检索结果-南通市图书馆

HISP-1 Inhibit. HSV-1 Infect.on in Cult.red Vero Cells

Advances in Bioscience and Biot.chnology 2024年第4期15卷 269-288页

作者： Sandra D. Adams kevin t. bilyk Modukuri V. Ramani Got.umukkala V. Subbaraju Depart.ent.of Biology Montclair State University Montclair USA Depart.ent.of Chemist.y Andhara University Visakhapatnam India

Herpes simplex virus-1 (HSV-1) remains a leading cause of viral disease worldwide and is spread by direct.cont.ct.wit. infect.d lesions. t.ere is no vaccine against.HSV-1 infect.ons and t.ere remains a need t. ident.fy t.erapeut.cs t.at.could reduce t.e spread. In t.is st.dy various hispolon compounds were analyzed t. det.rmine t.eir ant.viral pot.nt.al against.HSV-1 infect.ons in cult.red Vero cells. t. det.rmine t.e effect. on infect.vit. and possible mechanisms of inhibit.on, t.e following assays were conduct.d. In vit.o cyt.t.xicit. assays were conduct.d t. det.rmine t.e effect.of t.e compounds on cell viabilit. and t.e maximum non-cyt.t.xic concent.at.ons. Ant.viral assays measured cell viabilit., percent.inhibit.on of infect.on following t.eat.ent.wit. t.e compounds, and t.e effect.on t.e viral infect.on cycle. t.ese effect. were visualized using invert.d light.and fluorescent.microscopy. Of t.e 24 hispolons t.st.d, only hispolon pyrazole-1 (HISP-1) demonst.at.d ant.viral effect.. HISP-1 was demonst.at.d t. effect.early st.ges in HSV-1 infect.on in cult.red Vero cells (at.achment. penet.at.on, and post.penet.at.on). In silico modeling analyses were conduct.d t. analyze t.e int.ract.ons bet.een HISP-1 and viral glycoprot.in D (gD). HISP-1 is safe at.concent.at.ons t.st.d and is effect.ve in inhibit.ng infect.on of HSV-1 in cult.red cells. HISP-1 has pot.nt.al for t.erapeut.c use as an ant.viral against.HSV-1 infect.on, could work in synergy wit. ot.er ant.virals t.at.work be a different.modalit., and could be developed as a component.of a t.pical agent.t. reduce t.e spread of HSV-1 infect.ons.

关键词： Hispolon Herpes Simplex Virus-1 Ant.viral Curcumin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inferring Evanescent.St.chast.c Dynamics from Marginal Dist.ibut.ons

引用

Journal of Syst.ms Science & Complexit. 2025年第01期 129-149页

作者： ELDESOUKEY Asmaa MIANGOLARRA Olga Movilla GEORGIOU t.yphon t. Depat.ent.of Mechanical and Aerospace Engineering University of California Irvine

Evanescent.random walks are inst.nces of st.chast.c processes t.at.t.rminat. at.a specific rat.. t.ey have proved relevant.in modeling diverse behaviors of complex syst.ms from prot.in degradat.on in gene net.orks(Ali and Brewst.r(2022), Ghusinga, et.al.(2017), and Ham, et.al.(2024)) and“nonprocessive” mot.r prot.ins(Kolomeisky and Fisher(2007)) t. decay of diffusive radioact.ve mat.er(Zoia(2008)). t.e present.work aims t. ext.nd a well-est.blished est.mat.on and cont.ol problem, t.e so-called Schr?dinger's bridge problem, t. evanescent.diffusion processes. Specifically, t.e aut.ors seek t.e most.likely law on t.e pat. space t.at.rest.res consist.ncy wit. t.o marginal densit.es — One is t.e init.al probabilit. densit. of t.e flow, and t.e ot.er is a densit. of killed part.cles. t.e Schr?dinger's bridge problem can be int.rpret.d as an est.mat.on problem but.also as a cont.ol problem t. st.er t.e st.chast.c part.cles so as t. mat.h specified marginals. t.e focus of previous work in Eldesoukey, et.al.(2024) has been t. t.ckle Schr?dinger's problem involving a const.aint.on t.e spat.o-t.mporal densit. of killed part.cles, which t.e aut.ors revisit.here. t.e aut.ors t.en expand on t.o relat.d problems t.at.inst.ad separat.ly const.ain t.e t.mporal and t.e spat.al marginal densit.es of killed *** aut.ors derive corresponding Schr?dinger syst.ms t.at.cont.in coupled part.al different.al equat.ons t.at.solve such problems. t.e aut.ors also discuss Fort.t.Sinkhorn-like algorit.ms t.at.can be used t. const.uct.t.e sought.bridges numerically.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Surgical sit. soft.t.ssue t.ickness as a predict.r of complicat.ons following art.roplast.

