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交、直流电场作用下交联聚乙烯中的空间电荷习性（英文）

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高电压技术 2015年第4期41卷 1167-1177页

作者： c.zhou G.chen The Tony Davies High Voltage Laboratory University of Southampton

Polyethylene is one of the widely studied polymeric insulation materials,which have been used extensively for cable *** of the major issues related to polymeric materials is its easy formation of space charge,a high chance to cause electric field *** phenomenon is more significant under high voltage direct current(HVDc)*** charge can also be observed under high voltage alternative current(HVAc)stresses but with much less intensity due to the limited charge injection period and the effect of charge recombination caused by the constantly variance of the external *** considering the situation of an Ac voltage combined with a Dc offset,a possible scenario in HVDc technology,there was little research on charge dynamics in the insulation in terms of both experimental and simulation *** this paper,a numerical simulation based a bipolar charge injection/transport model is used to obtain characteristics of space charge in polyethylene under the combined Ac and Dc high voltage at room *** bipolar charge injection/transport model,which is widely used in HVDc space charge simulation,is applied in the combined *** overall applied voltage,consisted of root mean square(RMS)values of the Ac voltage and Dc voltage,is kept the same,while the Dc component’s voltage ratio and Ac component’s frequency are changed respectively,to illustrate their effects on the space charge dynamics within the insulation under combined electric *** simulated charge distributions present notable differences when Dc offset is increasingly added in,while relatively small differences when Ac component’s frequency altering,especially for the cases whose frequency exceeding 0.5 Hz.

关键词：空间电荷交流电场聚乙烯直流电行为研究聚合物绝缘材料 HVDc HVAc

Assessment of cOVID-19 aerosol transmission in a university campus food environment using a numerical method

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Geoscience Frontiers 2022年第6期13卷 265-278页

作者： M.Zhao c.zhou T.chan c.Tu Y.Liu M.Yu Laboratory of Aerosol Science and Technology China Jiliang UniversityHangzhouChina Department of Mechanical Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina college of Modern Science China Jiliang UniversityHangzhouChina

With the prevalence of cOVID-19,the phenomenon of viruses spreading through aerosols has become a focus of *** in university dining halls have a high risk of exposure to respiratory droplets from others without the protection of face masks,which greatly increases the risk of cOVID-19 ***,the transmission mechanism of respiratory droplets in extremely crowded dining environments should be *** this study,a numerical simulation of coughing at dining tables under two conditions was performed,namely the presence and absence of protective partitions,and the evaporation and condensation of aerosol droplets in the air were *** using the numerical method,we analyzed and verified the isolation effect of dining table partitions in the propagation of aerosol *** effect of changes in room temperature on the diffusion of coughed aerosols when partitions were present was *** demonstrated how respiratory droplets spread through coughing and how these droplets affect ***,we proposed a design for a dining table partition that minimizes the transmission of cOVID-19.

关键词： cOVID-19 transmission University dining hall cough Table partition computational fluid dynamics

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面向电力市场的配电管理信息系统设计

电力系统自动化 2000年第21期24卷 56-58页

作者：张华美 c.zhou 烟台东方电子信息产业股份有限公司烟台264001 Glasgow caledonian大学

介绍了一种面向电力市场的、集成的配电管理信息系统 ,分析了该配电管理信息系统所需要的商业信息 ,包括提供给监督机构所必须的信息 ,以及使配电系统高效管理、运行所需要的信息 ,同时 ,描述了该系统的业务模型。

关键词：配电系统管理信息系统电力市场系统设计

Antigen-specific mRNA lipid nanoparticle platforms for the prevention and treatment of allergy and autoimmune diseases

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BMEMat(BioMedical Engineering Materials) 2024年第2期2卷 61-68页

作者： Emma Y.Yim Amanda c.zhou Yvonne c.Yim Xiang Wang Tian Xia Department of Molecular Cell and Developmental BiologyUniversity of CaliforniaLos AngelesUSA Department of Bioengineering University of CaliforniaLos AngelesUSA Department of chemistry and Biochemistry University of CaliforniaLos AngelesUSA Division of NanoMedicine Department of MedicineCenter for Environmental Implications of Nanotechnology(UC CEIN)California NanoSystems InstituteUniversity of CaliforniaLos AngelesUSA

