检索结果-南通市图书馆

Using Pharmacokinetic Modeling and Electronic Health Record Data to Predict Clinical and Safety Outcomes after Methylprednisolone Exposure during Cardiopulmonary Bypass in Neonates

引用

Congenital Heart Disease 2023年第3期18卷 295-313页

作者： Henry P.Foote Huali Wu Stephen j.Balevic Elizabeth j.Thompson kevin D.Hill Eric M.Graham Christoph P.Hornik Karan R.Kumar Department of Pediatrics Duke UniversityDurhamUSA Duke Clinical Research Institute DurhamUSA Department of Pediatrics Medical University of South CarolinaCharlestonUSA

Background:Infants undergoing cardiac surgery with cardiopulmonary bypass(CPB)frequently receive intraoperative methylprednisolone(MP)to suppress CPB-related inflammation;however,the optimal dosing strategy and efficacy of MP remain ***:We retrospectively analyzed all infants under 90 days-old who received intra-operative MP for cardiac surgery with CPB from 2014–2017 at our *** combined real-world dosing data from the electronic health record(EHR)and two previously developed population pharmacokinetic/pharmacodynamic models to simulate peak concentration(Cmax)and area under the concentration-time curve for 24 h(AUC24)for MP and the inflammatory cytokines interleukin-6(IL-6)and interleukin-10(IL-10).We evaluated the relationships between post-operative,safety,and other clinical outcomes obtained from the EHR with each predicted exposure using non-parametric ***:A total of 142 infants with median post-natal age 8(interquartile range[IQR]:5,37)days received a total dose of 30(19,49)mg/kg of ***(8%)died,37(26%)met the composite post-operative outcome,114(80%)met the composite safety outcome,and 23(16%)had a major *** median Cmax and AUC24 IL-6 exposure was significantly higher for infants meeting the composite post-operative outcome and those with major *** median Cmax and AUC24 MP exposure was significantly higher for infants requiring *** exposure was associated with death or other safety ***:Pro-inflammatory IL-6,but not MP exposure,was associated with post-operative organ dysfunction,suggesting current MP dosing may not adequately suppress IL-6 or increase IL-10 to impact clinical *** study will be required to define the optimal exposure-efficacy and exposure-safety profiles in these infants.

关键词： Neonates cardiopulmonary bypass methylprednisolone exposure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Overcoming the limitations of gallium oxide through heterogeneous integration

引用

Science China(Physics,Mechanics & Astronomy) 2021年第1期64卷 118-119页

作者： Yuhao Zhang kevin jChen Center for Power Electronics Systems Virginia Polytechnic and State UniversityBlacksburgVA24060USA Departmnet of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong KongChina

Power electronics,processing over 50%of world's electric energy,enables very efficient electric energy conversion for a wide range of applications such as electric vehicles,data centers,autonomous driving,robotics and smart *** availability of low-cost,efficient,and reliable power semiconductor devices that can conduct high current,block high voltage,and switch at high frequencies are key to improving the performance of power electronics systems.

关键词： integration enable autonomous

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

FEARCF a multidimensional free energy method for investigating conformational landscapes and chemical reaction mechanisms

引用

中国科学：化学 2012年第1期42卷 119-120页

作者： NAIDOO kevin j. Scientific Computing Research Unit and Department of Chemistry. University of Cape Town. South Africa 7701

The development and implementation of a computational method able to produce free energies in multiple dimensions,descriptively named the free energies from adaptive reaction coordinate forces(FEARCF) method is described in this *** the method can be used to calculate free energies of association,conformation and reactivity here it is shown in the context of chemical reaction landscapes.A reaction free energy surface for the Claisen rearrangement of chorismate to prephenate is used as an illustration of the method's efficient *** simulations are shown to achieve flat histograms for complex multidimensional free energy *** sampling efficiency by which it produces multidimensional free energies is demonstrated on the complex puckering of a pyranose ring,that is described by a three dimensional W(θ1,θ2,θ3) potential of mean force.

