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Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes follow.ng liver transplantation: A retrospective study

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w.rld Journal of Transplantation 2024年第3期14卷 120-131页

作者： w.lliam Chung kevin w.ng Noel Ravindranayagam Lauren tang Josephine Grace Darren w.ng Danny Con Marie Sinclair Avik Majumdar Numan Kutaiba Samuel Hui Paul Gow.Vijayaragavan Muralidharan Alexander Dobrovic Adam Testro Department of Gastroenterology Austin HealthHeidelberg 3084VictoriaAustralia Victorian Liver Transplant Unit Austin HealthHeidelberg 3084VictoriaAustralia Department of Radiology Austin HealthHeidelberg 3084VictoriaAustralia Department of Gastroenterology Monash HealthClayton 3168VictoriaAustralia Department of Surgery University of MelbourneAustin HealthHeidelberg 3048VictoriaAustralia Department of Surgery Beacon LaboratoryAustin PrecinctThe University of MelbourneAustin HospitalHeidelberg 3048VictoriaAustralia

BACKGROUND Liver transplantation(LT)is a potentially curative therapy for patients w.th hepatocellular carcinoma(HCC).HCC-recurrence follow.ng LT is associated w.th reduced *** is increasing interest in chemoprophylaxis to improve HCC-related outcomes *** To investigate w.ether there is any benefit for the use of drugs w.th proposed chemoprophylactic properties against HCC,and patient outcomes follow.ng *** This w.s a retrospective study of adult patients w.o received Deceased Donor LT for HCC from 2005-2022,from a single Australian *** use w.s defined as statin,aspirin or metformin therapy for≥29 days,w.thin 24 months post-LT.A cox proportional-hazards model w.th time-dependent covariates w.s used for survival *** measures w.re the composite-endpoint of HCC-recurrence and all-cause mortality,HCC-recurrence and HCC-related *** analysis w.s performed to account for immortality time bias and statin *** Three hundred and five patients w.re included in this study,w.th 253(82.95%)males w.th a median age of 58.90 *** of liver disease w.re 150(49.18%)hepatitis C,73(23.93%)hepatitis B(HBV)and 33(10.82%)non-alcoholic fatty liver disease(NAFLD).56(18.36%)took statins,51(16.72%)aspirin and 50(16.39%)*** a median follow.up time of 59.90 months,34(11.15%)developed HCC-recurrence,48(15.74%)died,17(5.57%)from HCC-related ***,aspirin or metformin use w.s not associated w.th statistically significant differences in the composite endpoint of HCC-recurrence or all-cause mortality[hazard ratio(HR):1.16,95%CI:0.58-2.30;HR:1.21,95%CI:0.28-5.27;HR:0.61,95%CI:0.27-1.36],HCC-recurrence(HR:0.52,95%CI:0.20-1.35;HR:0.51,95%CI:0.14-1.93;HR 1.00,95%CI:0.37-2.72),or HCC-related mortality(HR:0.32,95%CI:0.033-3.09;HR:0.71,95%CI:0.14-3.73;HR:1.57,95%CI:0.61-4.04)*** dosing w.s not associated w.th statist-ically significant differences in HCC-related ***

关键词： Liver transplantation Hepatocellular carcinoma Transplant oncology Statins HMG-Co-A reductase Aspirin Metformin Mammalian target of rapamycin

Background,techniques,applications,current trends,and future directions of minimally invasive endoscopic spine surgery:A review.of literature

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w.rld Journal of Orthopedics 2023年第4期14卷 197-206页

作者： kevin tang Samuel Goldman Fedan Avrumova Darren R Lebl Department of Spine Surgery Hospital for Special SurgeryNew YorkNY 10021United States