While most nanomedicines primarily aim to stimulate the immune system against infections or tumors,there is a growing demand for inducing immune tolerance under certain conditions,such as allergic and autoimmune *** have explored nanotechnology-based strategies to induce immune tolerance in a targeted and specific *** approach involves the use of nanoparticles(NPs)to encapsulate immunosuppressive drugs and/or antigens to educate naïve T cells and promote the generation of antigen-specific regulatory T cells that inhibit immune ***,this approach has certain *** hydrophobicity of proteins or peptides restricts the degree to which they can be encapsulated in NPs,which in turn,affects their loading efficiency and treatment *** the emergence of mRNA lipid nanoparticle(LNP)platforms,there is the possibility of overcoming the limitations of protein and peptide *** date,mRNA LNP systems have been shown to provide organ,cellular,and subcellular targeting for the induction of immune *** method of drug delivery is flexible and scalable that can be customized for a specific patient,resulting in an effective means of administering relevant proteins or epitopes to induce antigen-specific immune *** continued research and development,this technology could offer a safer and more effective alternative to current therapies,ultimately improving the quality of life of patients worldwide.

关键词： allergy autoimmune diseases immune tolerance mRNA lipid nanoparticle nanomedicine

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao chaoyang chu Zhicheng Lin Tianyuan Fang Yuyu zhou chuxia Zhang Jianghui Shan Shiyu chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

Layer-layout-based heuristics for loading homogeneous items into a single container

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 1944-1952页

作者： WANG zhou-jing LI kevin W Department of Automation Xiamen University Xiamen 361005 China Odette School of Business University of Windsor Windsor Ontario N9B 3P4 Canada

The container loading problem (cLP) is a well-known NP-hard problem. Due to the computation complexity, heuristics is an often-sought approach. This article proposes two heuristics to pack homogeneous rectangular boxes into a single container. Both algorithms adopt the concept of building layers on one face of the container, but the first heuristic determines the layer face once for all, while the second treats the remaining container space as a reduced-sized container after one layer is loaded and, hence, selects the layer face dynamically. To handle the layout design problem at a layer's level, a block-based 2D packing procedure is also developed. Numerical studies demonstrate the efficiency of the heuristics.

关键词： container loading problem (cLP) Heuristic Laver Packing. Optimization

Approaches to Improving consistency of Interval Fuzzy Preference Relations

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Journal of Systems Science and Systems Engineering 2014年第4期23卷 460-479页

作者： Wu-Yong Qian kevin W.Li zhou-Jing Wang School of Business Jiangnan University OdetteSchool of Business University of WindsorWindsor OntarioN9B 3P4Canada School of Information Zhejiang University of Finance & Economics

This article introduces a consistency index for measuring the consistency level of an interval fuzzy preference relation（IFPR）.An approach is then proposed to construct an additive consistent IFPR from a given inconsistent *** using a weighted averaging method combining the original IFPR and the constructed consistent IFPR,a formula is put forward to repair an inconsistent IFPR to generate an IFPR with acceptable *** iterative algorithm is subsequently developed to rectify an inconsistent IFPR and derive one with acceptable consistency and weak *** proposed approaches can not only improve consistency of IFPRs but also preserve the initial interval uncertainty information as much as *** examples are presented to illustrate how to apply the proposed approaches.

关键词： Interval fuzzy preference relation additive consistency acceptable consistency weak transitivity decision making

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu chen Tong zhou Zhe-Yi Han Jun Xiao Jian-Feng Ma Wen Ma Peng Zang Ying chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BAcKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(ScF)/c-kit signaling pathway associated with intestinal flora and cajal stromal ***,intestinal flora can also affect the regulation of ScF/c-kit signaling pathway,thus affecting the expression of cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related ScF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of ScF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of ScF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway