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Microscopic colitis:A large retrospective analysis from a health maintenance organization experience

World Journal of Gastroenterology 2009年第25期15卷 3122-3127页

作者： kevin t kao Benito A Pedraza Amy C McClune David A Rios Yi-Qiong Mao Robert H Zuch Michael H Kanter Sony Wirio Chris N Conteas Department of Gastroenterology Kaiser PermanenteLos Angeles Medical Center Los Angeles California 90027United States Department of Internal Medicine Kaiser Permanente Los Angeles Medical Center Los Angeles California 90027 United States Department of Pathology Southern California Kaiser Permanente Medical Group California 90027 United States

AIM： to examine the demographic data on a large multi-ethnic population of patients with microscopic colitis （MC） in Southern California and to determine the association of MC with inflammatory bowel disease （IBD） and colorectal cancer. MEtHODS： All patients diagnosed with MC by co- Ionic biopsy from 1996-2005 were identified utilizing a pathology database. All biopsies were reviewed by experienced pathologists utilizing standard histologic criteria. Patients＇ medical records were reviewed and data regarding patient age, co-morbidities, sex, ethnic- ity, and medications were analyzed. An age- and sex- matched standard control group was also generated. Chi-square test was used to evaluate the associations of co-morbidities between lymphocytic colitis （LC）, col- lagenous colitis （CC） and the control group. RESULtS： A total of 547 cases of MC were identified, 376 patients with LC and 171 patients with CC. the fe- male/male ratio was 3：1 in CC and 2.7：1 in LC patients. Celiac disease （P 〈 0.001）, irritable bowel syndrome （IBS）（P 〈 0.001）, and thyroid diseases （P 〈 0.001） were found to have a higher occurrence in MC com- pared to the control group. No statistical differences in the occurrence of colorectal cancer, diabetes and IBD were found between the MC group and the control group. CONCLUSION： this is the largest group of patients with MC known to the authors that has been studied to date. Conditions such as celiac disease, IBS, and thyroid diseases were found to be related to MC. Fur- thermore, neither an increased risk of colorectal cancer nor IBD was associated with MC in this study.

关键词： Collagenous colitis Inflammatory bowel disease Lymphocytic colitis Microscopic colitis

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Cognitive function among military veterans with StEM occupations

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Military Medical Research 2024年第2期11卷 308-310页

作者： Justin t.McDaniel kevin N.Hascup Erin R.Hascup Ugochukwu G.Ezigbo Amanda M.Weidhuner Harvey Henson David L.Albright Dale and Deborah Smith Center for Alzheimer's Research and trEatment(CARE) Southern Illinois University School of MedicineSpringfieldIL 62794USA StEM Education Research Center Southern Illinois UniversityCarbondaleIL 62901USA Department of Political Science The University of AlabamaTuscaloosaAL 35487USA

Dear Editor,there is limited research on the relationship between science,technology,engineering,and mathematics(StEM)occupational history and cognitive function in later life,especially among military veterans,who may be at greater risk for later-life cognitive *** study examines a nationally representative sample of military veterans to address this gap in knowledge.

关键词： Alzheimer's disease Veterans Science technology engineering and mathematics(StEM) Animal fluency test Dementia

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Direct anterior compared to posterior approach for hip hemiarthroplasty following femoral neck fractures

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World Journal of Orthopedics 2024年第6期15卷 605-607页

作者： kevin A Wu Alexandra N Krez Albert t Anastasio Department of Orthopaedic Surgery Duke University HospitalDurhamNC 27710United States Department of Orthopaedic Surgery Duke University School of MedicineDurhamNC 27710United States

the differences in complication rates between the direct anterior and posterior approaches for hemiarthroplasty in elderly patients with femoral neck fractures are not yet fully ***,a severe complication associated with increased mortality and often requiring additional surgery,may occur less frequently with the direct anterior approach compared to the posterior *** consideration of patient demographics is essential when planning the surgical *** research in this area should focus on robust randomized controlled trials involving elderly patients recovering from femoral neck fractures.