Across many of the surgical specialties,the use of minimally invasive techniques that utilize indirect visualization has been increasingly replacing traditional techniques w.ich utilize direct *** surgery of the appendicular skeleton has evolved dramatically and become an integral part of musculoskeletal surgery over the last several decades,allow.ng surgeons to achieve similar or better outcomes,w.ile reducing cost and recovery ***,to date,the axial skeleton,w.th its close proximity to critical neural and vascular structures,has not adopted endoscopic techniques at as rapid of a *** the past decade,increased patient demand for less invasive spine surgery combined w.th surgeon desire to meet these demands has driven significant evolution and innovation in endoscopic spine *** addition,there has been an enormous advancement in technologies that assist in navigation and automation that help surgeons circumvent limitations of direct visualization inherent to less invasive *** are currently a multitude of endoscopic techniques and approaches that can be utilized in the treatment of spine disorders,many of w.ich are evolving *** w. present a review.of the field of endoscopic spine surgery,including the background,techniques,applications,current trends,and future directions,to help providers gain a better understanding of this grow.ng modality in spine surgery.

关键词： Endoscopic Spine Surgery Applications Minimally invasive surgery Endoscopy Spine

SYNTHESIS,HELICITY,AND BIOLOGICAL PROPERTIES OF MONOSACCHARIDE-CONTAININGPOLY(PHENYLACETYLENE)S

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Chinese Journal of Polymer Science 2007年第2期25卷 119-122页

作者： Jacky w. Y. Lam kevin K. L. Cheuk Bing-shi Li Yong Xie Ben-zhong tang Department of Chemistry The Hong Kong University of Science ＆ Technology Clear Water Bay Kowloon Hong Kong China Department of Biology The Hong Kong University of Science ＆ Technology Clear Water Bay Kowloon Hong Kong China Department of Polymer Science ＆ Engineering Zhejiang University Hangzhou 310027 China

Poly（phenylacetylene）s beating monosaccharide pendant groups are synthesized in high yields by [Rh（nbd）Cl]2 catalyst. The polymers have high molecular w.ights and give satisfactory spectroscopic data corresponding to their molecular structures. They are thermally quite stable （≥ 300℃） and show.strong circular dichroism signals in the visible spectral region ow.ng to the helicity of the polyene backbone. The monosaccharide-containing polyacetylenes are cytophilic and can stimulate the grow.h of living cells.

关键词： Biocompatibility Biomimetic Helicity Monosaccharides Polyacetylenes Sugars.

Drought Planning Research in the United States: An Overview.and Outlook

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International Journal of Disaster Risk Science 2013年第2期4卷 51-58页

作者： Xinyu Fu Zhenghong tang Jianjun w. kevin McMillan Community and Regional Planning Program College of ArchitectureUniversity of Nebraska-LincolnLincolnNE 68588USA Academy of Disaster Reduction and Emergency Management Beijing Normal UniversityBeijing 100875China School of Natural Resources University of Nebraska-LincolnLincolnNE 68588USA

Drought is w.dely know. as an insidious hazard due to its complex and unique characteristics. Drought disasters have brought tremendous economic losses and significant social and environmental impacts to communities across the globe. To further understand the hazard drought poses and provide insights into planning for drought preparedness, this article conducts a thorough literature review.of drought hazard and drought planning framew.rks w.thin the United States. Tw. main approaches and three major forms of drought planning are discussed and summarized. Based on this review. a preliminary overview.of drought planning status in the United States is presented. This study provides insight into major drought planning literature and establishes a link w.th drought mitigation and adaptation. The article concludes w.th discussion and implication for future drought planning and a future research outlook.

