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The Ca^(2+)-activated chloride channel ANO1/TMEM16A:An emerging therapeutic target for epithelium-originated diseases?

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1412-1433页

作者： Yani Liu Zongtao Liu kewei wang Department of Pharmacology School of PharmacyQingdao University Medical CollegeQingdao 266073China Institute of Innovative Drugs Qingdao UniversityQingdao 266021China Department of Clinical Laboratory Qingdao Third People's HospitalQingdao 266041China

Anoctamin 1(ANO1) or TMEM16 A gene encodes a member of Ca^(2+) activated Cl^(-) channels(CaCCs) that are critical for physiological functions,such as epithelial secretion,smooth muscle contraction and sensory signal *** attraction and interest in ANO1/TMEM16 A arise from a decade long investigations that abnormal expression or dysfunction of ANO1 is involved in many pathological phenotypes and diseases,including asthma,neuropathic pain,hypertension and ***,the lack of specific modulators of ANO1 has impeded the efforts to validate ANO1 as a therapeutic *** review focuses on the recent progress made in understanding of the pathophysiological functions of CaCC ANO1 and the current modulators used as pharmacological tools,hopefully illustrating a broad spectrum of ANO1 channelopathy and a path forward for this target validation.

关键词： Ca^(2+)-activated Cl^(-)channels(CaCCs) ANO1 TMEM16A CaCCinh-A01 T16Ainh-A01 Drug target Cancer Cystic fibrosis

Highlights for the 6th International Ion Channel Conference:ion channel structure,function,disease and therapeutics

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Acta Pharmaceutica Sinica B 2017年第6期7卷 665-669页

作者： Limei wang kewei wang Department of Pharmacology Qingdao University School of PharmacyQingdao 266021China

To foster communication and interactions amongst international scholars and scientists in the field of ion channel research, the 6 th International Ion Channel Conference(IICC-2017) was held between June 23–27, 2017 in the eastern coastal city of Qingdao, China. The meeting consisted of 450 attendees and 130 speakers and poster presenters. The program consisted of research progress, new findings and ongoing studies that were focused on(1) Ion channel structure and function;(2) Ion channel physiology and human diseases;(3) Ion channels as targets for drug discovery;(4) Technological advances in ion channel research. An insightful overview was presented on the structure and function of the mechanotransduction channel Drosophila NOMPC(No mechanoreceptor potential C), a member of the transient receptor potential(TRP) channel family. Recent studies on Transmembrane protein 16 or Anoctamin-1(TMEM16A, a member of the calcium-activated chloride channel [CaCC] family) were summarized as well. In addition, topics for ion channel regulation, homeostatic feedback and brain disorders were thoroughly discussed. The presentations at the IICC-2017 offer new insights into our understanding of ion channel structures and functions, and ion channels as targets for drug discovery.

关键词： Ion channel Structure Function Channelopathy Drug target Mechanotransduction Voltage-gated Ca2+ channel Anoctamin-1 Calcium activated chloride channel M-type potassium channel GIRK channel Voltage-gated sodium channel

Synthesis of Non-oxide Porous Ceramics Using Random Copolymers as Precursors

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Journal of Materials Science & Technology 2015年第1期31卷 120-124页

作者： Xiaoqian wang kewei wang Jie Kong Yiguang wang Linan An State Key Laboratory of Solidification Processing Northwestern Polytechnical University Science and Technology on Thermo structural Composite Materials Laboratory Northwestern Polytechnical University Department of Applied Chemistry School of ScienceNorthwestern Polytechnical University Department of Materials Science and Engineering Advanced Materials Processing and Analysis CenterUniversity of Central Florida

In this paper,we reported a novel method for synthesis of non-oxide porous ceramics by using random copolymers as precursors.A silazane oligomer and styrene monomer were used as starting materials,which were copolymerized at 120 ℃ to form random polysilazane-polystyrene *** copolymers were then pyrolyzed at 500 ℃ to obtain porous ceramics by completely decomposing polystyrene（PS） and converting polysilazane（PSZ） into non-oxide Si-C-N *** obtained material contained a bi-model pore-structure consisting of both micro-sized and nano-sized pores with very high surface area of more than500 m;/*** also demonstrated that the pore structure and surface area of the materials can be tailored by changing the ratio of the two *** results suggest a promising simple method for making multiscaled porous non-oxide materials.

关键词： Non-oxide porous ceramics Polymer-derived ceramics

The molecular regulation of autophagy in antimicrobial immunity

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Journal of Molecular Cell Biology 2022年第4期14卷 3-17页

作者： Chuan Qin Yalan Lu Lin Bai kewei wang Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences&Comparative Medical CenterPeking Union Medical CollegeBejing100021China

Autophagy is a catabolic process that can degrade worn-out organelles and invading *** activation of autophagy regulates innate and adaptive immunity,playing a key role in the response to microbial *** infection may cause different consequences such as the elimination of invaders through autophagy or xenophagy,host cell death,and symbiotic *** adapt to the autophagy mechanism and further relieve intracellular stress,which is conducive to host cell survival and microbial *** regulation of autophagy forms a complex network through which host immunity is modulated,resulting in a variety of pathophysiological *** of the autophagic pathway is an essential target for the development of antimicrobial drugs.