关键词： Direct anterior approach Posterior approach Hemiarthroplasty Femoral neck fractures Arthroplasty Dislocation Surgical technique

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Potential transformation of organic matter by microbes in cryoconite,tibetan Plateau

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Science China Earth Sciences 2024年第6期67卷 1978-1989页

作者： Bixi GUO Yongqin LIU kevin Xu ZHONG Quan SHI Chen HE Qiang ZHENG Ruanhong CAI State Key Laboratory of tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Center for the Pan-third Pole Environment Lanzhou UniversityLanzhou 730000China Department of Earth Oceanand Atmospheric SciencesUniversity of British ColumbiaVancouverBC V6T 1Z4Canada State Key Laboratory of Heavy Oil Processing Petroleum Molecules Engineering Center(PMEC)China University of PetroleumBeijing 102249China State Key Laboratory for Marine Environmental Science Collage of Ocean and Earth SciencesXiamen UniversityXiamen 361102China Fujian Key Laboratory of Marine Carbon Sequestration Xiamen UniversityXiamen 361005China

Microorganisms play an essential role in the glacier carbon cycle;how they transform organic matter in mountain glacial cryoconite remains to be ***,we applied ultra-high resolution Fourier transform ion cyclotron resonance mass spectrometry(Ft-ICR MS)and deep sequencing of 16S rRNA gene,to investigate the temporal microbial transformation of dissolved organic matter(DOM)of the tibetan Plateau *** the 60-day incubation,we found that DOM in cryoconite underwent a three-stage transformation,with decreasing bioavailability over *** microbial community did not change much in the first week while degrading DOM molecules that were associated with higher H/C_(wa)and lower O/C_(wa).During days 15-30,DOM composition remained stable while microbial diversity *** day 60,the DOM was microbially converted into a higher state of recalcitrance,with higher values of aromatic index,O/C_(wa),and lower H/C_(wa),which contained molecules containing more *** among various microbial taxa,like Cyanobacteria,Bacteroidota,Gammaproteobacteria,Firmicutes,and Actinobacteriota,drove the DOM transformation in *** study sheds light on the in-situ transformation of DOM composition meditated by microbial populations in cryoconite at a temporal scale,providing new insights into understanding the microbial roles in the glacier organic carbon transformation.

关键词： Cryoconite Dissolved organic matter Biodegradation Microbial community temporal variation

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Epidemiologic investigation of pediatric distal humerus fractures: An American insurance claims database study

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World Journal of Orthopedics 2024年第1期15卷 52-60页

作者： Kyle Jay Klahs Jake E Dertinger Grant t Mello kevin thapa Alexis B Sandler E'Stephan J Jesus Garcia Nata Parnes Department of Orthopaedic Surgery Texas Tech University Health Sciences-El PasoEl PasoTX 79905United States Medical School California Health Sciences University College of Osteopathic MedicineClovisCA 93611United States Undergraduate School Binghampton UniversityVestalNY 13902United States Department of Orthopaedic Surgery William Beaumont Army Medical CenterFort BlissTX 79918United States Department of Orthopaedic Surgery Carthage Area HospitalCarthageNY 13619United States

BACKGROUND Distal humerus elbow fractures are one of the most common traumatic fractures seen in pediatric patients and present as three main types:Supracondylar(SC),lateral condyle(LC),and medial epicondyle(ME)*** to evaluate the epidemiology of pediatric distal humerus fractures(SC,LC,and ME)from an American insurance claims *** A retrospective review was performed on patients 17 years and younger with the ICD 9 and 10 codes for SC,LC and ME fractures based on the IBM truven MarketScan®Commercial and IBM truven MarketScan Medicare Supplemental *** from 2015 to 2020 were queried for treatments,patient age,sex,length of hospitalization,and *** A total of 1133 SC,154 LC,and 124 ME fractures were *** fractures had the highest percentage of operation at 83%,followed by LC(78%)and ME fractures(41%).Male patients were,on average,older than female patients for both SC and ME *** In the insurance claims databases used,SC fractures were the most reported,followed by LC fractures,and finally ME *** was identified to be a factor for how a pediatric distal humerus fractures,with patients with SC and LC fractures being younger than those with ME *** peak age per injury per sex was similar to reported historic central tendencies,despite reported trends for younger physiologic development.