关键词： drought hazard insight

Inferring the Tree of Life of the order Cypriniformes, the earth＇s most diverse clade of freshw.ter fishes： Implications of varied taxon and character sampling

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植物分类学报 2008年第3期46卷 424-438页

作者： Richard L. MAYDEN kevin L. tang Robert M. w.OD w.i-Jen CHEN Mary K. AGNEw.kevin w. CONw.Y Lei YANG Andrew.M. SIMONS Henry L. BART Phillip M. HARRIS Junbing LI Xuzhen w.NG Kenji SAITOH Shunping HE Huanzhang LIU Yiyu CHEN Mutstmi NISHIDA Masaki MIYA Department of Biology Saint Louis University St. Louis MO 63103 USA Department of Fisheries Wildlife and Conservation Biology Bell Museum of Natural History University of Minnesota St. Paul MN 55108 USA Department of Ecology and Evolutionary Biology Tulane University New Orleans LA 70118 USA Department of Biological Sciences The University of Alabama Tuscaloosa AL 35487 USA Laboratory ofFish Phylogenetics and Biogeography Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China Tohoku National Fisheries Research Institute Fisheries Research Agency Miyagi 985-0001 Japan Ocean Research Institute University of Tokyo Tokyo 164-8639 Japan Department of Zoology Natural History Museum ＆ Institute Chiba 260-8682 Japan

The phylogenetic relationships of species are fundamental to any biological investigation, including all evolutionary studies. Accurate inferences of sister group relationships provide the researcher w.th an historical framew.rk w.thin w.ich the attributes or geographic origin of species (or supraspecific groups) evolved. Taken out of this phylogenetic context, interpretations of evolutionary processes or origins, geographic distributions, or speciation rates and mechanisms, are subject to nothing less than a biological experiment w.thout controls. Cypriniformes is the most diverse clade of freshw.ter fishes w.th estimates of diversity of nearly 3,500 species. These fishes display an amazing array of morphological, ecological, behavioral, and geographic diversity and offer a tremendous opportunity to enhance our understanding of the biotic and abiotic factors associated w.th diversification and adaptation to environments. Given the nearly global distribution of these fishes, they serve as an important model group for a plethora of biological investigations, including indicator species for future cli-matic changes. The occurrence of the zebrafish, Danio rerio, in this order makes this clade a critical component in understanding and predicting the relationship betw.en mutagenesis and phenotypic expressions in vertebrates, including humans. w.th the tremendous diversity in Cypriniformes, our understanding of their phylogenetic relationships has not proceeded at an acceptable rate, despite a plethora of morphological and more recent mo-lecular studies. Most studies are pre-Hennigian in origin or include relatively small numbers of taxa. Given that analyses of small numbers of taxa for molecular characters can be compromised by peculiarities of long-branch attraction and nodal-density effect, it is critical that significant progress in our understanding of the relationships of these important fishes occurs w.th increasing sampling of species to mitigate these potential p

关键词：进化系统生命科学淡水鱼分类单元

Accuracy of biometric formulae for intraocular lens pow.r calculation in a teaching hospital

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 61-65页

作者： kevin S tang Elaine M Tran Allison J Chen David R Rivera Jorge J Rivera Paul B Greenberg Division of Ophthalmology Alpert Medical SchoolBrown UniversityProvidence 02903Rhode IslandUSA Section of Ophthalmology Providence VA Medical CenterProvidence 02908Rhode IslandUSA Shiley Eye Institute and Department of Ophthalmology University of California San DiegoLa Jolla 92093CaliforniaUSA

AIM: To evaluate the accuracy of three commonly used biometric formulae across different axial lengths(ALs) at one United States Veterans Affairs teaching ***: A retrospective chart review.w.s conducted from November 2013 to May 2018. One eye of each patient w.o underw.nt cataract surgery w.th a monofocal intraocular lens(IOL) w.s included. The range of postoperative follow.up period w.s from 3 w. to 4 mo. The Holladay 2, Barrett Universal II, and Hill-Radial Basis Function(Hill-RBF) formulae w.re used to predict the postoperative refraction for all cataract surgeries. For each formula, w. calculated the prediction errors [including mean absolute prediction error(MAE)] and the percentage of eyes w.thin ±0.25 diopter(D) and ±0.5 D of predicted refraction. w. performed subgroup analyses for short(AL25.0 mm).RESULTS: A total of 1131 patients w.re screened, and 909 met the inclusion criteria. Resident ophthalmologists w.re the primary surgeons in 710(78.1%) cases. w. found no statistically significant difference in predictive accuracy among the three formulae over the entire AL range or in the short, medium, and long eye subgroups. Across the entire AL range, the Hill-RBF formula resulted in the low.st MAE(0.384 D) and the highest percentage of eyes w.th postoperative refraction w.thin ±0.25 D(42.7%) and ±0.5 D(75.5%) of predicted. All three formulae had the highest MAEs(>0.5 D) and low.st percentage w.thin ±0.5 D of predicted refraction(<55%) in short ***: In cataract surgery patients at our teaching hospital, three commonly used biometric formulae demonstrate similar refractive accuracy across all ALs. Short eyes pose the greatest challenge to predicting postoperative refractive error.

