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Evaluating the impact of targeting livestock for the prevention of human and animal trypanosomiasis,at village level,in districts newly affected with *** in Uganda

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Infectious Diseases of Poverty 2017年第1期6卷 128-139页

作者： louise Hamill Kim Picozzi Jenna Fyfe Beatrix von Wissmann Sally Wastling Nicola Wardrop Richard Selby Christine Amongi Acup kevin l.bardosh Dennis Muhanguzi John D.Kabasa Charles Waiswa Susan C.Welburn Edinburgh Infectious Diseases Division of Infection and Pathway MedicineEdinburgh Medical School:Biomedical SciencesThe University of EdinburghChancellor’s Building49 Little France CrescentEdinburgh EH164SBUK Department of Pharmacy Clinical and Comparative MedicineSchool of Veterinary Medicine and Animal ResourcesMakerere UniversityP.O.Box 7062KampalaUganda The Coordinating Office for Control of Trypanosomiasis in Uganda(COCTU) WandegeyaPlot 76/78 Buganda RoadP.O.Box 16345KampalaUganda

Background:Uganda has suffered from a series of epidemics of Human African Trypanosomiasis(HAT),a tsetse transmitted disease,also known as sleeping *** area affected by acute Trypanosoma brucei rhodesiense HAT(rHAT)has been expanding,driven by importation of infected cattle into regions previously free of the *** regions are also affected by African Animal Trypanosomiasis(AAT)demanding a strategy for integrated disease ***:In 2008,the Public Private Partnership,Stamp Out Sleeping Sickness(SOS)administered a single dose of trypanocide to 31486 head of cattle in 29 parishes in Dokolo and Kaberamaido *** study examines the impact of this intervention on the prevalence of rHAT and AAT trypanosomes in cattle from villages that had(HAT^(+ve))or had not(HAT^(-ve))experienced a recent case of *** herds from 20 villages were sampled and screened by PCR,pre-intervention and 6-months post-intervention,for the presence or absence of:Trypanosoma brucei s.l.;human infective ***;Trypanosoma vivax;and Trypanosoma congolense ***:Post-intervention,there was a significant decrease in the prevalence of *** *** the human infective sub-species *** in village cattle across all 20 *** prevalence of *** was reduced from 2.4%to 0.74%(Pllages containing cattle harbouring human infective parasites decreased from 15/20 to 8/20,with *** infection mainly persisting within cattle in HAT^(+ve) villages(six/eight).The proportion of *** *** identified as human infective *** decreased after the intervention from 8.3%(95%CI=11.1-5.9%)to 4.1%(95%CI=6.8-2.3%).Villages that had experienced a recent human case(HAT^(+ve) villages)showed a significantly higher prevalence for AAT both pre-and *** AAT the prevalence of *** was significantly red

关键词： African animal trypanosomiasis(AAT) Human African trypanosomiasis(HAT) Sleeping sickness Trypanosma brucei rhodesiense HAT(rHAT) Uganda T.b.brucei T.b.rhodesiense

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Model Change Active learning in Graph-Based Semi-supervised learning

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1270-1298页

作者： kevin S.Miller Andrea l.Bertozzi Department of Mathematics University of CaliforniaLos Angeles520 Portola PlazaLos AngelesCA 90095USA

Active learning in semi-supervised classification involves introducing additional labels for unlabelled data to improve the accuracy of the underlying classifier.A challenge is to identify which points to label to best improve performance while limiting the number of new labels."Model Change"active learning quantifies the resulting change incurred in the classifier by introducing the additional label(s).We pair this idea with graph-based semi-supervised learning(SSl)methods,that use the spectrum of the graph laplacian matrix,which can be truncated to avoid prohibitively large computational and storage *** consider a family of convex loss functions for which the acquisition function can be efficiently approximated using the laplace approximation of the posterior *** show a variety of multiclass examples that illustrate improved performance over prior state-of-art.

关键词： Active learning Graph-based methods Semi-supervised learning(SSl) Graph laplacian

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Batch Active learning for Multispectral and Hyperspectral Image Segmentation Using Similarity Graphs

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1013-1033页

作者： Bohan Chen kevin Miller Andrea l.Bertozzi Jon Schwenk Department of Mathematics University of CaliforniaLos Angeles520 Portola PlazaLosAngeles90095CAUSA Oden Institute for Computational Engineering and Sciences University of Texas at Austin201 E 24th StAustin 78712TXUSA los Alamos National laboratory Los AlamosNM 87545USA

Graph learning,when used as a semi-supervised learning(SSl)method,performs well for classification tasks with a low label *** provide a graph-based batch active learning pipeline for pixel/patch neighborhood multi-or hyperspectral image *** batch active learning approach selects a collection of unlabeled pixels that satisfy a graph local maximum constraint for the active learning acquisition function that determines the relative importance of each pixel to the *** work builds on recent advances in the design of novel active learning acquisition functions(e.g.,the Model Change approach in arXiv:2110.07739)while adding important further developments including patch-neighborhood image analysis and batch active learning methods to further increase the accuracy and greatly increase the computational efficiency of these *** addition to improvements in the accuracy,our approach can greatly reduce the number of labeled pixels needed to achieve the same level of the accuracy based on randomly selected labeled pixels.