关键词： Supracondylar humerus fracture Lateral condyle fracture Medial epicondyle fracture Pediatric elbow truven Epidemiology

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Source of metals related to gold occurrences in Cameroon, Central African Belt

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Acta Geochimica 2024年第2期43卷 308-324页

作者： kevin Igor Azeuda Ndonfack Jinlin Zhang Yuling Xie NSamiratou Yaya Emmanuel Archelaus Afanga Basua JCHX Mining Management Co. LtdBeijing 101500People’s Republic of China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037People’s Republic of China School of Civil and Environmental Engineering University of Science and Technology BeijingBeijing 100083People’s Republic of China Department of Earth Science University of BamendaBamendaRepublic of Cameroon

Suites of granitic and metamorphic rocks form a perfect geological environment in which to investigate the source of metals related to gold *** the East Province of Cameroon,the source of metals-related gold(grade~4.6 g/t)that occurs within metamorphic and granitic rocks remains *** host rocks were subjected to XRF and ICP-MS whole-rock geochemistry and BSE/EDS mineral analyses to investigate the source(s)of metals related to gold in the ***,chalcopyrite-pyrite and magnetite-ilmenite are the main sulfi des and oxides of granites,*** low-grade metamorphic rocks are sulfi de-rich consisting of arsenopyrite,chalcopyrite,pyrite,and sphalerite,and oxides include magnetite,ilmenite,hematite,and ***,Ni,Co,Sb,Sc,and Zn concentrations depleted in high-grade metamorphic rocks and granites compared to low-grade metamorphic *** well,Bi,Cd,Co,Cu,Ni,Sb,V,W,and Zn concentrations decrease with increasing temperatures from low-grade rocks to high-grade rocks and *** suite of depleted elements in high-grade rocks and granites is almost identical to those enriched in gold *** conclude that metals(Bi,Cd,Co,Cu,Ni,Sb,and Zn)related to gold mineralization in the East Province of Cameroon likely originated from metal-rich low-grade metamorphic rocks during prograde metamorphic processes prior to partial melting.

关键词： East Province of Cameroon Metamorphic rocks Granites Oxide–sulﬁdes Metal and gold Geochemistry

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Does a large prostate size,small lesion volume,or long needle distance from the probe to the lesion reduce magnetic resonance imaging–targeted cancer detection?

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Current Urology 2024年第2期18卷 144-147页

作者： Mark D.Bevill Justin N.Drobish kevin J.Flynn Maheen Rajput Catherine Metz Chad R.tracy Paul t.Gellhaus Department of Urology University of Iowa Carver College of MedicineIowa CityIAUSA Department of Radiology University of Iowa Carver College of MedicineIowa CityIAUSA

Background:We aimed to evaluate whether large prostate size,small lesion volume,or long lesion distance from the ultrasound probe tip would decrease cancer detection in transrectal magnetic resonance imaging(MRI)–targeted *** and methods:Patients who underwent MRI-targeted biopsy at our institution between May 2017 and August 2019 were enrolled in a prospective *** to 5 cores were obtained from≥2 prostate imaging reporting and data system v2 lesions.A multivariable model was created that included needle distance to the lesion,prostate specific antigen,prostate imaging reporting and data system,lesion volume,and prostate ***:A total of 377 patients with 533 lesions underwent a biopsy during the study period.A total of 233(44%)lesions were positive for prostate cancer,and 173(32%)lesions had clinically significant prostate *** mean needle distance to the lesion was 11.7mm(interquartile range,7.6–15.5mm).the likelihood of obtaining a positive core on biopsy decreased as the distance fromthe ultrasound probe increased for all prostate cancers and clinically significant prostate cancer(p=0.018 and p=0.004,respectively).Every 10mmfrom the rectum,there was an 8%–10%decrease in the rate of cancer ***,as the prostate volume increased,the odds of obtaining a positive core also decreased(p=0.039).there was no significant association between the lesion size and amount of cancer obtained on ***:Our data showed that transrectal MRI-targeted biopsy cancer detection modestly decreased the lesion from the ultrasound probe and with a large prostate volume but could not prove that lesion volume was a significant predictor of the amount of cancer detected.