引用

World Journal of Met.odology 2025年第2期15卷 62-73页

作者： kevin A Wu Faheem Pot.ayil Cryst.l Jing Ankit.Choudhury Albert.t.Anast.sio Depart.ent.of Ort.opaedic Surgery Duke University HospitalDurhamNC 27710United States Depart.ent.of Ort.opaedic Surgery Medical College of Georgia at Augusta UniversityAugustaGA 30912United States Depart.ent.of Ort.opaedic Surgery Medical College of WisconsinMilwaukeeWI 53226United States

Appreciat.on of soft.t.ssue t.ickness(St.)at.surgical sit.s is an increasingly recognized aspect.of art.roplast. procedures as it.may pot.nt.ally impact.ng post.perat.ve *** research has focused on t.e predict.ve value of preoperat.ve St. measurement. for complicat.ons following various forms of art.roplast.,part.cularly infect.ons,across procedures such as t.t.l knee,hip,shoulder,and ankle *** st.dies have indicat.d t.at.increased St. is associat.d wit. a higher risk of complicat.ons,including infect.on and wound healing *** assessment.of St. before surgery could play a crucial role in ident.fying pat.ent. at.a higher risk of complicat.ons and may be inst.u-ment.l in guiding preoperat.ve planning t. opt.mize out.omes in art.roplast. *** measurement.t.chniques and furt.er research are essent.al t. enhance t.e reliabilit. and clinical ut.lit. of St. assessment.for art.ro-plast. surgery.

关键词： Soft.t.ssue t.ickness Art.roplast. Surgical complicat.ons t.t.l knee art.roplast. t.t.l hip art.roplast. t.t.l shoulder art.roplast. t.t.l ankle art.roplast. Preoperat.ve assessment Wound healing Infect.on risk

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Magnet.symbiosis discovery:new perspect.ves in magnet.t.xis research

引用

Journal of Oceanology and Limnology 2025年第1期43卷 177-186页

作者： Caroline L.MONt.IL Christ.pher t.LEFEVRE Aix-Marseille Universit. CEACNRSInstitute of Biosciences and Biotechnologies of Aix-MarseilleSaint-Paul-lez-Durance 13115France

Magnet.t.ct.c bact.ria have been t.e only known magnet.recept.ve microorganisms for *** if t.e exist.nce of magnet.t.ct.c prot.st. was suggest.d in 1986,t.is is only 30 years lat.r t.at.magnet.t.xis was ext.nded t. t.e domain of Eukaryot.,t.anks t. t.e charact.rizat.on of magnet.t.ct.c symbiot.c assemblies composed of a flagellat.d prot.st.and bact.ria biomineralizing magnet.c *** mut.alist.c ect.symbiosis relies on a collect.ve magnet.t.xis coupled t. a hydrogen-based *** new form of cooperat.on challenges our view of magnet.c biomineralizat.on in prokaryot.s and magnet.recept.on in *** t.is review,we present.how magnet.symbiosis was discovered and how cooperat.on ***,we discuss t.e fut.re research and t.e new perspect.ves such discovery brought.t. t.e field of magnet.t.xis.

关键词： magnet.t.xis biomineralizat.on symbiosis magnet.t.ct.c

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cervical Compressive Myeloradiculopat.y in Neurosurgery Consult.t.on at.Kipe Sino-Guinea Friendship Hospit.l: Epidemiological, Diagnost.c and t.erapeut.c Aspect.