关键词：化学反应机理自由能景观多维能量法适应性反应反应势能面采样效率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correlation of MRI-determined small bowel Crohn’s disease categories with medical response and surgical pathology

引用

World journal of Gastroenterology 2009年第27期15卷 3367-3375页

作者： Ian Craig Lawrance Christopher j Welman Peter Shipman kevin Murray School of Medicine and Pharmacology University of Western AustraliaFremantle Hospital WA 6160 Australia Department of Gastroenterology Fremantle Hospital WA 6160 Australia Department of Radiology Fremantle Hospital WA 6160 Australia Statistical Consulting Group School of Mathematics and Statistics University of Western AustraliaWA 6160 Australia

AIM: To determine whether magnetic resonance imaging (MRI) can be used to categorize small bowel Crohn's disease (SB CD) into groups that correlate with response to medical therapy and surgical ***: Data was collected from all patients with MRI evidence of SB CD without significant colonic disease over a 32-mo period. Two radiologists, blinded to clinical findings, evaluated each MRI and grouped them based on bowel wall thickness and wall enhancement. These categories were: (1) "fibrosis", (2) "mild segmental hyper-enhancement and mild wall thickening", (3) "mild segmental hyper-enhancement and marked wall thickening", (4) "marked segmental transmural hyper-enhancement". Patient response to additional medical therapy post-MRI was prospectively determined at 8-wk. Non-responders underwent endoscopy and were offered therapeutic endoscopy or surgery. Surgical pathology was assessed against the MRI category. RESULTS: Fifty-five patients were included. Females and category "2" patients were more likely, and patients with luminal narrowing and hold-up less likely, to respond to medical therapy (P < 0.05). Seventeen patients underwent surgery. The surgical pathologicalfindings of fibrosis and the severity of inflammation correlated with the MRI category in all ***: Our fi ndings suggest that SB CD can be grouped by the MRI f indings and that these groups are associated with patients more likely to respond to continued medical therapy. The MRI categories also correlated with the presence and level of intestinal inflammation and fibrosis on surgical pathology, and may be of prognostic use in the management of CD patients.

关键词：病理反应 MRI 小肠外科医疗

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Small bowel MRI enteroclysis or follow through:Which is optimal?

引用

World journal of Gastroenterology 2009年第42期15卷 5300-5306页

作者： Ian C Lawrance Christopher j Welman Peter Shipman kevin Murray School of Medicine and Pharmacology University of Western AustraliaFremantle HospitalWA 6160Australia Centre for Inflammatory Bowel Disease Fremantle HospitalWA 6160Australia Department of Radiology Fremantle HospitalWA 6160Australia Statistical Consulting Group School of Mathe-matics and StatisticsUniversity of Western AustraliaWA 6009Australia

AIM:To determine if a nasojejunal tube(NjT) is required for optimal examination of enteroclysis and if patients can be examined only in the supine ***:Data were collected from all patients undergoing small bowel(SB) magnetic resonance imaging(MRI) examination over a 32-mo *** either underwent a magnetic resonance(MR) follow-through(MRFT) or a MR enteroclysis(MRE) in the supine *** quality of proximal and distal SB distension as well as the presence of motion artefact and image quality were assessed by 2 ***:One hundred and fourteen MR studies were undertaken(MRFT-49,MRE-65) in 108 patients in the supine position *** artefact was more frequent in MRE than in MRFT(29.2% vs 18.4%) ,but was not statistically significant(P = 0.30) .Adequate distension of the distal SB was obtained in 97.8% of MRFT examinations and in 95.4% of MRE examinations,*** SB distension was,however,less frequently optimal in MRFT than in MRE(P = 0.0036) ,particularly in patients over the age of 50 years(P = 0.0099) .Image quality was good in all ***:All patients could be successfully imaged in the supine *** and MRFT are equivalent for distal SB distension and artefact *** SB distension is frequently less optimal in MRFT than in *** is,therefore,the preferred MR examination method of the SB.

