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D'argile et de feu:la céramique de Chengdu

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今日中国（法文版） 2022年第7期60卷 72-75页

作者： li kexin 不详

L'art de la céramique en Chine,avec ses 3000 ans d’histoire,est à l’honneur dans certaines boutiques de Chengdu avec des créations qui entrent dans les foyers.Ces boutiques forment un écosystème culturel et touristique unique permettant de transmettre cet art dans des espaces insolites et de faire connaître les ateliers antiques comme ceux des créateurs.

关键词： des les Chengdu

益心舒片联合美托洛尔对冠心病心绞痛患者心功能、血液流变学和血管内皮功能的影响

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现代生物医学进展 2024年第1期24卷 117-120页

作者：王婷程秋雁张俐可欣胡楠黄海涛南京市中心医院药学部江苏南京210000 常州市第一人民医院药学部江苏常州213000

目的:探讨益心舒片联合美托洛尔对冠心病心绞痛患者心功能、血液流变学和血管内皮功能的影响。方法:纳入南京市中心医院2020年7月~2022年8月期间收治的冠心病心绞痛患者126例。采用随机数字表法分为对照组(n=63,接受美托洛尔治疗)和研究... 详细信息

目的:探讨益心舒片联合美托洛尔对冠心病心绞痛患者心功能、血液流变学和血管内皮功能的影响。方法:纳入南京市中心医院2020年7月~2022年8月期间收治的冠心病心绞痛患者126例。采用随机数字表法分为对照组(n=63,接受美托洛尔治疗)和研究组(n=63,对照组基础上接受益心舒片治疗)。对比两组临床症状、心功能[左心室射血分数(LVEF)、心输出量(CO)、左室舒张末期内径(LVEDD)]、血液流变学[血浆黏度、全血高切黏度、全血低切黏度]和血管内皮功能[一氧化氮(NO)、内皮素-1(ET-1)]变化情况,同时观察两组不良反应发生率。结果:两组治疗12周后心绞痛发作次数减少,心绞痛持续时间缩短,研究组的改善幅度大于对照组(P0.05)。结论:益心舒片联合美托洛尔治疗冠心病心绞痛患者,可有效改善患者的血液流变学、心功能和血管内皮功能。

关键词：益心舒片美托洛尔冠心病心绞痛心功能血液流变学血管内皮功能

First Record of Cyclocarya from the Early Oligocene Qaidam Basin,North Tibet:Implications for the Paleogeography and Paleoecology

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Journal of Earth Science 2024年第1期35卷 201-211页

作者： Yafei Hou Bowen Song Xiangchuan li Fang Han Xu Zhang kexin Zhang Institute of Geological Survey China University of GeosciencesWuhan 430074China Faculty of Materials Science and Chemistry China University of GeosciencesWuhan 430074China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China College of Earth Sciences and Resources&Key Laboratory of Western Mineral Resources and Geological Engineering of the Ministry of Education Chang'an UniversityXi'an 710054China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China School of Earth Sciences East China University of TechnologyNanchang 330013China

As the largest intermontane basin in the northeastern Tibetan Plateau(TP),the Qaidam Basin provides unique insight into paleoclimatic change and its relationship with global change and uplift on the TP.In this study,based on morphological comparison,fossil fruit of Cyclocarya from the Early Oligocene Shangganchaigou Formation in the Qaidam Basin is assigned as Cyclocarya cf.weylandii.The discovery of Cyclocarya cf.weylandii demonstrates the occurrence of Cyclocarya in the Oligocene sediment in Qaidam Basin.This is the first record of Cyclocarya fossil of Early Oligocene Age in China and indicates that Cyclocarya has existed on the northeastern TP since at least the Early Oligocene.The living analogues of the current fossil now lives in sub-tropical China,where the East Asian Monsoon is prevalent.Integrating the new fossils and previously reported fossil remains of plants and fishes,it can be inferred that the Early Oligocene Qaidam Basin was primarily influenced by westerly circulation and had a relatively warm and humid climate,which was in sharp contrast to the present-day climate in Qaidam Basin.

关键词： biostratigraphy climate change winged-fruit fossil Qaidam Basin Early Oligocene paleoclimate paleogeography

Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia

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Virologica Sinica 2024年第1期39卷 31-43页

作者： Dongyan Zhang Xiulin Wu Xing Xue Wenshi li Ping Zhou Zhao Lv kexin Zhao Fan Zhu State Key Laboratory of Virology and Department of Medical Microbiology School of Basic Medical SciencesWuhan UniversityWuhan430071China Hubei Province Key Laboratory of Allergy&Immunology Wuhan UniversityWuhan430071China