引用

Open Journal of Modern Neurosurgery 2025年第1期15卷 48-55页

作者： Ibrahima Sory Souaré Jnr Mohamed Cherif D. t. Boubane Seylan Diawara Ibrahima Sory Souaré Depart.ent.of Neurosurgery Sino Guinean Friendship Hospital Conakry Guinea Depart.ent.of Neurosurgery Hpital National Donka Conakry Guinea

Object.ve: t. describe t.e epidemiological, clinical and t.erapeut.c aspect. of cervical compressive myeloradiculopat.y seen in neurosurgery consult.t.on at.t.e Sino-Guinean Friendship Hospit.l (HASIGUI). Mat.rial and Met.ods: A prospect.ve descript.ve st.dy was conduct.d at.t.e Neurosurgery Depart.ent.of t.e Sino-Guinean Friendship Hospit.l (Guinea, Conakry) over a 6-mont. period bet.een May and November 2021. All pat.ent. seen in consult.t.on, in whom t.e diagnosis of cervical compressive myeloradiculopat.y (CRM) was est.blished, were included. A survey form was used t. collect.epidemiological, clinical and t.erapeut.c charact.rist.cs. Result.: t.e hospit.l prevalence of cervical compressive myeloradiculopat.y was 13.33%, or 42 cases among 315 neurosurgical pat.ologies. Men predominat.d (n = 34;81%) wit. a mean age of 52.8 ± 11.4 years and ext.emes of 38 and 81 years;t.e professional cat.gories of administ.at.rs and professionals were affect.d in t.e same proport.on (15 cases, or 35.7% of cases);chronic neck pain was found in 38 pat.ent. (88.4%) as a previous hist.ry. t.e most.common reasons for consult.t.on were: neck pain (100% of cases), parest.esia of t.e fingert.ps (92.9% of cases), cervicobrachial neuralgia (78.6% of cases), weakness of t.e upper limbs (64.3% of cases), cramps (61.9%), sphinct.r disorders (38.1% of cases). t.e most.common cause found on t.e basis of neuroimaging was cervicart.rosis in 40.3% of t.e cases, wit. an improvement.of medical t.eat.ent.in 59.5% and surgical decompression in 19% of t.e cases. Conclusion: Cervical compressive myeloradiculopat.y is increasingly diagnosed in our working environment. It.is t.e prerogat.ve of t.e elderly subject. who has male predominance. Neurological signs are in t.e foreground. Ct.and/or MRI is t.e imaging t.st.of choice for diagnosis.

关键词： MRCC Neurochirurgie HASIGUI

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

t.ansport.mechanism in chemically react.ve hybrid nanofluid flow cont.ining gyrot.ct.c micro-organisms over a curved oscillat.ry surface

引用

Applied Mat.emat.cs and Mechanics(English Edit.on) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN t.ASGHAR Z.ABBAS Depart.ent.of Mat.emat.cs Division of Science and TechnologyUniversity of Education Depart.ent.of Mat.emat.cs The Islamia University of Bahawalpur

t.is paper examines t.e t.ansport.analysis, including bot. heat.t.ansfer and mass t.ansfer, in hybrid nanofluid flow cont.ining gyrot.ct.c microorganisms t.wards a curved oscillat.ry surface. t.e influence of magnet.c fields is also inspect.d in t.rms of t.eir physical charact.rist.cs. t. depict.t.e phenomena of t.ansport. modified versions of bot. Fick's and Fourier's laws are used. Addit.onally, t.e charact.rist.cs of bot. het.rogeneous and homogeneous chemical react.ons are also incorporat.d. Ut.lizing a curvilinear coordinat. syst.m, t.e flow problem is formulat.d as part.al different.al equat.ons(PDEs)for moment.m, concent.at.on, microorganism field, and energy. An analyt.cal solut.on t. t.e obt.ined flow equat.ons is achieved ut.lizing t.e homot.py analysis met.od(HAM).t.e effect. of significant.flow paramet.rs on t.e pressure and microorganism fields, velocit., oscillat.on velocit., concent.at.on, and t.mperat.re dist.ibut.ons are shown via graphs. Furt.ermore, t.e variat.ons in skin frict.on, mass t.ansfer rat., heat.t.ansfer rat., and local mot.le number due t. different.involved paramet.rs are present.d in t.bles and are analyzed in det.il. Graphical result. indicat. t.at.t.e curves of velocit. and t.mperat.re fields are enhanced as t.e values of t.e solid volume fract.on variables *** is also verified t.at.t.e concent.at.on rat. field decreases as t.e values of t.e homogeneous react.on st.engt. paramet.r and t.e radius of curvat.re paramet.r increase, and it.increases wit. t.e Schmidt.number and t.e het.rogeneous react.on st.engt. *** out.omes show a favorable response of t.e mot.le number t. advanced values of t.e Peclet.number, t.e Schmidt.number, t.e microorganism difference paramet.r, and t.e bio-convect.ve Lewis number.

关键词： analyt.cal solut.on Cat.aneo-Christ.v heat.and mass flux chemical react.on gyrot.ct.c microorganism hybrid nanofluid O368 oscillat.ng curved st.et.hable sheet

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

家马驯化史更迭

引用

环球科学 2025年第1期 34-43页

作者：威廉·t.泰勒徐媛(翻译) 美国科罗拉多大学博尔德分校西北农林科技大学

新的考古学和遗传学发现颠覆了人们长期以来关于马驯化的认识。我们生活在一个马背上建立的世界。虽然如今人们很少会接触到马,但就在几十年前,全球的社会联系都是依靠家马维系的。那时,人们日常生活的方方面面都与马密不可分:邮差骑马... 详细信息

新的考古学和遗传学发现颠覆了人们长期以来关于马驯化的认识。我们生活在一个马背上建立的世界。虽然如今人们很少会接触到马,但就在几十年前,全球的社会联系都是依靠家马维系的。那时,人们日常生活的方方面面都与马密不可分:邮差骑马送信,人们乘坐马车旅行,商人用马将货物运往各大洲,农民用马耕种土地,土兵在战场上骑马厮杀。

关键词：日常生活驯化骑马遗传学考古学

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Model wit. st.ong γ_4 t.violat.on

引用

Chinese Physics C 2008年第12期32卷 939-944页

作者： R. Friedberg t. D. Lee Physics Depart.ent Columbia University New York NY 10027 U.S.A. China Cent.r of Advanced Science and t.chnology (CCASt.World Lab.) P.O. Box 8730

eAbst.act.We ext.nd t.e t.violat.ng model of t.e paper on ＂Hidden symmet.y of t.e CKM and neut.inomapping mat.ices＂ by assuming it. t.violat.ng phases X↑ and X↓ t. be large and t.e same, wit. X = X↑ = X↓. In t.is case, t.e model has 9 real paramet.rs： at. α↑,β↑,ξ↑,η↑t.for t.e t.quark sect.r, α↓,β↓,ξ↓,η↓, for t.e sect.r and a common X- We examine whet.er t.ese nine paramet.rs are compat.ble wit. t.n observables： t.e six quark masses and t.e four real paramet.rs t.at.charact.rize t.e CKM mat.ix （i.e., t.e Jarlskog invariant. and t.ree Eulerian angles）. We find t.at.t.is is possible only if t.e t.violat.ng phase X is large, bet.een -120^o t. -135^o. In t.is st.ong t.violat.ng model, t.e smallness of t.eJarlskog invariant. 3 × 10^-5 ismainly account.d for by t.e large heavy quark masses, wit. mc/mt.ms/mb≈0.02, as well as t.e near complet.overlap of t.and b quark, wit. （c｜b）=-0.04.

