检索结果-南通市图书馆

基于meta分析的鸦胆子油乳注射液联合长春瑞滨联合顺铂/卡铂方案治疗非小细胞肺癌临床效果和安全性

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

中国当代医药 2024年第7期31卷 7-13页

作者：李珂心袁晓燕李明娟张珞喻施蕾李欣坪大理大学药学院云南大理671003 四川省攀枝花市中心医院药学部四川攀枝花617067

目的系统评价鸦胆子油乳注射液联合长春瑞滨联合顺铂/卡铂(NP)方案化疗治疗非小细胞肺癌(NSCLC)的临床疗效和安全性。方法检索中国知网、SinoMed、VIP、万方数据库、the Cochrane library、PubMed、Embase数据库,搜索有关鸦胆子油乳注... 详细信息

目的系统评价鸦胆子油乳注射液联合长春瑞滨联合顺铂/卡铂(NP)方案化疗治疗非小细胞肺癌(NSCLC)的临床疗效和安全性。方法检索中国知网、SinoMed、VIP、万方数据库、the Cochrane library、PubMed、Embase数据库,搜索有关鸦胆子油乳注射液联合NP化疗治疗NSCLC的随机对照试验,检索时限均为从建库至2023年5月22日,由2名研究者独立筛选文献,提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.4.1及Stata 15.1软件进行meta分析和发表偏倚检验。结果共纳入12项随机对照试验,累计801例患者。Meta分析结果显示,对比仅使用NP化疗方案,鸦胆子油乳注射液联合NP方案化疗治疗NSCLC可提高临床受益率(RR=2.00,95%CI=1.34~2.98,P=0.0006),症状总改善率(RR=1.53,95%CI=1.19~1.96,P=0.0009)和生活质量改善率(RR=2.58,95%CI=1.95~3.41,P<0.00001),降低患者白细胞减少发生率(RR=0.73,95%CI=0.62~0.86,P<0.0001)。结论联合用药方案相较于单用NP化疗方案疗效更佳,且可提高患者临床受益率、症状总改善率,改善患者生活质量,增强患者免疫功能。但本研究结论仍需未来多中心、大样本随机盲法试验数据的支持。

关键词：鸦胆子油乳注射液非小细胞肺癌 NP化疗方案 meta分析

Understanding the Relationship Between Shrinking Cities and Land Prices:Spatial Pattern,Effectiveness,and Policy Implications

在线全文

学校读者我要写书评

暂无评论

Chinese Geographical Science 2024年第1期34卷 1-18页

作者： WANG Xiaohui PENG li HUANG kexin DENG Wei College of Geography and Resources Sichuan Normal UniversityChengdu610101China Key Laboratory of Land Resources Evaluation and Monitoring in Southwest Ministry of EducationSichuan Normal UniversityChengdu610101China

Urban shrinkage has emerged as a widespread phenomenon globally and has a significant impact on land,particularly in terms of land use and price.This study focuses on 2851 county-level cities in China in 2005–2018(excluding Hong Kong,Macao,Taiwan,and‘no data’areas in Qinhai-Tibet Plateau)as the fundamental units of analysis.By employing nighttime light(NTL)data to identify shrinking cities,the propensity score matching(PSM)model was used to quantitatively examine the impact of shrinking cities on land prices,and evaluate the magnitude of this influence.The findings demonstrate the following:1)there were 613 shrinking cities in China,with moderate shrinkage being the most prevalent and severe shrinkage being the least.2)Regional disparities are evident in the spatial distribution of shrinking cities,especially in areas with diverse terrain.3)The spatial pattern of land price exhibits a significant correlated to the economic and administrative levels.4)Shrinking cities significantly negatively impact on the overall land price(ATT=–0.1241,P<0.05).However,the extent of the effect varies significantly among different spatial regions.This study contributes novel insights into the investigation of land prices and shrinking cities,ultimately serving as a foundation for government efforts to promote the sustainable development of urban areas.

关键词： shrinking cities land price propensity score matching(PSM) relative effectiveness China

Bureaucratic Culture and Innovation

在线全文

学校读者我要写书评

暂无评论

China & World Economy 2024年第3期32卷 31-66页

作者： Shigang li kexin She li Zhang International School of Business and Finance Sun Yat-sen UniversityChina National School of Development Peking UniversityChina International School of Business and Finance Key Laboratory of Mesoeconomics and Coordinated Development of Regions and IndustriesSun Yat-sen UniversityChina

This study explores the effects of bureaucratic culture on innovation.We define bureaucratic culture as a culture in which power and officials are held in the highest regard.Using panel data of publicly listed Chinese manufacturing firms from 2007 to 2015,we found that bureaucratic culture negatively correlated with firms'patent output.A mechanism analysis shows that bureaucratic culture hindered corporate innovation by reducing firms'research and development inputs and decreasing innovation efficiency.Furthermore,we provided evidence that anti-corruption campaigns and the development of formal institutions could neutralize the negative impact of bureaucratic culture on corporate innovation.This study is the first to investigate quantitatively the causal effect of bureaucratic culture on corporate innovation and it can deepen the understanding of the relationship between culture and innovation in China.We speculate that promoting a creative culture,particularly one that fosters entrepreneurial spirit,is of utmost importance.

关键词： bureaucratic culture corporate innovation economic growth talent allocation

Incidence and Mortality of Cancers in Female Genital Organs—China,2022

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China CDC weekly 2024年第10期6卷 195-202,I0003,I0004页

作者： kexin Sun Bingfeng Han Hongmei Zeng Shaoming Wang li li Ru Chen Rongshou Zheng Wenqiang Wei National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Introduction:This study presented the incidence and mortality rates of cancers affecting the female genital organs in China,along with their trends spanning from 2010 to 2018.Methods:700 population-based cancer registries provided relevant cancer incidence and mortality data for the year 2018.Among these,106 registries had continuous monitoring data suitable for trend analysis from 2010 to 2018.We focused specifically on cancers affecting female genital organs(ICD10=C51-C54,C56)and projected their incidences and mortalities in China for 2022 based on data from 2018 and the trends observed from 2010 to 2018.Age-standardized incidence rate(ASIR)and mortality rate(ASMR)were calculated using Segi’s world standard population.Results:In 2022,there were an estimated 296,300 new cases and 104,900 deaths from female cancers in China.ASIRs for vulva(C51),vagina(C52),cervix uteri(C53),corpus uteri(C54),and ovary(C56)were 0.32,0.23,13.83,6.84,and 5.68 per 100,000 population.ASIRs for corpus uteri and ovary cancers were higher in urban areas.ASMRs for vulva,vagina,cervix,corpus uteri,and ovary cancers were 0.14,0.08,4.54,1.05,and 2.64 per 100,000 population,respectively.ASMR for ovarian cancer was higher in urban areas.ASIRs and ASMRs for most female genital organ cancers increased from 2010 to 2018,although the rate of increase for vulvar and cervical cancers in rural areas has slowed recently.Conclusions:Tailored cancer prevention and control programs specific to each region are necessary to address the growing disease burden.

关键词： ICD10 mortality organs

基于同位素的神东矿区植物吸水深度及生态水位研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

煤炭工程 2024年第4期56卷 199-203页

作者：赫云兰杨英明王玺凯李可新房鲁鹭刘卓鸣中国矿业大学(北京)煤炭精细勘探与智能开发全国重点实验室北京100083 国家能源集团煤炭开采水资源保护与利用国家重点实验室北京100011 中国矿业大学(北京)地球科学与测绘工程学院北京100083

为了研究神东矿区煤炭开采造成的地下水位下降是否会对地表植被的生存产生威胁,以神东矿区分布最广泛的植物沙蒿为研究对象,采用水稳定同位素示踪技术研究神东矿区成年沙蒿的根系吸水深度,通过MixSIAR同位素混合模型分析成年沙蒿的土壤... 详细信息

为了研究神东矿区煤炭开采造成的地下水位下降是否会对地表植被的生存产生威胁,以神东矿区分布最广泛的植物沙蒿为研究对象,采用水稳定同位素示踪技术研究神东矿区成年沙蒿的根系吸水深度,通过MixSIAR同位素混合模型分析成年沙蒿的土壤水分吸收策略。结果显示,研究区成年沙蒿的吸水的极限深度为2.5~3 m,沙蒿会较均匀的吸收不同深度的土壤水分,但其水分利用策略也会受到土壤含水率高低的影响。该研究揭示了研究区成年沙蒿的根系吸水深度和水分利用策略,从植物角度说明了该区域生态水位的下限是2.5~3 m。