关键词：磁共振成像灌肠小肠图像质量人工制品 MRI 核磁共振保安

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An approach to viscoelastic c haracterization of dispersive media by inversion of a general wave propagation model

引用

journal of Innovative Optical Health Sciences 2017年第6期10卷 73-88页

作者： Fernando Zvietcovich jannick P.Rolland kevin j.Parker Department of Electrical and Computer Engineering University of Rochester Rochester New York 14627USA The Institute of Optics University of Rochester Rochester New York 14627USA

In the characterization of elastic properties of tissue using dynarmic optical coherence elasto-graphy,shear/surface waves are propagated and tracked in order to estimate speed and Y oung's ***,for dispersive tssues,the displacement pulse is highly damped and distorted during propagation,diminishing the ffectiveness of peak tracking approaches,and leading to biased cstimates of wave ***,plane wave propagation is sometimes assumed,which contributes to estimation ***,we invert a wave propagation model that incorpo-rates propagation,decay,and distortion of pulses in a dispersive media in order to accurately estimate its elastic and viscous *** model uses a general first-order approximation of dispersion,avoiding the use of any particular rheological model of *** are conducted in elastic and viscoelastic tissue mimicking phantoms by producing a Gaussian push using acoustic radiation force excitation and measuring the wave propagation using a Fourier domain optical coherence tomography *** confirmed the ffectiveness of the inversion method in est imat ing viscoelastic parameters in both the viscoelastic and elastic phantoms when compared to mechanical ***,the viscoelastic characterization of a fresh porcine comea was *** results validate this approach when compared to other methods.

关键词： Elastography viscoelasticity cylindrical waves optical coherence tomography shear waves surface acoustic waves viscoelastic pha ntoms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Implementation of rotational resistance models＇ A critical appraisal

引用

Particuology 2017年第5期15卷 14-23页

作者： Xin Huang kevin j. Hanley Catherine O'Sullivan Chung-Yee Kwok a Department of Geotechnical Engineering Tongji University Shanghai 200092 China Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji University Shanghai 200092 China Institute for Infrastructure and Environment School of Engineering The University of Edinburgh Edinburgh EH9 3JL United Kingdom Skempton Building Department of Civil and Environmental Engineering Imperial College London London SW72AZ United Kingdom Haking Wong Building Department of Civil and Environmental Engineering The University ofHong Kong Hong Kong China

Contact models that simulate rotational resistance at particle contacts have been proposed as a means to capture the effect of shape in DEM simulations. This contribution critically explores some key issues related to the implementation of rotational resistance models; these include the need for physically meaningful model parameters, the impact of the model on the overall numerical stability/critical time increment for the DEM model, model validation, and the assessment of model performance relative to real physical materials. The discussion is centred around a rotational resistance model that captures the resistance provided by interlocking asperities on the particle surface. An expression for the maximum permissible integration time step to ensure numerical stability is derived for DEM simulations when rotational resistance is incorporated. Analytical solutions for some single-contact scenarios are derived for model validation. The ability of this type of model to provide additional fundamental insight into granular material behaviour is demonstrated using particle-scale analysis of triaxial compression simulations to examine the roles that contact rollin~ and slidin~ have on the stability of stron：~ force chains.

关键词： Granular mediaParticle shapeDiscrete element methodRollingTwistingRotational resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hydrodeoxygenation of Phenolic Model Compounds over MoS2 Catalysts with Different Structures

引用

Chinese journal of Chemical Engineering 2008年第5期16卷 733-739页

作者：杨运泉罗和安童刚生 kevin j. Smith TYE Ching Thian Department of Chemical Engineering Xiangtan University Xiangtan 411105 China Department of Chemical and Biological Engineering University of British Columbia Vancouver B.C V6T 1Z3 Canada

不同结构的几 MoS2 催化剂，准备了由在铵Keptamolyb日期( AHM )和铝 naphthenate ( MoNaph )的 situ 分解，并且由 MoS2 脱落( TDM )，被赌注描绘，X光检查衍射( XRD )，精力散X光检查( EDX )和传播电子显微镜学( TEM )。分析证明那 Mo... 详细信息