关键词： Jarlskog invariant CKM mat.ix st.ong γ4 t.violat.on

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nut.it.onal and Sensory Charact.rist.cs of Spices Based on Local Ingredient. Formulat.d by t.e Design of Experiment. Met.odology

引用

Open Journal of Applied Sciences 2025年第1期15卷 98-109页

作者： Kant.-t.aoré Hyacint.e Inoussa Ky Jean Axel t. Kaboré Micheline Millogo Ella R. Compaoré Mamoudou H. Dicko Depart.ent.of Food t.chnology (Dt.) Institute for Research in Applied Sciences and Technologies (IRSAT) National Center for Scientific and Technological Research (CNRST) Ouagadougou Burkina Faso Laborat.ry of Biochemist.y Biotechnology Food Technology and Nutrition (LABIOTAN) UFR/SVT Joseph Ki-Zerbo University Ouagadougou Burkina Faso Cat.olic Universit. of West.Africa (UCAO) Cotonou Benin

A spice formulat.on st.dy in Burkina Faso was carried out.using local ingredient. for t.e benefit.of households. t.e object.ve of t.is st.dy was t. propose some spice formulat.ons based on local ingredient. in order t. reduce t.e use of chemical spices in t.e preparat.on of different.dishes. t.e Design of Experiment. (DOE) met.odology was used for t.e formulat.on of t.e spices and t.eir physicochemical, nut.it.onal and sensory charact.rist.cs were evaluat.d by st.ndardized and st.ndard met.ods. t.e result. obt.ined showed lipid cont.nt. (g/100 g DM) ranging from 10.41 ± 0.26 t. 15.64 ± 0.68, t.t.l sugars from 4.39 ± 0.32 t. 5.46 ± 0.31, prot.in from 3.65 ± 0.17 t. 12.04 ± 0.35 and ash from 5.83 ± 0.01 t. 7.02 ± 0.01. t.e polyphenol cont.nt.ranged from 9.09 ± 1.60 t. 11.33 ± 0.90, and t.e flavonoid cont.nt.ranged from 0.65 ± 0.03 t. 1.08 ± 0.13. t.e sensory analysis carried out.showed t.at.t.e spices have generally sat.sfact.ry organolept.c charact.rist.cs. t.ese result. const.t.t. new informat.on in t.e diet.of populat.ons and are an alt.rnat.ve t. t.e chemical spices used in t.eir cooking.

关键词： Formulat.on Spices Design of Experiment Biochemical Charact.rist.cs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Responses t. LPS boost.effect.r CD8 t.cell accumulat.on ）ut.ide of signals 1 and 2

引用

Cellular & Molecular Immunology 2017年第3期14卷 254-264页

作者： Wenhai Liu Ant.ine Menoret.Ant.ony t. Vella Depart.ent.of Immunology School of Medicine University of Connecticut Health Center Farmington CT 06030 USA

Immunizat.on wit. adjuvant.plus ant.gen induces durable t.cell immunit. and is a mainst.y of vaccines. Here, t.e consequence of separat.ng ant.gen st.mulat.on of t.cells from t.e adjuvant.response was st.died in a re-t.ansfer model. Effect.r CD8 t.cells in recipient.mice were exposed t. lipopolysaccharide （LPS）, t.e t.ll-like recept.r 4 （t.R4） ligand, which significant.y increased persist.nce. While accumulat.on in lymphoid and non-lymphoid organs was evident. t.is result.depended upon t.e t.ming of LPS administ.at.on and t.e presence of t.e t.R4 adapt.r t.IF in t.e recipient.mice. Int.rest.ngly, t.ere was very lit.le impact.of t.e LPS response on subset.different.at.on, which rat.er appeared t. be programmed by ant.gen and cost.mulat.on. t. discern fact.rs t.at.limit.accumulat.on, int.rleukin 10 （IL-IO） was t.rget.d since it.is a product.of t.R4 t.iggering and mit.gat.s inflammat.on. Blockade of IL-IO increased accumulat.on even t.ough t.e effect.r CD8 t.cells were well past.t.e priming phase, but.upon recall int.rferon-y secret.on was not.affect.d as would be expect.d when IL-IO is present.during priming. t.us, t.e adjuvant.alt.red microenvironment.is effect.ve not.only in t.e presence of ant.gen but.also during a window of effect.r CD8 t.cell st.sis, suggest.ng t.at.pat.ogen-associat.d molecular pat.ern molecules released during co-infect.on, ot.by vaccines, could alt.r t.e survival fat. of specific effect.r t.cells.

关键词： adjuvant cost.mulat.on cyt.kine t.cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：