关键词： Image segmentation Graph learning Batch active learning Hyperspectral image

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Weight regain after intragastric balloon for pre-surgical weight loss

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2040-2046页

作者： Danielle Abbitt kevin Choy Alexandra Kovar Teresa S Jones Krzysztof J Wikiel Edward l Jones Department of Surgery University of ColoradoAuroraCO 80045United States Department of Surgery Rocky Mountain Regional Veteran Affairs Medical CenterAuroraCO 80045United States

BACKGROUND Over one-third of Americans carry the diagnosis of obesity,many also with obesity-related *** can place patients at increased risk of operative and postoperative *** intragastric balloon has been shown to aid in minor weight loss,however its weight recidivism in patients requiring short interval weight loss has not been well *** To evaluate weight loss,ability to undergo successful elective surgery after intragastric balloon placement,and weight management after balloon *** This study is a retrospective review of patients in a single academic institution undergoing intragastric balloon placement from 2019-2023 to aid in weight loss prior to undergoing elective *** outcomes including weight loss,duration of balloon placement,successful elective surgery,weight regain postballoon and post-procedure complications were *** criteria included those with balloon in place at time of *** Thirty-three patients completed intragastric balloon therapy from 2019-2023 as a bridge to elective *** patients were required to participate in a 12-month weight management program to be eligible for balloon *** surgeries included incisional hernia repair,umbilical hernia repair,inguinal hernia repair,and knee and hip *** average age at placement was 53 years±11 years,majority(91%)were *** average duration of intragastric balloon therapy was 186 days±41 *** average weight loss was 14.0 kg±7.4 kg and with an average percent excess body weight loss of 30.0%(7.9%-73.6%).Over half of the patients(52.0%)achieved the goal of 30-50 lbs(14-22 kg)weight ***-one patients(64%)underwent their intended elective surgery,2 patients(6%)deferred surgery due to symptom relief with weight loss ***-one of the patients(64%)have documented weights in 3 months after balloon removal,in these patients the majority(76%)gained weight after balloon *** pat

关键词： Intragastric balloon Weight loss Obesity Bariatric Body mass index

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Global aspirations, local realities: the role of social science research in controlling neglected tropical diseases

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Infectious Diseases of Poverty 2014年第1期3卷 310-324页

作者： kevin bardosh Centre of African Studies School of Social and Political ScienceCollege of Humanities and Social ScienceThe University of Edinburgh58 George SquareEdinburgh EH89LDUK Division of Pathway Medicine and Centre for Infectious Diseases School of Biomedical SciencesCollege of Medicine and Veterinary MedicineThe University of EdinburghChancellor’s Building49 Little France CrescentEdinburgh EH164SBUK

Neglected Tropical Diseases(NTDs)are both drivers and manifestations of poverty and social *** advocacy efforts since the mid-2000s have led to ambitious new control and elimination targets set for 2020 by the World Health *** these global aspirations represent significant policy momentum,there are multifaceted challenges in controlling infectious diseases in resource-poor local contexts that need to be acknowledged,understood and *** a number of recent publications have emphasised the“neglected”status of applied social science research on *** light of the 2020 targets,this paper explores the social science/NTD literature and unpacks some of the ways in which social inquiry can help support effective and sustainable *** priority areas are discussed,including on policy processes,health systems capacity,compliance and resistance to interventions,education and behaviour change,and community *** paper shows that despite the multifaceted value of having anthropological and sociological perspectives integrated into NTD programmes,contemporary efforts underutilise this *** is reflective of the dominance of top-down information flows and technocratic approaches in global *** counter this tendency,social research needs to be more than an afterthought;integrating social inquiry into the planning,monitoring and evaluating process will help ensure that flexibility and adaptability to local realities are built into *** emphasis on social science perspectives can also help link NTD control to broader social determinants of health,especially important given the major social and economic inequalities that continue to underpin transmission in endemic countries.

