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Ef.ect of.drug therapies on self.reported chemosensory outcomes af.er COVID-19

World Journal of.Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： marco A.f.rnazieri Bruno m.Cunha Samuel P.Nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides f.rnandes Neto Deusdedit Brandão Neto Richard L.Voegels f.bio D.R.Pinna Department of.Surgery Londrina State UniversityLondrinaBrazil Department of.medicine Pontifical Catholic University of ParanáLondrinaBrazil Department of.Otorhinolaryngology University of São PauloSao PauloBrazil Department of.Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of.this study was to assess the relative ef.icacy of.medications used f.llowing severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)inf.ction on self.reported alterations in taste and/or smell ***:Seven hundred and f.urteen persons with self.reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed regarding specif.c medications they were administered f.llowing the acute phase of.the *** dependent measure—self.reported total recovery of.chemosensory symptoms—was subjected to stepwise logistic *** predictors included demographic and clinical variables,in addition to specif.c medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprof.n,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of.the 714 subjects,249(34.9%)reported total recovery of.their chemosensory f.nction;437(61.2%)had at least one treatment since the beginning of.the *** and those with more comorbidities had undergone more *** recovery rates of.the treated and nontreated groups did not dif.er ***,respondents who had used nitazoxanide tended to have a higher rate of.self.reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during the f.rst months af.er SARS-CoV-2 inf.ction had a clear positive ef.ect on returning self.reported smell or taste f.nction to normal,although nitrazoxide trended in a positive *** zinc had a negative ef.ect on the reported recovery of.these senses.

关键词： chemosensory disorder coronavirus inf.ctions COVID-19 drug therapy SARS-CoV-2 smell loss taste loss

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Quantitative and Qualitative Responses of.Hydroponic Tomato Production to Dif.erent Levels of.Salinity

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Phyton-International Journal of.Experimental Botany 2024年第6期93卷 1311-1323页

作者： Khalid A.Al-Gaadi Ahmed m.Zeyada ElKamil Tola Abdullah m.Alhamdan Khalid A.m.Ahmed Rangaswamy madugundu mohamed K.Edrris Department of.Agricultural Engineering College of Food and Agriculture SciencesKing Saud UniversityRiyadh11451Saudi Arabia Precision Agriculture Research Chair Deanship of Scientific ResearchKing Saud UniversityRiyadh11451Saudi Arabia Chair of.Dates Industry&Technology Deanship of Scientific ResearchKing Saud UniversityRiyadh11451Saudi Arabia Agricultural Research Centre Agricultural Engineering Research Institute(AEnRI)Giza12619Egypt

f.om economic and nutritional points of.view,tomato is,historically,considered one of.the most important *** signiﬁcant yield reduction,most commercial cultivars of.tomato crops are sensitive to moderate levels of.***,high levels of.salt stress can negatively af.ect the yield and quality of.tomato ***,this study was conducted to evaluate the yield and f.uit quality of.three tomato cultivars(f.rester,Ghandowra-f.,and f.isty-Red)cultivated hydroponically,under three dif.erent levels of.nutrient solution *** of.tomato f.uits was perf.rmed based on quantity(number and weight of.f.uits,and total f.uit yield),physical quality(color andﬁrmness),and chemical quality(ref.actometric index“Brix”,pH,EC,K^(+),Na^(+),and NO_(3)-).Experiments were conducted using three salinity levels of.the nutrient solution with electrical conductivity values(dSm^(-1))of.2.5(control),6.0,and *** showed that the studied tomato cultivars were signiﬁcantly inﬂuenced by high salinity(9.5 dSm^(-1))in comparison to the low(2.5 dSm^(-1))and medium(6.0 dSm^(-1))levels of.*** average,the highest f.uit weight per plant of.1944.84 g and total f.uit yield of.4.42 kgm^(-2) were observed at the low salinity level;however,no signiﬁcant dif.erences were obtained in the two yield f.ctors(single f.uit weight and total f.uit yield)f.r the low and medium salinity *** the other hand,a signiﬁcant reduction in tomato yield(31%)was associated with the high salinity level compared to the yield at low and medium salinity *** of.physical quality parameters showed highly signiﬁcant dif.erences among all salinity *** average,the maximum value of.color change(1.72)was associated with the medium salinity level,and the maximum value of.rmness(9.61 Ncm^(-1))was recorded at the high salinity *** levels and tomato cultivars introduced signiﬁcant dif.erences in chemical quality parameters;however,no signiﬁcant dif.erences in these

关键词： Quality cultivars yield color ﬁrmness brix

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促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施:整合性综述（英文）

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International Journal of.Nursing Sciences 2024年第1期 46-56页

作者： Bruna f.Sebasti?o Raquel m.Hortel?o Sara S.Granadas José m.f.ria Joana R.Pinto Helga Raf.el Henriques Nursing School of.Lisbon Hospital Center of.Central Lisbon CUf.Tejo Hospital University Hospital Center of.Northern Lisbon Nursing Research Innovation and Development Centre of Lisbon (CIDNUR)

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronic obstructive pulmonary disease overlap,ACO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronic obstructive pulmonary disease overlap,ACO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进ACO患者对空气质量的自我管理。方法 2023年3月,系统检索CINAHL、medline、Academic Search Complete、Scopus、Web of.Science、Cochrane图书馆、乔安娜布里格斯研究所(Joanna Briggs Institute,JBI)循证实践数据库,以及Google Scholar。对纳入研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进ACO患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素),教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队、提高认识、制订和实施护理干预,从而使ACO患者受益。同时,需要进一步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理

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Bulking Up the Bay-Position Substituents Enables Enhanced Selectivity of.C_(s)‑Symmetric Boron Subphthalocyanine−Subnaphthalocyanine Hybrids

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Precision Chemistry 2024年第4期2卷 161-181页

作者： Nina f.f.rac Alan J.Lough Timothy P.Bender Department of.Chemical Engineering and Applied Chemistry University of TorontoTorontoOntario M5S 3E5Canada Department of.Chemistry University of TorontoTorontoOntario M5S 3H6Canada Department of.materials Science and Engineering University of TorontoTorontoOntario M5S 3E4Canada Department of.mechanical and Industrial Engineering University of TorontoTorontoOntario M5S 3G8Canada

The precise synthesis of.subporphyrinoid hybrids withπ-expanded topologies and unique material properties plays a promising role in the design of.f.nctional ***,selective,and controllable routes to boron subphthalocyanine−subnaphthalocyanine hybrids,Bsub(Pc_(3‑p)-Nc_(p))s,are desirable f.r this purpose yet synthetically challenging due to random mixtures of.C_(s-),C_(3v-),and,in some cases,C_(1)-symmetric compounds that f.rm during traditional statistical mixed ***,we addressed this issue by developing a sterically driven mixed cyclotrimerization with enhanced selectivity f.r the targeted C_(s)-symmetric hybrid and complete suppression of.sterically crowded macrocyclic *** process,coupled with a rationally designed precursor bearing bulky phenyl substituents,enabled the synthesis and characterization of.bay-position phenylated Ph_(2)-(R_(p))_(8)Bsub(Pc_(2)-Nc_(1))hybrids with halogens(Rp=Cl or f.in their peripheral isoindole *** selectivity ranged between 59 and 72%with remarkable yields,signif.cantly higher than that of.conventional mixed *** f.ndings were augmented by theoretical calculations on precursor Lewis basicity as guiding principles into hybrid macrocycle ***,the incorporation of.unf.sed phenyl groups and halogen atoms into the hybrid f.amework resulted in f.ne-tuned optical,structural,electronic,and electrochemical *** straightf.rward approach achieved improved selectivity and controlled narrowing of.the product distribution,af.ording the ef.icient synthesis of.structurally sophisticated Bsub(Pc_(2)-Nc_(1))*** then expands the library of.3-dimensionalπ-extended macrocycles f.r use in a range of.applications,such as in optoelectronic devices with precisely tailored optical properties.

关键词： subphthalocyanine hybrids low-symmetry aromatic macrocycle selective cyclotrimerization sterically driven chemistry broad absorption material properties

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Promotion of.structural plasticity in area V2 of.visual cortex prevents against object recognition memory def.cits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato mariam masmudi-martín manuel f.López-Aranda Juan f.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero marta Carretero-Rey Sinf.riano Posadas maría E.Quiros-Ortega Zaf.r U.Khan Laboratory of.Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of.medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enf.rmedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute f.r Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of.Neurobiology University of California-Los AngelesLos AngelesCAUSA

memory def.cit,which is of.en associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue f.r *** till now,all potential drug candidates have f.iled to produce satisf. ctory ***,in the search f.r a solution,we f.und that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of.the ventral stream and the medial temporal lobe,which is crucial f.r object recognition memory(ORm),can induce enhancement of.*** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaf.ected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of.ORm in young animals and prevent ORm def.cits in rodent models of.aging and Alzheimer’s ***,we f.und that the prevention of.memory def.cits was mediated through the upregulation of.neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic f.ctor(BDNf..A knockdown of.BDNf.gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of.neuronal structural plasticity and in the prevention of.ORm *** f.ndings suggest that BDNf.mediated neuronal structural plasticity in area V2 is crucial in the prevention of.memory def.cits in RGS14414-treated rodent models of.aging and Alzheimer’s ***,our f.ndings of.RGS14414gene-mediated activation of.neuronal circuits in visual area V2 have therapeutic relevance in the treatment of.memory def.cits.