关键词：同位素半干旱煤矿区根系吸水深度植物水分利用生态水位

Overcoming neutrophil-induced immunosuppression in postoperative cancer therapy: Combined sialic acid-modified liposomes with scaffold-based vaccines

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 153-169页

作者： Cong li lihong Wang kexin Zhang Zeyu Wang Zhihang li Zehao li lijiang Chen School of Pharmaceutical Science Liaoning UniversityShenyang 110036China

Immunotherapy is a promising approach for preventing postoperative tumor recurrence and metastasis. However, inflammatory neutrophils, recruited to the postoperative tumor site, have been shown to exacerbate tumor regeneration and limit the efficacy of cancer vaccines. Consequently, addressing postoperative immunosuppression caused by neutrophils is crucial for improving treatment outcomes. This study presents a combined chemoimmunotherapeutic strategy that employs a biocompatible macroporous scaffold-based cancer vaccine (S-CV) and a sialic acid (SA)-modified, doxorubicin (DOX)-loaded liposomal platform (DOX@SAL). The S-CV contains whole tumor lysates as antigens and imiquimod (R837, Toll-like receptor 7 activator)-loaded PLGA nanoparticles as immune adjuvants for cancer, which enhance dendritic cell activation and cytotoxic T cell proliferation upon localized implantation. When administered intravenously, DOX@SAL specifically targets and delivers drugs to activated neutrophils in vivo, mitigating neutrophil infiltration and suppressing postoperative inflammatory responses. In vivo and vitro experiments have demonstrated that S-CV plus DOX@SAL, a combined chemo-immunotherapeutic strategy, has a remarkable potential to inhibit postoperative local tumor recurrence and distant tumor progression, with minimal systemic toxicity, providing a new concept for postoperative treatment of tumors.

关键词： Postoperative tumor treatment Immunotherapy Scaffold-based cancer vaccine Inflammatory neutrophils Sialic acid-modied liposome

80例中国东部沿海某医院食管癌患者代谢指标特点及临床意义

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

老年医学与保健 2024年第3期30卷 662-665页

作者：于珍珍李轲鑫逄曜玮李昊燃李彬施新岗青岛市黄岛区中心医院消化内科山东青岛266555 中国人民解放军北部战区总医院消化内科辽宁沈阳110010 海军军医大学(第二军医大学)长海医院消化内科上海200433

目的旨在探讨食管癌患者代谢指标的变化及其与食管癌发生的相关性。方法选取2020年1月—2023年6月青岛市黄岛区中心医院食管癌患者80例,与同期健康体检者81例,分别纳入癌症组和对照组,收集他们的人口学特征及临床资料,检测血清总胆固醇(... 详细信息

目的旨在探讨食管癌患者代谢指标的变化及其与食管癌发生的相关性。方法选取2020年1月—2023年6月青岛市黄岛区中心医院食管癌患者80例,与同期健康体检者81例,分别纳入癌症组和对照组,收集他们的人口学特征及临床资料,检测血清总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、高密度脂蛋白(high-density lipoprotein,HDL)、低密度脂蛋白(low-density lipoprotein,LDL)、脂蛋白a(lipoprotein-a,LP-a)、尿酸(uric acid,UA)、血钙(calcium,Ca)等代谢指标水平,对比上述指标在2组间的差异,探讨血脂代谢水平、UA、Ca与食管癌的相关性。结果癌症组与对照组体质量指数(BMI)、TC、TG、LDL、Ca无统计学差异,与癌症组比差异有统计学意义的是饮酒史、吸烟史、LP-a、HDL、UA(P<0.05)。二元Logistic回归分析发现,食管癌的发生与吸烟有很大的关系,同时发现LP-a升高和UA降低与食管癌的发生发展密切相关。结论食管癌患者存在明显血脂代谢异常,其中吸烟史和LP-a是食管癌的危险因素,UA为食管癌的保护因素。

