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Cellular & Molecular Immunology 2024年第1期21卷 100-100页

作者： Zhengzhou Ying Swanand Hardikar Joshua B.Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu kevin M.McBride Taiping Chen Department of Epigenetics and Molecular Carcinogenesis The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Program in Genetics and Epigenetics The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Houston TX 77030 USA

In the sentence beginning‘To trace cell proliferation,FO and MZ B cells’and the sentence beginning‘For cell activation,naïve B cells or CH12F3 cells’in this article,the[10 ng/ml]‘F(ab’)_(2)fragment goat anti-mouse IgM’should have read‘10μg/ml F(ab’)_(2)fragment goat anti-mouse IgM’.The original article has been corrected.

关键词： immunodeficiency CD19 deficient

Low-temperature densification of high-entropy(Ti,Zr,Nb,Ta,Mo)C-Co composites with high hardness and high toughness

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Journal of Advanced Ceramics 2022年第5期11卷 805-813页

作者： Si-Chun LUO Wei-Ming GUO kevin PLUCKNETT Hua-Tay LIN School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006China School of Mechanical and Electronic Engineering Pingxiang UniversityPingxiang 337000China Department of Process Engineering and Applied Science Dalhousie UniversityHalifax B3J1ZICanada

In order to prepare high toughness(Ti,Zr,Nb,Ta,Mo)C ceramics at low temperatures while maintaining high hardness,a liquid-phase sintering process combined with Co-based liquid-phase extrusion strategy was adopted in this *** densification temperature can be lowered to 1350℃,which is much lower than the solid-state sintering temperature(~2000℃)generally employed for high-entropy carbide *** sintered at 1550℃and 30 MPa applied pressure,part of the Co-based liquid-phase was squeezed out of the graphite mold,such that only~3.21 vol%of Co remained in the high-entropy *** to the Co-free solid-state sintered(Ti,Zr,Nb,Ta,Mo)C ceramics,prepared at 2000℃and 35 MPa,the hardness was slightly decreased from 25.06±0.32 to 24.11±0.75 GPa,but the toughness was increased from 2.25±0.22 to 4.07±0.13 MPa·m^(1/2).This work provides a new strategy for low-temperature densification of high-entropy carbides with both high hardness and high toughness.

关键词： high-entropy carbide ceramics liquid-phase sintering microstructure grain size mechanical properties

Going nuclear: Molecular adaptations to exercise mediated by myonuclei

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运动医学与健康科学(英文) 2023年第1期5卷 2-9页

作者： Pieter J.Koopmans kevin A.Zwetsloot kevin A.Murach Molecular Muscle Mass Regulation Laboratory Exercise Science Research CenterDepartment of HealthHuman Performanceand RecreationUniversity of ArkansasFayettevilleARUSA Cell and Molecular Biology Program University of ArkansasFayettevilleARUSA Integrated Muscle Physiology Laboratory Appalachian State UniversityBooneNCUSA Department of Public Health and Exercise Science Appalachian State UniversityBooneNCUSA Department of Biology Appalachian State UniversityBooneNCUSA

Muscle fibers are multinucleated,and muscle fiber nuclei(myonuclei)are believed to be post-mitotic and are typically situated near the periphery of the *** to the unique organization of muscle fibers and their nuclei,the cellular and molecular mechanisms regulating myofiber homeostasis in unstressed and stressed conditions(e.g.,exercise)are unique.A key role myonuclei play in regulating muscle during exercise is gene *** recently have investigators had the capability to identify molecular changes at high resolution exclusively in myonuclei in response to perturbations in *** purpose of this review is to describe how myonuclei modulate their transcriptome,epigenetic status,mobility and shape,and microRNA expression in response to exercise in *** the relative paucity of high-fidelity information on myonucleus-specific contributions to exercise adaptation,we identify specific gaps in knowledge and provide perspectives on future directions of research.