不同结构的几 MoS2 催化剂，准备了由在铵Keptamolyb日期( AHM )和铝 naphthenate ( MoNaph )的 situ 分解，并且由 MoS2 脱落( TDM )，被赌注描绘，X光检查衍射( XRD )，精力散X光检查( EDX )和传播电子显微镜学( TEM )。分析证明那 MoS2 结构依赖于准备过程。催化剂的活动被用在氢并且温度从 320 鈥 ? 70qC 的 2.8 MPa 操作的一个批压热器反应堆测量酚， 4-methylphenol 和 4-methoxyphenol 的 hydrodeoxygenation (HDO ) 决定。由比较变换，催化剂的反应顺序是：AHM > TDM-D > MoNaph > 热 > MoS2 粉末 > TDM-W。另外， HDO 变换上的反应温度的效果以可逆反应动力学的平衡被解释。为酉分的混合物的 HDO 的主要产品被煤气的层析 / 团 spectrometry (GC/MS ) 识别。结果证明产品分发和 HDO 选择与反应温度被相关。二条平行反应线路，直接 hydrogenolysis 和联合 hydrogenation-hydrogenolysis，被产品分发的分析证实。高温度为酚和 4-methoxyphenol 的 HDO 在加氢上赞成了 hydrogenolysis，而为 4-methylphenol 颠倒是真的。

关键词：硫化钼催化剂酚类模型化合物加氢脱氧结构效应

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Introduction to the Mathematics of Operations Research with Mathematica®, Second Edition 2

引用

丛书名： Pure and applied mathematics 279

2006年

作者： Hastings, kevin j.

ISBN: (数字)9781315275987

ISBN: (纸本)9781574446128

The breadth of information about operations research and the overwhelming size of previous sources on the subject make it a difficult topic for non-specialists to grasp. Fortunately, Introduction to the Mathematics of Operations Research with Mathematica®, Second Edition delivers a concise analysis that benefits professionals in operations research and related fields in statistics, management, applied mathematics, and finance. The second edition retains the character of the earlier version, while incorporating developments in the sphere of operations research, technology, and mathematics pedagogy. Covering the topics crucial to applied mathematics, it examines graph theory, linear programming, stochastic processes, and dynamic programming. This self-contained text includes an accompanying electronic version and a package of useful commands. The electronic version is in the form of Mathematica notebooks, enabling you to devise, edit, and execute/reexecute commands, increasing your level of comprehension and problem-solving. Mathematica sharpens the impact of this book by allowing you to conveniently carry out graph algorithms, experiment with large powers of adjacency matrices in order to check the path counting theorem and Markov chains, construct feasible regions of linear programming problems, and use the "dictionary" method to solve these problems. You can also create simulators for Markov chains, Poisson processes, and Brownian motions in Mathematica, increasing your understanding of the defining conditions of these processes. Among many other benefits, Mathematica also promotes recursive solutions for problems related to first passage times and absorption probabilities.

关键词： Operations research

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Regulation of HMGB1 release by infl ammasomes

引用

Protein & Cell 2013年第3期4卷 163-167页

作者： Ben Lu Haichao Wang Ulf Andersson kevin j.Tracey Laboratory of Biomedical Science Feinstein Institute for Medical Research350 Community DriveManhassetNY 11030USA The Elmezzi Graduate School of Molecular Medicine North Shore-LIJ Health system350 Community DriveManhassetNY 11030USA Department of Emergency Medicine North Shore University HospitalManhassetNY 11030USA Department of Women’s and Children’s Health Karolinska InstitutetS-17677 StockholmSweden

High mobility group box 1(HMGB1)is an evolutionarily conserved non-histone chromatin-binding *** infection or injury,activated immune cells and damaged cells release HMGB1 into the extracellular space,where HMGB1 functions as a proinflammatory mediator and contributes importantly to the pathogenesis of inflammatory *** studies reveal that infl ammasomes,intracellular protein complexes,critically regulate HMGB1 release from activated immune cells in response to a variety of exogenous and endogenous danger *** stranded RNA dependent kinase(PKR),an intracellular danger-sensing molecule,physically interacts with inflammasome components and is important for infl ammasome activation and HMGB1 ***,these studies not only unravel novel mechanisms of HMGB1 release during infl ammation,but also provide potential therapeutic targets to treat HMGB1-related infl ammatory diseases.

关键词： HMGB1 infl ammasome PKR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：