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Cellular & Molecular Immunology 2021年第2期18卷 452-460页

作者： Amir Boufenzer kevin carrasco Lucie Jolly Benjamin Brustolin Elisa Di-Pillo Marc Derive Sébastien Gibot INOTREM Vandœuvre-lès-NancyNancyFrance UMR-S 1116 Défaillance Cardiovasculaire Aigue et ChroniqueVandœuvre-lès-NancyNancyFrance CHRU Nancy Hôpital CentralService de Réanimation MédicaleNancyFrance

During sepsis,neutrophil activation induces endothelial cell(EC)dysfunction partly through neutrophil extracellular trap(NET)*** triggering receptor expressed on myeloid cell-1(TREM-1)is an orphan immune receptor that amplifies the inflammatory response mediated by Toll-like receptor-4(TLR4)*** the key role of TLR4 signaling in NETosis is known,the role of TREM-1 in this process has not yet been ***,we report that TREM-1 potentiates NET release by human and murine neutrophils and is a component of the NET *** contrast,pharmacologic inhibition or genetic ablation of TREM-1 decreased NETosis in vitro and during experimental septic shock in ***,isolated NETs were able to activate ECs and impair vascular reactivity,and these deleterious effects were dampened by TREM-1 ***-1 may,therefore,constitute a new therapeutic target to prevent NETosis and associated endothelial dysfunction.

关键词： TREM-1 NETs sepsis endothelial cell activation vascular dysfunction LR12

TREM-1 multimerization is essential for its activation on monocytes and neutrophils

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Cellular & Molecular Immunology 2019年第5期16卷 460-472页

作者： kevin carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive INOTREM Vandœuvre-les-NancyFrance UMR-S 1116 Defaillance cardiovasculaire aigue et chroniqueVandœuvre-les-NancyFrance UMR7365 Ingénierie Moléculaire et Physiopathologie Articulaire(IMoPA)CNRS-Universitéde LorraineVandœuvre-les-NancyFrance Biomolecular Mass Spectrometry and Proteomics Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences and Netherlands Proteomics CenterUtrecht UniversityUtrechtThe Netherlands Innate Immunity German Cancer Research Center(DKFZ)HeidelbergGermany CovalX ZurichSwitzerland Service Commun de Biophysique Interactions Moléculaires(SCBIM) FR3209Biopole de l’Universitede LorraineVandœuvre-les-NancyFrance Inatherys Evry CedexFrance

The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune *** promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel ***,the molecular events leading to the activation of TREM-1 in innate immune cells remain ***,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 ***-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and *** addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its *** further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and ***-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 *** results provide evidence for ligand-induced,receptor-mediated dimerization of ***,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils.

关键词： TREM-1 multimerization activation monocytes neutrophils

Protecting critical infrastructure against cascading effects:The PRECINCT approach

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Resilient Cities and Structures 2024年第3期3卷 1-19页

作者： Meisam Gordan Djibrilla Amadou Kountche Daniel McCrum Stefan Schauer Sandra Konig Shirley Delannoy Lorcan Connolly Mircea Iacob Nicola Gregorio Durante Yash Shekhawat Carlos carrasco Takis Katsoulakos Páraic Carroll School of Civil Engineering University College DublinBelfield D04 V1W8 DublinIreland AKKODIS Research 1 7 Boulevard Jean ZieglerBlangac 31700France Austrian Institute of Technology(AIT) Safety&Security DepartmentViennaAustria VIAS Institute(VIAS) Haachtsesteenweg 1405Bruxelles 1130Belgium Research Driven Solutions Limited(RDS) 1A Saint Kevin S AvenueD08 TX29 DublinIreland Interuniversitair Micro-Electronica Centrum(IMEC) Kapeldreef 75Leuven 3001Belgium Engineering-Ingegneria Informatica Spa(ENG) Piazzale Dell’agricoltura 24Roma 00144Italy NUROGAMES GMBH(NURO) Schaafenstrasse 25Cologne 50676Germany Barcelona Supercomputing Centre(BSC) Jordi Girona 31Barcelona 08034Spain Inlecom Commercial Pathways(ICP) Core B Block 7The Plaza Park WestD12 WDN2Ireland