Human endogenous retroviruses(HERVs)are remnants of retroviral infections in human germline cells from millions of years ago.Among these,ERVW-1(also known as HERV-W-ENV,ERVWE1,or ENVW)encodes the envelope protein of the HERV-W family,which contributes to the pathophysiology of schizophrenia.Additionally,neuropathological studies have revealed cell death and disruption of iron homeostasis in the brains of individuals with schizophrenia.Here,our bioinformatics analysis showed that differentially expressed genes in the human prefrontal cortex RNA microarray dataset(GSE53987)were mainly related to ferroptosis and its associated pathways.Clinical data demonstrated significantly lower expression levels of ferroptosis-related genes,particularly Glutathione peroxidase 4(GPX4)and solute carrier family 3 member 2(SLC3A2),in schizophrenia patients compared to normal controls.Further in-depth analyses revealed a significant negative correlation between ERVW-1 expression and the levels of GPX4/SLC3A2 in schizophrenia.Studies indicated that ERVW-1 increased iron levels,malondialdehyde(MDA),and transferrin receptor protein 1(TFR1)expression while decreasing glutathione(GSH)levels and triggering the loss of mitochondrial membrane potential,suggesting that ERVW-1 can induce ferroptosis.Ongoing research has shown that ERVW-1 reduced the expression of GPX4 and SLC3A2 by inhibiting their promoter activities.Moreover,Ferrostatin-1(Fer-1),the ferroptosis inhibitor,reversed the iron accumulation and mitochondrial membrane potential loss,as well as restored the expressions of ferroptosis markers GSH,MDA,and TFR1 induced by ERVW-1.In conclusion,ERVW-1 could promote ferroptosis by downregulating the expression of GPX4 and SLC3A2,revealing a novel mechanism by which ERVW-1 contributes to neuronal cell death in schizophrenia.

关键词： ERVW-1 Glutathione peroxidase 4(GPX4) Solute carrier family 3 member 2(SLC3A2) Ferroptosis Schizophrenia

Insights into sensitizing and eliciting capacity of gastric and gastrointestinal digestion products of shrimp(Penaeus vannamei)proteins in BALB/c mice

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Food Science and Human Wellness 2024年第1期13卷 339-348页

作者： Yao liu Songyi lin kexin liu Shan Wang Wang li Na Sun National Engineering Research Center of Seafood School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

Shrimp(Penaeus vannamei)proteins have been shown an allergenic potential;however,little information is available on the sensitizing and eliciting capacity of shrimp protein digestion products.In this study,a BALB/c mice model was used to explore the allergenicity of shrimp protein sample(SPS)and their gastric and gastrointestinal digestion products(GDS/GIDS).As compared with the SPS groups,the GDS/GIDS groups caused lower specific immunoglobulins(Ig E/Ig G1)levels(Plity and histopathological changes of tissues were alleviated.Nevertheless,the allergenicity of digestion products cannot be eliminated and still cause systemic allergic reactions in mice.The study showed that the digestion products of shrimp still had high sensitizing and eliciting capacity.

关键词： Penaeus vannamei Allergenicity Digestion BALB/c mice model

Hexamerin and allergen are required for female reproduction in the American cockroach,Periplaneta americana

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Insect Science 2024年第1期31卷 186-200页

作者： Shiming Zhu Xiaoyi Chen Sishi Xia Qin li Ziqi Ye Shaoting Zhao kexin liu Fangfang liu Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and TechnologyInstitute of Insect Science and Technology&School of Life SciencesSouth China Normal UniversityGuangzhouChina Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouGuangdong ProvinceChina Guangdong Laboratory for lingnan Modern Agriculture South China Agricultural UniversityGuangzhouChina

Reproduction is of great importance for the continuation of the species.In insects,the fat body is the major tissue for nutrient storage and involved in vitellogenesis,which is essential for female reproduction.Here,2 proteins,hexamerin and allergen,were separated from the fat bodies of adult female American cockroaches(Periplaneta americana)and identified as storage proteins,encoding for 733 amino acids with molecular weight of 87.88 kDa and 686 amino acids with molecular weight of 82.18 kDa,respectively.The encoding genes of these 2 storage proteins are mainly expressed in the fat body.RNA interference-mediated knockdown of Hexamerin and Allergen in the early stage of the first reproductive cycle in females suppressed vitellogenesis and ovarian maturation,indicating that these storage proteins are involved in controlling reproduction.Importantly,the expression of Hexamerin and Allergen was repressed by knockdown of the juvenile hormone(JH)receptor gene Met and the primary response gene Kr-h1,and was induced by methoprene,a JH analog,in both in vivo and in vitro experiments.Altogether,we have determined that hexamerin and allergen are identified as storage proteins and play an important role in promoting female reproduction in the American cockroach.The expression of their encoding genes is induced by JH signaling.Our data reveal a novel mechanism by which hexamerin and allergen are necessary for JH-stimulated female reproduction.