关键词： Skeletal muscle Epigenetics Muscle memory Transcription myomiR

The valuation of barrier options under a threshold rough Heston model

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Journal of Management Science and Engineering 2023年第1期8卷 15-31页

作者： kevin Z.Tong Allen Liu Department of Mathematics and Statistics University of Ottawa585 King EdwardOttawaOntarioK1N 6N5Canada Enterprise Risk and Portfolio Management Bank of MontrealFirst Canadian PlaceTorontoOntarioM5X 1A3Canada

In this paper,we propose a novel model for pricing double barrier options,where the asset price is modeled as a threshold geometric Brownian motion time changed by an integrated activity rate process,which is driven by the convolution of a fractional kernel with the CIR *** new model both captures the leverage effect and produces rough paths for the volatility *** model also nests the threshold diffusion,Heston and rough Heston *** can derive analytical formulas for the double barrier option prices based on the eigenfunction expansion *** also implement the model and numerically investigate the sensitivities of option prices with respect to the parameters of the model.

关键词： Rough stochastic volatility Threshold diffusion Barrier options Eigenfunction expansion Stochastic time change

Operando electrochemical SERS monitors nanoparticle reactions by capping agent fingerprints

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Nano Research 2022年第5期15卷 4517-4524页

作者： kevin Wonner Steffen Murke Serena RAlfarano Pouya Hosseini Martina Havenith Kristina Tschulik Chair of Analytical Chemistry Ⅱ Faculty of Chemistry and BiochemistryRuhr University BochumBochum 44801Germany Chair of Physical Chemistry Ⅱ Faculty of Chemistry and BiochemistryRuhr University BochumBochum 44801Germany

Nanomaterials are frequently employed in daily life goods,including health,textile,and food industry.A comprehensive picture is lacking on the role of the capping agents,added ligand molecules,in case of nanoparticle reactions and degradation in aqueous solutions,like surface waters or ***,we aim to elucidate the capping agent influence on nanoparticle reactivity probing two commonly employed capping agents citrate and polyvinylpyrrolidone(PVP).Their influence on silver nanoparticle(AgNP)transformation is studied,which is particularly important due to its application as an antimicrobial *** induce oxidation and reduction processes of AgNPs in halide solutions and we monitor the associated transformations of particles and capping agents by spectro-electrochemical surface-enhanced Raman spectroscopy(SERS).Raman bands of the capping agents are used here to track chemical changes of the nanoparticles under operando *** sparingly soluble and non-plasmon active silver salts(AgBr and AgCl)are formed under potential *** addition,we spectroscopically observe plasmon-mediated structural changes of citrate to cis-or trans-aconitate,while PVP is *** different behavior of the capping agents implies a change in the physical properties on the surface of AgNPs,in particular with respect to the surface ***,we showcase that reactions of the capping agents induced by different external stimuli,such as applied bias or laser irradiation,can be *** results demonstrate how SERS of capping agents can be exploited to operando track nanoparticle conversions in liquid *** approach is envisaged to provide a more comprehensive understanding of nanoparticle fates in complex liquid environments and varied redox conditions.

关键词： capping agent electrochemical surface-enhanced Raman spectroscopy silver nanoparticle nanoparticle reaction

Whole mount of adult ear skin as a model to study vascular malformations

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动物模型与实验医学(英文) 2023年第4期6卷 362-368页

作者： Brandee Decker-Rockefeller Qingfen Li kevin Pumiglia Biology Department Utica UniversityUticaNew YorkUSA Department of Regenerative and Cancer Cell Biology Albany Medical CollegeAlbanyNew YorkUSA

Background:Genetic analysis in human patients has linked mutations in PIK3CA,the catalytic subunit of PI-3′Kinase,to sporadic incidences of vascular ***:We have developed a mouse model with inducible and endothelial-specific expression of PIK3CA H1047R,resulting in the development of vascular *** induction of this mutation in adult mice results in rapid lethality,limiting our ability to track and study these lesions;therefore,we developed a topical and local induction protocol using the active metabolite of tamoxifen,4OH-T,on the ear skin of ***:This approach allows us to successfully model the human disease in a mature and established vascular bed and track the development of vascular *** validate the utility of this model,we applied a topical rapamycin ointment,as rapamycin is therapeutically beneficial to patients in clinical *** found that the induced ear lesions showed significant attenuation after treatment,which was easily ***:These data collectively provide evidence of a new model to study vascular malformations in adult tissues,which should be particularly useful in environments lacking specialized small-animal imaging facilities.

关键词： animal disease models pathological angiogenesis PIK3CA rapamycin vascular malformations

Glymphatic imaging and modulation of the optic nerve

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Neural Regeneration Research 2022年第5期17卷 937-947页

作者： Anisha Kasi Crystal Liu Muneeb A.Faiq kevin C.Chan Department of Ophthalmology NYU Grossman School of MedicineNYU Langone HealthNew York UniversityNew YorkNYUSA Department of Radiology NYU Grossman School of MedicineNYU Langone HealthNew York UniversityNew YorkNYUSA Neuroscience Institute NYU Grossman School of MedicineNYU Langone HealthNew York UniversityNew YorkNYUSA Center for Neural Science College of Arts and ScienceNew York UniversityNew YorkNYUSA

Optic nerve health is essential for proper function of the visual ***,the pathophysiology of certain neurodegenerative disease processes affecting the optic nerve,such as glaucoma,is not fully ***,it was hypothesized that a lack of proper clearance of neurotoxins contributes to neurodegenerative *** ability to clear metabolic waste is essential for tissue homeostasis in mammals,including *** the brain lacks the traditional lymphatic drainage system identified in other anatomical regions,there is growing evidence of a glymphatic system in the central nervous system,which structurally includes the optic *** to acknowledge the supportive role of astroglial cells,this perivascular fluid drainage system is essential to remove toxic metabolites from the central nervous ***,we review existing literature describing the physiology and dysfunction of the glymphatic system specifically as it relates to the optic *** summarize key imaging studies demonstrating the existence of a glymphatic system in the optic nerves of wild-type rodents,aquaporin 4-null rodents,and humans;glymphatic imaging studies in diseases where the optic nerve is impaired;and current evidence regarding pharmacological and lifestyle interventions that may help promote glymphatic function to improve optic nerve *** conclude by highlighting future research directions that could be applied to improve imaging detection and guide therapeutic interventions for diseases affecting the optic nerve.

关键词： aquaporin-4 cerebrospinal fluid glaucoma glymphatic system hydrocephalus imaging metabolic waste clearance optic nerve perivascular pharmacological and lifestyle interventions

Active Machine Learning for Chemical Engineers:A Bright Future Lies Ahead!

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Engineering 2023年第8期27卷 23-30页

作者： Yannick Ureel Maarten R.Dobbelaere Yi Ouyang kevin De Ras Maarten K.Sabbe Guy B.Marin kevin M.Van Geem Laboratory for Chemical Technology Department of MaterialsTextiles and Chemical EngineeringGhent UniversityGhent 9052Belgium

By combining machine learning with the design of experiments,thereby achieving so-called active machine learning,more efficient and cheaper research can be *** learning algorithms are more flexible and are better than traditional design of experiment algorithms at investigating processes spanning all length scales of chemical *** active machine learning algorithms are maturing,their applications are falling *** this article,three types of challenges presented by active machine learning—namely,convincing the experimental researcher,the flexibility of data creation,and the robustness of active machine learning algorithms—are identified,and ways to overcome them are discussed.A bright future lies ahead for active machine learning in chemical engineering,thanks to increasing automation and more efficient algorithms that can drive novel discoveries.