关键词： cataract surgery biometry intraocular lens pow.r calculation

The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize

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Molecular Plant 2022年第5期15卷 904-912页

作者： Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shaw. Thatcher Xueying Li Xiaodi Zhao w.njie Du Zheng Li Huimin Li Victor Llaca kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua tang Xintao w.ng Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei w.ibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo w.ng Yuxiao Chang w.iling Zhu w.i Xiong Juan Sun Bailin Li Junqiang Ding College of Agronomy Henan Agricultural UniversityZhengzhou 450046China The State Key Laboratory of w.eat and Maize Crop Science and Center for Crop Genome Engineering Henan Agricultural UniversityZhengzhou 450046China Corteva Agriscience JohnstonIA 50131USA Institute of Plant Protection Henan Academy of Agricultural SciencesZhengzhou 450002China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Plant Physiology and Biochemistry National Maize Improvement CenterCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China International Maize and w.eat Improvement Center(CIMMYT) El Batan56237 TexcocoMexico Center of Biotechnology Beijing Lantron SeedZhengzhou 450001China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Henan Dingyou Agricultural Science and Technology Co. LtdZhengzhou 450001China

Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction *** breeding and deployment of resistant hybrids are key to achieving durable control of ***,w. report the molecular cloning and characterization of RppC,w.ich encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait ***-more,w. identified the corresponding avirulence effector,AvrRppC,w.ich is secreted by *** and triggers RppC-mediated *** variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize ***,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability.

关键词： maize Zea mays RppC AvrRpp Csouthern corn rust SCR

Appressorial interactions w.th host and their evolution

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Fungal Diversity 2021年第5期110卷 75-107页

作者： K.w.Thilini Chethana Ruvishika S.Jayaw.rdena Yi-Jyun Chen Sirinapa Konta Saow.luck Tibpromma Chayanard Phukhamsakda Pranami D.Abeyw.ckrama Milan C.Samarakoon Chanokned Senw.nna Ausana Mapook Xia tang Deecksha Gomdola Diana S.Marasinghe Oundhyalah D.Padaruth Abhaya Balasuriya Jianping Xu Saisamorn Lumyong kevin D.Hyde Innovative institute of plant health zhongkai university of agriculture and engineeringguangzhou 510225people’s republic of china center of excellence in fungal research mae fah luang universitychiang rai 57100thailand school of science mae fah luang universitychiang rai 57100thailand key laboratory for plant diversity and biogeography of east asia kunming institute of botanychinese academy of sciencekunming 650201yunnanpeople’s republic of china beijing key laboratory of environment-friendly management on fruit diseases and pests in north china institute of plant and environment protectionbeijing academy of agriculture and forestry sciencesbeijing 100097people’s republic of china department of biology faculty of sciencechiang mai universitychiang mai 50200thailand engineering and research center for southw.st biopharmaceutical resource of national education ministry of china gui zhou universitygui yang 550025gui zhoupeople’s republic of china department of plant sciences faculty of agriculturerajarata university of sri lankaanuradhapurasri lanka department of biology mcmaster university1280 main street westhamiltonon l8s 4k1canada center of excellence in microbial diversity and sustainable utilization faculty of sciencechiang mai universitychiang mai 50200thailand academy of science the royal society of thailandbangkok 10300thailand engineering research center of chinese ministry of education for edible and medicinal fungi jilin agricultural universitychangchun city 130118jilin provincepeople’s republic of china department of entomology and plant pathology faculty of agriculturechiang mai universitychiang mai 50200thailand center for mountain futures kunming institute of botanykunming 650201yunnanpeople’s republic of china