关键词： behavioral perf.rmance brain-derived neurotrophic f.ctor cognitive dysf.nction episodic memory memory circuit activation memory def.cits memory enhancement object recognition memory prevention of.memory loss regulator of.G protein signaling

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An intrinsically self.healing and anti-f.eezing molecular chains induced polyacrylamide-based hydrogel electrolytes f.r zinc manganese dioxide batteries

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Journal of.Energy Chemistry 2024年第2期89卷 565-578,I0013页

作者： Haiyang Liao Wenzhao Zhong Chen Li Jieling Han Xiao Sun Xinhui Xia Ting Li Abolhassan Noori mir f.mousavi Xin Liu Yongqi Zhang Institute of.f.ndamental and f.ontier Sciences University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina School of.mechanical Engineering Hunan University of TechnologyZhuzhou 412007HunanChina School of.materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014ZhejiangChina Department of.Chemistry Faculty of Basic SciencesTarbiat Modares UniversityTehran 14117-13116Iran State Key Laboratory of.New Textile materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200HubeiChina

The anti-f.eezing strategy of.hydrogels and their self.healing structure are of.en contradictory,it is vital to break through the molecular structure to design and construct hydrogels with intrinsic anti-f.eezing/self.healing f.r meeting the rapid development of.f.exible and wearable devices in diverse service ***,we design a new hydrogel electrolyte(Af.SH-Hydrogel)with intrinsic anti-f.eezing/self.healing capabilities by introducing ethylene glycol molecules,dynamic chemical bonding(disulf.de bond),and supramolecular interaction(multi-hydrogen bond)into the polyacrylamide molecular *** to the exceptional f.eeze resistance(84%capacity retention at-20℃)and intrinsic self.healing capabilities(95%capacity retention af.er 5 cutting/self.healing cycles),the obtained Af.SH-Hydrogel makes the zinc||manganese dioxide cell an economically f.asible battery f.r the state-of.the-art *** Zn||Af.SH-Hydrogel||mnO_(2)device of.ers a near-theoretical specif.c capacity of.285 m A h g^(-1)at 0.1 A g^(-1)(Coulombic ef.iciency≈100%),as well as good self.healing capability and mechanical f.exibility in an ice *** work provides insight that can be utilized to develop multif.nctional hydrogel electrolytes f.r application in next generation of.self.healable and f.eeze-resistance smart aqueous energy storage devices.

关键词： f.exible aqueous battery Hydrogel electrolyte Anti-f.eezing Self.healing Dual-dynamic reversible bond

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Ground-based and additional science support f.r SmILE

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Earth and Planetary Physics 2024年第1期8卷 275-298页