关键词： fat body juvenile hormone ovary reproduction storage protein vitellogenesis

Si-Wu-Tang attenuates liver fibrosis via regulating lncRNA H19-dependent pathways involving cytoskeleton remodeling and ECM deposition

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Chinese Journal of Natural Medicines 2024年第1期22卷 31-46页

作者： QU Jiaorong XUE Xiaoyong WANG Zhixing MA Zhi JIA kexin li Fanghong ZHANG Yinhao WU Ruiyu ZHOU Fei ZHAO Piwen li Xiaojiaoyang School of life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China

liver fibrosis is a dynamic wound-healing response characterized by the agglutination of the extracellular matrix(ECM).Si-Wu-Tang(SWT),a traditional Chinese medicine(TCM)formula,is known for treating gynecological diseases and liver fibrosis.Our previous studies demonstrated that long non-coding RNA H19(H19)was markedly upregulated in fibrotic livers while its deficiency markedly reversed fibrogenesis.However,the mechanisms by which SWT influences H19 remain unclear.Thus,we established a bile duct ligation(BDL)-induced liver fibrosis model to evaluate the hepatoprotective effects of SWT on various cells in the liver.Our results showed that SWT markedly improved ECM deposition and bile duct reactions in the liver.Notably,SWT relieved liver fibrosis by regulating the transcription of genes involved in the cytoskeleton remodeling,primarily in hepatic stellate cells(HSCs),and influencing cytoskeleton-related angiogenesis and hepatocellular injury.This modulation collectively led to reduced ECM deposition.Through extensive bioinformatics analyses,we determined that H19 acted as a miRNA sponge and mainly inhibited miR-200,miR-211,and let7b,thereby regulating the above cellular regulatory pathways.Meanwhile,SWT reversed H19-related miRNAs and signaling pathways,diminishing ECM deposition and liver fibrosis.However,these protective effects of SWT were diminished with the overexpression of H19 in vivo.In conclusion,our study elucidates the underlying mechanisms of SWT from the perspective of H19-related signal networks and proposes a potential SWT-based therapeutic strategy for the treatment of liver fibrosis.

关键词： liver fibrosis LncRNA H19 Si-Wu-Tang miRNAs Cytoskeleton ECM deposition

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冷等离子体处理在食品中的应用研究进展

食品研究与开发 2024年第12期45卷 181-188页

作者：刘非凡温纪平展小彬石松业李柯新唐浩洁河南工业大学粮油食品学院河南郑州450001 河南工业大学小麦理论与技术研究所河南郑州450001 河南工业大学国家小麦加工技术研发专业中心河南郑州450001

冷等离子体作为一种新兴的非热处理技术,因其具有降菌保鲜、改善食品原料加工品质、延长食品货架期和绿色安全等优点,在食品工业中得到广泛研究。该文对冷等离子体的概念、原理和作用机制以及冷等离子体在谷物、果蔬、水产品、肉制品和... 详细信息

冷等离子体作为一种新兴的非热处理技术,因其具有降菌保鲜、改善食品原料加工品质、延长食品货架期和绿色安全等优点,在食品工业中得到广泛研究。该文对冷等离子体的概念、原理和作用机制以及冷等离子体在谷物、果蔬、水产品、肉制品和乳制品等方面的应用进行概述,以期为提高食品的质量、安全和延长食品的保质期提供参考依据。

关键词：冷等离子体食品工业降菌食品保鲜货架期

网络文学作品对大学生出游意愿的影响--基于情节叙述、人物形象、作品类型的分析

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西安石油大学学报（社会科学版） 2024年第3期33卷 58-65页

作者：刘笑明罗洋曾才容魏雨可陈玉琳李可欣西安石油大学经济管理学院陕西西安710065

以大学生为研究对象,发放调查问卷并应用SPSS软件和AMOS Graphics软件进行整体分析,研究网络文学作品中情节叙述、人物形象、作品类型3个因素对大学生出游意愿的影响。结果表明,情节叙述对大学生出游意愿影响最大,精彩情节会对心理距离... 详细信息

以大学生为研究对象,发放调查问卷并应用SPSS软件和AMOS Graphics软件进行整体分析,研究网络文学作品中情节叙述、人物形象、作品类型3个因素对大学生出游意愿的影响。结果表明,情节叙述对大学生出游意愿影响最大,精彩情节会对心理距离产生正面影响,提升出游意愿;人物形象正向、饱满时会对心理距离产生正面影响,提升出游意愿;作品类型对出游意愿的影响与受众读者相关,当读者表现出对某作品类型感兴趣时,出游意愿会提升。提出借助网络文学作品塑造旅游地的形象,挖掘作品中的旅游资源,同时注重网络文学作品的社会责任。

关键词：网络文学作品情节叙述人物形象作品类型出游意愿心理距离