关键词： autophagy microbe antimicrobial immunity endoplasmic reticulum stress unfolded protein response apoptosis infectious disease

Dynamic Color Transform Networks for Wheat Head Detection

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Plant Phenomics 2022年第1期4卷 395-408页

作者： Chengxin Liu kewei wang Hao Lu Zhiguo Cao Key Laboratory of Image Processing and Intelligent Control Ministry of EducationSchool of Artificial Intelligence and AutomationHuazhong University of Science and TechnologyWuhanChina

Wheat head detection can measure wheat traits such as head density and head *** wheat breeding largely relies on manual observation to detect wheat heads,yielding a tedious and inefficient *** emergence of affordable camera platforms provides opportunities for deploying computer vision(CV)algorithms in wheat head detection,enabling automated measurements of wheat *** wheat head detection,however,is challenging due to the variability of observation circumstances and the uncertainty of wheat head *** this work,we propose a simple but effective idea—dynamic color transform(DCT)—for accurate wheat head detection.

关键词： Wheat breeding wheat

Inhibition of intracellular proton-sensitive Ca^(2+)-permeable TRPV3 channels protects against ischemic brain injury

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2330-2347页

作者： Xiaoling Chen Jingliang Zhang kewei wang Department of Molecular and Cellular Pharmacology State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Pharmacology Qingdao University School of PharmacyQingdao 266021China

Ischemic brain stroke is pathologically characterized by tissue acidosis, sustained calcium entry and progressive cell death. Previous studies focusing on antagonizing N-methyl-D-aspartate(NMDA) receptors have failed to translate any clinical benefits, suggesting a non-NMDA mechanism involved in the sustained injury after stroke. Here, we report that inhibition of intracellular proton-sensitive Ca^(2+)-permeable transient receptor potential vanilloid 3(TRPV3) channel protects against cerebral ischemia/reperfusion(I/R) injury. TRPV3 expression is upregulated in mice subjected to cerebral I/R injury. Silencing of TRPV3 reduces intrinsic neuronal excitability, excitatory synaptic transmissions, and also attenuates cerebral I/R injury in mouse model of transient middle cerebral artery occlusion(tMCAO). Conversely, overexpressing or re-expressing TRPV3 increases neuronal excitability, excitatory synaptic transmissions and aggravates cerebral I/R injury. Furthermore, specific inhibition of TRPV3 by natural forsythoside B decreases neural excitability and attenuates cerebral I/R injury. Taken together, our findings for the first time reveal a causative role of neuronal TRPV3 channel in progressive cell death after stroke, and blocking overactive TRPV3 channel may provide therapeutic potential for ischemic brain injury.

关键词： TRPV3 Ca^(2+)influx Acidosis Cerebral ischemia/reperfusion injury Excitotoxicity Neural excitability Forsythoside B tMACO OGD TRP

The current agonists and positive allosteric modulators ofα7 nAChR for CNS indications in clinical trials

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Acta Pharmaceutica Sinica B 2017年第6期7卷 611-622页

作者： Taoyi Yang Ting Xiao Qi Sun kewei wang Department of Molecular and Cellular Pharmacology School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Pharmacology School of PharmacyQingdao UniversityQingdao 266021China

The alpha-7 nicotinic acetylcholine receptor(α7 nAChR), consisting of homomeric α7 subunits, is a ligand-gated Ca^(2+)-permeable ion channel implicated in cognition and neuropsychiatric disorders. Enhancement of α7 nAChR function is considered to be a potential therapeutic strategy aiming at ameliorating cognitive deficits of neuropsychiatric disorders such as Alzheimer's disease(AD) and schizophrenia. Currently, a number of α7 nAChR modulators have been reported and several of them have advanced into clinical trials. In this brief review, we outline recent progress made in understanding the role of the α7 nAChR in multiple neuropsychiatric disorders and the pharmacological effects of α7 nAChR modulators used in clinical trials.

关键词： Alpha7 nAChR Positive allosteric modulators Schizophrenia Alzheimer’s disease Acetylcholine Ion channel

The inverse correlation between series resistance and parallel resistance of small molecule organic solar cells

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Progress in Natural Science:Materials International 2015年第4期25卷 323-326页

作者： kewei wang Yufeng Zheng Gu Xu Xiuping Xu State Nuclear Electric Power Planning Design & Research Institute College of Engineering Peking University Department of Materials Science and Engineering Mc Master University

Understanding the inversely correlated series resistance(Rs) and parallel resistance(Rp) remains a challenge. Here we report that the variation of Rs and Rp is inversely related through the morphology of the donor and acceptor interface in CuPc organic solar cells, when comparing the bilayer structure and bulk heterojunction structure. It was also found that the charge carrier concentration near the donor–acceptor interface plays an important role in the relationships of Rs and Rp under fixed interfacial morphology, which was verified by the change of Voc. The inversely correlated Rs and Rp contributes to the improvement of the fillfactor, and in turn the power conversion efficiency.

关键词： Organic solar cells Series resistance Parallel resistance Inverse correlation

Chemically robust carbon nanotube-PTFE superhydrophobic thin films with enhanced ability of wear resistance

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Progress in Natural Science:Materials International 2017年第3期27卷 396-399页

作者： kewei wang Pan Xiong Xiuping Xu Kan wang YanLong Li Yufeng Zheng State Nuclear Electric Power Planning Design & Research Institute College of Engineering Peking University

A chemically robust superhydrophobic nanocomposite thin film with enhanced wear resistance is prepared from a composite comprising polytetrafluoroethylene（PTFE） and carbon *** superhydrophobic thin films with hierarchical structure are fabricated by spraying an environmentally friendly aqueous dispersion containing carbon nanotubes and PTFE resin on silicon *** films with a contact angle of 154.1°± 2° and a sliding angle less than 2° remain superhydrophobic after abrading over 500 times under a pressure of 50 g/cm;.The thin film is also extremely stable even under much stress *** further the understanding of the enhancement of wear resistance,we investigated the formation of microsized structure and their *** growth of microbumps is caused by attracting solution droplet to the hydrophilic islands on hydrophobic surface.

关键词： Superhydrophobicity Thin film Carbon nanotube Wear resistance