关键词：老年食管癌血脂代谢尿酸血钙

混合钎料对镍基单晶高温合金大间隙钎焊接头组织和性能的影响

在线全文

学校读者我要写书评

暂无评论

焊接 2024年第6期 1-8页

作者：贺彤王诗洋李可馨侯星宇孙元东北大学沈阳110819 中国科学院金属研究所沈阳110016

【目的】采用一种新型镍基钎料和母材成分一致的高熔点合金粉混合的方法制备出混合钎料,研究了添加的高熔点合金粉的粒径和配比对钎缝微观组织和力学性能的影响。【方法】采用扫描电子显微镜对钎焊接头的析出相、元素分布、微观组织进... 详细信息

【目的】采用一种新型镍基钎料和母材成分一致的高熔点合金粉混合的方法制备出混合钎料,研究了添加的高熔点合金粉的粒径和配比对钎缝微观组织和力学性能的影响。【方法】采用扫描电子显微镜对钎焊接头的析出相、元素分布、微观组织进行了分析,并对钎焊接头的硬度及持久性能进行了测试。【结果】研究表明,接头主要由钎料合金区(FAZ)、界面连接区(IBZ)和扩散影响区(DAZ)三部分组成。钎料合金区主要由M3B2和M8B型硼化物及γ/γ′相组成。界面连接区由γ和γ′沉淀强化相组成。当合金粉粒径为44μm和75μm时,均可得到无缺陷的焊接接头;但当合金粉粒径尺寸达177μm时,钎缝内会形成孔洞缺陷。【结论】随着合金粉比例的提高,接头连接区的显微硬度有所上升。当合金配比由30%到50%,接头的持久寿命由15 h增加至34 h;但进一步提升比例至60%时,接头的持久寿命下降至0.6 h。该文的结果可为实现高温热端零部件的连接和修复工程应用提供理论依据和参考价值。

关键词：镍基单晶高温合金混合粉末钎料大间隙钎焊持久性能

脑脉利颗粒联合依达拉奉右莰醇注射用浓溶液对急性脑梗死患者神经功能、血液流变学和氧化应激的影响

在线全文

学校读者我要写书评

暂无评论

现代生物医学进展 2024年第6期24卷 1077-1081页

作者：王婷耿闪张俐可欣胡楠黄海涛南京市中心医院药学部江苏南京210000 南京市中心医院神经内科江苏南京210000 常州市第一人民医院药学部江苏常州213000

目的:探讨脑脉利颗粒联合依达拉奉右莰醇注射用浓溶液对急性脑梗死(ACI)患者神经功能、血液流变学和氧化应激的影响。方法:选取南京市中心医院及常州市第一人民医院在2022年7月-2023年7月收治的ACI患者140例,根据随机数字表法将患者分... 详细信息

目的:探讨脑脉利颗粒联合依达拉奉右莰醇注射用浓溶液对急性脑梗死(ACI)患者神经功能、血液流变学和氧化应激的影响。方法:选取南京市中心医院及常州市第一人民医院在2022年7月-2023年7月收治的ACI患者140例,根据随机数字表法将患者分为对照组(n=70,常规治疗联合依达拉奉右莰醇注射用浓溶液治疗)和观察组(n=70,对照组基础上接受脑脉利颗粒治疗)。对比两组疗效、神经功能、日常生活活动能力、血液流变学和氧化应激变化情况。结果:观察组的临床总有效率较对照组更高(P<0.05)。观察组治疗后美国国立卫生研究院卒中量表(NIHSS)、血浆黏度、全血低切黏度、全血高切黏度、红细胞压积、丙二醛(MDA)低于对照组,日常生活能力量表评分(Barthel指数)评分、超氧化物歧化酶(SOD)高于对照组(P<0.05)。结论:脑脉利颗粒联合依达拉奉右莰醇注射用浓溶液治疗ACI患者,有助于调节血液流变学,改善患者的神经功能,减轻氧化应激,提高其日常生活活动能力。

关键词：脑脉利颗粒依达拉奉右莰醇注射用浓溶液急性脑梗死神经功能血液流变学氧化应激