关键词： Active machine learning Active learning Bayesian optimization Chemical engineering Design of experiments

Effect of Ultraviolet Radiation on Hsp70 Protein Expression in HaCaT Cells

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World Journal of Nuclear Science and Technology 2024年第1期14卷 59-71页

作者： Sergio Hugo Sánchez Rodríguez Jesús Rodríguez Vergil Manuel Venancio Muñoz Juárez kevin Said Ramírez Dávila Luis Martín García Ortiz Germán Flores Cortés Luz Elena Vidales Rodríguez Jesús Adrián López David Alejandro García López Laboratorio de Biología Celular y Neurobiología Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México Laboatorio de Bacterias y Hongos Filamentosos Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México Laboratorio de MicroRNAs Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México

Ultraviolet radiation by its wavelength is divided into: UVA, UVB and UVC. Only UVA and UVB manage to penetrate the ozone layer, but due to anthropological activities, all of them are capable of interacting with humans to a greater or lesser extent, and can generate adverse effects such as cellular stress when interacting with intra-and extracellular biomolecules. The skin is the first organ in contact with UV radiation, and the stress it generates can be analyzed by the expression of a bioindicator of cellular damage such as Hsp70. Therefore, the objective of the project was: to determine the effect of UVA, UVB and UVC radiation on HaCaT epithelial cells, by analyzing the expression of Hsp70. Materials and methods: HaCaT cells were cultured in vitro, which were irradiated with UVA, UVB and UVC light at different doses, to subsequently determine the degree of Hsp70 expression by Immunodetection by PAGE-SDS and Western Blot. Results: Basal expression of Hsp70 was observed in no irradiated HaCaT cells. When HaCaT cells were irradiated with UVA, UVB, UVC, an increase in this Hsp70 protein was observed. With UVA, a higher degree of expression was observed at a time of 30 minutes of irradiation. With UVB the highest expression shifted to a time of 20 minutes. With UVC, overexpression was observed after 10 minutes. Conclusion: UV radiation generates cellular stress on HaCaT cells, evaluated by the stress bioindicator Hsp70. According to the wavelength of UV radiation, those that have a shorter wavelength have a greater potential for cellular damage, such as UVC.

关键词： Ultraviolet A Light (UVA) Ultraviolet B Light (UVB) Ultraviolet C Light (UVC) Heat Shock Protein 70 (Hsp70) HaCaT

Assembling a Photoactive 2D Puzzle: From Bulk Powder to LargeArea Films of Semiconducting Transition-Metal Dichalcogenide Nanosheets

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Accounts of Materials Research 2023年第4期4卷 348-358页

作者： Rebekah A.Wells kevin Sivula Laboratory for Molecular Engineering of Optoelectronic Nanomaterials Institute of Chemical Sciences and EngineeringÉcole Polytechnique FÉdÉrale de Lausanne1015 LausanneSwitzerland

Two-dimensional(2D)semiconducting materials are poised to revolutionize ultrathin,high-performance optoelectronic *** particular,transition-metal dichalcogenides(TMDs)are well-suited for applications requiring robust and stable materials such as electrocatalytic,photocatalytic,and photo-electrochemical *** of the most compelling assets of these materials is the ability to produce and process 2D TMDs in the nanosheet form using solution-based(SB)exfoliation *** to other methods,SB techniques are typically inexpensive,efficient,and more suitable for scale-up and industrial *** acknowledgment of the importance of this area,much work has been done to develop various SB methods starting from the exfoliation of bulk crystalline TMD materials to the chemical modification of final devices consisting of thin films of semiconducting 2D TMD ***,not all SB methods are equally compatible or interchangeable,and they result in very diverse material and device ***,the aim of this Account is to provide an overview of the developed SB techniques that can serve as a guide for assembling high-performance thin films of 2D *** start by introducing the most popular methods for producing 2D TMDs using liquid-phase exfoliation(LPE),discussing their working mechanisms as well as their advantages and *** we highlight a recently developed LPE technique using electro-intercalation that draws on the advantages of previously presented ***,we discuss processing the as-produced 2D TMD nanosheets via SB separating techniques designed for size and morphology selection while also presenting the ongoing challenges in this *** then examine SB methods for processing the selected 2D nanomaterial dispersions into semiconducting thin *** methods are compared and contrasted,and special attention is paid to a recently developed method that carefully deposits 2D TMD nanoflakes with preferentia

关键词： Transition critical sheets