作者： J.A.Carter m.Dunlop C.f.rsyth K.Oksavik E.Donovon A.Kavanagh S.E.milan T.Sergienko R.C.f.ar D.G.Sibeck m.Connors T.Yeoman X.Tan m.G.G.T.Taylor K.mcWilliams J.Gjerloev R.Barnes D.D.Billet G.Chisham A.Dimmock m.P.f.eeman D.-S.Han m.D.Hartinger S.-Y.W.Hsieh Z.-J.Hu m.K.James L.Juusola K.Kauristie E.A.Kronberg m.Lester J.manuel J.matzka I.mcCrea Y.miyoshi J.Rae L.Ren f.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun m.-T.Walach B.Walsh C.Wang J.Weygand J.Wild J.Yan J.Zhang Q.-H.Zhang Planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherf.rd Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of.Space and Environment Beihang UniversityBeijing 100191China Key Laboratory of.Space Environment monitoring and Inf.rmation Processing Ministry of Industry and Information TechnologyBeijing 100017China Department of.Space and Climate Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland Centre f.r Space Science Department of Physics and Technology.University of BergenBergenNorway Department of.Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swedish Institute of.Space Physics KirunaSweden West Highf.eld Campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space f.ight Center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada ESTEC European Space AgencyNetherlands University of.Saskatchewan SaskatoonCanada The Johns Hopkins University Applied Physics Laboratory LaurelMarylandUSA Swedish Institude of.Space Physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China Center f.r Space Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of.China Shanghai 200136China f.nnish meteorological Institute(f.I) Finland Department of.Earth and Environmental Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space Agency MontrealCanada Gf. German Research Centre f.r Geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria University Newcastle upon TyneTyne and WearUK NE18ST National Space Science Center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint European Space Agency and Chinese Academy of.Sciences Solar wind magnetosphere Ionosphere Link Explorer(SmILE)mission will explore global dynamics of.the magnetosphere under varying solar wind and interplanetary magnetic f.eld conditions,and simultaneously monitor the auroral response of.the Northern Hemisphere *** these large-scale responses with medium and f.ne-scale measurements at a variety of.cadences by additional ground-based and space-based instruments will enable a much greater scientif.c impact beyond the original goals of.the SmILE ***,we describe current community ef.orts to prepare f.r SmILE,and the benef.ts and context various experiments that have explicitly expressed support f.r SmILE can of.er.A dedicated group of.international scientists representing many dif.erent experiment types and geographical locations,the Ground-based and Additional Science Working Group,is f.cilitating these *** include constructing an online SmILE Data f.sion f.cility,the discussion of.particular or special modes f.r experiments such as coherent and incoherent scatter radar,and the consideration of.particular observing strategies and spacecraf. *** anticipate growing interest and community engagement with the SmILE mission,and we welcome novel ideas and insights f.om the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation SmILE conjunctions missions

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The Use of.Secondary Grape Biomass in Beef.Cattle Nutrition on Carcass Characteristics, Quality and Shelf.Lif. of.meat

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f.od and Nutrition Sciences 2024年第6期15卷 447-469页

作者： Vitor L. molosse Guilherme L. Deolindo Raf.el V. P. Lago Bruna Klein Claiton A. Zotti marcelo Vedovato marcylene V. da Silveira Priscila m. Copetti maria R. C. Schetinger Juscivete f. f.vero Eliana L. f.orentin Aleksandro S. da Silva Universidade do Estado de Santa Catarina (UDESC) Chapec Brazil Department of.Animal Science UDESC Chapec Brazil Department of.Animal Science Universidade do Oeste de Santa Catarina Xanxere Brazil Dean Lee Research and Extension Center Louisiana State University Alexandria LA USA Department of.Biochemistry Universidade Federal de Santa Maria Santa Maria Brazil Department of.medicina Veterinria UNOCHAPEC Chapec Brasil

We determined whether the inclusion of.100 g/kg dry matter of.grape pomace silage (GPS) and grape pomace bran (GPB) as substitutes f.r other traditional f.ber sources in the diet of.steers (Charolais x Nellore) would improve carcass characteristics, meat quality and composition, and shelf.lif.. Twenty-f.ur animals (248 ± 19.32 kg of.initial body weight) were f.d a high concentrate diet f.r 121 days. Carcass characteristics were measured, and the longissimus dorsi muscle was analyzed f.r f.tty acid (f.) prof.le and composition. The meat was sliced and stored in air-permeable packages f.r 10 days. On each sampling day (d 1, 3, 7, and 10), oxidative stability, bacterial load, lipid and protein oxidation, and staining were analyzed. The experimental diets inf.uenced the pH of.cold carcasses only. The GPS group had a higher pH than the control. The GPS and GPB groups showed improved oxidant status (i.e., lower lipid peroxidation and concentrations of.reactive oxygen species were in the meat of.both groups than in control). On the f.rst day of.storage, the antioxidant enzyme glutathione S-transf.rase activity was more signif.cant in the meat of.the GPS and GPB groups than in the control. The bacterial loads in the meat were attenuated by GPS inclusion;there were lower total colif.rm counts and a trend toward lower counts f.r enterobacteria in the control group. The diets altered the f. prof.le of.the meat;i.e., the GPB diet allowed f.r a more signif.cant amount of.the n-6 omegas in the meat, while the GPS diet showed a tendency f.r a more signif.cant amount of.n-6 and 9 omegas. Both diets (GPS and GPB) increased the amounts of.long-chain f.s. The GPS diet decreased saturated f. levels. We conclude that the dietary treatments GPS and GPB are a promising alternative to maintain meat quality standards throughout in real-world retail conditions. These treatments gave rise to an improvement in the nutritional value of.the meat due to the more signif.cant amounts of.f.s that im

关键词： Animal Nutrition Antioxidant Biomass Grape meat Quality microbiology Residue

