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Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

World journal of Gastroenterology 2016年第11期22卷 3117-3126页

作者： jonathan Landy Emma Ronde Nick english Sue K Clark Ailsa L Hart Stella C Knight Paul j Ciclitira Hafid Omar Al-Hassi IBD Unit St Mark's Hospital Harrow London HA1 3UJ United Kingdom Antigen Presentation Research Group Department of Immunology Imperial College London HA1 3UJ United Kingdom Department of Biosurgery and Surgical Technology Imperial College London HA1 3UJ United Kingdom Department of Gastroenterology The Rayne Institute St Thomas' Hospital London HA1 3UJ United Kingdom

Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer.

关键词： Claudin Tight junction Ulcerative colitis Pouchitis Crohn’ s disease

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james Ensor, 1860-1949

James Ensor, 1860-1949

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作者： Ulrike Becks-Malorny english translation john Gabriel.

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Rembrandt, 1606-1669

Rembrandt, 1606-1669

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作者： Michael Bockemuhl [english translation by Michael Claridge].

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Surrealism

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作者： Cathrin Klingsohr-Leroy Uta Grosenick (Ed.) english translation Isabel Varea.

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Odilon Redon, 1840-1916

Odilon Redon, 1840-1916

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作者： Michael Gibson [english text edited by Chris Miller].

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Exchange 2000 Server管理员手册

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丛书名：微软公司核心技术书库

2001年

作者：（美）Walter j.Glenn （美）Bill english 云舟工作室译

本书详细介绍Exchange 2000 Server的基本概念、安装使用方法、最新功能，涉及该软件的规划、部署、客户端、功能及维护等完整信息。

ISBN: (数字)7111089014

ISBN: (纸本)7111089014

本书详细介绍Exchange 2000 Server的基本概念、安装使用方法、最新功能，涉及该软件的规划、部署、客户端、功能及维护等完整信息。

关键词：互连网络应用程序数据交换

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Vincent van Gogh 1853-1890

Vincent van Gogh 1853-1890

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作者： Ingo F. Walther Rainer Metzger english translation by Valerie Coyle and Axel Molinski.

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Are there sex-based disparities in cataract surgery?

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International journal of Ophthalmology(english edition) 2024年第1期17卷 137-143页

作者： Matthew D.Geiger Anne M.Lynch Alan G.Palestine Nathan C.Grove Karen L.Christopher Richard S.Davidson Michael j.Taravella Naresh Mandava jennifer L.Patnaik Department of Ophthalmology University of Colorado School of MedicineAuroraCO 80045USA

AIM:To investigate sex-based differences in the occurrence of intra-operative and post-operative complications and associated visual outcomes following cataract ***:This was a retrospective study of patients who had phacoemulsification cataract surgery at the University of Colorado School of *** collected included the patient’s health history,ocular comorbidities,operative and post-operative complications,and the post-operative best corrected visual acuity(BCVA).The data were analyzed using univariate and multivariable logistic regression with generalized estimating equations to account for the correlation of some patients having two eyes included in the ***:A total of 11977 eyes from 7253 patients were included in the *** comorbidities differed by sex,with males having significantly higher percentages of traumatic cataracts(males 0.7%vs females 0.1%),prior ocular surgery(6.7%vs 5.5%),and mature cataracts(2.8%vs 1.9%).Conversely,females had significantly higher rates of pseudoexfoliation(2.0%vs 3.2%).In unadjusted analysis,males had higher rates of posterior capsular rupture(0.8%vs 0.4%)and vitreous loss(1.0%vs 0.6%),but this difference was not significant after adjustment for *** had a significantly increased risk of post-operative retinal detachment,but in multivariable analysis this was no longer *** were significantly less likely to undergo post-operative neodymium-doped yttrium aluminum garnet(Nd:YAG)laser capsulotomy for posterior capsule opacification(OR=0.8,95%CI=0.7-0.9,P=0.0005).The BCVA was slightly worse for males pre-operatively;but post-operatively,both sexes exhibited similar visual acuity of Snellen equivalent 20/***:The study finds that in a cohort of patients presenting for cataract surgery,sex differences exist in pre-operative comorbidities and surgical characteristics that contribute to higher rates of some complications for ***,observed surgical complicatio

关键词： cataract surgery sex-based disparity phacoemulsification outcomes

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