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Infectious Diseases of Poverty 2017年第1期6卷 128-139页

作者： louise Hamill Kim Picozzi Jenna Fyfe Beatrix von Wissmann Sally Wastling Nicola Wardrop Richard Selby Christine Amongi Acup kevin l.Bardosh Dennis Muhanguzi John D.Kabasa Charles Waiswa Susan C.Welburn Edinburgh Infectious Diseases Division of Infection and Pathway MedicineEdinburgh Medical School:Biomedical SciencesThe University of EdinburghChancellor’s Building49 Little France CrescentEdinburgh EH164SBUK Department of Pharmacy Clinical and Comparative MedicineSchool of Veterinary Medicine and Animal ResourcesMakerere UniversityP.O.Box 7062KampalaUganda The Coordinating Office for Control of Trypanosomiasis in Uganda(COCTU) WandegeyaPlot 76/78 Buganda RoadP.O.Box 16345KampalaUganda

Background:Uganda has suffered from a series of epidemics of Human African Trypanosomiasis(HAT),a tsetse transmitted disease,also known as sleeping *** area affected by acute Trypanosoma brucei rhodesiense HAT(rHAT)has been expanding,driven by importation of infected cattle into regions previously free of the *** regions are also affected by African Animal Trypanosomiasis(AAT)demanding a strategy for integrated disease ***:In 2008,the Public Private Partnership,Stamp Out Sleeping Sickness(SOS)administered a single dose of trypanocide to 31486 head of cattle in 29 parishes in Dokolo and Kaberamaido *** study examines the impact of this intervention on the prevalence of rHAT and AAT trypanosomes in cattle from villages that had(HAT^(+ve))or had not(HAT^(-ve))experienced a recent case of *** herds from 20 villages were sampled and screened by PCR,pre-intervention and 6-months post-intervention,for the presence or absence of:Trypanosoma brucei s.l.;human infective ***;Trypanosoma vivax;and Trypanosoma congolense ***:Post-intervention,there was a significant decrease in the prevalence of *** *** the human infective sub-species *** in village cattle across all 20 *** prevalence of *** was reduced from 2.4%to 0.74%(Pllages containing cattle harbouring human infective parasites decreased from 15/20 to 8/20,with *** infection mainly persisting within cattle in HAT^(+ve) villages(six/eight).The proportion of *** *** identified as human infective *** decreased after the intervention from 8.3%(95%CI=11.1-5.9%)to 4.1%(95%CI=6.8-2.3%).Villages that had experienced a recent human case(HAT^(+ve) villages)showed a significantly higher prevalence for AAT both pre-and *** AAT the prevalence of *** was significantly red

关键词： African animal trypanosomiasis(AAT) Human African trypanosomiasis(HAT) Sleeping sickness Trypanosma brucei rhodesiense HAT(rHAT) Uganda T.b.brucei T.b.rhodesiense

Impact of adalimumab on disease burden in moderate-to-severe ulcerative colitis patients: The one-year, real-world UCanADA study

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World Journal of Gastroenterology 2022年第34期28卷 5058-5075页

作者： Talat Bessissow Geoffrey C Nguyen Osman Tarabain laurent Peyrin-Biroulet Nathalie Foucault kevin McHugh Joannie Ruel Department of Medicine McGill University Health CenterMontreal H3G 1A4QuebecCanada Mount Sinai Hospital Inflammatory Bowel Disease Centre Toronto M5T 3L9OntarioCanada Dr.O.Tarabain Clinic Windsor N8W 1E6OntarioCanada Department of Gastroenterology University of LorraineCHRUNancyNancy F-54000France AbbVie Corporation Saint-Laurent H4S 1Z1QuebecCanada Department of Medicine Sherbrooke University Hospital CenterSherbrooke J1H 5N4QuebecCanada

BACKGROUND A gap remains in documenting the impact of anti-tumor necrosis factor therapy on disease burden in ulcerative colitis(UC)patients treated in a real-world *** use of patient-reported outcomes(PROs)has been discussed as a primary endpoint in the context of the FDA PRO Guidance,for labelling ***,the efficacy and safety of adalimumab have been demonstrated in pivotal trials;however,data are needed to understand how clinical results translate into improvements in key aspects of the daily lives of UC patients,such as symptoms,health-related quality of life(HRQol),and *** To assess real-world effectiveness of adalimumab on PRO measures in patients with moderate-to-severe *** UCanADA was a single arm,prospective,1-year multicenter Canadian post-marketing observational study in which multiple PRO questionnaires were completed—with psychologic distress/depression symptoms as the primary endpoint—by patients with moderate-to-severe *** were performed during patients’routine care visit schedule,which was at the initiation of adalimumab(baseline),after induction(approximately 8 wk),and 52 wk after *** optional assessments between weeks 8 and 52 were collected at least once but no more than two times during this *** safety events and per-protocol adverse events were *** From 23 Canadian centres,100 patients were enrolled and 48 completed the *** with the Patient Health Questionnaire–9 items at week 52,61.5%(40/65)[95%confidence interval(CI):49.7%-73.4%]of the patients improved in psychologic distress/depression symptoms,which was slightly higher in completers[65.9%(29/44);95%CI:51.9%-79.9%].At week 52,clinical response and clinical remission were achieved respectively by 65.7%(44/73)and 47.8%(32/73)of the *** odds of improving depressive symptoms for those achieving a clinical remission at week 52 was 7.94 higher compared with those not achieving a clinic

关键词： Disease burden Patient-reported outcome Depressive symptoms Ulcerative colitis Adalimumab Real-world data

Artificial Intelligence in Steam Cracking Modeling: A Deep learning Algorithm for Detailed Effluent Prediction

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Engineering 2019年第6期5卷 1027-1040页

作者： Pieter PPlehiers Steffen HSymoens Ismaël Amghizar Guy B.Marin Christian V.Stevens kevin M.Van Geem laboratory for Chemical Technology Department of MaterialsTextiles and Chemical EngineeringGhent UniversityGent 9052Belgium SynBioC Research Group Department of Green Chemistry and TechnologyFaculty of Bioscience EngineeringGhent UniversityGent 9000Belgium

Chemical processes can bene t tremendously from fast and accurate ef uent composition prediction for plant design, control, and optimization. The Industry 4.0 revolution claims that by introducing machine learning into these elds, substantial economic and environmental gains can be achieved. The bottleneck for high-frequency optimization and process control is often the time necessary to perform the required detailed analyses of, for example, feed and product. To resolve these issues, a framework of four deep learning arti cial neural networks (Dl ANNs) has been developed for the largest chemicals production process steam cracking. The proposed methodology allows both a detailed characterization of a naphtha feedstock and a detailed composition of the steam cracker ef uent to be determined, based on a limited number of commercial naphtha indices and rapidly accessible process characteristics. The detailed char- acterization of a naphtha is predicted from three points on the boiling curve and paraf ns, iso-paraf ns, ole ns, naphthenes, and aronatics (PIONA) characterization. If unavailable, the boiling points are also estimated. Even with estimated boiling points, the developed Dl ANN outperforms several established methods such as maximization of Shannon entropy and traditional ANNs. For feedstock reconstruction, a mean absolute error (MAE) of 0.3 wt% is achieved on the test set, while the MAE of the ef uent predic- tion is 0.1 wt%. When combining all networks using the output of the previous as input to the next the ef uent MAE increases to 0.19 wt%. In addition to the high accuracy of the networks, a major bene t is the negligible computational cost required to obtain the predictions. On a standard Intel i7 processor, predictions are made in the order of milliseconds. Commercial software such as COIlSIM1D performs slightly better in terms of accuracy, but the required central processing unit time per reaction is in the order of seconds. This tremendous speed-up an

关键词： Artificial intelligence Deep learning Steam cracking Artificial neural networks

Endoscopic features of early-stage signet-ring-cell carcinoma of the stomach

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World Journal of Gastrointestinal Endoscopy 2015年第7期7卷 741-746页

作者： Chainarong Phalanusitthepha kevin l Grimes Haruo Ikeda Hiroki Sato Chiaki Sato Chananya Hokierti Haruhiro Inoue Digestive Disease Center Showa University Koto-Toyosu Hospital Minimally Invasive Surgery Unit Division of General Surgery Department of Surgery Faculty of Medicine Siriraj HospitalMahidol University

AIM: To identify the features of early signet ring cell gastric carcinoma using magnification endoscopy with narrow band imaging(NBI).METHODS: A retrospective review was conducted of 12 cases of early signet ring cell gastric carcinoma who underwent treatment in a single institution between January 2009 and April 2013. All patients had magnification endoscopy with NBI and indigo carmine contrast to closely examine the mucosal architecture, including the microvasculature and arrangement of gastric pits. Histologic examination of the final endoscopic submucosal dissection or gastrectomy specimen was performed and compared with the endoscopic findings to identify patterns specific to signet ring cell ***: Twelve patients with early signet ring cell gastric carcinoma were identified; 75% were male, and average age was 61 years. Most of the lesions were stage T1a(83%), while the remainder were T1b(17%). The mean lesion size was 1.4 cm2. On standard endoscopy, all 12 patients had a pale, flat lesion without any evidence of mucosal abnormality such as ulceration, elevation, or depression. On magnification endoscopywith NBI, all of the patients had irregularities in the glands and microvasculature consistent with early gastric cancer. In addition, all 12 patients exhibited the "stretch sign", an elongation or expansion of the architectural structure. Histologic examination of the resected specimens demonstrated an expanded and edematous mucosal layer infiltrated with tumor ***: The "stretch sign" appears to be specific for signet ring cell carcinoma and may aid in the early diagnosis and treatment of this aggressive pathology.

关键词： Signet ring cells Early gastric cancer Magnification endoscopy Narrow band imaging Stretchsign Endoscopic submucosal dissection

Image-guided therapies in the treatment of hepatocellular carcinoma: A multidisciplinary perspective

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World Journal of Hepatology 2015年第2期7卷 235-244页

作者： Jonathon Willatt kevin K Hannawa Julie A Ruma Timothy l Frankel Dawn Owen Pranab M Barman University of Michigan and Veterans Administration Hospital

A multidisciplinary approach to the treatment of patients with unresectable hepatocellular carcinoma(HCC) has led to improvements in screening, detection,and treatments. Interventional techniques includethermal ablation, transarterial chemoembolization, and radioembolization whilst stereotactic body radiation therapy also uses imaging to target the radiation. Both survival rates and cure rates have improved markedly since the introduction of these techniques. This review article describes the image guided techniques used for the treatment of HCC.

关键词： Ablation Chemoembolization Radiation Hepatocellular carcinoma

Breeding for drought tolerance in perennial ryegrass(lolium perenne l.)and tall fescue(lolium arundinaceum[Schreb.]Darbysh.)by exploring genotype by environment by management interactions

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Grassland Research 2023年第1期2卷 22-36页

作者： Claudio C.Fernandes Filho Mario H.Murad leite Andrade Jose A.Rodrigues Nunes Joseph Wipff Debra l.Hignight Esteban F.Rios kevin Kenworthy Kenneth Hignight Biology Department Institute of Natural SciencesUniversidade Federal de LavrasLavrasBrazil Agronomy Department University of FloridaGainesvilleFloridaUSA NexGen Plant Science Center LLCAlbanyOregonUSA NexGen Turf Research LLCAlbanyOregonUSA

Background:Drought‐tolerant turfgrass cultivars are becoming more important each year as landscape irrigation practices are becoming more ***:In this study,we quantified the level of drought tolerance(DT)in perennial ryegrass and tall fescue genotypes across years under different mowing(MH)and fertility(Fl)rates.A total of 48 ryegrass and 38 tall fescue genotypes were planted in 2011 at NexGen,Albany,*** trial was divided into three subtrials:(i)DT;(ii)MH and DT;and(iii)Fl and ***:The results showed that there was significant genetic variance for most of the traits in both *** genotype×year interaction was predominantly simple,indicating small changes in genotype ranking for both *** MH improved DT in perennial ryegrass,whereas higher MH resulted in greater DT in tall *** both species,higher MH improved the population mean for turf *** Fl inputs led to higher turf quality for both species,but it did not affect the DT ***:Using a selection index,six genotypes for perennial ryegrass and four for tall fescue were selected.

关键词： drought stress ryegrass tall fescue turf quality turfgrass breeding

Surgical approaches to the petrous apex

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第2期6卷 106-114页

作者： kevin l.li Vijay Agarwal Howard S.Moskowitz Waleed M.Abuzeid Department of Otorhinolaryngology e Head and Neck Surgery Albert Einstein College of MedicineBronxNYUSA Department of Neurosurgery Albert Einstein College of MedicineBronxNYUSA

The petrous apex is a difficult to reach surgical area due to its deep position in the skull base and many vital surrounding *** apex pathology ranges from extradural cholesterol granulomas,cholesteatomas,asymmetric pneumatization,and osteomyelitis to intradural meningiomas and *** lesions,such as cholesterol granulomas,can be managed with drainage while neoplastic lesions must be completely *** options use open,endoscopic,and combined techniques and are categorized into anterior,lateral,and posterior *** choice of approach is determined by the nature of the pathology and location relative to vital structures and extension into surrounding structures and requires thorough preoperative evaluation and discussion of surgical goals with the *** purpose of this state-of-the-art review is to discuss the most commonly used surgical approaches to the petrous apex,and the anatomy on which these approaches are based.

关键词： Petrous apex Anterior approaches Endoscopic endonasal approach lateral approaches Surgical approaches

Aircraft Brake Dust Dispersion (Airwash) Testing

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Occupational Diseases and Environmental Medicine 2022年第4期10卷 255-261页

作者： Charles l. Blake Robert E. Bailey kevin M. Guth Raymond D. Harbison Apex Companies Marietta GA USA ESi Colorado Springs CO USA Center for Environmental and Occupational Risk Analysis and Management College of Public Health University of South Florida Tampa FL USA

Prior industrial hygiene research involving wheel brake changing on a light general aviation aircraft has shown negligible potential for asbestos fiber exposure to mechanics that perform such work. This is despite the use of organic-style brake friction pads that contained asbestos. It has been otherwise established that chrysotile asbestos is largely degraded to a non-crystalline, amorphous substance by the heat and mechanical shear forces inherent to the braking process. However, trace (le have been found in brake wear dust. Disc-style brakes, the types used on aircraft, are of open design, such that wear dust is typically dispersed into the ambient air during and after brake application. For fixed-gear aircraft, the brake assemblies are also subject to substantial air velocities while the aircraft is in flight. This research was undertaken to measure and characterize the airflows experienced by aircraft wheel assemblies during takeoff, cruise, and landing maneuvers. No wear (brake) dust was observed at any point during the study.

关键词： Aircraft Brakes Asbestos Airwash

Microfungi on Tamarix

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Fungal Diversity 2017年第1期82卷 239-306页

作者： Kasun M.Thambugala Dinushani A.Daranagama Alan J.l.Phillips Timur S.Bulgakov Darbhe J.Bhat Erio Camporesi Ali H.Bahkali Prapassorn D.Eungwanichayapant Zuo-Yi liu kevin D.Hyde Guizhou Key laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China Centre of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand State Key laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China Faculty of Sciences Biosystems and Integrative Sciences Institute(BioISI)University of LisbonCampo Grande1749-016 LisbonPortugal Academy of Biology and Biotechnology Southern Federal UniversityRostov-on-Don344090 Rostov RegionRussia Formerly Department of Botany Goa UniversityGoaIndia Curca No.128/1–JAzad Housing SocietyGoa VelhaIndia A.M.B.Gruppo Micologico ForliveseBAntonio Cicognani^ Via Roma 18ForlìItaly A.M.B.Circolo Micologico BGiovanni Carini^ C.P.314BresciaItaly Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia

Tamarix species are small trees that grow in various natural habitats and have a wide geographic *** species previously found on Tamarix and recently collected in Italy and Russia were identified based on morphological characters and analyses of gene sequence *** sexual morph of the coelomycetous genus Homortomyces was collected for the first time and is described and illustrated.A new family,Homortomycetaceae(Dothideomycetes,families incertae sedis)is introduced to accommodate *** new genera Neomicrosphaeropsis(Didymellaceae)and Tamaricicola(Pleosporaceae)are introduced in this *** tamaricicola was recollected and is placed in Neomicrosphaeropsis based on morphology and molecular *** new species,Cytospora italica,***,Diaporthe ravennica,Eutypella tamaricis,Neomicrosphaeropsis italica,***,***,Keissleriella tamaricicola,Paracamarosporium tamaricis and Tamaricicola muriformis are introduced,while Alternaria tenuissima,Dothiorella sarmentorum,Neofusicoccum luteum,Paraepicoccum amazonense,Pleospora herbarum and Pseudocamarosporium propinquum are reported for the first time on Tamarix *** descriptions and ***-gene analyses show that Paraepicoccum amazonense should be placed in Pleosporineae,Pleosporales,where it is closely related to Camarosporium sensu *** herbarium specimens were studied to illustrate other fungal species recorded on Tamarix species.A comprehensive account of microfungi on Tamarix is provided,which includes a list with data from the literature,as well as those identified in the present *** taxonomic placement of most taxa discussed in this study is based on a modern taxonomic framework based on analysis of multi-gene sequence data.

关键词： Dothideomycetes Homortomycetaceae Incertae sedis New species Phylogeny Pleosporales Sordariomycetes Tamaricaceae Taxonomy