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巴厘岛“村庄”酒店 Potato Heads Studio 印尼巴厘岛

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世界建筑导报 2022年第3期37卷 91-93页

作者： kevin mak(摄影) OMA

巴厘岛的精髓在于不同文化之间的碰撞。岛上遍布各地的度假村和热带景点给游客带来奢华享受,从当地的生活中完全抽离。该项目坐落在巴厘岛最后一块未被开发的水明漾沙滩上(Seminyak Beach),以最大程度地融入当地社区为设计宗旨,旨在挑... 详细信息

巴厘岛的精髓在于不同文化之间的碰撞。岛上遍布各地的度假村和热带景点给游客带来奢华享受,从当地的生活中完全抽离。该项目坐落在巴厘岛最后一块未被开发的水明漾沙滩上(Seminyak Beach),以最大程度地融入当地社区为设计宗旨,旨在挑战岛上目前既有的典型度假村类型以及它们背后所展现的割裂感。Potato Head Studios酒店作为Desa Potato Head(desa在印尼语中意为村庄)三座建筑中的其中一座,完全面向公众开放。而其他的两座建筑则是另一家酒店和一个沙滩俱乐部。新建的Potato Head Studios酒店在提供公共空间的同时,还容纳有一系列的基建设施和私人客房。建筑师设计了一个由底层架空柱所支撑的漂浮环状空间体块,来容纳酒店的私人客房、展览空间和一个巨大的日落观景酒吧。这样一来,这个空间就完美地成为了一个开放的公共平台,和外部的自然沙滩产生了紧密的联结。同时,这个位于度假村中心的开放平台,还为各式各样的活动提供了灵活的表演场所,例如各类文化活动、节日庆典和日常休闲娱乐等,旨在使来访者可以更好地了解巴厘岛当地的文化特征。

关键词：底层架空展览空间公共空间节日庆典公共平台开放平台印尼巴厘岛建筑师设计

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 945-997页

作者： Jian Sheng Loh Wen Qi mak Li Kar Stella Tan Chu Xin Ng Hong Hao Chan Shiau Hueh Yeow Jhi Biau Foo Yong Sze Ong Chee Wun How Kooi Yeong Khaw School of Pharmacy Monash University MalaysiaJalan Lagoon Selatan47500 Bandar SunwaySelangorMalaysia School of Pharmacy Faculty of Health&Medical SciencesTaylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia Digital Health&Medical Advancements Taylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia School of Biosciences Faculty of Health&Medical SciencesTaylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia UCL School of Pharmacy University College London29-39 Brunswick SquareLondon WC1N 1AXUK

The human gastrointestinal tract is populated with a diverse microbial *** vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology,including health maintenance,development,aging,and *** advent of new sequencing technologies and culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations to shed light on microbiome–host *** has unveiled the bidirectional communication between the gut microbiome and the central nervous system,referred to as the“microbiota–gut–brain axis”.The microbiota–gut–brain axis represents an important regulator of glial functions,making it an actionable target to ameliorate the development and progression of neurodegenerative *** this review,we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative *** the gut microbiome provides essential cues to microglia,astrocytes,and oligodendrocytes,we examine the communications between gut microbiota and these glial cells during healthy states and neurodegenerative ***,we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative diseases using a metabolite-centric approach,while also examining the role of gut microbiota-related neurotransmitters and gut ***,we examine the potential of targeting the intestinal barrier,blood–brain barrier,meninges,and peripheral immune system to counteract glial dysfunction in ***,we conclude by assessing the pre-clinical and clinical evidence of probiotics,prebiotics,and fecal microbiota transplantation in neurodegenerative diseases.A thorough comprehension of the microbiota–gut–brain axis will foster the development of effective therapeutic interventions for the management of neurodegenerative diseases.

关键词： degenerative therapeutic diseases

生物炭施加垄沟集雨种植对水土流失及紫花苜蓿草产量的影响

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草地学报 2024年第5期32卷 1314-1326页

作者：朱进辉赵武成 Erastus mak-Mensah 王琦张登奎周旭姣赵晓乐戚文佳马文崔循臻李旭春刘冰甘肃农业大学草业学院甘肃兰州730070 甘肃省定西市水利科学研究所甘肃定西743000 甘肃省定西市水土保持科学研究所甘肃定西743000 中国科学院西北生态环境资源研究院临泽内陆河流域研究站/中国科学院内陆河流域生态水文重点实验室甘肃兰州730000

为缓解我国黄土高原区干旱胁迫和控制水土流失,本研究采用裂区设计,生物炭施加模式(生物炭施加和无生物炭施加)为主区,耕作模式(打结垄、开敞垄和平作)为副区,研究不同生物炭施加模式和耕作模式对土壤水分、径流、泥沙流失、养分流失、... 详细信息

