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Chlorinated butyl rubber/two-step modified montmorillonite nanocomposites:Mechanical and damping properties

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Chinese Journal of Chemical Engineering 2022年第2期35卷 437-449页

作者： keya Tang Jincheng Wang College of Chemistry and Chemical Engineering Shanghai University of Engineering ScienceShanghai 201620China

Montmorillonite(MMT) was modified by ultrasound and castor oil quaternary ammonium salt intercalation method to prepare a new type of organic montmorillonite(OMMT). The surface structure, particle morphology, interlayer distance, and thermal behavior of the samples obtained were characterized. The modified OMMT was then added to chlorinated butyl rubber(CIIR) by mechanical blending, and a composite material with excellent damping properties was obtained. The mechanical experiment results of CIIR nanocomposites showed that the addition of OMMT improved their tensile strength, hardness,and stress relaxation rate. Compared with pure CIIR, when the content of OMMT was 5 phr(part per hundred of rubber), the tensile strength of the nanocomposite was increased by 677% and the elongation at break was also increased by 105.4%. The enhancement of this performance was mainly due to the dispersion of the nanosheets in CIIR rubber and the chemical interaction between the organoclay and the polymer matrix, which was confirmed by morphology and spectral analysis. OMMT also endowed a positive effect on the damping properties of CIIR nanocomposites. After adding 5 phr of OMMT, the nanocomposite owned the best damping performance, and the damping factor, tanδmax, was 37.9% higher than that of pure CIIR. Therefore, the good damping and mechanical properties of these CIIR nanocomposites provided some novel and promising methods for preparing high-damping rubber in a wide temperature range.

关键词： Montmorillonite Nanostructure Chlorinated butyl rubber Polymer processing Composites

Membranous nephropathy associated with tuberculosis-a case report

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Asian Pacific Journal of Tropical Medicine 2022年第4期15卷 183-185页

作者： Madhumita Pal Moumita Sengupta keya Basu Arpita Roychowdhury Department of Pathology IPGME&R and SSKM HospitalKolkataIndia Department of Nephrology IPGME&R and SSKM HospitalKolkataIndia

Rationale:Genitourinary tuberculosis can develop during the disease course of disseminated disease and the distinctive histological finding is epithelioid granuloma with or without caseation and accompanied Langhans-type giant cells.Barely,the lesion is only restricted to kidney involving both glomerular and extraglomerular compartment.Association with immune complex-mediated glomerulonephritis has been sparsely reported in the literature.Patient concern:A 42-year-old non-diabetic,non-hypertensive male presented with generalized body swelling and frothing of urine for 3 months.Diagnosis:Membranous nephropathy with tuberculous interstitial nephritis.Intervention:Anti-tuberculous therapy for extrapulmonary tuberculosis was administered along with low dose corticosteroid.Outcomes:Reduction of proteinuria was achieved at one month follow-up visit.Lessons:Tuberculosis should be considered as a potentially treatable cause of secondary membranous nephropathy as pharmacotherapy greatly helps improve the outcome.

关键词： Tuberculosis Membranous nephropathy Renal biopsy

Time-dependent diffusive interactions between dark matter and dark energy in the context of k-essence cosmology

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Research in Astronomy and Astrophysics 2021年第1期21卷 15-24页

作者： Abhijit bandyopadhyay Anirban Chatterjee Department of Physics Ramakrishna Mission Vivekananda Educational and Research InstituteBelur MathHowrah 711202India

We investigated the scenario of time-dependent diffusive interaction between dark matter and dark energy and showed that such a model can be accommodated within the observations of luminosity distanceredshift data in Supernova la(SN la)observations.We obtain constraints on different relevant parameters of this model from the observational data.We consider a homogeneous scalar field(t)driven by a k-essence Lagrangian of the form L=V(φ)F(X)with constant potential V(φ)=V,to describe the dynamics of dark energy in this model.Using the temporal behaviour of the FRW scale factor,the equation of state and total energy density of the dark fluid,extracted from the analysis of SN la(JLA)data,we have obtained the time-dependence of the k-essence scalar field and also reconstructed the form of the function F(X)in the k-essence Lagrangian.

关键词： Dark Energy Dark Matter k-essence

Spatiotemporal dynamics of the microbial diversity on salt-preserved goatskins assessed by culturing and 16S rRNA gene amplicon sequencing

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Journal of Leather Science and Engineering 2022年第1期4卷 440-451页

作者： Xiaoguang Li keya Sen Yuqin Zhang Yongqiang Tian Bi Shi Author details 1 Key Laboratory of Leather Chemistry and Engineering Ministry of Education and College of Biomass Science and EngineeringSichuan UniversityChengdu 610065People’s Republic of China Division of Biological Sciences STEMUniversity of WashingtonBothellWA 98011USA Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050People’s Republic of China

