin were administered,along with adequate drainage of the *** endobronchial mass was then *** the patient’s clinical symptoms and chest CT presentation resolved,he was switched to intravenous ciprofloxacin and azithromycin,followed by oral ciprofloxacin and *** patient was re-hospitalized 2 wk after discharge for recurrence of *** *** recovered after another round of adequate abscess drainage and intravenous ciprofloxacin and *** Infection with *** in renal transplant recipients is rare and complex,and the clinical presentation lacks *** antibiotic therapy is required,and adequate abscess drainage and s

关键词： Kidney transplantation Rhodococcus equi Pleural empyema Pulmonary atelectasis Immunosuppression Case report

情志干预结合正念训练对尘肺患者负性情绪的影响

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临床医学研究与实践 2024年第15期9卷 157-160页

作者：刘曼岳琴朱美君陕西省铜川市耀州区人民医院陕西铜川727100 府谷县人民医院陕西榆林719400 山阳县人民医院陕西商洛726400

目的探讨情志干预结合正念训练在尘肺患者中的应用效果。方法选择2020年1月至2021年12月就诊于本院的60例尘肺病患者,通过随机数字表法将其分为A组和B组,各30例。A组给予常规治疗及基础护理,B组给予情志干预结合正念训练。比较两组的干... 详细信息

目的探讨情志干预结合正念训练在尘肺患者中的应用效果。方法选择2020年1月至2021年12月就诊于本院的60例尘肺病患者,通过随机数字表法将其分为A组和B组,各30例。A组给予常规治疗及基础护理,B组给予情志干预结合正念训练。比较两组的干预效果。结果干预后,两组的贝克抑郁量表第二版(BDI-Ⅱ)、焦虑自评量表(SAS)评分均降低,且B组低于A组(P<0.05)。干预后,两组的用力肺活量占预计值百分比(FVC%)、肺最大通气量占预计值百分比(MVV%)及第1秒用力呼气容积占预计值百分比(FEV_1%)均升高,且B组高于A组(P<0.05)。干预后,两组的6 min步行试验(6MWT)大于干预前,Borg评分低于干预前,且B组优于A组(P<0.05)。结论情志干预结合正念训练能够缓解尘肺患者的负面情绪,并促进肺功能及运动耐力改善,缓解呼吸困难症状。

关键词：尘肺情志干预正念训练负性情绪肺功能

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Chemotherapy combined with bevacizumab for small cell lung cancer with brain metastases:A case report

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World Journal of Clinical Cases 2024年第2期12卷 405-411页

作者： Hong-Yu Yang Yu-Qing Xia Yu-Jia Hou Peng Xue Shi-Jie zhu Dian-Rong Lu Department of Oncology Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China Department of Oncology Tianjin University of Chinese MedicineTianjin 300000China Department of Electrothermal Acupuncture Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China Department of Acupuncture and Moxibustion Sihui Hospital of Traditional Chinese MedicineBeijing 100102China

BACKGROUND Small cell lung cancer(SCLC)is a common and aggressive subtype of lung *** is characterized by rapid growth and a high mortality *** 10%of patients with SCLC present with brain metastases at the time of diagnosis,which is associated with a median survival of 5 *** study aimed to summarize the effect of bevacizumab on the progression-free survival(PFS)and overall survival of patients with brain metastasis of *** SUMMARY A 62-year-old man was referred to our hospital in February 2023 because of dizziness and numbness of the right lower extremity without headache or fever for more than four *** patient was diagnosed with limited-stage *** received 8 cycles of chemotherapy combined with maintenance bevacizumab therapy and achieved a PFS of over 7 *** The combination of bevacizumab and irinotecan effectively alleviated brain metastasis in SCLC and prolonged PFS.

关键词： Small cell lung cancer Bevacizumab Brain metastasis Antineoplastic agents Target therapies Immunotherapy Radiotherapy Case report

二维斑点追踪技术评价小于胎龄儿心脏大小重塑的临床价值

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中国超声医学杂志 2024年第6期40卷 679-682页

作者：朱晨刘芮蔡琪李嫚项金莲任芸芸复旦大学附属妇产科医院超声科

目的利用二维斑点追踪胎心定量分析技术（fetalHQ）测量胎儿心脏大小，并探讨小于胎龄（SGA）胎儿心脏大小重塑的量化指标。方法前瞻性收集28～39+6周的单胎妊娠孕妇。采用fetalHQ对453例低风险胎儿和210例SGA胎儿的四腔心和心室的长... 详细信息

目的利用二维斑点追踪胎心定量分析技术（fetalHQ）测量胎儿心脏大小，并探讨小于胎龄（SGA）胎儿心脏大小重塑的量化指标。方法前瞻性收集28～39+6周的单胎妊娠孕妇。采用fetalHQ对453例低风险胎儿和210例SGA胎儿的四腔心和心室的长径、宽径（24节段）和面积进行测量计算。结果估测胎儿体质量的标准化后，脐动脉正常的SGA胎儿四腔心和右心室的宽径、面积均大于低风险胎儿（P95th%的比例，排前3位的依次为右心室宽径至少一个节段（35.0%）、右心室宽径中间段（22.9%）、四腔心宽径（19.7%）,均大于低风险胎儿（P<0.05）。结论 1/3的SGA胎儿出现右心室宽径异常增大（以中间段为著）早于脐动脉。

关键词：小于胎龄二维斑点追踪 fetalHQ 心脏大小重塑胎儿

基于servqual模型的中医家庭医生提升医养护一体化服务质量研究

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中医药管理杂志 2024年第11期32卷 127-129页

作者：凌天诸佳珍张曼浙江中医药大学浙江杭州310053

背景:随着我国居民生活水平不断提高,当前城镇医养护一体化服务已无法有效满足居民更高质量医疗服务的需求。目的:基于构建中医家庭医生的角度,以杭州市为研究范围,探索提升杭州市医养一体化医疗服务质量的策略。方法:采用六西格玛工具... 详细信息

背景:随着我国居民生活水平不断提高,当前城镇医养护一体化服务已无法有效满足居民更高质量医疗服务的需求。目的:基于构建中医家庭医生的角度,以杭州市为研究范围,探索提升杭州市医养一体化医疗服务质量的策略。方法:采用六西格玛工具,围绕服务质量SERVQUAL模型的可靠性、有形性、移情性、响应性、保证性等五个维度,对杭州市居民医养一体化现状进行抽样调查研究,并根据调查提出中医家庭医生介入医养一体化医疗服务的影响及相关建议策略。结果:SERVQUAL五维度与居民医疗的期望值存在不同程度的差距。结论:中医家庭医生建设对医养护一体化服务质量有着积极的影响,可以提供多元化的医疗服务,个性化的诊疗方案,有效提高居民的健康素养,整体推动医养护一体化医疗服务行业稳步发展。

关键词：医养护中医家庭医生 servqual 服务质量

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Molecular and functional characterization of three odorant-binding proteins from the wheat blossom midge,Sitodiplosis mosellana

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Insect Science 2020年第4期27卷 721-734页

作者： Wei-Ning Cheng Yu-Dong Zhang Wei Liu Guang-Wei Li keyan zhu-sal.man Key Laboratory of Integrated Pest management on Crops in Northwestern Loess Plateau Ministry of AgricultureNorthwest A&F UniversityYang lingShaanxiChina Shaanxi Key Laboratory of Chinese Jujube Van'an UniversityVan'anShaanxiChina Department of Entomology Texas A&M UniversityCollege StationTXUSA

Sitodiplosis mosellana,a periodic but devastating wheat pest,relies on wheat spike volatiles as a cue in sclecing hosts for *** odorant-binding proteins(OBPs)are thought to play essential roles in filtering,binding and transporting hydropho-bic odorant molecules to specific *** date,the molecular mechanisms underlying *** olfaction are poorly ***,three *** antenna-specific OBP genes,SmosOBPII,16 and 21,were cloned and bacterially *** properties of the recombinant proteins to 28 volatiles emitted from wheat spikes were in-vestigated using fluorescence competitive binding *** analysis suggested that these SmosOBPs belong to the Classic OBP ***-binding analysis showed that all three SmosOBPs preferentially bound alcohol,ester and ketone com-pounds,and SmosOBP11 and 16 also selectively bound terpenoid *** par-ticular,the three SmosOBPs had high binding affinities(Ki<20μmol/L)to 3-hexanol and cis-3-hexenylacetate that elicited strong electroantennogram(EAG)response fromfemale *** addition,SmosOBP11 displayed significantly higher binding(Ki<8μmo/L)than SmosOBP16 and 21 to l-octen-3-ol,D-panthenol,a-pinene and heptyl acetate which elicited significant EAG response,suggesting that SmosOBP11 plays a ma-jor role in recognition and transportation of these *** findings have provided important insight into the molecular mechanism by which *** specifically rec-ognizes plant volatiles for host selection,and have facilitated identification of effective volatile attractants that are potentially useful for pest monitoring and trapping.

关键词： binding assay electroantennogram response host selection odorant-binding protein Sitodiplosis mosellana wheat spike violates