为缓解我国黄土高原区干旱胁迫和控制水土流失,本研究采用裂区设计,生物炭施加模式(生物炭施加和无生物炭施加)为主区,耕作模式(打结垄、开敞垄和平作)为副区,研究不同生物炭施加模式和耕作模式对土壤水分、径流、泥沙流失、养分流失、紫花苜蓿(Medicago sativa L.)干草产量和水分利用效率的影响。试验结果表明,在2019和2020年紫花苜蓿生育期,与平作处理相比,开敞垄和打结垄处理的径流量、泥沙、全氮、全磷、有机质流失量分别减少20.1%~37.7%和60.1%~64.7%,54%~75.5%和77.1%~87.6%,44.4%~65.5%和49.0%~81.8%,36.7%~75.3%和48.6%~87.3%,48.2%~72.9%和58.6%~85.4%,土壤贮水量、紫花苜蓿干草产量和水分利用效率分别增加39.5~52.1和31.2~60.5 mm,26.2%~31.7%和26.5%~35.2%,10.07~14.86和12.14~16.55 kg·hm^(-2)·mm^(-1)。与无生物炭施加处理相比,生物炭施加处理的径流量、泥沙、全氮、全磷和有机质流失量分别减少48%~69%,94%~125%,12%~24%,28%~46%和35%~48%,土壤贮水量、紫花苜蓿干草产量和水分利用效率分别增加42.93~26.09 mm,106%~111%和1.96~6.90 kg·hm^(-2)·mm^(-1)。本研究表明,生物炭施加打结垄沟集雨种植是该区域适宜耕作模式。

关键词：生物炭添加模式耕作模式径流水土流失养分流失坡地

Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi mak Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,P<0.001),compared to *** both acute and post-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,P<0.001;post-acute:IRR:1.24,95%CI:1.14-1.36,P<0.001)and adverse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,P<0.001;post-acute:IRR:1.24,95%CI:1.13-1.35,P<0.001),compared to *** Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma

CDK5RAP2作为Wnt通路靶基因可促进口腔鳞状细胞癌干细胞活性和的肿瘤进展（英文）

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CDK5RAP2作为Wnt通路靶基因可促进口腔鳞状细胞癌干细胞活性和的...

2024中国肿瘤标志物学术大会暨CACA整合肿瘤学高峰论坛暨第十七届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者：沈月洪陈羽菱林云涛李一村刘朋菲张璧茹王宇帆 King-Chi Chan Nai-Ki mak Michael Kahn 齐众杨宏宇

Background: Head and neck squamous cell carcinoma(HNSCC) is a highly aggressive and frequently lethal malignancy. The 5-year survival rate of patients with HNSCC has remained low due to the tumor recurrence, metastasis, and treatment resistance. CDK5RAP2 is a microtubule regulatory protein. The role and underlying molecular mechanism of CDK5RAP2 in HNSCC are ***: CDK5RAP2 expression was examined using qRT-PCR and database analysis, and the biological role of CDK5RAP2 in HNSCC were investigated using colony formation assays,transwell assays, sphere formation assays, and in vivo tumorigenesis assays. Drug treatment,chromatin immunoprecipitation, and luciferase reporter assays were used to determine the regulation of CDK5RAP2 expression by the Wnt signaling pathway. Moreover, the gene expression profiles of CDK5RAP2-depleted cells were identified through RNA-sequencing and bioinformatics analyses. Lastly, spindle orientation was investigated through ***: CDK5RAP2 expression was upregulated in HNSCC tumor tissues and cells, and CDK5RAP2 knockdown inhibited cell tumorigenesis and migration. CDK5RAP2 expression was found to be regulated by the Wnt signaling pathway. Moreover, CDK5RAP2 depletion altered the cancer stem(-like) cell(CSC) signature of HNSCC cells. Notably, CDK5RAP2 was found to regulate spindle orientation in mitotic ***: CDK5RAP2 is identified here as a potential CSC marker of HNSCC that is regulated by the Wnt signaling pathway. CDK5RAP2 plays an indispensable role in HNSCC development and regulates the CSC signature of HNSCC by controlling spindle orientation during mitosis.

关键词： Head and neck squamous cell carcinoma(HNSCC) Wnt signaling pathway Cancer stem(-like) cell(CSC) CDK5RAP2 Spindle orientation

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麦锦泉:唯有热爱方能致远

中国宝石 2024年第2期 74-76页

作者： George(文) 麦锦泉(图) 不详香港珠宝玉石厂商会小组中国香港

出生于中国香港的麦锦泉(Ceorge mak)进入珠宝行业已有四十余年。学生时代的他没有接受过专业的珠宝设计训练,却凭借热爱、好学、勤奋,自学成才,并以强烈的个人设计风格享誉珠宝行业。他常说:“独特性是设计师的DNA,要让客人一望便知那... 详细信息

出生于中国香港的麦锦泉(Ceorge mak)进入珠宝行业已有四十余年。学生时代的他没有接受过专业的珠宝设计训练,却凭借热爱、好学、勤奋,自学成才,并以强烈的个人设计风格享誉珠宝行业。他常说:“独特性是设计师的DNA,要让客人一望便知那是你的作品。”

关键词：珠宝行业珠宝设计中国香港设计风格热爱独特性

Drugging IGF-1R in cancer: New insights and emerging opportunities

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Genes & Diseases 2023年第1期10卷 199-211页

作者： Panpan Wang Victor CY.mak Lydia WT.Cheung School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina

The insulin-like growth factor(IGF)axis plays important roles in cancer development and *** type 1 IGF receptor(IGF-1R)is a key member in the IGF axis and has long been recognized for its oncogenic role in multiple cancer *** we review the occurrence of IGF-1R aberrations and activation mechanisms in cancers,which justify the development of anti-IGF-1R *** describe the therapeutic agents available for IGF-1R inhibition,with focuses on the recent or ongoing pre-clinical and clinical *** include antisense oligonucleotide,tyrosine kinase inhibitors and monoclonal antibodies which may be conjugated with cytotoxic ***,simultaneous targeting of IGF-1R and several other oncogenic vulnerabilities has shown early promise,highlighting the potential benefits of combination ***,we discuss the challenges in targeting IGF-1R so far and new concepts to improve therapeutic efficacy such as blockage of the nuclear translocationofIGF-1R.

关键词： Cancer IGF-1R Targeted therapy Metastasis Combination therapy

Airborne transmission during short-term events: Direct route over indirect route

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Building Simulation 2022年第12期15卷 2097-2110页

作者： Xiujie Li Zhengtao Ai Jinjun Ye Cheuk Ming mak Hai Ming Wong Department of Building Environment and Energy Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Civil Engineering Hunan UniversityChangshaChina National Center for International Research Collaboration in Building Safety and Environment Hunan UniversityChangshaChina Faculty of Dentistry The University of Hong KongHong KongChina

Numerous short-term exposure events in public spaces were reported during the COVID-19 pandemic,especially during the spread of Delta and ***,the currently used exposure risk assessment models and mitigation measures are mostly based on the assumption of steady-state and complete-mixing *** present study investigates the dynamics of airborne transmission in short-term events when a steady state is not reached before the end of the ***-eddy simulation(LES)is performed to predict the airborne transmission in short-term events,and three representative physical distances between two occupants are *** time-averaged and phase-averaged exposure indices are used to evaluate the exposure *** results present that the exposure index in the short-term events constantly varies over time,especially within the first 1/ACH(air changes per hour)hour of exposure between occupants in close proximity,posing high uncertainty to the spatial and temporal evolutions of the risk of *** decoupling analysis of the direct and indirect airborne transmission routes indicates that the direct airborne transmission is the predominated route in short-term *** suggests also that the general dilution ventilation has a relatively limited efficiency in mitigating the risk of direct airborne transmission,but determines largely the occurrence time of the indirect *** the randomness,discreteness,localization,and high-risk characteristics of direct airborne transmission,a localized method that has a direct interference on the respiratory flows would be better than dilution ventilation for short-term events,in terms of both efficiency and cost.

关键词： airborne transmission short-term events direct exposure transient computational fluid dynamics(CFD) exposure risk

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台北艺术中心

城市环境设计 2014年第6期 54-59页

作者： Yannis Chan Hin-Yeung Cheung Inge Goudsmit Vincent Kersten Chiaju Lin kevin mak Jim Dodson Alasdair Graham Vivien Liu Kai Sun Luk Slobodan Radoman Roberto Requejo Saul Smeding Elaine Tsui Viviano Villarreal Casey Wang Leonie Wenz

为什么过去百年间最令人兴奋的剧场盛事总是发生在正规场所之外?建筑如何才能超越自身卑微的命运,摆脱那种限制各种可能的宿命?近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座... 详细信息

为什么过去百年间最令人兴奋的剧场盛事总是发生在正规场所之外?建筑如何才能超越自身卑微的命运,摆脱那种限制各种可能的宿命?近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座约2 000席的大型演艺厅和一个1 500席的中型剧院,再加上一个黑盒子剧场。标志性的外形掩饰以典型19世纪做法为基础的

关键词：艺术中心观众剧场文化机构剧院台北台湾