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A review:the mechanism of.plant-derived polysaccharides on osteoblasts and osteoclasts

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未来食品学报(英文) 2024年第3期4卷 183-192页

作者： mengjie Ren Adel f.Ahmed meng Li menghan Li Zhiruo Yan Jinmei Wang National R&D Center f.r Edible f.ngus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of.f.od&medicine Resource f.nction Henan ProvinceKaifeng 475004China medicinal and Aromatic Plants Researches Department Horticulture Research InstituteAgricultural Research CenterGiza 12511Egypt

Bone loss and deterioration of.bone microarchitecture would increase the bone f.agility and f.acture risk,leading to the *** and more evidences proved that plant-derived polysaccharides could have a remarkable inf.uence on osteoblasts and osteoclasts,exerting anti-osteoporosis *** to the previous research,the extract of.Cibotium barumoz,Achyranthes bidentata,Curculigo orchioides,Epimedium brevicornum,Angelica sinensis,Polygonatum sibiricum,Dendrobium of.icinale,morinda of.icinalis,Nelumbo mucif.ra,Diospyros kaki,Hordeum vulgare,Cistanche deserticola,Commiphora myrrha and other plant-derived polysaccharides could benef.t to the osteoblasts and *** essential mechanisms are mainly related to the activation or inhibition of.many f.ctors,including runt-related transcription f.ctor 2(Runx2),B-catenin,osterix(Osx),activator protein-1(AP-1),osteocalcin(OCN/BGP),alkaline phosphatase(ALP),osteopontin(OPN),bone morphogenetic protein(BmP),phosphatidylinositol 3-kinase(PI3K)/C-Jun N-terminal kinase(JNK)/extracellular regulated protein kinase(ERK),osteoprotegerin(OPG),receptor activator of.nuclear f.ctor-kB(RANK),monocyte/macrophage colony-stimulating f.ctor(m-CSf.,tumor necrosis f.ctor receptor-associated f.ctor 6(TRAf.6),receptor activator of.nuclear f.ctor(Nf.-KB ligand(RANKL),nuclear f.ctor of.activated T cells 1(Nf.Tc1),c-f.s,matrix metallopeptidase-9(mmP-9),glycogen synthase kinase 3β(GSK3B)/B-catenin,nuclear f.ctor E2-related f.ctor 2(Nf.),as well as these related pathways,such as Wnt/p-catenin,BmP-2/SmAD1/5/8,PI3K/AKT,OPG/RANKL/RANK,Nf.κB,mAPKs,*** plant-derived polysaccharides could improve the dynamic balance of.bone f.rmation and resorption through promoting the dif.erentiation and maturation of.osteoblast or inhibiting its *** reviewed plant-derived polysaccharides and their regulating mechanisms on the osteoclasts and osteoblasts provide the evidences f.r the development of.osteoporosis therapeutics.

关键词： Osteoporosis Plant-derived polysaccharides Osteogenesis promotion Osteoclasts inhibition

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Transcriptional reprogramming during human osteoclast dif.erentiation identif.es regulators of.osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： morten S.Hansen Kaja madsen maria Price Kent Søe Yasunori Omata mario m.Zaiss Caroline m.Gorvin morten f.ost Alexander Rauch molecular Endocrinology Laboratory(KmEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of.Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of.metabolism and Systems Research(ImSR)and Centre f.r Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre f.r membrane Proteins and Receptors(COmPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of.molecular medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of.Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of.Internal medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of.osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of.human osteoclastogenesis could help identif. potential treatment *** study aimed to provide an overview of.transcriptional reprogramming during human osteoclast *** were dif.erentiated f.om CD14+monocytes f.om eight f.male *** sequencing during dif.erentiation revealed 8980 dif.erentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular f.nctions associated with postmenopausal osteoporosis susceptibility genes based on RNA f.om iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specif.c transcriptional *** donor-specif.c expression patterns revealed genes at the monocyte stage,such as f.lamin B(f.NB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of.the resorptive activity of.mature *** expression of.dif.erentially expressed G-protein coupled receptors was strong during osteoclast dif.erentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast dif.erentiation and *** regulatory ef.ects of.three dif.erentially expressed G-protein coupled receptors were exemplif.ed by in vitro pharmacological modulation of.complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and f.ee f.tty acid receptor 4(f.AR4/GPR120).Activating C5AR1 enhanced osteoclast f.rmation,while activating SSTR2 decreased the resorptive activity of.mature osteoclasts,and activating f.AR4 decreased both the number and resorptive activity of.mature *** conclus

关键词： osteoclast programming identif

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