关键词： Neglected tropical diseases Applied social sciences Implementation research Social determinants Community participation Policy Global health Sociology Anthropology

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Disparate outcomes in Hispanic patients with metabolic dysfunctionassociated steatotic liver disease/steatohepatitis and type 2 diabetes: large cohort study

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World Journal of Diabetes 2024年第5期15卷 886-897页

作者： Joseph Matthew Gosnell George Golovko Esteban Arroyave Akshata Moghe Michael l Kueht Omar AbdulSaldarriaga kevin H McKinney Heather l Stevenson Monique R Ferguson Department of Pathology University of Texas Medical BranchGalvestonTX 77555United States Department of Pharmacology&Toxicology University of Texas Medical BranchGalvestonTX 77555United States Department of Medicine University of Texas Health Science Center at HoustonHoustonTX 77030United States Department of Surgery University of Texas Medical BranchGalvestonTX 77555United States Center for Tropical Diseases Department of Internal MedicineUniversity of Texas Medical BranchGalvestonTX 77555United States Department of Internal Medicine University of Texas Medical BranchGalvestonTX 77555United States

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASlD)and metabolic dysfunction-associated steatohepatitis(MASH)are a growing health burden across a significant portion of the global patient ***,these conditions seem to have disparate rates and outcomes between different ethnic *** combination of MASlD/MASH and type 2 diabetes increases the risk of hepatocellular carcinoma(HCC),and Hispanic patients experience the greatest burden,particularly those in South *** To compare outcomes between Hispanic and non-Hispanic patients in the United States,while further focusing on the Hispanic population within Southeast Texas to determine whether the documented disparity in outcomes is a function of geographical circumstance or if there is a more widespread reason that all clinicians must account for in prognostic *** This cohort analysis was conducted with data obtained from TriNetX,llC(“TriNetX”),a global federated health research network that provides access to deidentified medical records from healthcare organizations *** cohort networks were used:University of Texas Medical Branch(UTMB)hospital and the United States national database collective to determine whether disparities were related to geographic regions,like Southeast *** This study findings revealed Hispanics/latinos have a statistically significant higher occurrence of HCC,type 2 diabetes mellitus,and liver fibrosis/cirrhosis in both the United States and the UTMB Hispanic/latino *** mortality in Hispanics/latinos was lower within the United States group and not statistically elevated in the UTMB *** This would appear to support that Hispanic patients in Southeast Texas are not uniquely affected compared to the national Hispanic population.

关键词： Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis Hispanic Diabetes mellitus TriNetX Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Steatotic liver disease Hepatocellular carcinoma

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An Efficient Smoothing and Thresholding Image Segmentation Framework with Weighted Anisotropic-Isotropic Total Variation

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1369-1405页

作者： kevin Bui Yifei lou Fredrick Park Jack Xin Department of Mathematics University of CaliforniaIrvineIrvineCA 92697-3875USA Department of Mathematics University of North CarolinaChapel HillChapel HillNC 27599.USA Department of Mathematics and Computer Science Whittier CollegeWhittierCA 90602USA

In this paper,we design an efficient,multi-stage image segmentation framework that incorporates a weighted difference of anisotropic and isotropic total variation(AITV).The segmentation framework generally consists of two stages:smoothing and thresholding,thus referred to as smoothing-and-thresholding(SaT).In the first stage,a smoothed image is obtained by an AITV-regularized Mumford-Shah(MS)model,which can be solved efficiently by the alternating direction method of multipliers(ADMMs)with a closed-form solution of a proximal operator of the l_(1)-αl_(2) *** convergence of the ADMM algorithm is *** the second stage,we threshold the smoothed image by K-means clustering to obtain the final segmentation *** experiments demonstrate that the proposed segmentation framework is versatile for both grayscale and color images,effcient in producing high-quality segmentation results within a few seconds,and robust to input images that are corrupted with noise,blur,or *** compare the AITV method with its original convex TV and nonconvex TVP(Olitative and quantitative advantages of our proposed method.

关键词： Image segmentation Non-convex optimization Mumford-Shah(MS)model Alternating direction method of multipliers(ADMMs) Proximal operator

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Implementation and evaluation of Exercise is Medicine in primary care clinics within a large academic health system

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Family Medicine and Community Health 2024年第1期12卷 16-27页

作者： John kevin Ong Dayao Caroline E l Duffy Amalia M Cristiano Gene'Rusty'Kallenberg Sarah E linke University of California San Diego School of Medicine La JollaCaliforniaUSA Milken Institute of Public Health The George Washington UniversityWashingtonDistrict of ColumbiaUSA The University of Texas Medical Branch at Galveston School of Medicine GalvestonTexasUSA Scripps Family Medicine Residency Scripps Mercy Hospital Chula VistaChula VistaCaliforniaUSA Herbert Wertheim School of Public Health&Human longevity Science University of California San DiegoLa JollaCaliforniaUSA Department of Family Medicine University of California San DiegoLa JollaCaliforniaUSA Omada Health San FranciscoCaliforniaUSA

