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International Journal of Disaster Risk Science 2022年第3期13卷 415-434页

作者： Patrick D.Royer Wei Du kevin schneider Energy and Environment Pacific Northwest National LaboratoryRichlandWA99352USA

The disparate nature of data for electric power utilities complicates the emergency recovery and response *** reduced efficiency of response to natural hazards and disasters can extend the time that electrical service is not available for critical end-use loads,and in extreme events,leave the public without power for extended *** article presents a methodology for the development of a semantic data model for power systems and the integration of electrical grid topology,population,and electric distribution line reliability indices into a unified,cloud-based,serverless framework that supports power system operations in response to extreme *** iterative and pragmatic approach to working with large and disparate datasets of different formats and types resulted in improved application runtime and efficiency,which is important to consider in real time decision-making processes during hurricanes and similar catastrophic *** technology was developed initially for Puerto Rico,following extreme hurricane and earthquake events in 2017 and 2020,but is applicable to utilities around the *** the highly abstract and modular design approach,this technology is equally applicable to any geographic region and similar natural hazard *** addition to a review of the requirements,development,and deployment of this framework,technical aspects related to application performance and response time are highlighted.

关键词： Electrical grid Hurricane response Puerto Rico Resilience and geospatial technology Software applications

Clone-World:A visual analytic system for large scale software clones

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Visual Informatics 2019年第1期3卷 18-26页

作者： Debajyoti Mondal Manishankar Mondal Chanchal K.Roy kevin A.schneider Yukun Li Shisong Wang Department of Computer Science University of SaskatchewanSaskatoonSKCanada

With the era of big data approaching,the number of software systems,their dependencies,as well as the complexity of the individual system is becoming larger and more *** these evolving software systems is thus a primary challenge for cost-effective software management and *** this paper we perform a case study with evolving code *** programmers often need to manually analyze the co-evolution of clone fragments to decide about refactoring,tracking,and bug ***,manual analysis is time consuming,and nearly infeasible for a large number of clones,e.g.,with millions of similarity pairs,where clones are evolving over hundreds of software *** propose an interactive visual analytics system,Clone-World,which leverages big data visualization approach to manage code clones in large software ***-World,gives an intuitive yet powerful solution to the clone analytic ***-World combines multiple informationlinked zoomable views,where users can explore and analyze clones through interactive exploration in real *** studies and experts’reviews suggest that Clone-World may assist developers in many real-life software development and maintenance *** believe that Clone-World will ease the management and maintenance of clones,and inspire future innovation to adapt visual analytics to manage big software systems.

关键词： Visual analytics Software clones Multivariate networks

Current landscape in motoneuron regeneration and reconstruction for motor cranial nerve injuries

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Neural Regeneration Research 2020年第9期15卷 1639-1649页

作者： Yanjun Xie kevin J.schneider Syed A.Ali Norman D.Hogikyan Eva L.Feldman Michael J.Brenner Department of Otolaryngology-Head and Neck Surgery University of Michigan Medical SchoolAnn ArborMIUSA Department of Neurology University of Michigan Medical SchoolAnn ArborMIUSA

The intricate anatomy and physiology of cranial nerves have inspired clinicians and scientists to study their roles in the nervous system. Damage to motor cranial nerves may result from a variety of organic or iatrogenic insults and causes devastating functional impairment and disfigurement. Surgical innovations directed towards restoring function to injured motor cranial nerves and their associated organs have evolved to include nerve repair, grafting, substitution, and muscle transposition. In parallel with this progress, research on tissue-engineered constructs, development of bioelectrical interfaces, and modulation of the regenerative milieu through cellular, immunomodulatory, or neurotrophic mechanisms has proliferated to enhance the available repertoire of clinically applicable reconstructive options. Despite these advances, patients continue to suffer from functional limitations relating to inadequate cranial nerve regeneration, aberrant reinnervation, or incomplete recovery of neuromuscular function. These shortfalls have profound quality of life ramifications and provide an impetus to further elucidate mechanisms underlying cranial nerve denervation and to improve repair. In this review, we summarize the literature on reconstruction and regeneration of motor cranial nerves following various injury patterns. We focus on seven cranial nerves with predominantly efferent functions and highlight shared patterns of injuries and clinical manifestations. We also present an overview of the existing reconstructive approaches, from facial reanimation, laryngeal reinnervation, to variations of interposition nerve grafts for reconstruction. We discuss ongoing endeavors to promote nerve regeneration and to suppress aberrant reinnervation and the development of synkinesis. Insights from these studies will shed light on recent progress and new horizons in understanding the biomechanics of peripheral nerve neurobiology, with emphasis on promising strategies for optimizing

关键词： axon degeneration cranial neuropathy facial nerve facial paralysis motoneuron nerve regeneration peripheral nerve recurrent laryngeal nerve synkinesis vocal fold paralysis

Diagnostics for a troubled backbone:testing topological hypotheses of trapelioid lichenized fungi in a large-scale phylogeny of Ostropomycetidae(Lecanoromycetes)

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Fungal Diversity 2015年第4期73卷 239-258页

作者： Philipp Resl kevin schneider Martin Westberg Christian Printzen Zdeněk Palice Göran Thor Alan Fryday Helmut Mayrhofer Toby Spribille Institute of Plant Sciences NAWI GrazUniversity of GrazHolteigasse 6A-8010 GrazAustria Department of Botany Swedish Museum of Natural HistoryP.O.Box 50007SE-10405 StockholmSweden Senckenberg Forschungsinstitut und Naturmuseum Senckenberganlage 25D-60325 Frankfurt am MainGermany Institute of Botany Academy of Sciences of the Czech RepublicZámek 125243 PrůhoniceCzech Republic Department of Botany Faculty of SciencesCharles University in PragueBenátská212801 Praha 2Czech Republic Department of Ecology Swedish University of Agricultural SciencesP.O.Box 7044SE-75007 UppsalaSweden Herbarium Department of Plant BiologyMichigan State UniversityEast LansingMI 48824USA Division of Biological Sciences University of Montana32 Campus DriveMissoulaMT 59812USA

Trapelioid fungi constitute a widespread group of mostly crust-forming lichen mycobionts that are key to understanding the early evolutionary splits in the Ostropomycetidae,the second-most species-rich subclass of lichenized *** uncertain phylogenetic resolution of the approximately 170 species referred to this group contributes to a poorly resolved backbone for the entire *** on a data set including 657 newly generated sequences from four ribosomal and four protein-coding gene loci,we tested a series of a priori and new evolutionary hypotheses regarding the relationships of trapelioid clades within *** found strong support for a monophyletic group of nine core trapelioid genera but no statistical support to reject the long-standing hypothesis that trapelioid genera are sister to Baeomycetaceae or ***,we can reject a sister group relationship to Ostropales with high *** data also shed light on several longstanding questions,recovering Anamylopsoraceae nested within Baeomycetaceae,elucidating two major monophyletic groups within trapelioids(recognized here as Trapeliaceae and Xylographaceae),and rejecting the monophyly of the genus *** transfer eleven species of the latter genus to Lambiella and describe the genus Parainoa to accommodate a previously misunderstood species of *** phylogenetic studies in Ostropomycetidae have invoked Bdivergence order^for drawing taxonomic conclusions on higher level *** data show that if backbone support is lacking,contrasting solutions may be recovered with different or added *** accordingly urge caution in concluding evolutionary relationships from unresolved phylogenies.

关键词： Ascomycota Fungi Lambiella Lecanoromycetes Ostropomycetidae Parainoa Paraphyly SOWH test Taxon sampling

Proton pump inhibitors and all-cause mortality risk among cancer patients

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World Journal of Clinical Oncology 2025年第1期16卷 34-42页

作者： Arunkumar Krishnan Carolin Victoria schneider Declan Walsh Department of Supportive Oncology Atrium Health Levine CancerCharlotteNC 28204United States Department of Medicine Section of Hematology and OncologyWake Forest University School of MedicineWinston-SalemNC 27101United States Department of Medicine Ⅲ GastroenterologyMetabolic Diseasesand Intensive CareUniversity Hospital RWTH AachenAachen 52074Germany

BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related *** evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater *** To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize *** This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare *** study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer *** prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)*** primary outcome was all-cause *** patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding *** Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these *** a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individual

关键词： All-cause mortality Cancer Histamine-2 receptor antagonists Mortality Malignancy Proton pump inhibitors Carcinoma Outcome

Recurrence properties of sequences of integers

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Science China Mathematics 2010年第3期53卷 641-656页

作者： schneider Dominique CNRS LMPA J. Liouville FR 2956 University Lille Nord de France

In order to study the recurrence of sequences of integers, we investigate their L2-exactness and Θ-Hartman property (Θ being a set of rational numbers). Two classes of sequences of integers are well studied, which a... 详细信息

关键词： recurrent set random sequence Wiener-Wintner theorem

Insights into manganese transport: A matter of phosphorylation

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Molecular Plant 2022年第3期15卷 385-387页

作者： Anja schneider Plant Science Faculty of BiologyLudwig-Maximilians-Universität MünchenMunichGermany

Manganese(Mn)is an essential element required for the growth of all known living *** plants acquire Mn from the rhizosphere,and its translocation into,and distribution within,the plant involves a multitude of transporters(Alejandro et al.,2020).In the aerial part of the green plant,the most prominent reaction that depends on Mn is the water-splitting reaction of photosystem II,which employs a tetra-Mn cluster located in the thylakoid lumen of ***,no less important reactions take place in mitochondria,where a Mn superoxide dismutase acts as a scavenger of reactive oxygen species,and in the Golgi apparatus,where Mn-dependent glycosyltransferases are involved in cell wall biosynthesis.

