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关节假体真菌感染的微生物学临床及手术特点：一项多机构经验

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中华骨科杂志 2010年第9期30卷 I0019-I0024页

作者： Khalid Azzam, md Javad Parvizi, md FRCS, Donald Jungkind, PhD Diplomate (ABMM) Arlen Hanssen, md ThomasFehring, md Bryan Springer, md kevin bozic, md Craig Della Valle, md Luis Pulido, md Robert Barrack, md 曹沛宏(译) 不详天津医院关节科 300211

关节假体周围感染是关节置换术后最可怕、最复杂的并发症。关节假体周围感染是目前全膝关节置换失败的最主要原因，是全髋关节置换失败原因的第三位。估计关节假体周围感染的发病率正逐渐上升。很多原因导致关节假体周围感染，最主要的... 详细信息

关节假体周围感染是关节置换术后最可怕、最复杂的并发症。关节假体周围感染是目前全膝关节置换失败的最主要原因，是全髋关节置换失败原因的第三位。估计关节假体周围感染的发病率正逐渐上升。很多原因导致关节假体周围感染，最主要的原因是革兰氏阳性细菌感染，特别是链球菌。

关键词：关节假体手术特点微生物学真菌感染假体周围感染革兰氏阳性细菌感染全膝关节置换临床

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美国全髋置换关节负重面应用的流行情况调研

中华骨科杂志 2010年第3期30卷 I0012-I0017页

作者： kevin J. bozic, md MBA Steven Kurtz, PhD Edmund Lau, MS kevin Ong, PhD Vanessa Chiu, MPH Thomas P. Vail, md Harry E. Rubash, md Danie J. Berry, md 田丰德(译) 赵德伟(译) Investigation performed at the Department of Orthopaedic Surgery and Philip R. Lee Institute for Health Policy Studies University of California San Francisco San Francisco California and Exponent Inc. Philadelphia Pennsylcanina 大连大学附属中山医院 116001

背景：硬性对硬性材料的负重面有提高全髋关节置换假体植入物生存的潜力。然而，对于使用这些先进技术的特定适应证仍然存在争议。本研究的日的是从患者、医院、地域和支付人特点几方面对美国全髋关节置换中负重面应用情况进行流行病学... 详细信息

背景：硬性对硬性材料的负重面有提高全髋关节置换假体植入物生存的潜力。然而，对于使用这些先进技术的特定适应证仍然存在争议。本研究的日的是从患者、医院、地域和支付人特点几方面对美国全髋关节置换中负重面应用情况进行流行病学研究。方法：应用全国住院病例数据库资料，对从2005年10月1日至2006年12月31日，在美国进行的112095例初次全髋关节置换病例的负重面类型及其人口统计学特征进行分析。病例按照年龄、性别、普查区域、付款人类别和医院的类型进行分组，计算每种类型髋关节负重面在各组中的使用率。

关键词：关节负重流行情况应用全髋置换美国全髋关节置换病例数据库调研

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David Hudson kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

Designing high-TC superconductors with BCS-inspired screening,density functional theory,and deep-learning

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npj Computational Materials 2022年第1期8卷 2331-2342页

作者： Kamal Choudhary kevin Garrity Material Measurement Laboratory GaithersburgMD20899USA National Institute of Standards and Technology GaithersburgMD20899USA Theiss Research La JollaCA92037USA

We develop a multi-step workflow for the discovery of conventional superconductors,starting with a Bardeen–Cooper–Schrieffer inspired pre-screening of 1736 materials with high Debye temperature and electronic density of ***,we perform electron-phonon coupling calculations for 1058 of them to establish a large and systematic database of BCS superconducting *** the McMillan-Allen-Dynes formula,we identify 105 dynamically stable materials with transition temperatures,TC≥5 ***,we analyze trends in our dataset and individual materials including MoN,VC,VTe,KB_(6),Ru_(3)NbC,V_(3)Pt,ScN,LaN_(2),RuO_(2),and *** demonstrate that deep-learning(DL)models can predict superconductor properties faster than direct first-principles ***,we find that by predicting the Eliashberg function as an intermediate quantity,we can improve model performance versus a direct DL prediction of *** apply the trained models on the crystallographic open database and pre-screen candidates for further DFT calculations.

关键词： database BCS faster

New Record Ocean Temperatures and Related Climate Indicators in 2023

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Advances in Atmospheric Sciences 2024年第6期41卷 1068-1082页

作者： Lijing CHENG John ABRAHAM kevin E.TRENBERTH Tim BOYER Michael EMANN Jiang ZHU Fan WANG Fujiang YU Ricardo LOCARNINI John FASULLO Fei ZHENG Yuanlong LI Bin ZHANG Liying WAN Xingrong CHEN Dakui WANG Licheng FENG Xiangzhou SONG Yulong LIU Franco RESEGHETTI Simona SIMONCELLI Viktor GOURETSKI Gengxin CHEN Alexey MISHONOV Jim REAGAN Karina VON SCHUCKMANN Yuying PAN Zhetao TAN Yujing ZHU Wangxu WEI Guancheng LI Qiuping REN Lijuan CAO Yayang LU International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of St.Thomas School of EngineeringMinnesota 55105USA NSF National Center for Atmospheric Research BoulderColorado 80307USA University of Auckland Auckland 1010New Zealand National Oceanic and Atmospheric Administration National Centers for Environmental InformationSilver SpringMaryland 20910USA Department of Earth and Environmental Science University of PennsylvaniaPhiladelphiaPennsylvania 19104USA Institute of Oceanology Chinese Academy of SciencesQingdao 266071China National Marine Environmental Forecasting Center Ministry of Natural Resources of ChinaBeijing 100081China Oceanographic Data Center Chinese Academy of SciencesQingdao 266071China College of Oceanography Hohai UniversityNanjing 210098China National Marine Data and Information Service Tianjin 300171China Italian National Agency for New Technologies Energy and Sustainable Economic DevelopmentS.Teresa Research CenterLerici 19032Italy Istituto Nazionale di Geofisica e Vulcanologia Sede di BolognaBologna 40128Italy South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China ESSIC/CISESS-md University of MarylandCollege ParkMD20740USA Mercator Ocean International Toulouse 31400France Eco-Environmental Monitoring and Research Center Pearl River Valley and South China Sea Ecology and Environment AdministrationMinistry of Ecology and EnvironmentPRCGuangzhou 510611China National Meteorological Information Center China Meteorological AdministrationBeijing 100081China International Research Center of Big Data for Sustainable Development Goals Beijing 100094China