Objective Exercise is Medicine(EIM)is a global initiative encouraging healthcare providers to routinely assess and promote physical activity(PA)among *** objective of this study was to evaluate the feasibility,adoption,implementation and effectiveness of EIM from patient,clinician and healthcare staff perspectives using a combination of electronic health record(EHR),survey and interview *** This study used a combination of the Practical Robust Implementation and Sustainability Model(PRISM)and the learning Evaluation model to implement *** captured from the EHR,including Physical Activity Vital Sign(PAVS)scores,and data collected from qualitative surveys and interviews were used to evaluate the programme’s Reach,Effectiveness,Adoption,Implementation,Maintenance(RE-AIM,which is embedded within PRISM)from provider,staff and patient *** Five primary care clinics within a large academic health *** A total of 24443 patients from all participating clinics had at least one PAVS score during the study period.A total of 17 clinicians completed surveys,and 4 clinicians,8 medical assistants and 9 patients completed *** Implementation fidelity metrics varied widely between components and across clinics but were generally consistent over time,indicating a high degree of programme *** was highest during the first 6 months of the COVID-19 pandemic when most visits were *** PAVS scores increased from 57.7(95%CI:56 to 59.4)to 95.2(95%CI:91.6 to 98.8)min per week at 6 months for patients not meeting PA guidelines at baseline and decreased from 253.84(95%CI:252 to 255.7)to 208.3(95%CI:204.2 to 212.4)min per week at 6 months for patients meeting PA guidelines at *** EIM implementation,clinician-estimated time spent discussing PA with patients increased for 35%of providers and stayed the same for 53%.Conclusion Overall,this study established EIM’s feasibility,adoption,implementation

关键词： routine qualitative completed

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Cognitive function among military veterans with STEM occupations

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Military Medical Research 2024年第2期11卷 308-310页

作者： Justin T.McDaniel kevin N.Hascup Erin R.Hascup Ugochukwu G.Ezigbo Amanda M.Weidhuner Harvey Henson David l.Albright Dale and Deborah Smith Center for Alzheimer's Research and trEatment(CARE) Southern Illinois University School of MedicineSpringfieldIL 62794USA STEM Education Research Center Southern Illinois UniversityCarbondaleIL 62901USA Department of Political Science The University of AlabamaTuscaloosaAL 35487USA

Dear Editor,There is limited research on the relationship between science,technology,engineering,and mathematics(STEM)occupational history and cognitive function in later life,especially among military veterans,who may be at greater risk for later-life cognitive *** study examines a nationally representative sample of military veterans to address this gap in knowledge.

关键词： Alzheimer's disease Veterans Science technology engineering and mathematics(STEM) Animal fluency test Dementia

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Asbestos Exposure during Gasket Removal from Aircraft Engine

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Occupational Diseases and Environmental Medicine 2024年第2期12卷 59-67页

作者： Charles l. Blake kevin M. Guth Raymond D. Harbison Apex Companies Marietta USA Center for Environmental and Occupational Risk Analysis and Management College of Public Health University of South Florida Tampa USA

We have previously evaluated asbestos exposure associated with various maintenance procedures on light aircraft. The purpose of this study was to evaluate asbestos exposure during engine maintenance on light aircraft. This test was designed to evaluate the potential for asbestos exposure to mechanics and others who remove asbestos-containing engine gaskets from reciprocating style aircraft engines. Utilized in this test was an air cooled, horizontally opposed, aviation gasoline burning engine, assembled during 1986 and operated intermittently up into 2015, having accumulated 1680 hours run time. Nearly 75% of the asbestos-containing gaskets installed during 1986 were still in place at the time of testing. Chrysotile asbestos contents of such gaskets ranged from 55% to 60% by area, for those of sheet style and 5% by area, for the spiral wound metal/asbestos style. Despite the levels of effort required to effect gasket removals, the professional aircraft mechanic was not exposed to airborne asbestos fibers at the lower limits of sampling and analytical detection achieved;all of which were substantially less than the current Occupational Safety and Health Administration Permissible Exposure limits for asbestos. The results of this testing indicate an absence of gasket related asbestos exposure risk to mechanics who work with light aircraft engines, including those having asbestos-containing gaskets. These results are consistent with the findings of Mlyarek and Van Orden who studied the asbestos exposure risk occasioned during overhaul of larger radial style reciprocating aircraft engines [1].

关键词： Asbestos Exposure Gaskets Aircraft Engine Friction Materials

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