关键词： manganese apparatus splitting

Evolving Perspectives on Abrupt Seasonal Changes of the General Circulation

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Advances in Atmospheric Sciences 2017年第10期34卷 1185-1194页

作者： Jianhua LU Tapio schneider School of Atmospheric Science Sun Yat-sen University Department of Environmental Science and Engineering California Institute of Technology

Professor Duzheng YE（Tu-cheng YEH） was decades ahead of his time in proposing a model experiment to investigate whether abrupt seasonal changes of the general circulation can arise through circulation feedbacks alone, unrelated to underlying inhomogeneities at the lower boundary. Here, we introduce Professor YEH＇s ideas during the 1950 s and 1960 s on the general circulation and summarize the results and suggestions of Yeh et al.（1959） on abrupt seasonal changes. We then review recent advances in understanding abrupt seasonal changes arising from model experiments like those proposed by Yeh et al.（1959）. The model experiments show that circulation feedbacks can indeed give rise to abrupt seasonal *** these transitions, large-scale eddies that originate in midlatitudes and interact with the zonal mean flow and meridional overturning circulations in the tropics play central roles.

关键词： abrupt change general circulation Hadley cell large-scale eddies

Karyotype analysis and polyploidy in Palaua and a comparison with its sister group Fuertesimalva(Malvaceae)

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Journal of Systematics and Evolution 2010年第3期48卷 175-182页

作者： Julio V schneider Marilú L HUERTAS Systematic Botany Biologie IUniversity of Leipzig Botany and Molecular Evolution Research Institute and Natural History Museum Senckenberg and Johann Wolfgang Goethe-Universitt

Palaua(Malveae,Malvaceae)comprises 15 species endemic to the hyperarid coastal desert of Chile and *** far,chromosome counts have been known for two diploid species(2n=2x=10)*** we report new chromosome numbers for 12 species of Palaua and four of its sister group *** including 4,6-diamidino-2-phenylindole dihydrochloride(DAPI)/chromomycin(CMA3)fluorescent banding are presented for selected species representative of each of the main clades of *** important finding is the discovery of polyploids in one exclusively tetraploid species(***)and four species with mixed diploid and tetraploid cytotypes(***,***,***,and ***).The diploid and tetraploid karyotypes are all unimodal,symmetrical and show one or two pairs of satellite chromosomes with their associated CMA+/DAPI- band depending on the *** some of the tetraploids an autopolyploid origin is suggested.

关键词： autopolyploidy chromosome base number desert fluorochrome staining lomas Malveae Urocarpidium.

APPROXIMATING THE STATIONARY BELLMAN EQUATION BY HIERARCHICAL TENSOR PRODUCTS

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Journal of Computational Mathematics 2024年第3期42卷 638-661页

作者： Mathias Oster Leon Sallandt Reinhold schneider Technische Universität Berlin Strasse des 17.Juni 13510623 BerlinGermany

We treat infinite horizon optimal control problems by solving the associated stationary Bellman equation numerically to compute the value function and an optimal feedback *** dynamical systems under consideration are spatial discretizations of non linear parabolic partial differential equations(PDE),which means that the Bellman equation suffers from the curse of *** non linearity is handled by the Policy Iteration algorithm,where the problem is reduced to a sequence of linear equations,which remain the computational bottleneck due to their high *** reformulate the linearized Bellman equations via the Koopman operator into an operator equation,that is solved using a minimal residual *** the Koopman operator we identify a preconditioner for operator equation,which deems essential in our numerical *** overcome computational infeasability we use low rank hierarchical tensor product approximation/tree-based tensor formats,in particular tensor trains(TT tensors)and multi-polynomials,together with high-dimensional quadrature,*** controlling a destabilized version of viscous Burgers and a diffusion equation with unstable reaction term numerical evidence is given.

关键词： Feedback control Dynamic programming Hamilton-Jacobi-Bellman Tensor product approximation Variational Monte-Carlo