The global physical and biogeochemical environment has been substantially altered in response to increased atmospheric greenhouse gases from human *** 2023,the sea surface temperature(SST)and upper 2000 m ocean heat content(OHC)reached record *** 0–2000 m OHC in 2023 exceeded that of 2022 by 15±10 ZJ(1 Zetta Joules=1021 Joules)(updated IAP/CAS data);9±5 ZJ(NCEI/NOAA data).The Tropical Atlantic Ocean,the Mediterranean Sea,and southern oceans recorded their highest OHC observed since the *** with the onset of a strong El Niño,the global SST reached its record high in 2023 with an annual mean of~0.23℃ higher than 2022 and an astounding>0.3℃ above 2022 values for the second half of *** density stratification and spatial temperature inhomogeneity indexes reached their highest values in 2023.

关键词： ocean heat content salinity stratification global warming climate

Chowing down:diet considerations in rodent models of metabolic disease

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Life Metabolism 2023年第3期2卷 10-18页

作者： kevin C.Klatt kevin Bass John R.Speakman kevin D.Hall Department of Nutritional Sciences and Toxicology University of California BerkeleyBerkeleyCA 94720United States Garrison Institute of Aging Texas Tech University Health Science CenterLubbockTX 79430United States Center for Energy Metabolism and Reproduction Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of HealthBethesdaMD 20892United States

Diet plays a substantial role in the etiology, progression, and treatment of chronic disease and is best considered as a multifacetedset of modifiable input variables with pleiotropic effects on a variety of biological pathways spanning multiple organ systems. Thisbrief review discusses key issues related to the design and conduct of diet interventions in rodent models of metabolic disease andtheir implications for interpreting experiments. We also make specific recommendations to improve rodent diet studies to help betterunderstand the role of diet on metabolic physiology and thereby improve our understanding of metabolic disease.

关键词： diet composition nutrition chow study design recommendations

Author Correction:Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24

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Cellular & Molecular Immunology 2024年第1期21卷 100-100页

作者： Zhengzhou Ying Swanand Hardikar Joshua B.Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu kevin M.McBride Taiping Chen Department of Epigenetics and Molecular Carcinogenesis The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Program in Genetics and Epigenetics The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Houston TX 77030 USA

In the sentence beginning‘To trace cell proliferation,FO and MZ B cells’and the sentence beginning‘For cell activation,naïve B cells or CH12F3 cells’in this article,the[10 ng/ml]‘F(ab’)_(2)fragment goat anti-mouse IgM’should have read‘10μg/ml F(ab’)_(2)fragment goat anti-mouse IgM’.The original article has been corrected.

关键词： immunodeficiency CD19 deficient

ezQTL:A Web Platform for Interactive Visualization and Colocalization of QTLs and GWAS Loci

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 541-548页

作者： Tongwu Zhang Alyssa Klein Jian Sang Jiyeon Choi kevin M.Brown Division of Cancer Epidemiology and Genetics National Cancer InstituteBethesdaMD 20892USA

Genome-wide association studies(GWAS)have identified thousands of genomic loci associated with complex diseases and traits,including *** vast majority of common traitassociated variants identified via GWAS fall in non-coding regions of the genome,posing a challenge in elucidating the causal variants,genes,and mechanisms *** quantitative trait locus(eQTL)and other molecular QTL studies have been valuable resources in identifying candidate causal genes from GWAS loci through statistical colocalization *** QTL colocalization is becoming a standard analysis in post-GWAS investigation,an easy web tool for users to perform formal colocalization analyses with either user-provided or public GWAS and eQTL datasets has been ***,we present ezQTL,a web-based bioinformatic application to interactively visualize and analyze genetic association data such as GWAS loci and molecular QTLs under different linkage disequilibrium(LD)patterns(1000 Genomes Project,UK Biobank,or user-provided data).This application allows users to perform data quality control for variants matched between different datasets,LD visualization,and two-trait colocalization analyses using two state-of-the-art methodologies(eCAVIAR and HyPrColoc),including batch *** is a free and publicly available cross-platform web tool,which can be accessed online at https://***/ezqtl.

关键词： Genome-wide association study Expression quantitative trait locus Colocalization Linkage disequilibrium Visualization

Climate change and surgical implications

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Emergency and Critical Care Medicine 2023年第1期3卷 4-5页

作者： Clifton Ewbank kevin Gianaris Adam L.Kushner Department of Surgery University of California San Francisco–East BayOaklandCAUSA Indiana University College of Medicine IndianapolisINUSA Bloomberg School of Public Health Johns Hopkins UniversityBaltimoreMDUSA

The healthcare sector contributes nearly 5%of the total global carbon emissions,and much of this is attributable to the delivery of surgical *** this article,we reviewthe impact of surgery on climate change and propos... 详细信息

关键词： Climate change Global surgery Surgery