Wet-salted skin,as a special artificial high-salt environment,is rich in protein,fat,collagen and other nutrient substrates,and is a rich resource of halotolerant and halophilic microorganisms.However,knowledge gaps regarding the microbial community structure and inter taxa associations of wet-salted skin are large.In this study,the spatiotemporal dynamics and community structure of microorganisms present on wet-salted goatskins were investigated using 16S rRNA gene amplicon sequencing and culturable technique.Alpha diversity analysis based on Sobs,Chao,Ace and Shannon indices revealed that microbial diversity on the wet-salted goatskins exhibited a trend of‘down→up→down→flat’with time.During preservation,genera belonging to the bacteria domain such as Aci-netobacter,Weissella and Streptococcus were slowly dying out,whereas those belonging to halophilic archaea such as Natrialba and Haloterrigena were gradually flourishing.Moreover,to resist high-salt stress,microorganisms on the wet-salted goatskin gradually migrated from the outside to the inside,eventually leading to the microbial diversity inside the skin being the same as or even higher than that on the skin surface.Venn diagram analysis revealed that the strains of some genera,including Psychrobacter,Salimicrobium,Salinicola,Ornithinibacillus,Halomonas,Bacillus and Chromohalobacter,were distributed throughout the interior and exterior of the wet-salted goatskin and existed during various periods.Accordingly,45 protease-producing halophilic or halotolerant microorganisms were isolated and screened from the wet-salted goatskin using the gradient dilution plate method.Importantly,16S rRNA genes of some bacteria exhibited less than 99.5%similarity to valid published species,indicating that they likely are novel spe-cies and have a good potential for application.

关键词： Wet-salted skin Spatiotemporal dynamics Community structure 16S rRNA gene amplicon sequencing

Engineered magnetic core shell nanoprobes:Synthesis and applications to cancer imaging and therapeutics

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World Journal of Biological Chemistry 2016年第1期7卷 158-167页

作者： Samir Mandal keya Chaudhuri Molecular and Human Genetics Division CSIR-Indian Institute of Chemical Biology

Magnetic core shell nanoparticles are composed of a highly magnetic core material surrounded by a thin shell of desired drug, polymer or metal oxide. These magnetic core shell nanoparticles have a wide range of applications in biomedical research, more specifically in tissue imaging, drug delivery and therapeutics. The present review discusses the up-to-date knowledge on the various procedures for synthesis of magnetic core shell nanoparticles along with their applications in cancer imaging, drug delivery and hyperthermia or cancer therapeutics. Literature in this area shows that magnetic core shell nanoparticle-based imaging, drug targeting and therapy through hyperthermia can potentially be a powerful tool for the advanced diagnosis and treatment of various cancers.

关键词： Magnetic core shell nanoparticles Magnetic resonance imaging Cancer therapeutics Drug delivery Hyperthermia

Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization:State-of-the-art in bone and associated tissue regeneration

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Bioactive Materials 2023年第10期28卷 284-310页

作者： Sayan Deb Dutta Tejal V.Patil keya Ganguly Aayushi Randhawa Ki-Taek Lim Department of Biosystems Engineering Kangwon National UniversityChuncheon24341Republic of Korea Institute of Forest Science Kangwon National UniversityChuncheon24341Republic of Korea Interdisciplinary Program in Smart Agriculture Kangwon National UniversityChuncheon24341Republic of Korea

Macrophage-assisted immunomodulation is an alternative strategy in tissue engineering, wherein the interplay between pro-inflammatory and anti-inflammatory macrophage cells and body cells determines the fate of healing or inflammation. Although several reports have demonstrated that tissue regeneration depends on spatial and temporal regulation of the biophysical or biochemical microenvironment of the biomaterial, the underlying molecular mechanism behind immunomodulation is still under consideration for developing immunomodulatory scaffolds. Currently, most fabricated immunomodulatory platforms reported in the literature show regenerative capabilities of a particular tissue, for example, endogenous tissue (e.g., bone, muscle, heart, kidney, and lungs) or exogenous tissue (e.g., skin and eye). In this review, we briefly introduced the necessity of the 3D immunomodulatory scaffolds and nanomaterials, focusing on material properties and their interaction with macrophages for general readers. This review also provides a comprehensive summary of macrophage origin and taxonomy, their diverse functions, and various signal transduction pathways during biomaterial-macrophage interaction, which is particularly helpful for material scientists and clinicians for developing next-generation immunomodulatory scaffolds. From a clinical standpoint, we briefly discussed the role of 3D biomaterial scaffolds and/or nanomaterial composites for macrophage-assisted tissue engineering with a special focus on bone and associated tissues. Finally, a summary with expert opinion is presented to address the challenges and future necessity of 3D bioprinted immunomodulatory materials for tissue engineering.

关键词： Macrophage Immunomodulation Biomaterials 3D bioprinting Tissue engineering

From occupants to occupants:A review of the occupant information understanding for building HVAC occupant-centric control

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Building Simulation 2022年第6期15卷 913-932页

作者： Tao Yang Arkasama bandyopadhyay Zheng O’Neill Jin Wen Bing Dong mike walker’66 department of mechanical engineering texas a&m universitycollege stationtx77843usa department of civil architectural&environmental engineeringdrexel universityphiladelphiapa19104usa department of mechanical and aerospace engineering syracuse universitysyracuseny13244usa

Occupants are the core of the built environment.Traditional heating,ventilation,and air-conditioning(HVAC)systems operate with predefined schedules and maximum occupancy assumptions with no consideration of specific occupant information.These generalized assumptions usually do not align with the actual demand and result in over-conditioning and occupant discomfort.In recent years,with the aid of Information&Communication Technology(ICT)and Computer Science(CS),it is possible to acquire real-time and accurate occupant information to satisfy the exact thermal requirement through specific HVAC control in one particular built environment.This mechanism is called HVAC“Occupant-centric Control(OCC).”HVAC OCC strategy starts with collecting the occupant’s information(e.g.,presence/absence)and then applies it to meet the occupant’s requirement(e.g.,thermal comfort).However,even though some research studies and field pilot demonstrations have been devoted to the field of OCC,there is a lack of systematic knowledge about occupant data,which is the principal component of OCC for HVAC researchers and practitioners.To fill this gap,this review paper discusses OCC with a particular emphasis on occupant information and investigates how this information can assist HVAC operation in providing an acceptable built environment in required spaces during the required time.We provide a fine-grained,comprehensive picture of occupant information,discuss its features,the modalities of information feed-in into the HVAC control,and the application of commonly utilized occupant information for OCC.

关键词： occupant information occupant-centric control smart building HVAC energy efficiency

Heterozygous lipoprotein lipase knockout mice exhibit impaired hematopoietic stem/progenitor cell compartment

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Animal Models and Experimental Medicine 2021年第4期4卷 418-425页

作者： Guiying Shi Xinyue Li keya Li Yiying Huang Xuepei Lei Lin Bai Chuan Qin The Institute of Laboratory Animal Sciences CAMS&PUMCBeijing Engineering Research Center for Experimental Animal Models of Human Critical DiseasesBeijingP.R.China

Background : Hematopoietic stem cells (HSC) maintain the hematopoietic system homeostasis through self- renewal and multilineage differentiation potential. HSC are regulated by the microenvironment, cytokine signaling, and transcription factors. Recent results have shown that lipid pathways play a key role in the regulation of HSC quiescence, proliferation, and division. However, the mechanism by which lipid metabolism regulates HSC proliferation and differentiation remains to be clarified. Lipoprotein lipase (LPL) is an essential enzyme in the anabolism and catabolism of very low- density lipoprotein, chylomicrons, and triglyceride- rich lipoproteins. Methods : The percentage of hematopoietic stem/progenitor cells and immune cells were determined by fluorescence- activated cell sorting (FACS). The function and the mechanism of HSCs were analyzed by cell colony forming assay and qPCR analysis. The changes in LPL^(+/−) HSC microenvironment were detected by transplantation as- says using red fluorescent protein (RFP) transgenic mice. Results : To explore the function of LPL in HSC regulation, heterozygous LPL- knockout mice (LPL^(+/−)) were established and analyzed by FACS. LPL^(+/−) mice displayed decreased hematopoietic stem/progenitor cell compartments. In vitro single- cell clono- genic assays and cell-cycle assays using FACS promoted the cell cycle and increased proliferation ability. qPCR analysis showed the expression of p57^(KIP2) and p21^(WAF1)/ ^(CIP1) in LPL^(+/−) mice was upregulated. Conclusions : LPL^(+/−) mice exhibited HSC compartment impairment due to promotion of HSC proliferation, without any effects on the bone marrow (BM) microenvironment.

关键词： cell cycle HSCs LPL

Study of Ce-modified antibacterial 316L stainless steel

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China Foundry 2012年第4期9卷 307-312页

作者： Yuan Junping Li Wei Shen keya Material Science and Engineering Department Jinan University Guangzhou 510632 China Jewelry Institute of Guangzhou Panyu Polytechnic Guangzhou 511483 China

316L stainless steel is widely used for fashion jewelry, but it can carry a large number of bacteria and bring the risk of infection since the steel has no antimicrobial performance. In this paper, the effects of Ce on the antibacterial property, corrosion resistance and processability of 316L were studied by microscopic observation, thin- film adhering quantitative bacteriostasis, and electrochemical and mechanical tests. The results show that a trace of Ce can distribute uniformly in the matrix of 316L and slightly improve its corrosion resistance in artificial sweat. With an increase in Ce content, the Ce is prone to form clustering, which degrades the corrosion resistance and the processability. The Ce-containing 316L exhibits Hormesis effect against S. aureus. A small Ce addition stimulates the growth of S. aureus. As the Ce content increases, the modified 316L exhibits an improved antibacterial efficacy. The more Ce is added, the better antibacterial capability is achieved. Overall, if the 316L is modified with Ce alone, it is difficult to obtain the optimal combination of corrosion resistance, antibacterial performance and processability. In spite of that, 0.15 wt.%-0.20 wt.% Ce around is inferred to be the best trade-off.

关键词：金属材料不锈钢钢材组织结构