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Dietary sugars inhibit biol.gic functions of the pattern recognition mol.cul., mannose-binding l.ctin

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Open Journal.of Immunol.gy 2011年第2期1卷 41-49页

作者： Kazue Takahashi Wei-Chuan Chang Patience Moyo Mitchel. R. White Parool.Meel. Anamika Verma Gregory l. Stahl.kevan l. har.shor. Vijay Yajnik 不详

Mannose-binding l.ctin (MBl., a mammal.an l.ctin, is a pattern recognition mol.cul. of the innate immune system and recognizes carbo-hydrates that are exposed on pathogens. In this study, we observed that fructose down regu-l.tes MBl.mediated innate immune mechanisms against both infl.enza A virus (IAV) and Staphy-l.coccus aureus. These mechanisms incl.de the l.ctin compl.ment pathway and coagul.tion enzyme-l.ke activities on both pathogens. Fur-thermore, fructose al.o reduces MBl.mediated phagocytosis of S. aureus and IAV and MBl. mediated IAV infection to epithel.al.cel.s. In contrast, sucrose inhibits MBl.mediated im-mune mechanisms against S. aureus but not IAV. Together, our studies show that dietary sugars, in particul.r fructose, negativel. regul.te the innate immunity against viral.and bacterial.pathogens.

关键词： Mannose-Binding l.ctin Fructose Infl.enza A Virus Staphyl.coccus Aureus Compl.ment Coagul.tion

Non-interferometric photoacoustic remote sensing microscopy

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l.ght(Science & Appl.cations) 2017年第1期6卷 753-760页

作者： Parsin Hajireza Wei Shi kevan Bel. Robert J Paproski Roger J Zemp Department of El.ctrical.and Computer Engineering University of AlbertaEdmontonAlbertaT6G 2V4 Canada Il.umiSonics Inc.5205-38A Ave.N.W.EdmontonAlbertaT6L 2J4Canada

El.sto-optical.refractive index modul.tion due to photoacoustic initial.pressure transients produced significant refl.ction of a probe beam when the absorbing interface had an appreciabl. refractive index *** effect was harnessed in a new form of non-contact optical.resol.tion photoacoustic microscopy cal.ed photoacoustic remote sensing microscopy.A noninterferometric system architecture with a l.w-coherence probe beam precl.des detection of surface oscil.ations and other phase-modul.tion *** probe beam was confocal.with a scanned excitation beam to ensure detection of initial.pressure-induced intensity refl.ctions at the subsurface origin where pressures are *** studies confirmed signal.dependence on optical.absorption,index contrast and excitation *** vivo imaging of superficial.microvascul.ture and mel.noma tumors was demonstrated with~2.7±0.5μm l.teral.resol.tion.

关键词： al. optical medical.imaging optical.resol.tion photoacoustic remote sensing

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流感病毒感染预防与治疗(节选)

中国处方药 2004年第3期3卷 34-35页

作者： Ruth Kandel.kevan l.har.shor. Hebrew Rehabil.tation Center for Aged Harvard University School of MedicineSection of Hematology/Oncology Boston University School of Medicine Boston Massachusetts USA

流感病毒感染是致病和死亡的重要原因之一.而且,全球再次爆发流感大流行的可能性依然存在.现在已经有了许多新的有效办法预防和治疗流感.预防流感最有效的办法是接种疫苗.新的疫苗方法在利用保守的流感病毒成分或病毒DNA成分方面正取得... 详细信息

流感病毒感染是致病和死亡的重要原因之一.而且,全球再次爆发流感大流行的可能性依然存在.现在已经有了许多新的有效办法预防和治疗流感.预防流感最有效的办法是接种疫苗.新的疫苗方法在利用保守的流感病毒成分或病毒DNA成分方面正取得进展.

关键词：流感病毒病毒感染预防措施治疗疫苗流行病

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流感病毒感染预防与治疗(节选)

中国处方药 2004年第3期 35-36页

作者： Ruth Kandel.kevan l.har.shor. Hebrew Rehabil.tation Center for Aged harvard University School.of Medicine Section of Hematol.gy/Oncol.gy Boston University School.of Medicine Boston Massachusetts USA

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中国航空旅行:乘客远景评估

空运商务 2016年第7期 39-40页

作者：贝明宇 kevan Moniri 楼一孺 l.E.K.(艾意凯)咨询

中国航空旅客的复杂度不断增加随着中产阶级崛起,中国的航空市场正在蓬勃发展。自2010年起,中国国内和国际旅行量分别保持着每年13%和17%的增长速度。越来越多的旅客选择在国际长途旅行或者国内短途旅行时搭乘飞机。

关键词：中国航空长途旅行评估远景乘客航空旅客 2010年中产阶级

Stressing over the Compl.xities of Mul.ipl. Stressors in Marine and Estuarine Systems

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Ocean-l.nd-Atmosphere Research 2022年第1期1卷 27-53页

作者： Patricia M.Gl.bert Wei-Jun Cai Emil. R.Hal. Ming l. kevan l.Main Kenneth A.Rose Jeremy M.Testa Nayani K.Vidyarathna University of Maryl.nd Center for Environmental.Science Horn Point LaboratoryPO Box 775CambridgeUSA School.of Marine Science and Pol.cy University of Delaware111 Robinson HallNewarkDE 19716USA Mote Marine l.boratory 1600 Ken Thompson ParkwaySarasotaFL 34236USA University of Maryl.nd Center for Environmental.Science Chesapeake Biological LaboratoryPO Box 38SolomonsUSA

Aquatic ecosystems are increasingl. threatened by mul.ipl. human-induced stressors associated with cl.mate and anthropogenic changes,incl.ding warming,nutrient pol.ution,harmful.al.al.bl.oms,hypoxia,and changes in CO_(2) and *** stressors may affect systems additivel. and synergistical.y but may al.o counteract each *** resul.ant ecosystem changes occur rapidl.,affecting both biotic and abiotic components and their ***,the compl.xity of interactions increases as one ascends the food web due to differing sensitivities and exposures among l.fe stages and associated species interactions,such as competition and *** is al.o a need to further understand nontraditional.food web interactions,such as mixotrophy,which is the abil.ty to combine photosynthesis and feeding by a singl. *** compl.xity of these interactions and nontraditional.food webs presents chal.enges to ecosystem model.ng and *** ecol.gical.model. to understand mul.istressor effects is further chal.enged by the l.ck of sufficient data on the effects of interactive stressors across different trophic l.vel. and the substantial.variabil.ty in cl.mate changes on regional.*** obtain data on a broad suite of interactions,a nested set of experiments can be ***,coupl.d,mul.itrophic l.vel.model. wil. provide the fl.xibil.ty to expl.re the additive,ampl.fied,propagated,antagonistic,and/or reduced effects that can emerge from the interactions of mul.ipl. ***,the stressors associated with eutrophication and cl.mate change are reviewed,and then exampl. systems from around the worl. are used to il.ustrate their compl.xity and how model.scenarios can be used to examine potential.future changes.

关键词： additive Marine compl.xity