关键词： Prostate cancer Biopsy Magnetic resonance imaging

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HISP-1 Inhibits HSV-1 Infection in Cultured Vero Cells

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Advances in Bioscience and Biotechnology 2024年第4期15卷 269-288页

作者： Sandra D. Adams kevin t. Bilyk Modukuri V. Ramani Gottumukkala V. Subbaraju Department of Biology Montclair State University Montclair USA Department of Chemistry Andhara University Visakhapatnam India

Herpes simplex virus-1 (HSV-1) remains a leading cause of viral disease worldwide and is spread by direct contact with infected lesions. there is no vaccine against HSV-1 infections and there remains a need to identify therapeutics that could reduce the spread. In this study various hispolon compounds were analyzed to determine their antiviral potential against HSV-1 infections in cultured Vero cells. to determine the effects on infectivity and possible mechanisms of inhibition, the following assays were conducted. In vitro cytotoxicity assays were conducted to determine the effect of the compounds on cell viability and the maximum non-cytotoxic concentrations. Antiviral assays measured cell viability, percent inhibition of infection following treatment with the compounds, and the effect on the viral infection cycle. these effects were visualized using inverted light and fluorescent microscopy. Of the 24 hispolons tested, only hispolon pyrazole-1 (HISP-1) demonstrated antiviral effects. HISP-1 was demonstrated to effect early stages in HSV-1 infection in cultured Vero cells (attachment, penetration, and post-penetration). In silico modeling analyses were conducted to analyze the interactions between HISP-1 and viral glycoprotein D (gD). HISP-1 is safe at concentrations tested and is effective in inhibiting infection of HSV-1 in cultured cells. HISP-1 has potential for therapeutic use as an antiviral against HSV-1 infection, could work in synergy with other antivirals that work be a different modality, and could be developed as a component of a topical agent to reduce the spread of HSV-1 infections.

关键词： Hispolon Herpes Simplex Virus-1 Antiviral Curcumin

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学科背景下的元话语:概述

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Chinese Journal of Applied Linguistics 2024年第2期47卷 163-177页

作者： Feng(kevin)JIANG Erdem AKBAŞ Jilin University Erciyes University Türkiye

*** Central to successful communication is an integration of talk about the experiential world and how this is made coherent,intelligible and persuasive to a particular *** equips us to achieve this ***,metadiscourse captures the ways writers organize their texts to help readers interpret,evaluate,and react to the propositional information they supply(Hyland,2005a;Jiang,2022;Jiang&Hyland,2018).

关键词： discourse 元话语 coherent

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Nitrogen fertilization has minimal influence on rhizosphere effects of smooth crabgrass (Digitaria ischaemum) and bermudagrass (Cynodon dactylon)

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Journal of Plant Ecology 2015年第4期8卷 390-400页

作者： Biao Zhu kevin Panke-Buisse Jenny kao-Kniffin Earth Sciences Division Lawrence Berkeley National LaboratoryCyclotron RoadBerkeleyCA 94720USA School of Integrative Plant Science Cornell University134 Plant Sciences BuildingIthacaNY 14853USA

Aims Plants generally respond to nitrogen(N)fertilization with increased growth,but N addition can also suppress rhizosphere effects,which consequently alters soil *** quantified the influence of N addition on rhizosphere effects of two C4 grasses:smooth crabgrass(Digitaria ischaemum)and bermudagrass(Cynodon dactylon).Methods Plants were grown in nutrient-poor soil for 80 days with either 20 or 120μg NH4No3-N g dry soil−1.N mineralization rates,microbial biomass,extracellular enzyme activities and bacterial community structure were measured on both rhizosphere and bulk(unplanted)soils after plant *** Findings Fertilization showed nominal differences in net N mineralization,extracellular enzyme activity and microbial biomass between the rhizosphere and bulk soils,indicating minimal influence of N on rhizosphere ***,the presence of plant roots showed the strongest impact(up to 80%)on rates of net N mineralization and activities of three soil enzymes indicative of N release from organic *** component analysis of terminal restriction fragment length polymorphism(t-rFlP)also reflected these trends by highlighting the importance of plant roots in structuring the soil bacterial community,followed by plant species and N fertilization(to a minor extent).overall,the results indicate minor contributions of short-term N fertilization to changes in the magnitude of rhizos-phere effects for both grass species.

关键词： rhizosphere effect N fertilization belowground carbon allocation microbial biomass extracellular enzyme net N mineralization microbial community composition

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