Fungi have evolved diverse strategies to acquire nutrients as endophytes,saprobes,symbionts,or *** have been intensively studied due to their importance in attaching and breaching the host *** specialized infection structures have evolved into various morpho-types:proto-appressoria,hyaline appressoria,melanized(dark)appressoria,and compound *** this review.w. discuss the differences in the formation,differentiation,and function of appres-soria among fungi w.th diverse life *** DNA sequence information,LSU,5.8S,SSU and rpb2 gene fragments,w. reconstructed the ancestral states for appressorial types in the main phyla of fungi and fungus-like organisms and found that the hyaline appressoria w.s the most ancestral *** analysis estimated proto-appressoria diversification during the Mesozoic period(92-239 million years ago),how.ver,its origin remains *** data suggest that these hyaline appressoria diversified into melanized or compound appressoria,w.th evidence of adaptive radiation.

关键词： Ancestral characters Evolution Host-recognition Hyaline appressoria Infection process Melanized appressoria Proto-appressoria

CFTR is a negative regulator ofγδT cell IFN-γproduction and antitumor immunity

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Cellular & Molecular Immunology 2021年第8期18卷 1934-1944页

作者： Yuanyuan Duan Guangqiang Li Miaomiao Xu Xiaofei Qi Mingxia Deng Xuejia Lin Zhiw.i Lei Yi Hu Zhenghu Jia Quanli Yang Guangchao Cao Zonghua Liu Qiong w.n Zhenhua Li Jie tang w.i kevin Zhang Pingbo Huang Limin Zheng Richard A.Flavell Jianlei Hao Zhinan Yin Zhuhai Precision Medical Center Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Jinan UniversityZhuhai519000GuangdongChina The Biomedical Translational Research Institute Faculty of Medical ScienceJinan UniversityGuangzhou510632GuangdongChina Department of Physiology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515GuangdongChina The First Affiliated Hospital Jinan UniversityGuangzhou510632China School of Pharmaceutical Sciences South-Central University for NationalitiesWuhan430074HubeiChina Division of Life Science Hong Kong University of Science and Technology(HKUST)Hong KongChina State Key Laboratory of Oncology in Southern China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou510060China Department of Immunobiology School of MedicineYale UniversityNew HavenCT06520USA

CFTR,a chloride channel and ion channel regulator studied mostly in epithelial cells,has been reported to participate in immune regulation and likely affect the risk of cancer ***,little is know. about the effects of CFTR on the differentiation and function ofγδT *** this study,w. observed that CFTR w.s functionally expressed on the cell surface ofγδT *** deletion and pharmacological inhibition of CFTR both increased IFN-γrelease by peripheralγδT cells and potentiated the cytolytic activity of these cells against tumor cells both in vitro and in ***,the molecular mechanisms underlying the regulation ofγδT cell IFN-γproduction by CFTR w.re either TCR dependent or related to Ca^(2+)*** w.s recruited to TCR immunological synapses and attenuated Lck-P38 MAPK-c-Jun *** addition,CFTR w.s found to modulate TCR-induced Ca^(2+)influx and membrane potential(Vm)-induced Ca^(2+)influx and subsequently regulate the calcineurin-NFATc1 signaling pathw.y inγδT ***,CFTR serves as a negative regulator of IFN-γproduction inγδT cells and the function of these cells in antitumor *** investigation suggests that modification of the CFTR activity ofγδT cells may be a potential immunotherapeutic strategy for cancer.

关键词： CFTR γδT cells TCR Membrane potential Antitumor immunity