Critical Infrastructures(CIs),which serve as the foundation of our modern society,are facing increasing risks from cyber threats,physical attacks,and natural ***,the interdependencies between CIs through-out their operational lifespan can also significantly impact their integrity and *** a result,enhancing the resilience of CIs has emerged as a top priority for many countries,including the European *** involves not only understanding the threats/attacks themselves but also gaining knowledge about the areas and infrastruc-tures that could potentially be affected.A European Union-funded project named PRECINCT(Preparedness and Resilience Enforcement for Critical INfrastructure Cascading Cyber-Physical Threats),under the Horizon 2020 program,tries to connect private and public stakeholders of CIs in a specific geographical *** key objec-tive of this project is to establish a common cyber-physical security management approach that will ensure the protection of both citizens and infrastructures,creating a secure *** paper presents the components of PRECINCT,including a directory of PRECINCT Critical Infrastructure Protection(CIP)*** blueprints support CI communities in designing integrated ecosystems,operating and replicating PRECINCT components(or toolkits).The integration enables coordinated security and resilience management,incorporating improved’installation-specific’security ***,Serious Games(SG),and Digital Twins(DT)are a significant part of this project,serving as a novel vulnerability evaluation method for analysing complicated multi-system cascading effects in the PRECINCT Living Labs(LLs).The use of SG supports the concentrated advancement of innovative resilience enhancement services.

关键词： Critical infrastructure protection Serious games Digital twins Blueprints OASIS TOSCA Industry 4.0 Resilience Interdependencies Cyber-physical

Calibration of SWAT2009 Using Crop Biomass, Evapotranspiration, and Deep Recharge: Calera Watershed in Zacatecas, Mexico Case Study

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Journal of Water Resource and Protection 2012年第7期4卷 439-450页

作者： Jose R. ávila-carrasco Francisco Mojarro Dávila Daniel N. Moriasi Prasanna H. Gowda Carlos Bautista-Capetillo Francisco G. Echavarria-Cháirez Jurgen D. Garbrecht Jean L. Steiner Terry A. Howell Edward T. Kanemasu Alan J. Verser kevin Wagner Jairo Hernandez Department of Civil Engineering Boise State University Boise USA Instituto Nacional de Investigaciones Forestales Agricolas y Pecuarias (INIFAP) Zacatecas Calera de V.R. Zac. Mexico Office of Global Programs University of Georgia Georgia USA Texas Water Resources Institute Texas A&M Institute of Renewable Natural Resources College Station USA Universidad Autónoma de Zacatecas Zacatecas México USDA-ARS-Conservation and Production Research Laboratory Bushland USA USDA-ARS-Grazinglands Research Laboratory El Reno USA

Groundwater is the main source of water in the semi-arid Calera watershed, located in the State of Zacatecas, Mexico. Due to increasing population, rapid industrial growth, and increased irrigation to meet growing food demand, groundwater extraction in the Calera watershed are exceeding recharge rates. Therefore, development and evaluation of alter-native water management strategies are needed for sustainable development of the region. The Soil and Water Assessment Tool (SWAT) model was selected for this purpose as it has been used to simulate a wide range of agricultural production, the extensive testing and application in diverse watersheds worldwide, and the potential for future linkage of this model to groundwater models. However, crucial flow data which are commonly used for calibrating hydrologic models are not available in this watershed. This paper describes a novel calibration methodology that uses biomass and water balance approach which has potential for calibration of hydrologic models in ungauged or data-scarce watersheds, which are prevalent in many parts of the world. Estimated long-term annual average actual evapotranspiration (AET), and deep aquifer recharge rates and plant biomass values based on the expert knowledge of researchers and managers in the watershed were used as targets for calibration. The model performance was assessed using the Nash-Sutcliffe effi-ciency coefficient (NSE), coefficient of determination (R2), and percent bias (PBIAS, %) statistics. On average, the calibrated SWAT model yielded annual Nash-Sutcliffe efficiency coefficient values of 0.95, 0.99, and 0.85 for AET, recharge, and biomass, respectively. The coefficient of determination, values for AET, recharge, and biomass were 0.95, 0.94, and 0.99 respectively. The percent bias values of ±2.21%, ±0.18%, and ±0.96% for AET, recharge, and biomass, respectively, indicated that the model reproduced the calibration target values of the three water budget variables within an acce

关键词： SWAT Calera Watershed Scenarios Recharge Evapotranspiration Runoff Erosion